Abstract:
OBJECTIVE:The aim of this work was to verify the tolerability and the preliminary clinical results of intensive intravesical instillations of a mitomycin C (MMC) regimen. PATIENTS AND METHODS:From September 2007 to November 2009, 40 consecutive evaluable patients with pathologically confirmed intermediate-risk non-muscle-invasive bladder cancer (NMIBC) were enrolled after complete transurethral resection of all visible tumors. The mean age of the patients was 64.5 years. 40 mg MMC diluted in 50 ml of saline was instilled in the bladder three times a week for 2 weeks. The median follow-up was 9 months. RESULTS:All patients fulfilled the scheduled treatment. The local adverse events seen were negligible, while no significant deviation from normal values was observed in blood counts for each patient. Twenty-three of 40 patients (57.5%) showed negative at the cystoscopic control which was performed every 3 months with normal spontaneous and washing cytological exams. CONCLUSION:MMC is a well-known chemotherapeutic agent for the intravesical therapy of NMIBC. With a view to improving its results, we changed the frequency and intensity of the instillations. No significant local or systemic toxicity was reported. Intensive intravesical instillations of MMC might become a tool in the management of NMIBC.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Racioppi M,Volpe A,Cappa E,D'Agostino D,Pinto F,D'Addessi A,Sacco E,Bassi Pdoi
10.1159/000315492subject
Has Abstractpub_date
2010-01-01 00:00:00pages
266-9issue
3eissn
0042-1138issn
1423-0399pii
000315492journal_volume
85pub_type
杂志文章abstract:AIM:To compare the efficacy and safety of silodosin versus tamsulosin as medical expulsive therapy for stones of lower-third ureter in children. PATIENTS AND METHODS:This prospective single-blind placebo-controlled randomized study included 167 pediatric patients who presented with distal ureteric stone (DUS) less tha...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000513074
更新日期:2021-02-01 00:00:00
abstract::Urinoma as a presenting sign of carcinoma of the bladder, as occurred in this case, is rare. Aspiration of the cystic mass under sonography and chemistry of the fluid confirmed the diagnosis. The inferior extension of the urinoma on CT scan confirmed the gradual fading of Gerota's fascia into the retroperitoneum. Abdo...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281044
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVES:To review the incidence of healthcare-associated infections/urinary tract infection (UTI), risk factors, microorganisms isolated and antibiotic resistances in patients who underwent lower urinary tract endoscopic surgery (LUTES) in a tertiary care hospital. METHODS:A prospective observational study was carr...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000488251
更新日期:2018-01-01 00:00:00
abstract::Disseminated aspergillosis is a systemic fungal infection that may occur in previously healthy or immunocompromised patients. The condition, although rare, is being recognized with increasing frequency in persons with the human immunodeficiency virus. Clinical genitourinary involvement is unusual. We present a case of...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282752
更新日期:1995-01-01 00:00:00
abstract:INTRODUCTION:Wnt-1 is capable of inducing metanephric mesenchyme to undergo tubulogenesis. A relationship between the degree of cystogenesis and reduced E-cadherin (E-cad) expression was described. Syndecan-1 (Sdc-1) has a critical role in kidney development. MATERIALS AND METHODS:Ten multicystic dysplastic kidneys (M...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000296285
更新日期:2010-01-01 00:00:00
abstract::Of 211 incontinent women the answer to each item of a questionnaire is correlated with the urodynamical data and the discriminative value for the type of incontinence is calculated. The relevant questions are discussed. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281355
更新日期:1988-01-01 00:00:00
abstract:INTRODUCTION:The percentage of positive prostate biopsy cores (%PBC) has been shown to be a prognostic factor in localized prostate cancer. We hypothesized that it would predict time to hormonal independence and survival in prostate cancer patients treated with androgen deprivation therapy (ADT). PATIENTS AND METHODS:...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000230017
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:We report our prospective clinical result of transurethral resection in saline (TURIS) versus monopolar transurethral resection of the prostate (TURP) system in treating large-volume benign prostatic hyperplasia (BPH). PATIENTS AND METHODS:Patients with BPH (volume >50 ml) were enrolled in the study. An int...
journal_title:Urologia internationalis
pub_type: 杂志文章,随机对照试验
doi:10.1159/000224869
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy of transobturator tape (TOT) in the management of stress urinary incontinence at a medium term follow-up. METHODS:TOT is a polypropylene tape positioned through the obturator foramen. 70 patients with type II urinary stress incontinence were treated with TOT between June 2003 and May 2...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000127340
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:To assess the association of prostate volume index (PVI), defined as the ratio of the central transition zone volume to the peripheral zone volume, and prostatic chronic inflammation (PCI) as predictors of prostate cancer (PCA) risk in patients presenting with normal digital rectal exam and prostate-specif...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000502659
更新日期:2019-01-01 00:00:00
abstract::Recordings of local pressure within the membranous urethra were performed in 15 male spinal cord injury patients before and after external sphincterotomy. Transurethral division of the external sphincter reduced the intraurethral pressure by 55% in the upper part of the membranous urethra and by 66% in the lower part....
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000279962
更新日期:1975-01-01 00:00:00
abstract::Emphysematous cystitis is a rare disorder most commonly seen in patients with urinary tract infection and diabetes mellitus. We present a nondiabetic case of a 46-year-old woman with this entity following brain contusion. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030520
更新日期:2000-01-01 00:00:00
abstract::Technetium-labeled red blood cell scintigraphy using a bolus injection was used to obtain a noninvasive quantitative measurement of renal blood flow. The method used is an adaptation of the one used for calculating cerebral blood flow which involves deconvolution of the first pass of the isotope through the kidneys. T...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281863
更新日期:1987-01-01 00:00:00
abstract::A case of spontaneous, partial, unilateral thrombosis of the corpus cavernosum is described. A 35-year-old white male presented with a painful mass in the perineum without priapism. Diagnostic evaluation with sonography and magnetic resonance imaging revealed a thrombosis in the left posterior corporal body. Treatment...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030246
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:To cultivate primary human bladder smooth muscle cells (hBSMCs) in vitro and to study the influences of different sustained hydrostatic pressures upon hBSMCs in terms of cell proliferation and expression of gap-junction connexin 43 (Cx43). METHODS:hBSMCs were exposed to 0, 20, 40, 60, 80 and 100 cm H(2)O su...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000338924
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Augmentation cystoplasty is an effective approach to the detrusor hyperreflexia which is refractory to conservative treatment. Sporadic data have been published in patients with progressive diseases such as multiple sclerosis (MS). MATERIALS AND METHODS:Augmentation ileocystoplasty (Goodwin 'cup-patch') w...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000067708
更新日期:2003-01-01 00:00:00
abstract::Vesicovaginal fistula (VVF) is a quite rare complication of gynecological surgery. The first attempt to repair the fistulous tract offers the best opportunity for cure. We report the successful repair of VVF in 2 patients using a combined anterior vaginal approach and porcine dermal collagen grafting as interposition ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000176038
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:The German Research Activities on Natural Urologicals (GRANU) study was a randomized, partially blinded, placebo-controlled, parallel-group trial that investigated the efficacy of pumpkin seed in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH/LUTS). SUBJECTS AND METH...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000362903
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:We aimed to assess the outcome of free tube graft urethroplasty for single-stage repair of hypospadias with chordee in children. MATERIALS AND METHODS:We retrospectively evaluated a series of 56 patients (16 months to 9 years old, median 24 months) who underwent free graft urethroplasty for repair of hypo...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000504146
更新日期:2020-01-01 00:00:00
abstract::Paragangliomas or extra-adrenal pheochromocytomas account for approximately 15% of all pheochromocytomas. They are usually found in an intradiaphragmatic location. Paragangliomas of the urinary bladder are infrequent and represent 6% of the paragangliomas and 0.06% of all bladder tumors. We describe 2 cases of urinary...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000080841
更新日期:2004-01-01 00:00:00
abstract::The rate of recurrence after internal urethrotomy a.m. Sachse was studied in a prospective, consecutive, randomized series of 43 patients using short-term (1 day) and long-term (14 days) postoperative catheter treatment. No significant difference was found between the two groups according to voiding interview, flowmet...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000280991
更新日期:1984-01-01 00:00:00
abstract:AIM:To analyze demographics, perioperative mortality and overall survival of radical cystectomy (RC) in patients aged 70+ years in Austria in a nation-wide registry cohort. PATIENTS AND METHODS:All patients >69 years who underwent RC in public hospitals (covering >95% of all surgical procedures) in Austria between 199...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000316100
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:This study aimed to determine the safety and efficacy of a modified technique for performing transurethral resection of the prostate (TURP) combined with percutaneous cystolithotripsy (PCCL). METHODS:Clinical data from 24 patients with benign prostate hyperplasia (BPH) and aggregate stone sizes ≥3 cm were...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000437213
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:Basic science studies of ureteral physiology and pathophysiology are commonly performed on animal ureters due to several limitations associated with human ureteral sampling. In this work we question whether animal ureters are good replicas of human ureteral behavior for pharmacological studies. MATERIALS AN...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000358601
更新日期:2015-01-01 00:00:00
abstract::We describe the results after implantation of a urethral stent in 6 patients with recurrent urethral strictures. Four patients had strictures located in close vicinity to the external sphincter. In 3 of these 4 patients open urethroplasty procedures had failed. The treatment was successful in 5 of the 6 patients with ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282181
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:The objective of this study is to describe and analyze the experience over a period of 10 years at our center through a retrospective study of a series of diagnosed and treated cases of penile fracture. MATERIAL AND METHODS:From 2005 to 2009 the Urology Department of the Hospital Clínico San Carlos of Madri...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000324249
更新日期:2011-01-01 00:00:00
abstract::A partial urethral obstruction was induced in female rats. After 6 weeks, detrusor weight had increased eightfold and collagen concentration had decreased to about 40% compared to controls. Due to the weight gain, the total amount of detrusor collagen had increased more than threefold. Removal of the obstruction led t...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282230
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:This study sought to investigate whether ischemia-induced prostate damage during cardiac surgery involving cardiopulmonary bypass causes bladder outlet obstruction. MATERIALS AND METHODS:The study involved 37 men who underwent elective cardiac surgery involving cardiopulmonary bypass. Prostate-specific antig...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000084434
更新日期:2005-01-01 00:00:00
abstract::To evaluate the possible effect of urinary tract infection (UTI) on the fragility of calcium-containing stones (calcium-oxalate, calcium-phosphate), the results of extracorporeal shock wave lithotripsy (ESWL) therapy in 81 patients with UTI and 30 patients with no sign of UTI were comparatively evaluated. ESWL paramet...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282908
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND/AIMS:Periurethral cysts are a rare entity that may be confused with urethral diverticula. The protocol for diagnosis and management of these lesions is still unclear. We present our experience with six patients presenting with periurethral cysts. METHODS:From 2001 to 2005 we evaluated six patients with a pa...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000098068
更新日期:2007-01-01 00:00:00