Abstract:
INTRODUCTION:Epididymitis is an inflammation or infection of the epididymis, a convoluted duct that lies on the posterior surface of the testicle. Oxidative stress due to excessive production of reactive oxygen species in epididymitis, impaired antioxidant defense mechanisms, or both, precipitates a range of pathologies that are currently believed to negatively affect the male reproductive function. How oxidative stress affects the testes is still unknown. We aimed to investigate the oxidative and antioxidative status of testes of rats with unilateral acute Escherichia coli epididymitis. METHODS:The study included 36 male Wistar albino rats which were divided into three groups. In the epididymitis group (n = 12), an E. coli suspension was injected into the right ductus deferens of rats, and the same amount of saline was injected in the saline groups (n = 12). No surgery was performed in the control group (n = 12) for baseline values. Rats were sacrificed after 24 h and the epididymis and testes removed. The infection was confirmed by histopathologic evaluation and microbiological tests. The oxidative status of testes was evaluated by measuring myeloperoxidase (MPO) activity, and antioxidative status was evaluated by measuring total antioxidant response (TAR) and total antioxidant capacity levels (TAC). RESULTS:MPO activity in both the ipsilateral and contralateral testes of the epididymitis group was significantly higher than those of the saline and control groups (p < 0.05). The TAR and TAC levels in both testes were also significantly elevated in the epididymitis group versus the two other groups (p < 0.05). CONCLUSIONS:Acute epididymitis causes an increase of oxidative stress in the ipsilateral and contralateral testes, but this condition is strived for to tolerate the increase of endogenous antioxidants.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Kaya M,Boleken ME,Zeyrek F,Ozardali I,Kanmaz T,Erel O,Yücesan Sdoi
10.1159/000092063subject
Has Abstractpub_date
2006-01-01 00:00:00pages
353-8issue
4eissn
0042-1138issn
1423-0399pii
92063journal_volume
76pub_type
杂志文章abstract:BACKGROUND:Cyclooxygenase-2 (COX-2) is a key enzyme involved in the production of prostaglandins and its inhibitors have been shown to induce apoptosis in a variety of cancer cells. We reasoned that combination treatment of renal cell carcinoma (RCC) cells with COX-2 inhibitors and anticancer agents may result in syner...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000288243
更新日期:2010-01-01 00:00:00
abstract::Alpha-fetoprotein (AFP) is recognized as a tumor marker of yolk sac tumors, liver cancer and some other cancers of the digestive organs. Renal cell carcinoma (RCC) producing AFP is a rare entity. A case of AFP-producing RCC with solitary bone metastasis, but without liver involvement, is reported. The stain specific t...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000050982
更新日期:2001-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000496208
更新日期:2019-01-01 00:00:00
abstract::Fifty consecutive female patients with genuine urinary stress incontinence were randomized either to surgery or to a pelvic floor training program. The operative procedure was chosen according to the type of bladder suspension defect on micturition cystourethrography. The training program was given 5 times in weekly l...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000281181
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abstract:OBJECTIVES:We compared the applicability and reproducibility of the condom catheter method for noninvasive urodynamics in two Dutch studies. MATERIALS AND METHODS:A longitudinal study of changes in bladder contractility secondary to benign prostatic enlargement is taking place at the Erasmus MC in Rotterdam. Volunteer...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
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journal_title:Urologia internationalis
pub_type: 杂志文章
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journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析,评审
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journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Urologia internationalis
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000368912
更新日期:2015-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000075277
更新日期:2004-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282625
更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章,随机对照试验
doi:10.1159/000345050
更新日期:2013-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000056561
更新日期:2001-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000144071
更新日期:2008-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030222
更新日期:1998-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000030246
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更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000448482
更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000279981
更新日期:1975-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000067708
更新日期:2003-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1992-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000072690
更新日期:2003-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000350237
更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
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更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00