Oncologic Response and Hospitalization Rate of Patients Receiving Cabazitaxel in the Fourth-Line and Beyond in Castration-Resistant Prostate Cancer: Analysis of a Retrospective Cohort and a Structured Literature Review.

Abstract:

BACKGROUND:Limited data are available for the use of agents in metastatic castration-resistant prostate cancer (mCRPC) beyond the third-line. We provide data during treatment with cabazitaxel (CAB), helping to improve the informed-consent process. PATIENTS AND METHODS:We retrospectively reviewed patients treated with fourth-line or beyond CAB for mCRPC after failure of previous therapies with docetaxel, abiraterone acetate, enzalutamide and/or radium-223. The progression-free survival (PFS) and the overall survival (OS) were estimated using the Kaplan-Meier method and compared to published data based on a structured literature review. The hospitalization rate was recorded. Factors influencing 6-months OS were analyzed. RESULTS:Fifteen patients were identified at 4 institutions and included in the analysis. The median PFS was 104 days (range 47-397 days). The median time to death was 10 months (range 2-16). PFS and OS data are in accordance with 17 published patients so far. During the therapy, eleven (73%) of the patients were hospitalized. Prostate-specific antigen (PSA, 500 units; hazards ratio [HR] 1.491, 95% CI 1.000-2.0175), white blood cell count (HR 0.425, 95% CI 0.108-0.952), hemoglobin (HR 0.6014, 95% CI 0.2942-1.0758), and alkaline phosphatase (100 units; HR 1.0964, 95% CI 1.000-1.2859) correlate with 6-months OS. CONCLUSIONS:CAB beyond the third-line is often accompanied by hospitalization. PFS is a significant proportion of the median time of OS. The baseline laboratory might be a good indicator for the decision between CAB and best-supportive care.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

von Hardenberg J,Schwartz M,Werner T,Fuxius S,Strauss A,Worst TS,Nuhn P,Bolenz C,Heinrich E

doi

10.1159/000477943

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

414-421

issue

4

eissn

0042-1138

issn

1423-0399

pii

000477943

journal_volume

99

pub_type

杂志文章,多中心研究,评审
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    pub_type: 临床试验,杂志文章,多中心研究

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    pub_type: 杂志文章,meta分析,评审

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    authors: Li T,Gao L,Chen P,Bu S,Cao D,Yang L,Wei Q

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  • The Effect of Hyperbaric Oxygen Therapy on Erectile Functions: A Prospective Clinical Study.

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  • [In vitro sensitivity testing of human kidney tumors to cytostatic drugs with a rapid in vitro test].

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    authors: de Riese W,Aeikens B,Lenis G,Schindler E

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    pub_type: 杂志文章

    doi:10.1159/000330911

    authors: Dong ZL,Lu ZP,Wang HZ,Zhang LY,Wang ZP,Zhang YF,Ma BL

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    pub_type: 杂志文章

    doi:10.1159/000477446

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    pub_type: 杂志文章

    doi:10.1159/000106334

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    更新日期:2007-01-01 00:00:00

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    pub_type: 杂志文章,meta分析

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    authors: Takaiwa M,Shiraiwa Y

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