Mitomycin C in multiple superficial bladder tumors: short-term therapy, long-term results.

Abstract:

:At the Institute of Urology, University of Padova, 125 patients with multifocal superficial bladder cancer underwent treatment with intravesical Mitomycin C (MMC; 1 weekly instillation of 40 mg for 8 consecutive weeks) between January 1982 and December 1988. Eighty-four patients had multifocal papillary tumors (stages Ta-T1) and 41 patients had carcinoma in situ of the bladder. At 6 and 36 months the tumor free percentage in the group with papillary tumors was 69 and 36%, respectively; for carcinoma in situ the complete response percentage at the same intervals was 80 and 36%. Thirty-one patients previously unsuccessfully treated with adriamycin did not show any difference compared to untreated ones. The authors emphasize the efficacy and low toxicity of intravesical MMC in multiple superficial bladder cancer. The possibility of long-term relapse suggests maintenance therapy.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Milani C,Bassi P,Meneghini A,Garbeglio A,Zattoni F,Piazza N,Maruzzi D,Drago-Ferrante GL,Pagano F

doi

10.1159/000282320

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

154-6

issue

2

eissn

0042-1138

issn

1423-0399

journal_volume

48

pub_type

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