Abstract:
OBJECTIVES:This open label, phase I clinical trial (NCT02945462) using 2 consecutive intracavernous autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) for the first time in the treatment of diabetic patients with erectile dysfunction (ED). The primary outcome is to assess the safety and tolerability of intracavernous autologous BM-MSCs, the secondary outcome is to assess efficacy of the procedure. PATIENTS AND METHODS:Four diabetic patients with refractory ED were included. Two consecutive intracavernous autologous BM-MSC injections were performed. Tolerability was assessed immediately and at 24 h, safety was evaluated for 2 years. Efficacy was assessed using International Index of Erectile Function-15 (IIEF-15) and Erection Hardness Score (EHS) for 12 months. RESULTS:procedure was well tolerated and no patients reported significant adverse effects. There was significant improvement of IIEF-15 and EHS; IIEF-15 (p = 0.04), Erectile Function (p = 0.03), Sexual Desire (p = 0.04), Intercourse Satisfaction (p = 0.04), and Overall Satisfaction (p = 0.04). CONCLUSION:This is the first human study with proven tolerability, safety and efficacy of intracavernous autologous BM-MSC injections for treatment of diabetic patients with ED.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Al Demour S,Jafar H,Adwan S,AlSharif A,Alhawari H,Alrabadi A,Zayed A,Jaradat A,Awidi Adoi
10.1159/000492120subject
Has Abstractpub_date
2018-01-01 00:00:00pages
358-365issue
3eissn
0042-1138issn
1423-0399pii
000492120journal_volume
101pub_type
杂志文章abstract::A case of benign leiomyoma of the urinary bladder was discovered incidentally and treated successfully with endoscopic enucleation. We describe the technique of this new surgical approach and discuss its advantages. We recommend this minimally invasive approach over open surgical resection. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000085919
更新日期:2005-01-01 00:00:00
abstract::The objective of this case report is to present a rare bladder tumour in a young patient 25 years after the treatment with cyclophosphamide because of a neuroblastoma of the right eye. The first symptom of the tumour was macroscopic haematuria with dysuria and pollakiuria. The final diagnosis was dictaminated by the p...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000437442
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:Activated nuclear factor-ĸB is associated with the pathogenesis of numerous malignancies, including renal cell carcinoma (RCC). This study aimed to clarify the influence of a common insertion/deletion polymorphism (-94 ins/del ATTG, rs28362491) in the NFKB1 promoter on RCC susceptibility. METHODS:We genotype...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000345630
更新日期:2013-01-01 00:00:00
abstract::A 63-year-old man with primary malignant lymphoma of the prostate is presented. The patient underwent total cystoprostatectomy and ileal conduit construction. The specimen revealed malignant lymphoma, diffuse small cleaved cell of the gland. Three months after the operation, local recurrence and enlarged lymph node de...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282216
更新日期:1991-01-01 00:00:00
abstract::The anterior nutcracker syndrome is defined by the compression of the left renal vein between the aorta and superior mesenteric artery, usually related to the occurrence of hematuria. We report the case of an uncommon complication of the nutcracker syndrome. A 75-year-old woman was referred to our institution for left...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000381270
更新日期:2016-01-01 00:00:00
abstract::A method of synchronous study for monitoring the pressure activity of the rectum, bladder and urethral sphincter was described. Intrarectal pressures were obtained using a 8 F custom made balloon catheter. Constant urethral infusion with intrasphincteric pressure recording was arranged through a specially designed 12 ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280126
更新日期:1977-01-01 00:00:00
abstract:PURPOSE:To compare the safety and efficacy of standard-tract combined with mini-tract to single standard-tract in percutaneous nephrolithotomy (PCNL) for renal staghorn calculi. METHODS:The records of 216 patients with staghorn calculi (110 (50.9%) had complete and 106 (49.1%) had partial) who received PCNL were revie...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000354427
更新日期:2014-01-01 00:00:00
abstract::The intracavernosal pressure changes induced by 3 vasodilating drugs, diazoxide, glyceryltrinitrate and verapamil were investigated during autologous extracorporeal penile blood perfusion in an experimental rabbit model. In order to separate the arterial and venous components the experiments were performed with both i...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282454
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:This study sought to investigate whether ischemia-induced prostate damage during cardiac surgery involving cardiopulmonary bypass causes bladder outlet obstruction. MATERIALS AND METHODS:The study involved 37 men who underwent elective cardiac surgery involving cardiopulmonary bypass. Prostate-specific antig...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000084434
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:This meta-analysis was to assess solifenacin and tolterodine in patients with overactive bladder. METHODS:We searched PubMed, the Cochrane Library, EMBASE, CNKI, Wanfang, and ClinicalTrials.gov databases for randomized controlled trials (RCTs). The efficacy endpoint was daily micturition frequency, daily ur...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析
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更新日期:2019-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000090872
更新日期:2006-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000241662
更新日期:2009-01-01 00:00:00
abstract::The prevalence of Chlamydia trachomatis and other microbes was studied in 94 semen samples from asymptomatic infertile males. Simultaneously, we sought evidence for inflammation of the genital tract by determining the polymorphonuclear granulocyte (PMN)-elastase concentration in the seminal plasma. The C. trachomatis ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282675
更新日期:1994-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000348542
更新日期:2013-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000504790
更新日期:2020-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282261
更新日期:1991-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000343993
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Splenectomy had been previously performed in ABO-incompatible kidney transplantation to reduce the B cell pool. However, studies have shown that patients undergoing splenectomy may have a lifelong susceptibility to infection and mortality. Splenectomy may affect the incidence of cytomegalovirus (CMV) disea...
journal_title:Urologia internationalis
pub_type:
doi:10.1159/000504862
更新日期:2020-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000443185
更新日期:2016-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282337
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Phosphatidylinositol 3-kinase (PI3K)-AKT signaling is a well-characterized pathway involved in the control of cell proliferation, apoptosis and oncogenesis. LY294002 is a commonly used pharmacologic inhibitor which acts at the ATP-binding site of the PI3K enzyme, thus selectively inhibiting the PI3K-AKT nexu...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000322849
更新日期:2011-01-01 00:00:00
abstract::Twenty males underwent transrectal ultrasonography before and after ejaculation to examine possible alterations that could influence interpretation of seminal vesicle ultrasonography. The preejaculation length of 35 mm was significantly (p < 0.05) decreased to 30 mm after ejaculation. The mean width of the seminal ves...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282404
更新日期:1992-01-01 00:00:00
abstract:AIM:Since DNA damage-related apoptosis is raising concerns regarding abnormal spermatogenesis, we investigated the changes in γ-H2AX during testicular germ cell apoptotic responses in the varicocele model. MATERIALS AND METHODS:Varicocele was induced by partial ligation of the left renal vein and animals were sacrific...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000316356
更新日期:2010-01-01 00:00:00
abstract::In addition to an increase in contractility, contracted fibers and small and electron-dense mitochondria have suggested an increase of cytosolic Ca(2+) within the cremaster muscles (CM) associated with undescended testis. Therefore, the Ca(2+) content of CM associated with an undescended testis was determined and comp...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000065558
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy and safety of fesoterodine extended-release (ER) plus tamsulosin in men with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). PATIENTS AND METHODS:Men aged ≥50 years, with LUTS, prostate volume ≤60 ml and International Prostate Symptom Score (IP...
journal_title:Urologia internationalis
pub_type: 杂志文章,随机对照试验
doi:10.1159/000345050
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Planification of living donor nephrectomy requires exact knowledge of the renal vascular architecture because of the high prevalence of anatomical variants. After magnetic resonance angiography (MRA) challenged CT angiography for preoperative assessment over the last years, we revisit in this study the rel...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000273467
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:The initial objective of this renal cancer study was to identify gene sets in clear cell renal cell carcinoma (ccRCC) to support grading of ccRCC histopathology. MATERIALS AND METHODS:Preselected ccRCC tumor tissues of grade 1 (G1, n = 14) and grade 3 (G3, n = 15) as well es 14 normal kidney tissues thereof ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000328196
更新日期:2011-01-01 00:00:00
abstract::In order to assess the clinical implications of the cytology of voided urine we analyzed 65 patients among 147 cases of transitional cell carcinoma (TCC) in relation to the cytohistologic correlation and prognostic significance. Urinary cytology detected 42.6% of bladder tumors, 59% of renal pelvic tumors, and 35.3% o...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282625
更新日期:1994-01-01 00:00:00
abstract::Human infestation with Dioctophyma renale is presented. Clinical signs and diagnostic findings are unspecific. They are discussed and a conservative therapeutic approach is suggested. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000067695
更新日期:2003-01-01 00:00:00
abstract:INTRODUCTION:Male infertility caused by azoospermia due to non-reconstructable obstruction or non-obstructive azoospermia can be treated by microsurgical epididymal aspiration (MESA) or testicular sperm extraction (TESE) followed by an intracytoplasmatic spermatozoa injection (ICSI). MATERIAL AND METHODS:From 9/93 to ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000068185
更新日期:2003-01-01 00:00:00