Prognostic impact of intratumoral C-reactive protein expression in patients with clear cell renal cell carcinoma.

Abstract:

BACKGROUND:Elevated serum C-reactive protein (CRP) level has been demonstrated to predict poorer survival of both localized and metastatic renal cell carcinoma. However, the prognostic value of intratumoral CRP expression has not been sufficiently studied. PATIENTS AND METHODS:In the present study, the expression of CRP was evaluated with immunohistochemical analysis in 127 patients who had undergone curative surgery for clear cell renal cell carcinoma. CRP staining was scored using the immunoreactivity score. An immunoreactivity score of 4 (median value) or lower was considered negative, a score higher than 4 was considered positive CRP expression. RESULTS:Univariate analysis revealed that Fuhrman grade, necrosis, vascular invasion, TNM stage and CRP expression were associated with tumor-specific survival. Multivariate analysis using the Cox proportional hazards regression method revealed only TNM stage as an independent predictor of tumor-specific survival (p = 0.001). A trend towards significance (p = 0.066) was observed with CRP expression, but it did not reach significance. Patients with a positive CRP score were 3.46 times more likely to die than patients with a negative CRP score. CONCLUSION:Our results suggest that the assessment of intratumoral CRP expression may be a useful tool for predicting the prognosis in patients with clear cell renal cell carcinoma.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Can C,Acikalin MF,Ozen A,Dundar E

doi

10.1159/000353401

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

270-5

issue

3

eissn

0042-1138

issn

1423-0399

pii

000353401

journal_volume

92

pub_type

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