Abstract:
INTRODUCTION:To identify the risk factors, characteristics and prognosis of patients treated with docetaxel-based chemotherapy for peritoneal carcinomatosis due to metastatic castrate-resistant prostate cancer (mCRPC). METHODS:We retrospectively reviewed our series of mCRPC patients with peritoneal metastases treated with docetaxel-based chemotherapy between 2004 and 2010. RESULTS:Six patients were identified from our institutions' internal cancer registry. Three out of these patients had been treated with laparoscopic radical prostatectomy (LRP). In addition to peritoneal metastases, other metastatic sites were mainly visceral. Only 1 patient developed bone metastases. Peritoneal carcinomatosis occurred mainly in patients with a high Gleason (= or >6) score since 5 out of our 6 patients had a Gleason score ≥7. All 6 patients were treated with docetaxel-based chemotherapy when they developed castration resistance. Five patients benefitted from chemotherapy according to their PSA or RECIST responses. Median survival from the start of docetaxel was 24.5 months. CONCLUSIONS:Our retrospective analysis suggests that peritoneal carcinomatosis occurs mainly in patients with a high Gleason score. It is also possible that tumor seeding occurs during LRP. Patients with peritoneal carcinomatosis resistant to castration seem to benefit from docetaxel-based chemotherapy.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Rizk R,Danse E,Aydin S,Tombal B,Machiels JPdoi
10.1159/000354396subject
Has Abstractpub_date
2014-01-01 00:00:00pages
49-54issue
1eissn
0042-1138issn
1423-0399pii
000354396journal_volume
93pub_type
杂志文章abstract::With this letter to the editor we present for the first time a study on CHEK2 expression in normal urothelium of healthy male smokers, former smokers and non-smokers. We could show a statistically significant downregulation of this DNA repair gene in current smokers compared to non-smokers, suggesting that smoking dow...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000446827
更新日期:2016-01-01 00:00:00
abstract::Membrane fluidity and lipid composition of rat testis in experimental bilateral cryptorchidism were studied. Membrane fluidity measured by fluorescence anisotropy of diphenylhexatriene decreased on the 3rd day of intraabdominal fixation, at an early stage of cryptorchidism. Lipid composition of testicular membrane was...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281725
更新日期:1990-01-01 00:00:00
abstract::The effects of ammonium chloride, methenamine hippurate and ascorbic acid on urinary pH was studied in 14 normal subjects. A statistically significant reduction of urinary pH was recorded with ammonium chloride in daily doses of 1.5 and 3 g, but not with 2 g of methenamine hippurate or 1.8 g of ascorbic acid. Long-ter...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281732
更新日期:1990-01-01 00:00:00
abstract::Ischemia, induced by atherosclerosis, is a common cause of disorders in the elderly. Bladder dysfunction in older people may be caused by detrusor ischemia. We compared blood flow to the bladder and detrusor function in vivo and in vitro in young (6-month-old) and aged (24-month-old) male Sprague-Dawley rats. In both ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030365
更新日期:1999-01-01 00:00:00
abstract::Of 211 incontinent women the answer to each item of a questionnaire is correlated with the urodynamical data and the discriminative value for the type of incontinence is calculated. The relevant questions are discussed. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281355
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:To report conservative and surgical strategies for treatment of mesh erosion after pelvic organ prolapse (POP) repair. METHODS:Between 1998 and 2008, 179 patients underwent integral pelvic floor reconstruction for advanced POP in our tertiary urogynecological unit. Patients' charts and follow-up data were en...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000324243
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:We compared the applicability and reproducibility of the condom catheter method for noninvasive urodynamics in two Dutch studies. MATERIALS AND METHODS:A longitudinal study of changes in bladder contractility secondary to benign prostatic enlargement is taking place at the Erasmus MC in Rotterdam. Volunteer...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000144051
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Interest in the regulation of nerve growth factor (NGF) production in the urinary tract derives from its probable involvement in obstructive, inflammatory and developmental disorders. Our aim was to investigate the presence of low-affinity nerve growth factor receptor (LNGFR) in the vesical urothelium of p...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000092939
更新日期:2006-01-01 00:00:00
abstract::In 231 adults the frequency and the pattern of the retroaortic left renal vein were studied. We observed a retroaortic left renal vein in 9.09% ("renal collar" in 5.62%, single retroaortic left renal vein in 3.46%. According to our results and to the findings in the literature a retroaortic left renal vein can be expe...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000279997
更新日期:1975-01-01 00:00:00
abstract::The sequential expressed prostatic secretion (EPS) levels of latamoxef (LMOX) were measured in 14 patients with acute bacterial prostatitis to evaluate the diffusion of this antibiotic from the plasma into the prostatic fluid. All patients received 2 g of LMOX on the 1st, 4th, and 7th days of hospitalization. The mean...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282760
更新日期:1995-01-01 00:00:00
abstract:PURPOSE:Chronic renal damage due to tubulointerstitial fibrosis is one of several complications of posterior urethral valves in a significant number of children. As activation of the renin-angiotensin system plays an important role in this injury, we conducted this study to investigate whether administration of captopr...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000098078
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:Activated nuclear factor-ĸB is associated with the pathogenesis of numerous malignancies, including renal cell carcinoma (RCC). This study aimed to clarify the influence of a common insertion/deletion polymorphism (-94 ins/del ATTG, rs28362491) in the NFKB1 promoter on RCC susceptibility. METHODS:We genotype...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000345630
更新日期:2013-01-01 00:00:00
abstract::A prospective study on 16 patients with advanced (stage III and IV) prostate cancer was carried out. TNM stage, general clinical status, serum PSA level, the histological type and Gleason's grade of the tumor were registered. Total androgen blockade or single-drug therapy (flutamide) was performed. On average, 4.81 mo...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030429
更新日期:1999-01-01 00:00:00
abstract::Nutrition plays a major role in the pathogenesis of the most widespread forms of nephrolithiasis, i.e. calcium (calcium oxalate and phosphate) and uric acid stone disease. For this reason, dietary measures are the first level of intervention in primary prevention, as well as in secondary prevention of recurrences. An ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000076588
更新日期:2004-01-01 00:00:00
abstract::Carcinoma of the bladder following augmentation cystoplasty is rare. Only 15 cases have been reported worldwide. We report a further 2 cases, 1 of which, a squamous cell carcinoma, has not previously been described in this context. ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000030479
更新日期:2000-01-01 00:00:00
abstract::Bladder tumors were staged preoperatively before and/or after M-VEC poly-chemotherapy using transrectal ultrasonography and magnetic resonance imaging in 46 patients. The resultant findings were each compared with histomorphologic results. The sensitivity of both methods compared with pathohistology was 88%. Using thi...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282472
更新日期:1993-01-01 00:00:00
abstract:INTRODUCTION:Open radical cystectomy (ORC) is currently the standard treatment for muscle-invasive bladder cancer (MIBC) without metastasis, while many patients with MIBC are not always appropriate candidates due to multiple comorbidities. To evaluate the bladder-preservation strategy, we compared the results with thos...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000477912
更新日期:2017-01-01 00:00:00
abstract::Considerable progress has been made regarding pathogenesis, diagnosis and conservative management of urolithiasis. The cause of the disease can now be determined in nearly 80% of the patients. New stone formation may be prevented in the majority of patients by selective medical treatment. The metabolic, physicochemica...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000281240
更新日期:1986-01-01 00:00:00
abstract::Clinical and experimental investigations seem to underline the important role of fatty acids in the pathogenesis of hypercalciuria, a well-known risk factor for lithogenesis. To evaluate the relationships between the previously reported increase in plasma phospholipid arachidonic acid level and the factors responsible...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000087161
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the management of urolithiasis in children since the development of extracorporeal shock-wave lithotripsy (ESWL). METHODS:Between 1988 and 1994, 37 children, aged from 2 to 15 years (mean 10), with upper tract urolithiasis were evaluated and treated. Lithogenic metabolic disorders or anomalies of...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282882
更新日期:1996-01-01 00:00:00
abstract::Adenosine triphosphate (ATP) and adenosine diphosphate (ADP) have been correlated with traditional semen parameters such as forward motility and sperm count. ATP and ADP were determined by a bioluminescence assay using the luciferin-luciferase reaction. Short boiling of the ejaculate was performed to inactivate phosph...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282361
更新日期:1992-01-01 00:00:00
abstract::Lipoma of the adrenal gland is an extremely uncommon tumor detected incidentally at postmortem or during life when the patient undergoes investigations for other reasons. All tumors reported in the literature were very small in size. We report a case of lipoma of the adrenal gland in a 45-year-old male patient who was...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030265
更新日期:1998-08-01 00:00:00
abstract::We present a case of an appendicular mass mimicking symptoms of a bladder tumour in a 27-year-old female. The patient initially presented with a 5-month history of intermittent lower abdominal pain associated with dysuria, anorexia and weight loss. Cystoscopy revealed an erythematous urothelium with the appearance of ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000089178
更新日期:2005-01-01 00:00:00
abstract::The momentary entry of urine into the proximal urethra during coughing can be demonstrated by a new test which can be conducted using apparatus now commonly available for urodynamic investigations. If the bladder neck opens, a fluid bridge is established between points of pressure measurement in the bladder and in the...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280287
更新日期:1979-01-01 00:00:00
abstract:PURPOSE:The study aimed to investigate clinical factors associating with occult lymph node micrometastases (pN1 disease) in a contemporary cohort of organ-confined prostate cancer (PCA) patients staged as cN0. MATERIALS AND METHODS:The study evaluated 184 consecutive patients. Associations of clinical factors with pN1...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000458763
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:We aimed to evaluate the effects of hyperbaric oxygen therapy (HBOT) on erectile function in patients who had no cavernosal or urethral injury by using International Index of Erectile Function (IIEF) questionnaire. MATERIALS AND METHODS:The male patients who were treated by HBOT for several diseases betwe...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000490356
更新日期:2018-01-01 00:00:00
abstract::Testicular sperm extraction and intracytoplasmic sperm injection (TESE-ICSI) is a frequently used therapeutic option in azoospermic males. Genetic imprinting is a mechanism of gene regulation - mediated by the methylation of deoxyribonucleic acids (DNA) - by which only one of the parental copies of a gene is expressed...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000050972
更新日期:2001-01-01 00:00:00
abstract::Bladder carcinoma with transitional cells is the most frequent neoplasia in the urinary system, but it is quite rare in patients under 40 years of age (0.4-2%). An analysis of 21 patients under 40 and a review of other reports show that tumors in patients under 20 years old have little tendency to recur and to progres...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000050992
更新日期:2001-01-01 00:00:00
abstract:INTRODUCTION:Gene-modified cell vaccines are now considered to be the best way to achieve immunotherapy for a variety of cancers including prostate cancer (PCa). XAGE-1b is a member of the cancer/testis antigen family which has demonstrated strong immunogenicity. We investigated whether XAGE-1b is an ideal target for P...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000363333
更新日期:2015-01-01 00:00:00
abstract::Interstitial cystitis is a chronic benign disease of the bladder that causes bothersome and debilitating symptoms and mainly affects women. Since interstitial cystitis (IC) might result from a defective glycosaminoglycan layer of the bladder epithelium, we conducted a trial of hyaluronic acid (HA), used intravesically...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000283012
更新日期:1997-01-01 00:00:00