Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study.

Abstract:

INTRODUCTION:The German Research Activities on Natural Urologicals (GRANU) study was a randomized, partially blinded, placebo-controlled, parallel-group trial that investigated the efficacy of pumpkin seed in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH/LUTS). SUBJECTS AND METHODS:A total of 1,431 men (50-80 years) with BPH/LUTS were randomly assigned to either pumpkin seed (5 g b.i.d.), capsules with pumpkin seed extract (500 mg b.i.d.) or matching placebo. The primary response criterion was a decrease in International Prostate Symptom Score (IPSS) of ≥5 points from baseline after 12 months. Secondary outcome measures included IPSS-related quality of life, IPSS single items and diary-recorded nocturia. RESULTS:After 12 months, the response rate (intention-to-treat/last-observation-carried-forward approach) did not differ between pumpkin seed extract and placebo. In the case of pumpkin seed (responders: 58.5%), the difference compared with placebo (responders: 47.3%) was descriptively significant. The study products were well tolerated. Overall, in men with BPH, 12 months of treatment with pumpkin seed led to a clinically relevant reduction in IPSS compared with placebo. CONCLUSION:In order to fully justify a recommendation for the use of pumpkin seed to treat moderate LUTS, these findings need to be substantiated in a confirmatory study or systematic review.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Vahlensieck W,Theurer C,Pfitzer E,Patz B,Banik N,Engelmann U

doi

10.1159/000362903

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

286-95

issue

3

eissn

0042-1138

issn

1423-0399

pii

000362903

journal_volume

94

pub_type

杂志文章,多中心研究,随机对照试验
  • Enuresis prevalence and accompanying factors in schoolchildren: a questionnaire study from southeast Anatolia.

    abstract:INTRODUCTION:The aims of this study were to establish the prevalence of enuresis, to determine accompanying factors, and to identify common methods in the management of enuresis in Turkish children aged between 6 and 11 years living in eastern Anatolia. METHODS:The parents of 3,527 schoolchildren aged between 6 and 11...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000079696

    authors: Ozkan KU,Garipardic M,Toktamis A,Karabiber H,Sahinkanat T

    更新日期:2004-01-01 00:00:00

  • Adenocarcinoma of the urachus associated with stromal osseous metaplasia.

    abstract::Urachal adenocarcinoma is a rare bladder tumor, occasionally associated with calcification. We report a case of urachal adenocarcinoma with remarkable stromal osseous metaplasia and review the literature on this rare condition. This is the first complete case report in English of this uncommon entity. ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282554

    authors: Okamoto K,Fukuyama T,Okamoto E,Yoshida O,Hiai H

    更新日期:1993-01-01 00:00:00

  • Long-term acidification of urine in patients treated for infected renal stones.

    abstract::The effects of ammonium chloride, methenamine hippurate and ascorbic acid on urinary pH was studied in 14 normal subjects. A statistically significant reduction of urinary pH was recorded with ammonium chloride in daily doses of 1.5 and 3 g, but not with 2 g of methenamine hippurate or 1.8 g of ascorbic acid. Long-ter...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000281732

    authors: Wall I,Tiselius HG

    更新日期:1990-01-01 00:00:00

  • Experimental partial ureteric obstruction in newborn rats. VIII. Contralateral kidney weight after release of the obstruction.

    abstract::In unilateral kidney disease, it has been suggested that the ipsilateral state could be estimated by measuring contralateral kidney size; thus, a contralateral increase should reflect an ipsilateral impairment and vice versa. This could easily be performed using ultrasound. In our experiments with partial obstruction ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282898

    authors: Josephson S,Larsson E

    更新日期:1996-01-01 00:00:00

  • Healthcare-Associated Infections after Lower Urinary Tract Endoscopic Surgery: Analysis of Risk Factors, Associated Microorganisms and Patterns of Antibiotic Resistance.

    abstract:OBJECTIVES:To review the incidence of healthcare-associated infections/urinary tract infection (UTI), risk factors, microorganisms isolated and antibiotic resistances in patients who underwent lower urinary tract endoscopic surgery (LUTES) in a tertiary care hospital. METHODS:A prospective observational study was carr...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000488251

    authors: Sopeña-Sutil R,Medina-Polo J,Justo-Quintas J,Gil-Moradillo J,Garcia-Gonzalez L,Benítez-Sala R,Alonso-Isa M,Lara-Isla A,Tejido-Sanchez A

    更新日期:2018-01-01 00:00:00

  • EMG-patterns of pelvic floor muscles with surface electrodes.

    abstract::On reviewing the literature most authors were found to have used needle electrodes for recording muscle potentials of pelvic floor muscles. We used for the first time a vaginal tampon electrode to record potentials of musculus levator ani in females and the same electrode to record potentials of the external anal sphi...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审

    doi:10.1159/000280033

    authors: Kiesswetter H

    更新日期:1976-01-01 00:00:00

  • Extramedullary hematopoiesis in chronic myelofibrosis encasing the pelvicaliceal system and perirenal spaces: CT findings.

    abstract::We examined a 46-year-old male patient with idiopathic myelofibrosis diagnosed 28 months earlier. After chemotherapy and irradiation, CT showed nonnodular, soft tissue masses in the renal hilum, pelvicaliceal system, perirenal and periureteral spaces. Ultrasound-guided biopsy showed extramedullary hematopoiesis (EMH)....

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000087809

    authors: La Fianza A,Torretta L,Spinazzola A

    更新日期:2005-01-01 00:00:00

  • [Parameters of incurability in urinary bladder cancer].

    abstract::Curative treatment of bladder cancer is limited to superficial tumors (Ta-T2). Advanced stages (T3a + T3b) can be treated only palliatively even when confined to the bladder (N0, M0). Nevertheless the differentiation between curable and incurable tumors is difficult. The classification of patients into the two differe...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000281064

    authors: Egghart G,Schutz AJ,Altwein JE

    更新日期:1985-01-01 00:00:00

  • Comparison of retroperitoneoscopic and transperitoneal laparoscopic adrenalectomy for right-sided benign tumors: a single-institute experience.

    abstract:INTRODUCTION:There is a lack of data regarding the appropriateness of transperitoneal and retroperitoneal approaches for right-sided laparoscopic adrenalectomy. The aim of this study was to determine whether there is any difference between right-sided transperitoneal laparoscopic adrenalectomy (TLA) and retroperitoneal...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000357627

    authors: Chiang PH,Yu CJ,Lee WC,Wang HJ,Hsu WC

    更新日期:2015-01-01 00:00:00

  • Barium granuloma involving urinary bladder.

    abstract::The first case of barium granuloma involving urinary bladder is reported. Surgical removal was the treatment of choice. Histological diagnosis was foreign body granuloma with xanthomatous inflammation. The foreign body was identified as barium by analytical electron microscopy. ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000281516

    authors: Yanagi S,Ishii T,Tsuji Y,Ariyoshi A

    更新日期:1989-01-01 00:00:00

  • Urinary excretion of inorganic pyrophosphate by normal subjects and patients with renal calculi in north-western India and the effect of diclofenac sodium upon urinary excretion of pyrophosphate in stone formers.

    abstract::24 h urinary pyrophosphate excretion was studied in 20 normal healthy subjects and 75 idiopathic stone formers from north-western regions of India. The mean 24-hour urinary excretion of pyrophosphate was significantly low in stone formers (50.67 +/- 2.16 mumol/24 h) as compared to that of normal subjects (71.46 +/- 5....

    journal_title:Urologia internationalis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000282364

    authors: Sharma S,Vaidyanathan S,Thind SK,Nath R

    更新日期:1992-01-01 00:00:00

  • In-Hospital Outcomes after Radical Cystectomy for Bladder Cancer: Comparing National Trends in the United States and Germany from 2006 to 2014.

    abstract:BACKGROUND:Radical cystectomy (RC) still poses a significant risk for mortality and morbidity. OBJECTIVES:We compared in-hospital outcomes after RC in the United States and -Germany using population-based data. METHODS:We compared data from the US Nationwide Inpatient Sample to the German hospital billing database. M...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000496347

    authors: Groeben C,Koch R,Baunacke M,Borkowetz A,Wirth MP,Huber J

    更新日期:2019-01-01 00:00:00

  • Malignant lymphoma of the prostate. Report of a case.

    abstract::A 63-year-old man with primary malignant lymphoma of the prostate is presented. The patient underwent total cystoprostatectomy and ileal conduit construction. The specimen revealed malignant lymphoma, diffuse small cleaved cell of the gland. Three months after the operation, local recurrence and enlarged lymph node de...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282216

    authors: Suzuki H,Nakada T,Iijima Y,Kaneko H,Suzuki Y,Ishii N,Onmura Y,Takamizawa A,Saito M

    更新日期:1991-01-01 00:00:00

  • Pressure-flow studies in men with benign prostatic hypertrophy before and after treatment with transurethral needle ablation.

    abstract:BACKGROUND/AIMS:In this study we wanted to examine the effects that transurethral needle ablation (TUNA) might have on the urodynamic characteristics of bladder outlet obstruction and to evaluate the clinical changes and the safety profile in patients undergoing the TUNA procedure, including the effects on erectile and...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000056577

    authors: Minardi D,Garofalo F,Yehia M,Cristalli AF,Giammarco L,Galosi AB,Muzzonigro G

    更新日期:2001-01-01 00:00:00

  • The effect of sunitinib on immune subsets in metastatic clear cell renal cancer.

    abstract:BACKGROUND:Sunitinib is standard first-line therapy for metastatic clear cell renal cancer (MCRC). It is associated with leucopenia; however, its effects on specific immune cell subsets are unclear. Alterations in immune cell subsets may contribute to tumour progression. METHODS:Lymphocyte subsets (CD3, 4, 8, 19 and 5...

    journal_title:Urologia internationalis

    pub_type: 临床试验,杂志文章

    doi:10.1159/000319498

    authors: Powles T,Chowdhury S,Bower M,Saunders N,Lim L,Shamash J,Sarwar N,Sadev A,Peters J,Green J,Boleti K,Augwal S

    更新日期:2011-01-01 00:00:00

  • Managing mesh erosion after abdominal pelvic organ prolapse repair: ten years' experience in a single center.

    abstract:OBJECTIVE:To report conservative and surgical strategies for treatment of mesh erosion after pelvic organ prolapse (POP) repair. METHODS:Between 1998 and 2008, 179 patients underwent integral pelvic floor reconstruction for advanced POP in our tertiary urogynecological unit. Patients' charts and follow-up data were en...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000324243

    authors: Costantini E,Zucchi A,Lazzeri M,Del Zingaro M,Vianello A,Porena M

    更新日期:2011-01-01 00:00:00

  • Does sildenafil affect uroflowmetry values in men with lower urinary tract symptoms suggestive of benign prostatic enlargement?

    abstract:AIMS:To investigate the effect of sildenafil on uroflowmetry values of patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic enlargement (BPE). METHODS:Thirty-eight consecutive patients and 15 control subjects without voiding symptoms were enrolled in the study. All patients underwent uroflo...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000112611

    authors: Güler C,Tüzel E,Doğantekin E,Kiziltepe G

    更新日期:2008-01-01 00:00:00

  • [Endometriosis of the efferent urinary pathways].

    abstract::Two cases of ureteral endometriosis and 1 case of vesical endometriosis are reported and a short review of the literature is presented. The diagnostic problems, despite modern image procedures, and therapeutic modalities are discussed. ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000281099

    authors: Maros TG,Terhorst B

    更新日期:1985-01-01 00:00:00

  • Familial occurrence of congenital stricture of bulbar urethra.

    abstract::We report on the familial occurrence of congenital bulbar urethral stricture in 2 brothers. Embryological mechanisms are briefly discussed and the literature reviewed. ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审

    doi:10.1159/000281795

    authors: Aragona F,Maio G,Oliva G,Calabrò A,Ostardo E,Artibani W

    更新日期:1991-01-01 00:00:00

  • Collagen graft interposition in vesicovaginal fistula treatment.

    abstract::Vesicovaginal fistula (VVF) is a quite rare complication of gynecological surgery. The first attempt to repair the fistulous tract offers the best opportunity for cure. We report the successful repair of VVF in 2 patients using a combined anterior vaginal approach and porcine dermal collagen grafting as interposition ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000176038

    authors: Robles JE,Saiz A,Rioja J,Brugarolas X,Berian JM

    更新日期:2009-01-01 00:00:00

  • Urgency, detrusor overactivity and posterior vault prolapse in women who underwent pelvic organ prolapse repair.

    abstract:INTRODUCTION:We investigated the relationship between posterior vault prolapse and overactive bladder (OAB) symptoms or detrusor overactivity (DO) and their changes after surgical repair. METHODS:Forty-three patients with vault prolapse and prevalent posterior compartment prolapse underwent pelvic organ prolapse repai...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000345944

    authors: Costantini E,Lazzeri M,Zucchi A,Mearini L,Fragalà E,Del Zingaro M,Bini V,Porena M

    更新日期:2013-01-01 00:00:00

  • Extrarenal calyces: a rarity.

    abstract::Extrarenal calyces are an extremely rare entity and only a few cases have been reported worldwide. We report a case with extrarenal calyces and give a brief review of the literature. Awareness of this rare entity can prevent inadvertent injury to the pelvicalyceal system during surgery. ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审

    doi:10.1159/000072690

    authors: Garg P,Godara R,Karwasra RK

    更新日期:2003-01-01 00:00:00

  • Diagnostic value of the nuclear matrix protein 22 test and urine cytology in upper tract urothelial tumors.

    abstract:OBJECTIVE:To investigate the diagnostic value of the nuclear matrix protein 22 (NMP22) test in comparison to urine cytology for the detection of upper tract urothelial carcinoma. PATIENTS AND METHODS:Patients with transitional cell carcinoma of the upper urinary tract (n = 34) and patients with renal calculosis (n = 2...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000330246

    authors: Jovanovic M,Soldatovic I,Janjic A,Vuksanovic A,Dzamic Z,Acimovic M,Hadzi-Djokic J

    更新日期:2011-01-01 00:00:00

  • Prophylactic intravesical chemotherapy to prevent bladder tumors after nephroureterectomy for primary upper urinary tract urothelial carcinomas: a systematic review and meta-analysis.

    abstract:INTRODUCTION:Intravesical recurrence after treatment of primary upper urinary tract urothelial carcinomas (UUT-UCs) is common. While intravesical instillation is widely used to prevent recurrence after transurethral resection for primary bladder tumors, there is still no consensus on the prophylactic capability of intr...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000350508

    authors: Fang D,Li XS,Xiong GY,Yao L,He ZS,Zhou LQ

    更新日期:2013-01-01 00:00:00

  • Lymphoceles Post-Radical Retropubic Prostatectomy: A Retrospective Evaluation of Epidemiology, Risk Factors and Outcome.

    abstract:INTRODUCTION:We aimed at evaluating the incidence of lymphoceles, a common complication after radical retropubic prostatectomy (RRP), at a high volume centre, define risk factors and assess the clinical outcome. MATERIALS AND METHODS:454 patients receiving RRP and pelvic lymph node dissection were assessed for postope...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000381463

    authors: Heers H,Laumeier T,Olbert PJ,Hofmann R,Hegele A

    更新日期:2015-01-01 00:00:00

  • Effect of mineral water containing calcium and magnesium on calcium oxalate urolithiasis risk factors.

    abstract::Calcium oxalate kidney stone formers are invariably advised to increase their fluid intake. In addition, magnesium therapy is often administered. Recently, a prospective study showed that a high dietary intake of calcium reduces the risk of symptomatic kidney stones. The present study was performed to test whether sim...

    journal_title:Urologia internationalis

    pub_type: 临床试验,杂志文章

    doi:10.1159/000282958

    authors: Rodgers AL

    更新日期:1997-01-01 00:00:00

  • Renal injury: 5-year experience and literature review.

    abstract:INTRODUCTION:Appropriate management of renal trauma is controversial. The purpose of this study is to present our 5-year experience in renal trauma and review the literature. MATERIALS AND METHODS:From 1999 to 2003, 28 patients were identified with renal injuries. 25 (89.3%) of the injuries were caused by blunt trauma...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审

    doi:10.1159/000093899

    authors: Gourgiotis S,Germanos S,Dimopoulos N,Vougas V,Anastasiou T,Baratsis S

    更新日期:2006-01-01 00:00:00

  • Antitumor effects of interleukin 2 against renal cell carcinoma: basic study and clinical application.

    abstract::In order to determine an optimum mode for systemic administration of recombinant interleukin 2 (rIL2), the effects of rIL2 on lymphocyte-mediated cytotoxicity against renal carcinoma cells were studied in vitro. Augmentation of the cytotoxicity by rIL2 was dose- and time-dependent. The optimum dose of rIL2 was 100-500...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282272

    authors: Marumo K,Ueno M,Muraki J,Tachibana M,Deguchi N,Baba S,Jitsukawa S,Hata M,Tazaki H

    更新日期:1991-01-01 00:00:00

  • Incontinence operation for postprostatectomy incontinence.

    abstract::The pathophysiological considerations for regaining continence are discussed first. Our operation method for postprostatectomy incontinence is described and the results enumerated. The success rate is approximatively 80%. ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000281155

    authors: Hauri D

    更新日期:1986-01-01 00:00:00

  • Changes in symptoms and colpo-cystourethrography in 35 patients before and after total abdominal hysterectomy: a prospective study.

    abstract::35 women, referred for simple total hysterectomy, were evaluated pre- and postoperatively for bladder suspension and urodynamic changes. Although all patients denied urological problems, more than half of the patients had some degree of stress and/or urge incontinence. 40% had radiological signs of bladder suspension ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000281085

    authors: Hansen BM,Bonnesen T,Hvidberg JE,Eliasen B,Nielsen K,Frimodt-Møller C

    更新日期:1985-01-01 00:00:00