Abstract:
:A prospective study on 16 patients with advanced (stage III and IV) prostate cancer was carried out. TNM stage, general clinical status, serum PSA level, the histological type and Gleason's grade of the tumor were registered. Total androgen blockade or single-drug therapy (flutamide) was performed. On average, 4.81 months after the start of therapy rebiopsy, serum PSA determination and general clinical examination were performed. Histologic examination before and after treatment of HE-stained slides, as well as apop-tag reaction to show apoptotic cells, p53, bcl(2), and Ki-67 immunostaining. Clinical improvement manifested by regression or lack of progression was observed in 10 patients. Increase of the apoptotic index and decrease of the mitotic index was detected in these cases. Serum PSA level decreased in all patients except in 3 fatal cases. The 6 clinically nonresponders who died after the second biopsy did not show an increased apoptotic or decreased mitotic index. Ki-67 positivity correlated well with the mitotic activity. Mutant p53 expression was higher in patients in whom antiandrogen therapy was ineffective. The bcl(2) expression was a characteristic of the tumors of patients who later died. These results show that the degree of induction of apoptosis in prostate carcinoma by hormonal therapy varies from case to case. A given prostate cancer patient's response to therapy may be predicted by following apoptotic and mitotic activity, as well as Ki-67 and p53 expression in repeated biopsies.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Szende B,Romics I,Torda I,Bély M,Szegedi Z,Lovász Sdoi
10.1159/000030429subject
Has Abstractpub_date
1999-01-01 00:00:00pages
115-9issue
2eissn
0042-1138issn
1423-0399pii
30429journal_volume
63pub_type
杂志文章abstract:INTRODUCTION:Male infertility caused by azoospermia due to non-reconstructable obstruction or non-obstructive azoospermia can be treated by microsurgical epididymal aspiration (MESA) or testicular sperm extraction (TESE) followed by an intracytoplasmatic spermatozoa injection (ICSI). MATERIAL AND METHODS:From 9/93 to ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000068185
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Multi-parametric magnetic resonance imaging (mpMRI)-directed biopsy for prostate cancer (PC) diagnosis improves the detection of clinically significant prostate cancer (CSPC) and decreases the rate of over-diagnosis of insignificant disease. The aim of this study was to investigate the value of mpMRI combine...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000500350
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:Our aim was to review our pathological archive to find out the actual incidence of micropapillary pattern (MPP) in our urothelial carcinoma patient population and determine its correlation with clinical outcome. PATIENTS AND METHODS:14 out of 170 cases with complete clinical follow-up were clinicopathologic...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000241672
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To assess the role of primary open surgery versus the recommended combination approach (percutaneous and lithotripsy) to treat staghorn calculi in a developing country. PATIENTS AND METHODS:Available records (n = 91) of patients with staghorn managed during the last 4 years were retrieved. Patients were plac...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030456
更新日期:1999-01-01 00:00:00
abstract::51 biopsies from healthy and diseased epithelium from human urinary bladders were examined by scanning electron microscopy. The luminal surface of the cover cells was marked by microvilli and microplicae. The replacement of the cover cells takes place by simple desquamination. This exposes cover cells having numerous ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280109
更新日期:1977-01-01 00:00:00
abstract::Considerable progress has been made regarding pathogenesis, diagnosis and conservative management of urolithiasis. The cause of the disease can now be determined in nearly 80% of the patients. New stone formation may be prevented in the majority of patients by selective medical treatment. The metabolic, physicochemica...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000281240
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:Routine follow-up after cystectomy for bladder cancer detect patients with local recurrence late in the course of disease. We set out to determine the value of transrectal ultrasound (TRUS) as diagnostic tool to diagnose local failure. PATIENTS AND METHODS:Between 1986 and 2003, radical cystectomy for bladde...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000176018
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:To assess the effectiveness and long-term results after finasteride treatment of recurrent hematuria associated with benign prostatic hyperplasia (BPH). MATERIALS AND METHODS:The study comprised 80 patients, aged 62-86 (mean 74) years, of whom 50 received finasteride 5 mg once daily for 4 years and 30 were ...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章
doi:10.1159/000050948
更新日期:2001-01-01 00:00:00
abstract::119 patients with stage-IV renal cell carcinoma were treated using immunotherapy with autologous tumor vaccine. The immunization was carried out at monthly intervals, the patients were restaged every 3 months using X-ray, ultrasound scanning or computed tomography as well as bone scintigraphy in the follow-up. The pat...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1159/000281439
更新日期:1989-01-01 00:00:00
abstract::The effect of vinblastine sulfate on the acceptance and growth of a very malignant, human adenocarcinoma of the kidney (RCCI) on nude mice was investigated. Without any treatment, this tumor has an acceptance rate of 100%. Subcutaneously transplanted pieces of tumor, measuring 3 X 3 X 1 mm, commence to grow rapidly 1 ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280404
更新日期:1981-01-01 00:00:00
abstract::A case of primary carcinoma of the urinary bladder associated with a primary retroperitoneal leiomyosarcoma is presented. Due to the lack of early symptoms, diagnosis of the retroperitoneal leiomyosarcoma was late and therefore the prognosis was poor. Twelve months after diagnosis the patient died not of the bladder t...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282996
更新日期:1997-01-01 00:00:00
abstract::To our knowledge only a few cases of renal milk of calcium have been reported. We have encountered 5 such patients. The diagnosis depends upon the demonstration of half-moon-shaped calcification in the lateral decubitus or upright roentgenograms. This condition should be differentiated from a renal calculus to avoid u...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000282538
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study is to modify and validate a novel screening tool to determine the necessity of bone scans in Chinese PCa patients at the time of diagnosis. METHODS:Five-hundred-and-one patients diagnosed with PCa between 2010 and 2013 at Zhongshan Hospital, Fudan University, were included in the study...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000368912
更新日期:2015-01-01 00:00:00
abstract::Myelolipomas are rare benign neoplasms of the adrenal glands, characterized by the presence of adipose tissue and elements of bone marrow in various degrees of differentiation. Usually asymptomatic, they are discovered incidentally or at autopsy; sometimes larger masses may cause local symptoms. We report clinical, ra...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282612
更新日期:1994-01-01 00:00:00
abstract:PURPOSE:To assess our short-term experience with transurethral microwave thermotherapy (TUMT) for symptomatic benign prostatic hyperplasia (BPH). PATIENTS AND METHODS:From August 1993 through July 1994, in total 65 patients with symptomatic BPH were enrolled into this study. The patients' ages ranged from 56 to 95 yea...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章
doi:10.1159/000064846
更新日期:2000-01-01 00:00:00
abstract::We studied the impact of antireflux surgery on bladder compliance, which was an important clinical parameter in terms of urinary incontinence and upper tract deterioration, in 20 myelodysplastics (group A). For control groups, 31 myelodysplastic children with or without reflux who were conservatively treated (group B)...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282253
更新日期:1991-01-01 00:00:00
abstract::A partial urethral obstruction was induced in female rats. After 6 weeks, detrusor weight had increased eightfold and collagen concentration had decreased to about 40% compared to controls. Due to the weight gain, the total amount of detrusor collagen had increased more than threefold. Removal of the obstruction led t...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282230
更新日期:1991-01-01 00:00:00
abstract::Controversies abound in relation to the treatment of every stage of prostate cancer and its natural history. We critically evaluate the controversies and information that exist. An ongoing autopsy project at Wayne State University aims to: define the prevalence of incidental cancer in subjects between 20 and 70 years ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000282860
更新日期:1996-01-01 00:00:00
abstract:INTRODUCTION:We investigated the relationship between posterior vault prolapse and overactive bladder (OAB) symptoms or detrusor overactivity (DO) and their changes after surgical repair. METHODS:Forty-three patients with vault prolapse and prevalent posterior compartment prolapse underwent pelvic organ prolapse repai...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000345944
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To conduct a meta-analysis examining p53 expression as a potential risk factor in upper urinary tract urothelial carcinoma (UUT-UC) and to systematically review the available data. METHODS:A comprehensive literature review was performed from January 1991 to August 2012, using search engines such as PubMed, E...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000360227
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The principle of treating male infertility in those with chromosomal aberrations should change according to progress in treatment modalities. METHODS:In this study, ten patients with Robertsonian translocation were assessed for their cytogenetic and clinical characteristics to establish guidelines for treat...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000066122
更新日期:2002-01-01 00:00:00
abstract:INTRODUCTION:We reviewed our experiences in performing cytoreductive metastatectomy before initiating systemic immunochemotherapy and tried to investigate potential prognostic factors for such an approach. PATIENTS AND METHODS:A retrospective analysis of 57 patients who received interleukin-2, interferon-alpha, and 5-...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000091630
更新日期:2006-01-01 00:00:00
abstract::We report on the familial occurrence of congenital bulbar urethral stricture in 2 brothers. Embryological mechanisms are briefly discussed and the literature reviewed. ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000281795
更新日期:1991-01-01 00:00:00
abstract:INTRODUCTION:We aimed to evaluate the effects of hyperbaric oxygen therapy (HBOT) on erectile function in patients who had no cavernosal or urethral injury by using International Index of Erectile Function (IIEF) questionnaire. MATERIALS AND METHODS:The male patients who were treated by HBOT for several diseases betwe...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000490356
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:The study aimed to investigate clinical factors associating with occult lymph node micrometastases (pN1 disease) in a contemporary cohort of organ-confined prostate cancer (PCA) patients staged as cN0. MATERIALS AND METHODS:The study evaluated 184 consecutive patients. Associations of clinical factors with pN1...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000458763
更新日期:2017-01-01 00:00:00
abstract::The introduction in 1982 of vasoactive agents for intracavernous injection represents a milestone in the diagnosis and treatment of erectile dysfunction. Two preparations, the single drug papaverine hydrochloride and the combination of phentolamine mesylate and papaverine hydrochloride, hold great promise. In the last...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000281308
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy of transobturator tape (TOT) in the management of stress urinary incontinence at a medium term follow-up. METHODS:TOT is a polypropylene tape positioned through the obturator foramen. 70 patients with type II urinary stress incontinence were treated with TOT between June 2003 and May 2...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000127340
更新日期:2008-01-01 00:00:00
abstract::During the past 10 years, buccal mucosa grafting for urethroplasty has gained widespread acceptance. In general the reported success rates are 80% and higher. Typical complications are recurrent strictures, fistula, and, especially when the technique of ventral onlay urethroplasty has been used, sacculations that are ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000096344
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:The use of cadaveric pediatric kidneys has been suggested as a means to overcome organ shortage, but is debated because of technical complications and an increased incidence of functional allograft impairment. METHODS:We experienced 2 cases of cadaveric renal transplantation from a non-heart-beating pedia...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000068778
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:To determine the efficacy and safety of laparoscopic deroofing of symptomatic simple renal cysts. METHODS:A Cochrane style systematic review was conducted on published literature from 1990 to 2017, to include case series and randomised controlled trials. A pooled meta-analysis was conducted. RESULTS:A tota...
journal_title:Urologia internationalis
pub_type: meta分析
doi:10.1159/000497313
更新日期:2019-01-01 00:00:00