Pilot Experience with ABO-Incompatible Kidney Transplantation as a Second Transplant.

Abstract:

BACKGROUND:Despite advances in immunosuppressant medications, improvement in long-term survival for kidney transplant recipients has been more difficult to achieve. In fact, the number of patients with failing grafts who must either return to dialysis or undergo a second transplant is increasing. Second transplantation is associated with reduced mortality rates compared to remaining on dialysis after an initial graft loss. Nowadays, excellent ABO-incompatible kidney transplant outcomes have been achieved. However, there have been no reports on ABO-incompatible kidney transplantation as a second transplant. PATIENTS AND METHODS:Three patients who received their graft from an ABO-incompatible living donor at our institution as a second transplant were enrolled in this study. We focused on immunosuppressive therapy for second ABO-incompatible kidney transplantation, donor-specific antibody status before the second transplant, patient and graft survivals, and complications. RESULTS:All 3 patients successfully underwent ABO-incompatible kidney transplantation as a second transplant with a follow-up period of 141, 39, and 24 months. Patient and graft survival rates were 100%. CONCLUSIONS:ABO-incompatible kidney transplantation may be an acceptable treatment for patients who need a second renal replacement therapy after their initial graft failure.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Uchida J,Kosoku A,Kabei K,Nishide S,Shimada H,Iwai T,Kuwabara N,Naganuma T,Maeda K,Yoshikawa Y,Kumada N,Takemoto Y,Nakatani T

doi

10.1159/000499490

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

441-448

issue

4

eissn

0042-1138

issn

1423-0399

pii

000499490

journal_volume

102

pub_type

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