Abstract:
INTRODUCTION:Wnt-1 is capable of inducing metanephric mesenchyme to undergo tubulogenesis. A relationship between the degree of cystogenesis and reduced E-cadherin (E-cad) expression was described. Syndecan-1 (Sdc-1) has a critical role in kidney development. MATERIALS AND METHODS:Ten multicystic dysplastic kidneys (MCDKs) were stained with hematoxylin and eosin and immunohistochemistry was performed using Wnt-1, E-cad and Sdc-1 antibodies. Eight unaffected kidneys were used as controls. RESULTS:Strong Wnt-1 immunostaining occurred inside cystic/tubular epithelial cells and in blastematous foci. An immunoreaction was observed in glomerular epithelial cells. In controls, just weak cytoplasmic Wnt-1 positivity was seen in tubular epithelial cells. E-cad reaction was negative in MCDKs while strong immunostaining was common in tubular cells of controls. A strong Sdc-1 immunoreaction depicted cystic, tubular and glomerular epithelial cells in MCDKs while Sdc-1 expression documented weak positivity in tubular epithelium alone. CONCLUSIONS:Our data are in accordance with an involvement of Wnt-1 in normal nephrogenesis and with its role in altered epithelial differentiation of metanephric mesenchyme in MCDKs. Wnt-1 signal may function to suppress E-cad expression, a predisposing event for cystogenesis. High expression of Sdc-1 in tubular/cystic epithelial cells of MCDKs might alter the normal transition of stages of the developmental process and modify the anion charge of the glomerular barrier.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Arena S,Fazzari C,Scuderi MG,Implatini A,Villari D,Torre S,Arena F,Di Benedetto Vdoi
10.1159/000296285subject
Has Abstractpub_date
2010-01-01 00:00:00pages
106-11issue
1eissn
0042-1138issn
1423-0399pii
000296285journal_volume
85pub_type
杂志文章abstract::A 50-year-old man with hemophilia A presented with recurrent hematuria due to renal stone disease. He was receiving approximately 50,000 units of recombinant factor (rF) VIII concentrate every year due to hematuria. Between 1996 and 2002, his serum creatinine level increased from 0.7 to 1.2 ng/ml. In an effort to reso...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000100846
更新日期:2007-01-01 00:00:00
abstract::A 74-year-old man with a right inguinal hernia since 15 years was admitted because of inguinal pain and enlarged ipsilateral testis. Surgical exploration revealed a hernia with an empty hernial sac and three tumoral masses in the spermatic cord. Tumoral masses, spermatic cord, and testis were removed. Histological exa...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281335
更新日期:1988-01-01 00:00:00
abstract:INTRODUCTION:Epididymitis is an inflammation or infection of the epididymis, a convoluted duct that lies on the posterior surface of the testicle. Oxidative stress due to excessive production of reactive oxygen species in epididymitis, impaired antioxidant defense mechanisms, or both, precipitates a range of pathologie...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000092063
更新日期:2006-01-01 00:00:00
abstract::Injuries of the penis are uncommon but represent urological emergencies. We report 3 cases of penile trauma illustrating the diversity of penile injury presentation. Radiological investigations are only mandatory if there is any suspicion of a urethral injury. Primary surgical approach is recommended in cases of penil...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000151421
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Male infertility caused by azoospermia due to non-reconstructable obstruction or non-obstructive azoospermia can be treated by microsurgical epididymal aspiration (MESA) or testicular sperm extraction (TESE) followed by an intracytoplasmatic spermatozoa injection (ICSI). MATERIAL AND METHODS:From 9/93 to ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000068185
更新日期:2003-01-01 00:00:00
abstract::Idiopathic scrotal calcinosis is a rare, benign condition characterized by progressive calcification of the scrotal skin. A 29-year-old man who had undergone primary surgical excision of idiopathic scrotal calcinosis 7 years previously presented with recurrence that he had first noticed 3 years after surgery. Multiple...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000350240
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:To evaluate the association between preoperative serum prolactin (PRL) levels and risk of non-organ confined prostate cancer (PCa) in clinically localized disease. MATERIALS AND METHODS:From December 2007 to December 2011, 124 patients with clinically localized PCa were retrospectively evaluated. Non-orga...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000496833
更新日期:2019-01-01 00:00:00
abstract::To evaluate the possible effect of urinary tract infection (UTI) on the fragility of calcium-containing stones (calcium-oxalate, calcium-phosphate), the results of extracorporeal shock wave lithotripsy (ESWL) therapy in 81 patients with UTI and 30 patients with no sign of UTI were comparatively evaluated. ESWL paramet...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282908
更新日期:1996-01-01 00:00:00
abstract::We performed sonography in 7 males with membranous and posterior urethral calculi. Sonography demonstrated the urethral calculi in all 7 patients. These findings suggest that sonography is useful as a noninvasive screening technique for urethral calculi. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282484
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVES:To provide a systematic review and meta-analysis of studies comparing ureterolithotripsy (URS) with percutaneous nephrolithotripsy (PCNL) or laparoscopic ureterolithotomy (LU) techniques for the management of large proximal ureteral stones (diameter greater than 10 mm). METHODS:A literature search was perfo...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000471773
更新日期:2017-01-01 00:00:00
abstract:AIM:To clarify the factors affecting the success rate of endoscopic subureteral injection (ESI) treatment of vesicoureteral reflux (VUR). METHOD:All patients who had ESI treatment for VUR at our unit between 1999 and 2002 were retrospectively reviewed with regard to age, gender, causes of VUR, reflux grade, type of in...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000137639
更新日期:2008-01-01 00:00:00
abstract::We present a 17-year-old patient with a right testicular dislocation. In this case, dislocated testis had been considered as hematoma and therefore remained untreated for 4 months. The patient underwent right orchiopexy 4 months after the injury. Intraoperative testicular biopsy revealed impaired spermatogenesis and e...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282830
更新日期:1996-01-01 00:00:00
abstract:INTRODUCTION:In order to accurately assess the extent of chronic pelvic pain syndrome (CPPS) and to objectively measure symptoms for natural history studies and to assess the outcome parameters for clinical trials, the National Institutes of Health (NIH) Chronic Prostatitis Collaborative Research Network developed and ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000094814
更新日期:2006-01-01 00:00:00
abstract::Both under physiologic conditions and after short-term ischemia (1-3 min) kallikrein and locally synthesized prostaglandins contribute to control renal blood flow. In the present experiment the antiproteases aprotinin and gabexate-mesilate were administered to rabbits in an attempt to show whether the hemodynamic chan...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280880
更新日期:1983-01-01 00:00:00
abstract::Bacillus Calmette-Guérin (BCG) immunotherapy is the most effective treatment for carcinoma in situ and high-risk non-muscle invasive bladder cancer (NMIBC). However, it can also provoke diverse side effects. We found 1 patient with a significantly and rapidly reduced bladder volume after the instillation of BCG. Few s...
journal_title:Urologia internationalis
pub_type:
doi:10.1159/000510167
更新日期:2021-01-01 00:00:00
abstract::The purpose of this study was to make a model of renal vasoconstriction induced by mechanical manipulation of the renal artery and to investigate the influence of endothelin (ET) in renal vasoconstriction. Renal arteries of anesthetized rats were stretched with a 30-gram weight for 5 min, and released. Renal blood flo...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030510
更新日期:2000-01-01 00:00:00
abstract:AIM:To evaluate the efficacy of a new sclerotization technique with pure ethanol in the treatment of symptomatic renal cysts. PATIENTS AND METHODS:Fourteen patients having renal cysts with a meant diameter of 10 (range 5-15) cm were treated. Our technique includes: ultrasound-guided percutaneous puncture with an 18-ga...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000071846
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:To assess MRI/Transrectal Ultrasound (TRUS) fusion three-dimensional model-guided targeted biopsy (3D-Tb) versus TRUS-guided systematic biopsy (Sb) in detecting overall and high-Gleason-score (≥7) prostate cancer (PCa). METHODS:Pubmed and Web of science were searched. Studies with men having a suspicious lesio...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000484144
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:Intravesical epirubicin is a widely used agent for the treatment of superficial bladder cancer. A direct relationship between dose and activity has been reported: unfortunately the dose increase also increased the frequency and the intensity of treatment-related side effects. MATERIALS AND METHODS:A phase...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章
doi:10.1159/000058438
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Limited data are available for the use of agents in metastatic castration-resistant prostate cancer (mCRPC) beyond the third-line. We provide data during treatment with cabazitaxel (CAB), helping to improve the informed-consent process. PATIENTS AND METHODS:We retrospectively reviewed patients treated with ...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究,评审
doi:10.1159/000477943
更新日期:2017-01-01 00:00:00
abstract::We report on a unique-sized large leiomyoma of the bladder wall in a male patient. After open surgical intervention all symptoms resolved spontaneously and no relapse occurred within a 3-year follow-up period. In conclusion, for symptomatic leiomyoma of the bladder surgical intervention should be considered as an earl...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030317
更新日期:1998-01-01 00:00:00
abstract:INTRODUCTION:There are relatively few studies that compare the use of transrectal ultrasound (TRUS) to magnetic resonance imaging (MRI) to estimate the prostate volume. In this study, we compared the prostate volumes measured with MRI and TRUS with a surgical specimen volume. PATIENTS AND METHODS:Seventy-three patient...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000100836
更新日期:2007-01-01 00:00:00
abstract::A new device for the simultaneous in vivo measurement of pressure and developed force in the ureter is introduced. The 5-French catheter was cystoscopically inserted into the ureters of 12 dogs under anesthesia. The forms of the peristaltic waves for pressure and force show considerable differences. A basal force anal...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282119
更新日期:1991-01-01 00:00:00
abstract:INTRODUCTION:The urinary bladder is commonly involved in pelvic malignancy. The incidence of apparent extension into adjacent organs in locally advanced colorectal malignancy is 5-12%. It is not known with other pelvic malignancy. No guidelines are available for its management. Often a dilemma exists between cystectomy...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000092929
更新日期:2006-01-01 00:00:00
abstract::Cystinuria is a rare cause of renal calculi, whose management presents a complex problem mainly due to the hardness and high recurrence rate of cystine stones. During the period 1987-1991, 28 established cases of cystine calculi were treated by extracorporeal shock wave lithotripsy (ESWL) and percutaneous nephrolithot...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282836
更新日期:1996-01-01 00:00:00
abstract:INTRODUCTION:The aim of our study was to determine the validity of the updated nomogram [Briganti et al.: Eur Urol 2012;61:480-487] as a prediction tool for pelvic lymph node invasion (LNI) in the current era by using a large multicentric population of men who underwent extended pelvic lymph node dissection (ePLND) at ...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000343993
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Microchimerism (MC) is the presence of a small amount of foreign cells or DNA within a person's circulation or tissues. It has been identified also in recipients of solid organ transplants where it seems to be critical for the development and maintenance of immunological tolerance. Nevertheless, natural an...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000508796
更新日期:2020-01-01 00:00:00
abstract::Presuming that complications associated with ureteral stenting vary in type and occurrence depending on the material and cross-section of the stent, six types of stents immersed in 48 different preparations of artificial urine for 1 month to observe surface changes with a scanning electron microscope. As a result, the...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282206
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Despite advances in immunosuppressant medications, improvement in long-term survival for kidney transplant recipients has been more difficult to achieve. In fact, the number of patients with failing grafts who must either return to dialysis or undergo a second transplant is increasing. Second transplantation...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000499490
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:The purpose of this study was to determine whether periurethral injection of allogenic mesenchymal stem cells (MSCs) could increase the leak point pressure (LPP) in a rat model of stress urinary incontinence. MATERIALS AND METHODS:Female Sprague-Dawley rats (230-240 g, n = 30) were divided into 3 groups: sham ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000317322
更新日期:2011-01-01 00:00:00