Abstract:
OBJECTIVE:This present study was undertaken to determine the levels of malondialdehyde (MDA), nitric oxide (NO) and total antioxidant status (TAS) in testes of adolescent rats with experimental bilateral varicocele and to determine the effects of oxidative stress on testis produced by varicocele. METHODS:6-week-old, male Wistar rats, weighing 146-334 g (228.37 +/- 41.34 g), were randomly allocated into two groups. The first group underwent selective and bilateral partial ligation of the spermatic vein (n = 28), and the second group underwent a sham operation and served as the controls (n = 15). Animals were sacrificed 12 weeks after surgery and dilatation of the spermatic veins was observed in the first study group. Bilateral orchiectomy was performed in all rats, and MDA, NO and TAS levels were measured. RESULTS:In the study group, the mean MDA (SEM) level was 15.58 +/- 6.07 micromol/g protein, and in the control group, it was 11.59 +/- 3.86 micromol/g protein, respectively; this difference was statistically significant (p < 0.05). The mean NO level was 82.73 +/- 77.84 nmol/g protein in the study group, whereas 28.65 +/- 20.18 nmol/g protein in the control group, this difference was also statistically significant (p < 0.005). The mean TAS levels of the study and control groups were 0.91 +/- 0.32 and 1.78 +/- 0.46 nmol/g tissue, respectively, and this difference was also statistically significant (p < 0.001). But there was no correlation between these three parameters (MDA<-->TAS: r = -0.103, p > 0.05; MDA<-->NO: r = -0.104, p > 0.05; NO<-->TAS: r = -0.123, p > 0.05). CONCLUSION:These findings suggest that varicocele may change the testicular oxidative status and may play a role in testicular dysfunction that causes infertility.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Ozdamar AS,Soylu AG,Culha M,Ozden M,Gökalp Adoi
10.1159/000081596subject
Has Abstractpub_date
2004-01-01 00:00:00pages
343-7issue
4eissn
0042-1138issn
1423-0399pii
81596journal_volume
73pub_type
杂志文章abstract:BACKGROUND:Laparoscopic adrenalectomy is the gold standard for treatment of benign adrenal lesions. Tumor size is a factor that might influence decision-making concerning the use of laparoscopic approach. The aim of this study was to analyze the results of adrenalectomy for tumors ≥6 cm in diameter. METHODS:Two groups...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000444146
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Distal ureteric calculi remain a widely debated topic without clear consensus on expectant management. This systematic review aims to assess the placebo arms of RCTs to extrapolate data on the natural history of distal ureteral stones and ascertain the success rate of expectant management. METHODS:A liter...
journal_title:Urologia internationalis
pub_type:
doi:10.1159/000510136
更新日期:2021-01-01 00:00:00
abstract:INTRODUCTION:Urethral valves can be of enormous clinical importance. Both the prognosis for an affected fetus and the indication for a prenatal therapeutic intervention depend to a high degree on the accuracy of the prenatal diagnosis. PATIENTS AND METHODS:The sonographic findings and the results of the postnatal diag...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000081586
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:The aim of this work was to verify the tolerability and the preliminary clinical results of intensive intravesical instillations of a mitomycin C (MMC) regimen. PATIENTS AND METHODS:From September 2007 to November 2009, 40 consecutive evaluable patients with pathologically confirmed intermediate-risk non-mus...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000315492
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:International guidelines are ambivalent regarding the recommendations for the management of clinical stage 1 (CS1) seminoma. PATIENTS AND METHODS:During 2008-2013, 1,050 patients with seminoma CS1 were prospectively registered with regard to assessing management modality (radiotherapy, carboplatin, survei...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000443214
更新日期:2016-01-01 00:00:00
abstract::A review of the recent literature on the surgical management of anterior urethral stricture was performed. The literature was searched via PubMed using the search terms 'urethral stricture' and 'urethroplasty' from 1996 to 2009. The management of anterior urethral strictures is changing rapidly in the sense that the r...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000319501
更新日期:2011-01-01 00:00:00
abstract::An important aspect of modern extracorporeal shock wave lithotripsy is the ability to perform the procedure without anesthesia. Between June 1987 and April 1990, a total of 7,500 treatments were performed in our Lithotripsy Unit, using the Lithostar (Siemens AG, Erlangen, FRG): moreover 80% of the treatments were carr...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282191
更新日期:1991-01-01 00:00:00
abstract::High concentrations of phosphate, oxalate, and calcium ions in urine may cause formation of mineral deposits, i.e., urolithiasis. This is prevented in healthy individuals by substances present in trace quantities. However, there is no recognizable difference between normals and stone formers in urinary substance conte...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281098
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVE:This study sought to investigate whether ischemia-induced prostate damage during cardiac surgery involving cardiopulmonary bypass causes bladder outlet obstruction. MATERIALS AND METHODS:The study involved 37 men who underwent elective cardiac surgery involving cardiopulmonary bypass. Prostate-specific antig...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000084434
更新日期:2005-01-01 00:00:00
abstract::Carcinoma of the bladder following augmentation cystoplasty is rare. Only 15 cases have been reported worldwide. We report a further 2 cases, 1 of which, a squamous cell carcinoma, has not previously been described in this context. ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000030479
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Elevated serum C-reactive protein (CRP) level has been demonstrated to predict poorer survival of both localized and metastatic renal cell carcinoma. However, the prognostic value of intratumoral CRP expression has not been sufficiently studied. PATIENTS AND METHODS:In the present study, the expression of C...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000353401
更新日期:2014-01-01 00:00:00
abstract::A prospective study on 16 patients with advanced (stage III and IV) prostate cancer was carried out. TNM stage, general clinical status, serum PSA level, the histological type and Gleason's grade of the tumor were registered. Total androgen blockade or single-drug therapy (flutamide) was performed. On average, 4.81 mo...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030429
更新日期:1999-01-01 00:00:00
abstract::Clear cell adenocarcinoma arising in the lower urinary tract is unusual. We report a case of clear cell adenocarcinoma of the bladder in a 54-year-old male. Cystoscopic examination revealed a tumour arising from the dome of the urinary bladder. Histologically, the tumour was chiefly composed of tubulocystic and papill...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000071856
更新日期:2003-01-01 00:00:00
abstract::Adherence of human prostate carcinoma (PC 3, DU 145), bladder (647 V, J 82) carcinoma and melanoma (RPMI-8252) cell lines to plastic and bovine endothelial monolayers (BEM) was tested in the presence of 0.5, 1, 5, 10, 20 IU of low-molecular-weight heparin (LMWH), unfractionated heparin (UFH) or saline as a control. Cu...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282848
更新日期:1996-01-01 00:00:00
abstract:INTRODUCTION:Radical prostatectomy (RP) in patients with locally advanced (cT3) prostate cancer (PCa) is considered an optional therapy. AIM:To evaluate outcomes of surgery for cT3 disease and to compare results with those of patients treated for cT1-T2 PCa. PATIENTS AND METHODS:Data of 74 consecutive patients with c...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000316944
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:The aim of our study was to determine the validity of the updated nomogram [Briganti et al.: Eur Urol 2012;61:480-487] as a prediction tool for pelvic lymph node invasion (LNI) in the current era by using a large multicentric population of men who underwent extended pelvic lymph node dissection (ePLND) at ...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000343993
更新日期:2013-01-01 00:00:00
abstract::Nutrition plays a major role in the pathogenesis of the most widespread forms of nephrolithiasis, i.e. calcium (calcium oxalate and phosphate) and uric acid stone disease. For this reason, dietary measures are the first level of intervention in primary prevention, as well as in secondary prevention of recurrences. An ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000076588
更新日期:2004-01-01 00:00:00
abstract::Cystinuria is a rare cause of renal calculi, whose management presents a complex problem mainly due to the hardness and high recurrence rate of cystine stones. During the period 1987-1991, 28 established cases of cystine calculi were treated by extracorporeal shock wave lithotripsy (ESWL) and percutaneous nephrolithot...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282836
更新日期:1996-01-01 00:00:00
abstract::Urinary incontinence in 80 men was classifed by combined radiological and urodynamic techniques. 28 cases of pure stress incontinence were evaluated for grading of sphincteric loss. Clinical and sphincterometric data were correlated. Functional urethral length, urethral closure pressure at rest and with voluntary sphi...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280348
更新日期:1980-01-01 00:00:00
abstract::With this letter to the editor we present for the first time a study on CHEK2 expression in normal urothelium of healthy male smokers, former smokers and non-smokers. We could show a statistically significant downregulation of this DNA repair gene in current smokers compared to non-smokers, suggesting that smoking dow...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000446827
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:Urolithiasis in children is recognized with an increasing frequency, while exact etiological factors remain to be determined. The aim of this study is to compare the metabolic risk factors and saturation of urine in pediatric and adult calcium oxalate (Ca-Ox) stone formers. METHODS:A total of 33 pediatric (...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000070134
更新日期:2003-01-01 00:00:00
abstract:AIM:To compare the efficacy and safety of silodosin versus tamsulosin as medical expulsive therapy for stones of lower-third ureter in children. PATIENTS AND METHODS:This prospective single-blind placebo-controlled randomized study included 167 pediatric patients who presented with distal ureteric stone (DUS) less tha...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000513074
更新日期:2021-02-01 00:00:00
abstract:INTRODUCTION:The treatment of T1G3 bladder cancer is still a controversial issue. Nowadays, intravesical bacillus Calmette-Guérin (BCG) instillation is considered to be the treatment of choice for patients with high-grade superficial bladder tumour after transurethral resection of all visible tumour. The aim of this re...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000066121
更新日期:2002-01-01 00:00:00
abstract::By transforming uroflowmetrograms from curves of flow rate versus time into curves of flow rate versus instantaneous bladder volume, additional information about the variation of the flow rate during voiding is obtained. These curves show that, within a certain volume range, the maximum flow rate is more or less indep...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280157
更新日期:1977-01-01 00:00:00
abstract:OBJECTIVES:This open label, phase I clinical trial (NCT02945462) using 2 consecutive intracavernous autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) for the first time in the treatment of diabetic patients with erectile dysfunction (ED). The primary outcome is to assess the safety and tolerability of int...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000492120
更新日期:2018-01-01 00:00:00
abstract::Concomitance of different primary malignant neoplasms in the same individual has been observed and explained by several possible mechanisms. For urogenital malignancies in concomitance with lymphoid or with intestinal malignancies some data indicate that common etiologic factor(s) with pleiotropic effects may be invol...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281069
更新日期:1985-01-01 00:00:00
abstract::We present an unusual case of condylomata acuminata arising in the transplanted skin of a neovagina in a male-to-female transsexual. The neovagina had been constructed using a penile and a scrotal skin flap. Resection of the larger condylomata was performed; then all visible lesions were ablated by electrovaporization...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000078811
更新日期:2004-01-01 00:00:00
abstract::A total of 51 consecutive female patients with genuine stress incontinence who underwent a Burch or Stamey operation were clinically and urodynamically evaluated preoperatively at least 8 months postoperatively. Our study group consisted of 27 women who underwent the Burch colposuspension and 24 who had the Stamey end...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000282803
更新日期:1996-01-01 00:00:00
abstract:INTRODUCTION:Renal cell carcinoma (RCC) reveals a tendency towards venous invasion in its advanced stages, making clinical management challenging. Survival may be improved following surgery, but is less clear if it applies to patients with metastatic disease at diagnosis. MATERIALS AND METHODS:Review of clinical files...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000493510
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To investigate the reliability of the physician-assisted International Index of Erectile Function (IIEF). PATIENTS AND METHODS:374 patients who applied to our clinic with erectile dysfunction problems were asked to complete the IIEF questionnaire; 225 patients who visited the clinic again within 1-3 days com...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000335432
更新日期:2012-01-01 00:00:00