Abstract:
OBJECTIVES:Basic science studies of ureteral physiology and pathophysiology are commonly performed on animal ureters due to several limitations associated with human ureteral sampling. In this work we question whether animal ureters are good replicas of human ureteral behavior for pharmacological studies. MATERIALS AND METHODS:Ureteral rings from human, porcine and ovine ureters underwent the same organ bath protocol. After stimulation with KCl, ureters were subjected to different doses of vardenafil. Basic contractility and ureteral response to vardenafil were analyzed. RESULTS:A different pattern of basic contractility was evidenced between species. Vardenafil administration induced a dose-dependent reduction in KCl-induced amplitude increase in human ureters and a dose-dependent reduction in autonomic contractile rhythm of porcine and ovine ureters. Although animal ureters could predict the relaxant response of human samples to vardenafil, its effect would have been overestimated using only animal models. CONCLUSIONS:Human ureteral investigations cannot entirely be replaced by existing animal models since results of the latter will vary significantly according to the tested pharmaceutical agent.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Kyriazis I,Kallidonis P,Georgiopoulos I,Al-Aown A,Sakellaropoulos G,Stolzenburg JU,Liatsikos Edoi
10.1159/000358601subject
Has Abstractpub_date
2015-01-01 00:00:00pages
234-9issue
2eissn
0042-1138issn
1423-0399pii
000358601journal_volume
94pub_type
杂志文章abstract::Marfan syndrome is a genetic disease responsible for causing cardiovascular, eye and musculoskeletal damages. Urinary disorders are not common. We present 4 cases of chronic urinary tract symptoms, with 2 different pathophysiological processes. Three patients presented with spinal cord infarct following aortic dissect...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000484696
更新日期:2018-01-01 00:00:00
abstract::Laparoscopic partial nephrectomy (LPN) is increasingly becoming a definitive therapeutic option for the treatment of small (less than 4 cm) and select moderate-sized (less than 7 cm) renal tumors. Postoperative hemorrhage and urine leak are the most pertinent complications after nephron-sparing surgery, open or laparo...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000331905
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:To introduce our modified retroperitoneoscopic living-donor nephrectomy (RPLDN) techniques and estimate the learning curve. METHODS:We retrospectively evaluated 121 consecutive donors who underwent modified RPLDN performed by a single surgeon. While the surgeon controlled the renal vessels, one hand was ins...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000493765
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:We aimed to perform a multi-institutional study using a national database led by the Japanese Society of Endourology to investigate the effect of surgeon or hospital volume on the safety of robot-assisted radical prostatectomy (RARP). MATERIALS AND METHODS:Clinical data of 3,214 patients who underwent RAR...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000460304
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:The treatment of T1G3 bladder cancer is still a controversial issue. Nowadays, intravesical bacillus Calmette-Guérin (BCG) instillation is considered to be the treatment of choice for patients with high-grade superficial bladder tumour after transurethral resection of all visible tumour. The aim of this re...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000066121
更新日期:2002-01-01 00:00:00
abstract:EPIDEMIOLOGY:The annual incidence of urolithiasis in the population is at least 0.1%. In rural areas, there are remarkably less actual stone formers than in urban districts, and also vegetarians show less stone diseases. Calcium carbonate as a urinary calculus compound is not in the strict sense impossible, but often a...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280781
更新日期:1981-01-01 00:00:00
abstract::Nutrition plays a major role in the pathogenesis of the most widespread forms of nephrolithiasis, i.e. calcium (calcium oxalate and phosphate) and uric acid stone disease. For this reason, dietary measures are the first level of intervention in primary prevention, as well as in secondary prevention of recurrences. An ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000076588
更新日期:2004-01-01 00:00:00
abstract:INTRODUCTION:Obesity is usually considered a risk factor for postoperative complications; however, previous studies conclude contradictory results in retroperitoneal laparoscopic adrenalectomy (LA). We aim to evaluate the impact of obesity on the perioperative outcomes of LA. METHODS:A retrospective cohort study from ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000431183
更新日期:2015-01-01 00:00:00
abstract::We performed four living related kidney transplantations from donors with double inferior vena cava (D-IVC), in which the left kidney was selected in two cases and the right in two cases. By dissecting the right internal iliac vein and isolating the right external iliac vein, the surgical procedure of the recipient si...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000077695
更新日期:2004-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280157
更新日期:1977-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282554
更新日期:1993-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析
doi:10.1159/000493169
更新日期:2019-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章,随机对照试验
doi:10.1159/000356327
更新日期:2014-01-01 00:00:00
abstract::A small group of patients with nephrolithiasis who forms mixed (calcium oxalate and uric acid) calculi presents particular problems in their clinical management. In 3,158 stones analyzed in our laboratory, we found 158 mixed calculi in 86 of the patients. In this work, the clinical and biochemical results obtained fro...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:To describe our surgical experience and clinical outcome in laparoscopic radical nephrectomy (LRN) for renal cell carcinoma (RCC) with level 1 renal vein tumor thrombus. PATIENTS AND METHODS:11 patients with RCC level 1 renal vein tumor thrombus were treated by LRN plus thrombectomy. The mean age was 66.8 ye...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000363580
更新日期:2015-01-01 00:00:00
abstract::Varicocele is one of the causes of male infertility. Treatment aims to improve the chance of conception despite lasting controversies about benefits of varicocele repair on fertility. Many techniques have been described for varicocele management including the antegrade scrotal sclerotherapy (ASS). Interestingly, ASS i...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000481831
更新日期:2018-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000132697
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:To evaluate the feasibility and safety of bilateral single-session ureteroscopy in the treatment of bilateral stones with different localizations. MATERIALS AND METHODS:Between February 2001 and October 2006, a total of 1,296 patients underwent ureteroscopy with pneumatic lithotripsy. Of these, 38 patient...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000144061
更新日期:2008-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030510
更新日期:2000-01-01 00:00:00
abstract:PURPOSE:This article describes our experience of using a totally extraperitoneal approach for endoscopic pelvic lymphadenectomy and inguinal hernia repair with the mesh technique in one procedure. MATERIALS AND METHODS:A total of 52 patients underwent modified pelvic lymph node dissection for the staging of prostate c...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000050938
更新日期:2001-01-01 00:00:00
abstract::Marked differences were observed in the mechanical reactions of human and guinea pig vas deferens to prostaglandins, irradiation, and cooling. In human preparations prostaglandin E1 (0.1-1 ng/ml) had an augmentory effect on the contractile response after electrical neurostimulation (10 Hz, 0.3 ms, 3 s), but no visible...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280898
更新日期:1983-01-01 00:00:00
abstract::A medium that had been conditioned by PC-3 cells stimulated the calcification of a human osteoblastic cell line, Tak-10, in a nonmitogenic culture. The calcification of the osteoblasts was stimulated maximally at a 25% concentration of the conditioned medium. Calcification activity was markedly enhanced by the additio...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282291
更新日期:1992-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000448434
更新日期:2017-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280126
更新日期:1977-01-01 00:00:00
abstract::The momentary entry of urine into the proximal urethra during coughing can be demonstrated by a new test which can be conducted using apparatus now commonly available for urodynamic investigations. If the bladder neck opens, a fluid bridge is established between points of pressure measurement in the bladder and in the...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280287
更新日期:1979-01-01 00:00:00
abstract::In 231 adults the frequency and the pattern of the retroaortic left renal vein were studied. We observed a retroaortic left renal vein in 9.09% ("renal collar" in 5.62%, single retroaortic left renal vein in 3.46%. According to our results and to the findings in the literature a retroaortic left renal vein can be expe...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000279997
更新日期:1975-01-01 00:00:00
abstract:INTRODUCTION:Intravesical epirubicin is a widely used agent for the treatment of superficial bladder cancer. A direct relationship between dose and activity has been reported: unfortunately the dose increase also increased the frequency and the intensity of treatment-related side effects. MATERIALS AND METHODS:A phase...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章
doi:10.1159/000058438
更新日期:2002-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282354
更新日期:1992-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000324098
更新日期:2011-01-01 00:00:00
abstract::Between January 1985 and October 1991, 54 patients with calculi in a solitary kidney were treated by ESWL using the Dornier HM-3 lithotriptor. The mean age of the patients was 53.9 years (range 24-77 years). In 51.9% of the cases the stones measured > 1 cm in diameter, in 42.6% between 0.4 and 1 cm, and in 5.5% < 0.4 ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000282591
更新日期:1994-01-01 00:00:00