Abstract:
:In order to determine an optimum mode for systemic administration of recombinant interleukin 2 (rIL2), the effects of rIL2 on lymphocyte-mediated cytotoxicity against renal carcinoma cells were studied in vitro. Augmentation of the cytotoxicity by rIL2 was dose- and time-dependent. The optimum dose of rIL2 was 100-500 units (Jurkat units)/ml, and cytotoxicity increased significantly even at a low concentration such as 4 units/ml. We thus chose daily administration of multiple repeated dose for inpatients. To prevent withdrawal from the therapy as a result of untolerable adverse effects, the daily dose was set at 1 X 10(6) units, and rIL2 was given to 12 patients with metastatic renal cell carcinoma. Two-hour intravenous drip infusions containing 5 X 10(5) units of rIL2 was given daily 2 times to inpatients and after at least 28 days of this mode of administration, subcutaneous injection at a dose of 1 X 10(6) units was given 6 days a week to outpatients. Three patients showed complete response, 7 patients no change, and 2 patients progressive disease. Serious adverse effects due to capillary leak syndrome were not observed. We conclude that low-dose rIL2 is safe and has potential antitumor effects.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Marumo K,Ueno M,Muraki J,Tachibana M,Deguchi N,Baba S,Jitsukawa S,Hata M,Tazaki Hdoi
10.1159/000282272subject
Has Abstractpub_date
1991-01-01 00:00:00pages
132-7eissn
0042-1138issn
1423-0399journal_volume
47 Suppl 1pub_type
杂志文章abstract:OBJECTIVES:To investigate the protective role of thymoquinone (TQ) on unilateral testicular ischemia-reperfusion (I/R) injury in mice. MATERIALS AND METHODS:Experiments were performed on male C57BL/6 mice (8 weeks old, 20-25 g). The animals were divided into 3 groups including 6 mice in each group: control (sham), tor...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000318890
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:To evaluate the role of serum carbohydrate antigen 19-9 (CA19-9) in the prognosis and follow-up evaluation of patients with urothelial carcinoma, the authors studied the association of the serum level and positive rate with clinical features such as infiltration and metastasis in 164 patients admitted to t...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000075963
更新日期:2004-01-01 00:00:00
abstract:INTRODUCTION:The German Research Activities on Natural Urologicals (GRANU) study was a randomized, partially blinded, placebo-controlled, parallel-group trial that investigated the efficacy of pumpkin seed in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH/LUTS). SUBJECTS AND METH...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000362903
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVE:When feasible, the treatment for all-invasive bladder cancer is radical cystectomy. The aim of the present study was to analyze the prognostic difference, disease-specific survival rate, of muscle-invasive transitional cell cancer of the bladder (TCCB) for progressive invasive TCCB. PATIENTS...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000107950
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Laparoscopic adrenalectomy is the gold standard for treatment of benign adrenal lesions. Tumor size is a factor that might influence decision-making concerning the use of laparoscopic approach. The aim of this study was to analyze the results of adrenalectomy for tumors ≥6 cm in diameter. METHODS:Two groups...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000444146
更新日期:2016-01-01 00:00:00
abstract::In a combined (cross-sectional and longitudinal) study, the serum concentration of laminin P1 was measured by radioimmunoassay in 16 patients with benign inflammatory bladder disorders and 47 patients with transitional cell carcinoma of the bladder. The results were compared with the serum laminin P1 values in 50 heal...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282410
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVES:To cultivate primary human bladder smooth muscle cells (hBSMCs) in vitro and to study the influences of different sustained hydrostatic pressures upon hBSMCs in terms of cell proliferation and expression of gap-junction connexin 43 (Cx43). METHODS:hBSMCs were exposed to 0, 20, 40, 60, 80 and 100 cm H(2)O su...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000338924
更新日期:2013-01-01 00:00:00
abstract::Between March 1983 and March 1988 we registered and treated 49 patients with bladder cancer less than 40 years of age (7 patients less than 30 years of age). Hematuria was present in 40 cases (81.6%). 33 of the patients had a pTA tumor (67.3%). 47 patients had transitional carcinoma of the bladder, of which 21 (44.7%)...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281475
更新日期:1989-01-01 00:00:00
abstract::We report a rare case of massive bilateral staghorn calculi in a spinal cord injury patient with significant renal compromise. The patient was successfully treated with percutaneous nephrolithotomy to achieve a stone-free status. The various options of treatment are discussed with special attention to the technical as...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030340
更新日期:1998-01-01 00:00:00
abstract::Tumour markers which occur in blood or urine are of value in the management of cancer patients because they allow disease status to be monitored by non-invasive techniques at low cost. An antigen, 'B5', on erythrocytes has been shown to become enhanced when cancer develops, regardless of tumour type, and thus the B5 a...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281951
更新日期:1987-01-01 00:00:00
abstract::Cystinuria is a rare cause of renal calculi, whose management presents a complex problem mainly due to the hardness and high recurrence rate of cystine stones. During the period 1987-1991, 28 established cases of cystine calculi were treated by extracorporeal shock wave lithotripsy (ESWL) and percutaneous nephrolithot...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282836
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:The treatment approach for enuresis is controversial due to the lack of consensus as to the exact causes of nocturnal enuresis. Despite various treatment modalities, pharmacotherapy still appears to be the common choice. The aim of this prospective study was the evaluation of the efficacy of combination therapy...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000064858
更新日期:2000-01-01 00:00:00
abstract:PURPOSE:To assess MRI/Transrectal Ultrasound (TRUS) fusion three-dimensional model-guided targeted biopsy (3D-Tb) versus TRUS-guided systematic biopsy (Sb) in detecting overall and high-Gleason-score (≥7) prostate cancer (PCa). METHODS:Pubmed and Web of science were searched. Studies with men having a suspicious lesio...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000484144
更新日期:2018-01-01 00:00:00
abstract::Carcinoma of the bladder following augmentation cystoplasty is rare. Only 15 cases have been reported worldwide. We report a further 2 cases, 1 of which, a squamous cell carcinoma, has not previously been described in this context. ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000030479
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:To assess the role of primary open surgery versus the recommended combination approach (percutaneous and lithotripsy) to treat staghorn calculi in a developing country. PATIENTS AND METHODS:Available records (n = 91) of patients with staghorn managed during the last 4 years were retrieved. Patients were plac...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030456
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:To assess the association between the development of a urethral stricture (US) and disease-free survival for patients with localized prostate cancer treated with high-intensity focused ultrasound (HIFU). PATIENTS AND METHODS:Patients with clinical stage T1-T2N0M0 prostate cancer were eligible for treatment wit...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000330909
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:To assess the association of prostate volume index (PVI), defined as the ratio of the central transition zone volume to the peripheral zone volume, and prostatic chronic inflammation (PCI) as predictors of prostate cancer (PCA) risk in patients presenting with normal digital rectal exam and prostate-specif...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000502659
更新日期:2019-01-01 00:00:00
abstract::During infancy, the renal parenchyma and pelvicalyceal system are relatively fragile. Therefore, percutaneous nephrolithotomy for the management of renal stones in this age group is a challenging procedure for urologists. Herein, we present the uneventful management of bilateral renal stones using micropercutaneous ne...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000360645
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:The study aimed to evaluate the predictive value of ureteral wall thickness (UWT) and stone-related parameters for medical expulsive therapy (MET) success with an alpha blocker in pediatric upper ureteral stones. PATIENTS AND METHODS:A total of 35 children receiving MET ureteral stones (<10 mm) were evaluate...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000453668
更新日期:2017-01-01 00:00:00
abstract:AIM:To evaluate the efficacy of a new sclerotization technique with pure ethanol in the treatment of symptomatic renal cysts. PATIENTS AND METHODS:Fourteen patients having renal cysts with a meant diameter of 10 (range 5-15) cm were treated. Our technique includes: ultrasound-guided percutaneous puncture with an 18-ga...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000071846
更新日期:2003-01-01 00:00:00
abstract::Blind-ending bifid ureter in a woman with urinary tract infection and a duplicated renal pelvis in her twin sister are reported. The blind-ending bifid ureter terminated as a fibrous cord with a terminal mass of immature renal tissue. This type of ureter may be a transitional form between histologically blind-ending b...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280110
更新日期:1977-01-01 00:00:00
abstract::Urinary incontinence in 80 men was classifed by combined radiological and urodynamic techniques. 28 cases of pure stress incontinence were evaluated for grading of sphincteric loss. Clinical and sphincterometric data were correlated. Functional urethral length, urethral closure pressure at rest and with voluntary sphi...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280348
更新日期:1980-01-01 00:00:00
abstract:AIMS AND OBJECTIVE:To describe the technique, results and follow-up of dynamic rectus abdominis tendon colposuspension (DRTC) in the management of female stress urinary incontinence (SUI). PATIENTS AND METHODS:Eighteen patients with SUI were studied prospectively from 1998 to 1999 who underwent DRTC. Type I and type I...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000071093
更新日期:2003-01-01 00:00:00
abstract::Marked differences were observed in the mechanical reactions of human and guinea pig vas deferens to prostaglandins, irradiation, and cooling. In human preparations prostaglandin E1 (0.1-1 ng/ml) had an augmentory effect on the contractile response after electrical neurostimulation (10 Hz, 0.3 ms, 3 s), but no visible...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280898
更新日期:1983-01-01 00:00:00
abstract::Disseminated aspergillosis is a systemic fungal infection that may occur in previously healthy or immunocompromised patients. The condition, although rare, is being recognized with increasing frequency in persons with the human immunodeficiency virus. Clinical genitourinary involvement is unusual. We present a case of...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282752
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Robotic-assisted laparoscopy (RAL) is being widely accepted in the field of urology as a replacement for conventional laparoscopy (CL). Nevertheless, the process of its integration in clinical routines has been rather spontaneous. OBJECTIVE:To determine the prevalence of robotic systems (RS) in urological c...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000430502
更新日期:2015-01-01 00:00:00
abstract::The pathophysiological considerations for regaining continence are discussed first. Our operation method for postprostatectomy incontinence is described and the results enumerated. The success rate is approximatively 80%. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281155
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVES:To prospectively evaluate the prognostic utility of the traditional prognostic factors and molecular markers p53 and Ki-67 in a homogeneous series of patients with non-muscle-invasive bladder cancer (NMIBC) treated with Bacillus Calmette-Guérin (BCG). PATIENTS AND METHODS:192 intermediate- and high-risk NMI...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000343431
更新日期:2013-01-01 00:00:00
abstract::Sacrocolpopexy, a surgical technique with a low morbidity rate, is a valid procedure for repairing vaginal vault prolapse. To our knowledge, only 1 case of rectum erosion after open sacrocolpopexy has been reported in the literature, and there is no record of any such incident after laparoscopic sacrocolpopexy. We rep...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000353421
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To investigate whether or not the age of spontaneous resolution of monosymptomatic nocturnal enuresis (MNE) was familial. PATIENTS AND METHODS:A questionnaire was administered to more than 1,500 people, and 100 appropriate participants were identified from four referral hospitals. We included the participants ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000370166
更新日期:2015-01-01 00:00:00