Abstract:
:Marked differences were observed in the mechanical reactions of human and guinea pig vas deferens to prostaglandins, irradiation, and cooling. In human preparations prostaglandin E1 (0.1-1 ng/ml) had an augmentory effect on the contractile response after electrical neurostimulation (10 Hz, 0.3 ms, 3 s), but no visible influence (at concentrations ranging from 1 ng to 10 micrograms/ml) on the contractile response after electrical muscle stimulation (10 Hz, 40 ms, 3 s). In contrast, in guinea pig preparations (PGE1 (0.1-1 ng/ml) had an inhibitory effect on the contractile response after electrical neurostimulation and an augmentory effect (0.1-1 micrograms/ml) on the contractile response after electrical muscular stimulation. Human vas deferens showed higher radiosensitivity than guinea pig preparations. The neurotransmitters acetylcholine and catecholamines increased the radiosensitivity of guinea pig preparations, but not of human ones. Vas deferens reacted to short-time (15-120 s) cooling with an immediate temporary contraction, at 25 degrees C of short (seconds), at 5 degrees C of long (minutes) duration; after rewarming (5-37 degrees C) a second contraction appeared in guinea pig preparations, but not in human ones. Whereas the contraction to electrical neurostimulation (10 Hz, 0.3 ms, 3 s) was abolished in human preparations by cooling, it was only inhibited in guinea pig vas deferens. Electron microscopy showed differences in the ultrastructure of human and guinea pig vas deferens. Muscle cells were more widely separated in human vas deferens (generally 400 nm or more) than in guinea pig (approximately 100-200 nm), and the intracellular space in human preparations contained more collagen. The axons in human preparations contained predominantly large granular and agranular vesicles, those in guinea pig preparations small granular and agranular vesicles. The possible correlation between the physiological response of human and guinea pig vas deferens and the ultrastructural differences is discussed. The results indicate the possibility that other pharmacophysiological and toxicological phenomena could be essentially different in human and guinea pig material.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Michailov MC,Murray AB,Zettler F,Grindler-Greimel HWdoi
10.1159/000280898subject
Has Abstractpub_date
1983-01-01 00:00:00pages
234-42issue
4eissn
0042-1138issn
1423-0399journal_volume
38pub_type
杂志文章abstract:AIM:To evaluate outcomes of laparoscopic adrenalectomy (LA) and laparoendoscopic single-site surgery (LESS) for adrenal masses in the light of changing laparoscopic surgical techniques. MATERIALS AND METHODS:Seventy-three patients were analyzed retrospectively. There were 2 groups; group 1 included patients who had co...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000351959
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:The study aimed to evaluate the predictive value of ureteral wall thickness (UWT) and stone-related parameters for medical expulsive therapy (MET) success with an alpha blocker in pediatric upper ureteral stones. PATIENTS AND METHODS:A total of 35 children receiving MET ureteral stones (<10 mm) were evaluate...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000453668
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:The aim of this work was to verify the tolerability and the preliminary clinical results of intensive intravesical instillations of a mitomycin C (MMC) regimen. PATIENTS AND METHODS:From September 2007 to November 2009, 40 consecutive evaluable patients with pathologically confirmed intermediate-risk non-mus...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000315492
更新日期:2010-01-01 00:00:00
abstract::We examined Southern blot analysis of genomic DNAs from 70 patients with sporadic renal cell carcinoma, using the human L-myc oncogene fragment as a hybridization probe. Our purpose was to study the relationship between the restriction fragment length polymorphism (RFLP) of the L-myc and the frequencies of metastasis....
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282261
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:The principle of treating male infertility in those with chromosomal aberrations should change according to progress in treatment modalities. METHODS:In this study, ten patients with Robertsonian translocation were assessed for their cytogenetic and clinical characteristics to establish guidelines for treat...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000066122
更新日期:2002-01-01 00:00:00
abstract::Modern LDR brachytherapy has drastically reduced rectal toxicity and decreased the occurrence of rectourethral fistulas to <0.5% of patients. Therefore, symptoms of late-onset sequelae are often ignored initially. These fistulas cause severe patient morbidity and require interdisciplinary treatment. We report on the o...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000209374
更新日期:2009-01-01 00:00:00
abstract::Prazosin HCl was administered to 20 patients with urinary obstructions associated with prostatic hypertrophy. Significant reductions were recorded in the nighttime and the mean 24-hour urination frequencies. Patient-assessed symptoms diminished significantly, and uroflowmetry revealed significant increases in average ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282023
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:The initial objective of this renal cancer study was to identify gene sets in clear cell renal cell carcinoma (ccRCC) to support grading of ccRCC histopathology. MATERIALS AND METHODS:Preselected ccRCC tumor tissues of grade 1 (G1, n = 14) and grade 3 (G3, n = 15) as well es 14 normal kidney tissues thereof ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000328196
更新日期:2011-01-01 00:00:00
abstract::The term infection stones refers to calculi that occur following urinary tract infections (UTIs) caused by urease-producing gram-negative organisms. They consist of magnesium ammonium phosphate, carbonate apatite and monoammonium urate. Alkaline urine is most favorable to their formation. Urinary tract obstruction, ne...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000104439
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:To assess the role of color Doppler flow imaging (CDFI) in the evaluation of Chinese patients with erectile dysfunction (ED) and to explore the association between penile rigidity and hemodynamic parameters of CDFI. METHODS:Totally 74 ED patients with an age range of 22-69 (median age 47) were included in o...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000127350
更新日期:2008-01-01 00:00:00
abstract::Chromosomal anomalies may be a reason for male infertility. To find out whether this is true mitotic chromosome studies were performed on 41 males with azoospermia and 61 males with oligozoospermia. A constitutional chromosomal abnormality was diagnosed in 14 (34.1%) azoospermic patients and in 2 (3.3%) oligozoospermi...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030280
更新日期:1998-10-01 00:00:00
abstract::In unilateral kidney disease, it has been suggested that the ipsilateral state could be estimated by measuring contralateral kidney size; thus, a contralateral increase should reflect an ipsilateral impairment and vice versa. This could easily be performed using ultrasound. In our experiments with partial obstruction ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282898
更新日期:1996-01-01 00:00:00
abstract::The first case of carcinosarcoma in the spermatic cord is reported in a 40-year-old man. The tumor was a 2.5 X 2 cm pseudoencapsulated formation located in the connective tissue of the spermatic cord among the blood vessels. Light microscopy examination of the neoplasm revealed two different histological patterns: epi...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281727
更新日期:1990-01-01 00:00:00
abstract::Disseminated aspergillosis is a systemic fungal infection that may occur in previously healthy or immunocompromised patients. The condition, although rare, is being recognized with increasing frequency in persons with the human immunodeficiency virus. Clinical genitourinary involvement is unusual. We present a case of...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282752
更新日期:1995-01-01 00:00:00
abstract::Adrenocortical carcinoma (ACC) is a rare and highly malignant neoplasm. We present the case of a 51-year-old male patient with a left-sided ACC admitted to hospital with ipsilateral flank pain, weight loss, difficulty in breathing, abdominal discomfort and swelling and bilateral leg edema. Thoracoabdominal computed to...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000144071
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the intervention effect of sacral neuromodulation (SNM) in the treatment of lower urinary tract dysfunction after spinal cord injury (SCI). METHODS:We selected relevant studies published between January 1, 1971 and November 15, 2018 by searching the PubMed, EMBASE, Cochrane databases. The outcome...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析
doi:10.1159/000501529
更新日期:2019-01-01 00:00:00
abstract::A review of the recent literature on the surgical management of anterior urethral stricture was performed. The literature was searched via PubMed using the search terms 'urethral stricture' and 'urethroplasty' from 1996 to 2009. The management of anterior urethral strictures is changing rapidly in the sense that the r...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000319501
更新日期:2011-01-01 00:00:00
abstract::During 1986 and 1987, 47 patients with renal cell carcinoma were evaluated preoperatively with CT, angiography and MRI. The preoperative tumor stage (T), lymph node metastases and venous involvement determined with the three methods were compared to the operative and histopathological findings. For T stage, angiograph...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282219
更新日期:1991-01-01 00:00:00
abstract::In order to assess the clinical implications of the cytology of voided urine we analyzed 65 patients among 147 cases of transitional cell carcinoma (TCC) in relation to the cytohistologic correlation and prognostic significance. Urinary cytology detected 42.6% of bladder tumors, 59% of renal pelvic tumors, and 35.3% o...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282625
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND/AIMS:Periurethral cysts are a rare entity that may be confused with urethral diverticula. The protocol for diagnosis and management of these lesions is still unclear. We present our experience with six patients presenting with periurethral cysts. METHODS:From 2001 to 2005 we evaluated six patients with a pa...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000098068
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Micropapillary carcinoma (MPC) of the bladder is a rare and aggressive histologic variant of urothelial carcinoma (UC). At the time of presentation, most MPC are muscle invasive with frequent vascular invasion (VI). Our series explores protein expression of markers known to be indicators of poor clinical o...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000209364
更新日期:2009-01-01 00:00:00
abstract::We report the first case of aspergillus mycotic aneurysm as a sequel to concomitant prostatic and renal aspergillosis. The patient had undergone left nephrectomy and transurethral resection of prostate for aspergillus infection one year ago. He again presented with LUTS and backache and clinical examination showed vis...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000056561
更新日期:2001-01-01 00:00:00
abstract::A medium that had been conditioned by PC-3 cells stimulated the calcification of a human osteoblastic cell line, Tak-10, in a nonmitogenic culture. The calcification of the osteoblasts was stimulated maximally at a 25% concentration of the conditioned medium. Calcification activity was markedly enhanced by the additio...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282291
更新日期:1992-01-01 00:00:00
abstract::Testicular sperm extraction and intracytoplasmic sperm injection (TESE-ICSI) is a frequently used therapeutic option in azoospermic males. Genetic imprinting is a mechanism of gene regulation - mediated by the methylation of deoxyribonucleic acids (DNA) - by which only one of the parental copies of a gene is expressed...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000050972
更新日期:2001-01-01 00:00:00
abstract:INTRODUCTION:We aimed to evaluate the predictive factors in a holistic manner for ureterorenoscopy (URS) outcomes in proximal ureteral stones by a multicenter study. MATERIALS AND METHODS:The data of patients who underwent URS for proximal ureteral stones between the years 2015 and 2018 in eight centers were recorded ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000504790
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Wnt-1 is capable of inducing metanephric mesenchyme to undergo tubulogenesis. A relationship between the degree of cystogenesis and reduced E-cadherin (E-cad) expression was described. Syndecan-1 (Sdc-1) has a critical role in kidney development. MATERIALS AND METHODS:Ten multicystic dysplastic kidneys (M...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000296285
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVES:To develop risk predictive models of postpartum stress urinary incontinence (SUI) for both primiparous and multiparous women. MATERIALS AND METHODS:From July 2016 to July 2017, 815 singleton pregnant women without incontinence before pregnancy who were 18 years or older and admitted to 2 hospitals in Shenzh...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000508416
更新日期:2020-01-01 00:00:00
abstract::An unusual case of metastatic carcinoma of prostate, which presented as a huge abdominal mass and responded extremely well to endocrine therapy, is presented. The literature is reviewed. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281205
更新日期:1986-01-01 00:00:00
abstract::Carcinoma of the bladder following augmentation cystoplasty is rare. Only 15 cases have been reported worldwide. We report a further 2 cases, 1 of which, a squamous cell carcinoma, has not previously been described in this context. ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000030479
更新日期:2000-01-01 00:00:00
abstract::Ninety-five patients with erectile dysfunction underwent standardized cavernosometry and cavernosography. In a first stage, the investigation was performed in each patient without and in a second stage with 60 mg papaverine injected intracavernously. A pathological maintenance flow rate between 20 and 120 ml/min decre...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282389
更新日期:1992-01-01 00:00:00