Diagnostic value of the nuclear matrix protein 22 test and urine cytology in upper tract urothelial tumors.

Abstract:

OBJECTIVE:To investigate the diagnostic value of the nuclear matrix protein 22 (NMP22) test in comparison to urine cytology for the detection of upper tract urothelial carcinoma. PATIENTS AND METHODS:Patients with transitional cell carcinoma of the upper urinary tract (n = 34) and patients with renal calculosis (n = 25) were included in this study. Voided urine samples and separated catheter urine specimens were assayed for NMP22 and cytological examination. RESULTS:The sensitivity of the NMP22 test in separated and voided urine was 73.2 and 70.5%, respectively, compared to 64.7 and 58.8% of urine cytology. The specificity of the NMP22 test in separated and voided urine was 88 and 92%, respectively, compared to 96 and 96% of urine cytology. The combination of separated and voided urine is the best method because the sensitivity is 79.41% and specificity 88%. There is a high agreement of the NMP22 test in voided and separated urine (kappa = 0.795, p < 0.01), indicating that the voided urine is adequate for diagnosis. CONCLUSIONS:The NMP22 test has higher sensitivity but lower specificity than cytology. The combination of these two tests could be a very useful diagnostic method for detection of upper urothelial tumors.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Jovanovic M,Soldatovic I,Janjic A,Vuksanovic A,Dzamic Z,Acimovic M,Hadzi-Djokic J

doi

10.1159/000330246

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

134-7

issue

2

eissn

0042-1138

issn

1423-0399

pii

000330246

journal_volume

87

pub_type

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