Abstract:
INTRODUCTION:The German Research Activities on Natural Urologicals (GRANU) study was a randomized, partially blinded, placebo-controlled, parallel-group trial that investigated the efficacy of pumpkin seed in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH/LUTS). SUBJECTS AND METHODS:A total of 1,431 men (50-80 years) with BPH/LUTS were randomly assigned to either pumpkin seed (5 g b.i.d.), capsules with pumpkin seed extract (500 mg b.i.d.) or matching placebo. The primary response criterion was a decrease in International Prostate Symptom Score (IPSS) of ≥5 points from baseline after 12 months. Secondary outcome measures included IPSS-related quality of life, IPSS single items and diary-recorded nocturia. RESULTS:After 12 months, the response rate (intention-to-treat/last-observation-carried-forward approach) did not differ between pumpkin seed extract and placebo. In the case of pumpkin seed (responders: 58.5%), the difference compared with placebo (responders: 47.3%) was descriptively significant. The study products were well tolerated. Overall, in men with BPH, 12 months of treatment with pumpkin seed led to a clinically relevant reduction in IPSS compared with placebo. CONCLUSION:In order to fully justify a recommendation for the use of pumpkin seed to treat moderate LUTS, these findings need to be substantiated in a confirmatory study or systematic review.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Vahlensieck W,Theurer C,Pfitzer E,Patz B,Banik N,Engelmann Udoi
10.1159/000362903subject
Has Abstractpub_date
2015-01-01 00:00:00pages
286-95issue
3eissn
0042-1138issn
1423-0399pii
000362903journal_volume
94pub_type
杂志文章,多中心研究,随机对照试验abstract:INTRODUCTION:The aims of this study were to establish the prevalence of enuresis, to determine accompanying factors, and to identify common methods in the management of enuresis in Turkish children aged between 6 and 11 years living in eastern Anatolia. METHODS:The parents of 3,527 schoolchildren aged between 6 and 11...
journal_title:Urologia internationalis
pub_type: 杂志文章
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journal_title:Urologia internationalis
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doi:10.1159/000282554
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journal_title:Urologia internationalis
pub_type: 杂志文章
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journal_title:Urologia internationalis
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journal_title:Urologia internationalis
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journal_title:Urologia internationalis
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,meta分析,评审
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journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章
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