Abstract:
:Multiple oral doses of alpha-difluoromethyl-ornithine (alpha-DFMO), 18-24 g/day for up to 2 months, were administered to 2 patients with invasive and metastatic carcinoma of the bladder and to 3 patients with metastatic renal cancer in an open study. The moderate antigrowth effect of alpha-DFMO in these patients was concluded from the results of serial kidney, liver and bone scintigrams, from the low frequency of a local recurrence of bladder carcinoma and from the survival rate of 4 of 5 patients after 12 months. Increased excretion of hydroxyproline and beta2-microglobulin were measured 1 month following alpha-DFMO treatment suggesting initial tumor necrosis and degradation. Treatment was poorly tolerated with gastrointestinal side effects (e.g. gastritis, vomiting, diarrhea) in all subjects, erythropenia in 2 subjects (associated with thrombocytopenia and leucopenia in 1 subject each), and audiovestibular symptoms in 2 patients. All side effects were reversible and normal function returned 2-4 months after stopping therapy.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Dunzendorfer Udoi
10.1159/000280403subject
Has Abstractpub_date
1981-01-01 00:00:00pages
128-36issue
2eissn
0042-1138issn
1423-0399journal_volume
36pub_type
杂志文章abstract:PURPOSE:To compare the safety and efficacy of standard-tract combined with mini-tract to single standard-tract in percutaneous nephrolithotomy (PCNL) for renal staghorn calculi. METHODS:The records of 216 patients with staghorn calculi (110 (50.9%) had complete and 106 (49.1%) had partial) who received PCNL were revie...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000354427
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Immunotherapy effectively treats advanced renal cell carcinoma in only a limited number of patients. However, the predicted prognosis for each patient in relation to immune status and response to immunotherapy remains problematic. We analyzed tumor-infiltrating lymphocyte (TIL) subsets to determine whether...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000064361
更新日期:2002-01-01 00:00:00
abstract::The influence of unilateral ureteral ligation in the rat nephron has been morphometrically analysed. The glomeruli show no significant differences compared with the control groups. The lumen of the tubulus rectus I increases significantly, but irregularly, after the 6th day of ureter ligation. The brush border is most...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280329
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Functional magnetic resonance imaging (MRI) seems to be a useful tool for prostate cancer (PCa) detection in patients with a previous negative biopsy but persistently increased prostate-specific antigen (PSA) values. Additionally, it enables correct cancer localization in patients with known PCa under active...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000338808
更新日期:2012-01-01 00:00:00
abstract:INTRODUCTION:MicroRNA (miR)371a-3p was suggested to be a sensitive and specific new serum biomarker of germ cell tumours (GCTs); however, its clinical usefulness remains unproven. PATIENTS, METHODS:In 312 consecutive cases with various testicular diseases, serum levels of miR371a-3p were measured. Measurement results ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000477446
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:The study aimed to evaluate the effects of metformin on insulin, C-peptide and body weight in Chinese men undergoing androgen deprivation therapy (ADT). METHODS:Between March 2013 and June 2014, 62 newly diagnosed patients of prostate cancer (PCa) due to receive ADT were recruited from 7 hospitals in Shanghai....
journal_title:Urologia internationalis
pub_type: 杂志文章,随机对照试验
doi:10.1159/000448691
更新日期:2017-01-01 00:00:00
abstract::A medium that had been conditioned by PC-3 cells stimulated the calcification of a human osteoblastic cell line, Tak-10, in a nonmitogenic culture. The calcification of the osteoblasts was stimulated maximally at a 25% concentration of the conditioned medium. Calcification activity was markedly enhanced by the additio...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282291
更新日期:1992-01-01 00:00:00
abstract::Presuming that complications associated with ureteral stenting vary in type and occurrence depending on the material and cross-section of the stent, six types of stents immersed in 48 different preparations of artificial urine for 1 month to observe surface changes with a scanning electron microscope. As a result, the...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282206
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:This study aims to examine the relationship between chronic prostatic inflammation and prostatic calculi, and clinical parameters of benign prostatic hyperplasia (BPH). MATERIALS AND METHODS:This study was based on 225 patients who underwent transurethral resection of the prostate for BPH. Chronic inflammati...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000342643
更新日期:2013-01-01 00:00:00
abstract::We examined a 46-year-old male patient with idiopathic myelofibrosis diagnosed 28 months earlier. After chemotherapy and irradiation, CT showed nonnodular, soft tissue masses in the renal hilum, pelvicaliceal system, perirenal and periureteral spaces. Ultrasound-guided biopsy showed extramedullary hematopoiesis (EMH)....
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000087809
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:To investigate the reliability of the physician-assisted International Index of Erectile Function (IIEF). PATIENTS AND METHODS:374 patients who applied to our clinic with erectile dysfunction problems were asked to complete the IIEF questionnaire; 225 patients who visited the clinic again within 1-3 days com...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000335432
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:The aim of this work was to verify the tolerability and the preliminary clinical results of intensive intravesical instillations of a mitomycin C (MMC) regimen. PATIENTS AND METHODS:From September 2007 to November 2009, 40 consecutive evaluable patients with pathologically confirmed intermediate-risk non-mus...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000315492
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:To compare the effects of retroperitoneal laparoscopic surgery (RPL) and transperitoneal laparoscopic surgery (TPL) on the hemodynamic and ventilatory functions in old patients. METHODS:Thirty-two senior patients underwent either RPL or TPL. Swan-Ganz and radial artery catheters were placed to monitor hemodyna...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000251183
更新日期:2009-01-01 00:00:00
abstract::In an experimental canine model, topical application of phenylephrine hydrochloride (Neo-Synephrine) to the urethral mucosa was demonstrated to cause a rise of intraurethral pressure which persisted for over 2 h without any rise of arterial pressure. There was no intraurethral pressure change after the topical applica...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280047
更新日期:1976-01-01 00:00:00
abstract::We present a 17-year-old patient with a right testicular dislocation. In this case, dislocated testis had been considered as hematoma and therefore remained untreated for 4 months. The patient underwent right orchiopexy 4 months after the injury. Intraoperative testicular biopsy revealed impaired spermatogenesis and e...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282830
更新日期:1996-01-01 00:00:00
abstract::The bladder pressure necessary to cause vesicoureteral reflux (VUR) was measured in 16 female rats. Under general anesthesia, the ureters were exposed via an abdominal incision and a pressure catheter was placed near the ureterovesical junction. Values of bladder distension and bladder pressure increase to cause VUR w...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281195
更新日期:1986-01-01 00:00:00
abstract::We evaluated whether sensations recorded during a medium-fill cystometry are reproducible. In 10 patients, the evaluation was done during two successive bladder distentions. In 95 patients, the results of a sensory evaluation during urodynamic tests with a mean interval of 15 months were compared. An identity of sensa...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282354
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:To investigate patients' opinions on the degree of pain during shock wave lithotripsy, and the need for analgesics in patients with urinary stone. METHODS:A prospective questionnaire study involving subjective pain assessment during and just after shock wave lithotripsy was performed in consecutive patients ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000082710
更新日期:2005-01-01 00:00:00
abstract::An unusual case of a double testicular tumor, with different histology and the same marker chromosome, led to a search of the literature for cases of testicular tumors that were double, bilateral, or familial. The literature on abnormal chromosomes in tumors of the testis is also reviewed. After a discussion of the fa...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000281443
更新日期:1989-01-01 00:00:00
abstract::The intracavernosal pressure changes induced by 3 vasodilating drugs, diazoxide, glyceryltrinitrate and verapamil were investigated during autologous extracorporeal penile blood perfusion in an experimental rabbit model. In order to separate the arterial and venous components the experiments were performed with both i...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282454
更新日期:1993-01-01 00:00:00
abstract:INTRODUCTION:Male infertility caused by azoospermia due to non-reconstructable obstruction or non-obstructive azoospermia can be treated by microsurgical epididymal aspiration (MESA) or testicular sperm extraction (TESE) followed by an intracytoplasmatic spermatozoa injection (ICSI). MATERIAL AND METHODS:From 9/93 to ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000068185
更新日期:2003-01-01 00:00:00
abstract::Dependent drainage of a lower pole pyelocaliceal diverticulum was achieved by uretero-diverticulostomy in eight patients who already had compromised renal function due to bilateral megaureters or posterior urethral valves. This procedure preserves all functional renal parenchyma and the ureteropelvic junction is left ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280071
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:Salvage high-intensity focused ultrasound (HIFU) and cryotherapy (CRYO) have emerged as interesting alternatives in the treatment of local radio-recurrent prostate cancer. Currently, recommendations concerning the use of CRYO and HIFU in the salvage setting are still evolving. AIM:The objective of this revi...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000339616
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:The initial objective of this renal cancer study was to identify gene sets in clear cell renal cell carcinoma (ccRCC) to support grading of ccRCC histopathology. MATERIALS AND METHODS:Preselected ccRCC tumor tissues of grade 1 (G1, n = 14) and grade 3 (G3, n = 15) as well es 14 normal kidney tissues thereof ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000328196
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:We aimed at evaluating the incidence of lymphoceles, a common complication after radical retropubic prostatectomy (RRP), at a high volume centre, define risk factors and assess the clinical outcome. MATERIALS AND METHODS:454 patients receiving RRP and pelvic lymph node dissection were assessed for postope...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000381463
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To assess clinical outcomes and reimbursement costs of open and robotic-assisted radical prostatectomies in Germany. METHODS:Perioperative data of 499 open (2003-2006) and 932 (2008-2010) robotic-assisted radical prostatectomies as well as longitudinal reimbursement costs of an anonymized health insurance rese...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000431104
更新日期:2016-01-01 00:00:00
abstract::Technetium-labeled red blood cell scintigraphy using a bolus injection was used to obtain a noninvasive quantitative measurement of renal blood flow. The method used is an adaptation of the one used for calculating cerebral blood flow which involves deconvolution of the first pass of the isotope through the kidneys. T...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281863
更新日期:1987-01-01 00:00:00
abstract::It is well known that diabetes mellitus is accompanied by complications of sexual dysfunction and it is believed that diabetic neuropathy may cause impotence. In our study, we found that not all the patients who visited our center with the chief complaint of diabetic impotence were suffering from organic impotence, an...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282978
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Open radical cystectomy (ORC) is the gold standard of treatment for muscle-invasive bladder cancer. Laparoscopic radical cystectomy (LRC) has emerged to provide an alternative. METHODS:Between 2006 and 2012, 155 patients who underwent LRC or ORC were compared (mean follow-up 53 months). RESULTS:The ORC gro...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000350237
更新日期:2013-01-01 00:00:00
abstract::Prostate cancer is one of the most common malignancies occurring in men. During the last decade, several advances have been made in decreasing the morbidity of surgical therapy. Two major advances have included an improved understanding of the physiology of erection and anatomy of pelvic parasympathetic nerves mediati...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000282149
更新日期:1991-01-01 00:00:00