Abstract:
INTRODUCTION:We aimed to assess the diagnostic accuracy of radiolabeled prostate-specific membrane antigen positron emission tomography (PSMA PET) or positron emission tomography/computed tomography (PET/CT) for primary lymph node (LN) staging in newly diagnosed intermediate to high-risk prostate cancer (PCa) patients. MATERIAL AND METHODS:The MEDLINE, PubMed, EMBASE, and Cochrane Library database from the earliest available date of indexing through May 31, 2018, were searched for studies evaluating the diagnostic performance of radiolabeled PSMA PET or PET/CT for primary LN staging in newly diagnosed intermediate to high-risk PCa. We determined the sensitivities and specificities across studies, calculated positive and negative likelihood ratios (LR+ and LR-), and constructed summary receiver operating characteristic curves. RESULTS:Across 6 studies (298 patients), the pooled sensitivity was 0.71 (95% CI 0.59-0.81) and a pooled specificity of 0.95 (95% CI 0.87-0.99). Likelihood ratio (LR) syntheses gave an overall positive likelihood ratio (LR+) of 15.6 (95% CI 5.6-43.0) and negative likelihood ratio (LR-) of 0.30 (95% CI 0.21-0.43). The pooled diagnostic odds ratio (DOR) was 51 (95% CI 21-126). CONCLUSION:Radiolabeled PSMA PET/CT shows a moderate sensitivity and high specificity for the detection of metastatic LNs in patients with newly diagnosed intermediate to high-risk PCa.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Kim SJ,Lee SW,Ha HKdoi
10.1159/000493169subject
Has Abstractpub_date
2019-01-01 00:00:00pages
27-36issue
1eissn
0042-1138issn
1423-0399pii
000493169journal_volume
102pub_type
杂志文章,meta分析abstract::In 153 patients with verified neoplasias of the genitourinary tract, urinary neopterin excretion was monitored under different conditions. As control, urinary neopterin values were taken from 208 male and 209 female volunteers. Neopterin excretion was measured by high performance liquid chromatography. Patients with e...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281071
更新日期:1985-01-01 00:00:00
abstract::We report a rare case of massive bilateral staghorn calculi in a spinal cord injury patient with significant renal compromise. The patient was successfully treated with percutaneous nephrolithotomy to achieve a stone-free status. The various options of treatment are discussed with special attention to the technical as...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030340
更新日期:1998-01-01 00:00:00
abstract:INTRODUCTION:The regulation proteins retinoblastoma protein (pRb) and p16 play an important role in the cell cycle as tumor suppressors. pRb is the main substrate for the function of cyclin-dependent kinases during the cell cycle in the transition from G(1) to S phase. In this study, the immunohistochemical expression ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000320510
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Salvage high-intensity focused ultrasound (HIFU) and cryotherapy (CRYO) have emerged as interesting alternatives in the treatment of local radio-recurrent prostate cancer. Currently, recommendations concerning the use of CRYO and HIFU in the salvage setting are still evolving. AIM:The objective of this revi...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000339616
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:This study aims to examine the relationship between chronic prostatic inflammation and prostatic calculi, and clinical parameters of benign prostatic hyperplasia (BPH). MATERIALS AND METHODS:This study was based on 225 patients who underwent transurethral resection of the prostate for BPH. Chronic inflammati...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000342643
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the intervention effect of sacral neuromodulation (SNM) in the treatment of lower urinary tract dysfunction after spinal cord injury (SCI). METHODS:We selected relevant studies published between January 1, 1971 and November 15, 2018 by searching the PubMed, EMBASE, Cochrane databases. The outcome...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析
doi:10.1159/000501529
更新日期:2019-01-01 00:00:00
abstract::The rate of recurrence after internal urethrotomy a.m. Sachse was studied in a prospective, consecutive, randomized series of 43 patients using short-term (1 day) and long-term (14 days) postoperative catheter treatment. No significant difference was found between the two groups according to voiding interview, flowmet...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000280991
更新日期:1984-01-01 00:00:00
abstract::Sperm-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) originates from spermatogenic cells of the human testis. A strong staining of GAPDS was detected in epididymal epithelium, especially in principal cells and basal cells of the epithelium. GAPDS also bound to the fibrous sheet of the sperm tail and inhibit...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000345629
更新日期:2013-01-01 00:00:00
abstract::Intestinal ischemia is reported to be the most common gastrointestinal complication of renal transplantation and a potential cause of morbidity and mortality. The recent use of more potent immunosuppressive drug regimens has reduced the incidence of acute rejection, increasing the incidence of potentially fatal infect...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000106334
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:To evaluate the difference at different steps of follow-up of the postoperative quality of life (QoL) in patients who had undergone radical cystectomy and ileal orthotopic neobladder derivation. PATIENTS AND METHODS:A multicentric, cross-qualitative study was performed in 5 Italian centers of reference for ...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000443185
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:The study aimed to present our experience of surgical treatment for urorectal fistulas (URF) that develop after cancer surgery. MATERIALS AND METHODS:Fourteen patients with URF who were treated at our institution from 2005 through 2015 were retrospectively analyzed. Among these, 7 patients had previous su...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000457835
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:Basic science studies of ureteral physiology and pathophysiology are commonly performed on animal ureters due to several limitations associated with human ureteral sampling. In this work we question whether animal ureters are good replicas of human ureteral behavior for pharmacological studies. MATERIALS AN...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000358601
更新日期:2015-01-01 00:00:00
abstract::By transforming uroflowmetrograms from curves of flow rate versus time into curves of flow rate versus instantaneous bladder volume, additional information about the variation of the flow rate during voiding is obtained. These curves show that, within a certain volume range, the maximum flow rate is more or less indep...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280157
更新日期:1977-01-01 00:00:00
abstract::The term infection stones refers to calculi that occur following urinary tract infections (UTIs) caused by urease-producing gram-negative organisms. They consist of magnesium ammonium phosphate, carbonate apatite and monoammonium urate. Alkaline urine is most favorable to their formation. Urinary tract obstruction, ne...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000104439
更新日期:2007-01-01 00:00:00
abstract::A case of benign leiomyoma of the urinary bladder was discovered incidentally and treated successfully with endoscopic enucleation. We describe the technique of this new surgical approach and discuss its advantages. We recommend this minimally invasive approach over open surgical resection. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000085919
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:To present the long-term outcome of high-risk prostate cancer patients treated by radical retropubic prostatectomy (RRP) and stage-dependent adjuvant androgen deprivation therapy. PATIENTS AND METHODS:Between 1989 and 2005, 2,655 patients underwent RRP by 9 surgeons. All cases (n = 372) with high-risk prostate...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000277593
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:Meatal stenosis usually presents in adults with a history of urethral trauma or inflammation or as a complication after hypospadias repair. The objective of this study is to present the correction of meatal stenosis using a preputial island flap, created on the dorsal surface of the penis. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000102905
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The best technique of radical prostatectomy--open retropubic versus robot-assisted surgery--is a subject of controversy. PATIENTS AND METHODS:Between January 1st, 2007 and December 31st, 2011, 2,177 men underwent radical prostatectomy at our department. 252 (12%) cases were laparoscopic robot-assisted, the ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000345320
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:The aims of this study were to establish the prevalence of enuresis, to determine accompanying factors, and to identify common methods in the management of enuresis in Turkish children aged between 6 and 11 years living in eastern Anatolia. METHODS:The parents of 3,527 schoolchildren aged between 6 and 11...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000079696
更新日期:2004-01-01 00:00:00
abstract::From July 1992 to April 1994, 70 patients with prostatic cancer underwent laparoscopic pelvic lymph-node dissection (LPLD) before retropubic radical prostatectomy or afterloading therapy in our clinic. After an initial learning phase, the accuracy of LPLD was excellent, with only 3.0% residual nodes and no false-negat...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282756
更新日期:1995-01-01 00:00:00
abstract:INTRODUCTION:The German Research Activities on Natural Urologicals (GRANU) study was a randomized, partially blinded, placebo-controlled, parallel-group trial that investigated the efficacy of pumpkin seed in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH/LUTS). SUBJECTS AND METH...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000362903
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study is to modify and validate a novel screening tool to determine the necessity of bone scans in Chinese PCa patients at the time of diagnosis. METHODS:Five-hundred-and-one patients diagnosed with PCa between 2010 and 2013 at Zhongshan Hospital, Fudan University, were included in the study...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000368912
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Urologists have to master a variety of techniques to be able to offer the most appropriate surgical stone treatment for each individual patient. Therefore, we performed a survey among board-certified Swiss urologists to assess the availability of the different surgical methods, the current practices of sur...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000502806
更新日期:2019-01-01 00:00:00
abstract::Seven cases of adrenal myelolipoma comprising 5.8% of total adrenal tumors are described with a male-to-female ratio of 1.3:1. Five were symptomatic, of which 4 had a palpable abdominal mass, 2 cases detected incidentally were associated with carcinoma of the uterine cervix and renal cell carcinoma, respectively. The ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000283044
更新日期:1997-01-01 00:00:00
abstract::Fifty consecutive female patients with genuine urinary stress incontinence were randomized either to surgery or to a pelvic floor training program. The operative procedure was chosen according to the type of bladder suspension defect on micturition cystourethrography. The training program was given 5 times in weekly l...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000281181
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:To determine association between urine pH and OAB symptoms and to determine if urinary alkalization improves overactive bladder (OAB) symptoms. METHODS:659 patients with OAB were enrolled in this study between June 2012 and May 2014. 329 patients (group 1) were included in the final analysis. 201 adults wer...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000375322
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:The short-term effects of intravesical chemoimmunotherapy with epirubicin and bacillus Calmette-Guérin (BCG) administered repeatedly for prophylaxis of recurrence of superficial bladder cancer (pTa, pT1) were investigated in 24 patients aged a median of 70 years between March 1996 and February 1999, and were co...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000051005
更新日期:2001-01-01 00:00:00
abstract:AIMS:To investigate the effect of sildenafil on uroflowmetry values of patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic enlargement (BPE). METHODS:Thirty-eight consecutive patients and 15 control subjects without voiding symptoms were enrolled in the study. All patients underwent uroflo...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000112611
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:To give an overview of the literature concerning the clinical practice of Botulinum toxin A (BTA) treatment to meet the needs and knowledge of urologists. METHODS:A literature search was performed to BTA treatment, together with a survey among Dutch urologist. RESULTS:The registration trials used strict in...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000381881
更新日期:2015-01-01 00:00:00
abstract::Myelolipomas are rare benign neoplasms of the adrenal glands, characterized by the presence of adipose tissue and elements of bone marrow in various degrees of differentiation. Usually asymptomatic, they are discovered incidentally or at autopsy; sometimes larger masses may cause local symptoms. We report clinical, ra...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282612
更新日期:1994-01-01 00:00:00