The Relationship between Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms and Mean Platelet Volume: The Role of Metabolic Syndrome.

Abstract:

OBJECTIVE:The aim of the present study was to investigate the relationship among serum mean platelet volume (MPV) levels, benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS) and metabolic syndrome (MetS), and study the potential role of serum MPV levels in BPH/LUTS progression in an indirect manner. METHODS:Five hundred fifty-one men aged 45 or older with moderate to severe LUTS due to benign prostatic enlargement were recruited into this study by consecutive routine physical examination programs. Urologic evaluation included transrectal ultrasound, International Prostate Symptom Score and maximum urinary flow rate (Qmax). Overnight fasting venous blood specimens were collected and serum levels of prostate-specific antigen, fasting blood glucose, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol, triglyceride and C-reactive protein (CRP) were recorded. In addition, MPV were determined by automated hematology analyzer. We divided subjects into 2 groups according to the presence of MetS. We also took the MPV values as a categorical variable and divided subjects into 2 groups (≥11.8 or <11.8 fl) or 4 groups according to the different levels of MPV (9.3-11.0, 11.1-11.5, 11.6-11.9, 12.0-12.5 and ≥12.5 fl). The clinical characteristics and parameters of BPH/LUTS in different groups were measured and compared to identify their relationships. RESULTS:MetS was diagnosed in 37.0% of the subjects. There were significant interactive correlation among the number of positive MetS components, CRP, MPV and parameters of BPH/LUTS. The ratio of PV ≥31 ml and Qmax <10.6 ml/s were positively correlated with the increased level of MPV. Additionally, the OR in relation to PV ≥31 ml and Qmax <10.6 ml/s significantly rose as the level of MPV increased after adjusting for age, suggesting of a threshold effect at 12.0-12.5 fl for PV ≥31 ml (OR 2.678, 95% CI 1.425-5.035) and at >12.5 fl for Qmax <10.6 ml/s (OR 3.190, 95% CI 1.768-5.755). However, only the value of MPV more than 12.5 fl still showed statistically significant effect on Qmax <10.6 ml/s after adjusting for age and the presence of MetS (OR 2.164, 95% CI 1.162-4.032). CONCLUSIONS:Our results add to the evidence that chronic inflammation is a candidate mechanism at the crossroad between MetS and BPH/LUTS, and the presence of elevated MPV may serve as a predictor of MetS-induced inflammation in the progression of BPH/LUTS.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Zhao S,Tang J,Shao S,Yan Y

doi

10.1159/000443313

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

449-58

issue

4

eissn

0042-1138

issn

1423-0399

pii

000443313

journal_volume

96

pub_type

杂志文章
  • Malignant peripheral nerve sheath tumor of the urinary bladder in von Recklinghausen disease.

    abstract::A case of malignant peripheral nerve sheath tumor of the bladder in a 57-year-old man with multiple neurofibromatosis type 1 is presented. The patient had a recent history of a transurethrally resected bladder ganglioneuroma. A probable histogenetic association between these two extremely rare neoplasms is proposed. ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000065568

    authors: Kalafatis P,Kavantzas N,Pavlopoulos PM,Agapitos E,Politou M,Kranides A

    更新日期:2002-01-01 00:00:00

  • Effects of prolactin and dihydrotestosterone upon the rat prostate gland.

    abstract::The simultaneous subcutaneous injections of dihydrotestosterone (0.5 mg/kg) and/or ovine prolactin (5 or 50 IU/kg) to mature castrate rats for periods of 5-10 days led to an augmentation of prostate gland levels of RNA, DNA and protein. Of the various lobes of the prostate gland, the dorsal portion seemed to be partic...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000280062

    authors: Thomas JA,Manandhar MS,Keenan EJ,Edwards WD,Klase PA

    更新日期:1976-01-01 00:00:00

  • A new testis prosthesis material: polymethylmethacrylate.

    abstract:INTRODUCTION:Silicone has been the standard prosthesis material for the last three decades but new materials are being searched because of the known disadvantages of silicone such as migration and high cost. We wanted to test in rats whether or not polymethylmethacrylate could be an alternative to silicone. MATERIALS ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000075277

    authors: Karademir K,Senkul T,Demir S,Erden D,Iseri C,Baykal K

    更新日期:2004-01-01 00:00:00

  • Determination of carcinoembryonic antigen in tissue, serum and urine in patients with transitional cell carcinoma of the urinary bladder.

    abstract::Carcinoembryonic antigen (CEA) is elevated in urine and/or serum of patients with transitional cell carcinoma (TCC) of the urinary bladder. A group of 26 patients with TCC of the urinary bladder were evaluated with regard to urine/serum CEA levels and CEA tissue content. CEA could be detected in normal, metaplastic an...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000280875

    authors: Jakse G,Rauschmeier H,Rosmanith P,Hofstädter F

    更新日期:1983-01-01 00:00:00

  • Transobturator tape in the management of female stress incontinence: clinical outcomes at medium term follow-up.

    abstract:OBJECTIVE:To assess the efficacy of transobturator tape (TOT) in the management of stress urinary incontinence at a medium term follow-up. METHODS:TOT is a polypropylene tape positioned through the obturator foramen. 70 patients with type II urinary stress incontinence were treated with TOT between June 2003 and May 2...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000127340

    authors: Kocjancic E,Crivellaro S,Oyama IA,Singla A,Ranzoni S,Carone R,Manassero A,Gontero P,Frea B

    更新日期:2008-01-01 00:00:00

  • MALT-type primary lymphoma of the urinary bladder: clinicopathological study of 2 cases and review of the literature.

    abstract::Primary lymphoma of the bladder is a rare non-epithelial bladder tumour. It is usually non-Hodgkin's lymphoma with mucosa-associated lymphoid tissue (MALT) lymphoma being its predominant subtype. Most of the literature has been limited to individual sporadic case reports. We present 2 cases of the MALT-type primary ly...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审

    doi:10.1159/000056619

    authors: Wazait HD,Chahal R,Sundurum SK,Rajkumar GN,Wright D,Aslam MM

    更新日期:2001-01-01 00:00:00

  • Effect of mineral water containing calcium and magnesium on calcium oxalate urolithiasis risk factors.

    abstract::Calcium oxalate kidney stone formers are invariably advised to increase their fluid intake. In addition, magnesium therapy is often administered. Recently, a prospective study showed that a high dietary intake of calcium reduces the risk of symptomatic kidney stones. The present study was performed to test whether sim...

    journal_title:Urologia internationalis

    pub_type: 临床试验,杂志文章

    doi:10.1159/000282958

    authors: Rodgers AL

    更新日期:1997-01-01 00:00:00

  • Cystic dysplasia of the testis: a very rare paediatric tumor of the testis.

    abstract:OBJECTIVES:To describe a case of cystic dysplasia of the testis (CDT), an uncommon cause of scrotal swelling in the pediatric patient. Clinic, therapy, fertility, and radiographic and pathologic findings are discussed and the 30 previously reported cases are reviewed. METHODS:A 9-year-old boy presented with asymptomat...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审

    doi:10.1159/000064351

    authors: Eberli D,Gretener H,Dommann-Scherrer C,Pestalozzi D,Fehr JL

    更新日期:2002-01-01 00:00:00

  • A functional insertion/deletion polymorphism (-94 ins/del ATTG) in the promoter region of the NFKB1 gene is related to the risk of renal cell carcinoma.

    abstract:OBJECTIVE:Activated nuclear factor-ĸB is associated with the pathogenesis of numerous malignancies, including renal cell carcinoma (RCC). This study aimed to clarify the influence of a common insertion/deletion polymorphism (-94 ins/del ATTG, rs28362491) in the NFKB1 promoter on RCC susceptibility. METHODS:We genotype...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000345630

    authors: Cai H,Sun L,Cui L,Cao Q,Qin C,Zhang G,Mao X,Wang M,Zhang Z,Shao P,Yin C

    更新日期:2013-01-01 00:00:00

  • Managing mesh erosion after abdominal pelvic organ prolapse repair: ten years' experience in a single center.

    abstract:OBJECTIVE:To report conservative and surgical strategies for treatment of mesh erosion after pelvic organ prolapse (POP) repair. METHODS:Between 1998 and 2008, 179 patients underwent integral pelvic floor reconstruction for advanced POP in our tertiary urogynecological unit. Patients' charts and follow-up data were en...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000324243

    authors: Costantini E,Zucchi A,Lazzeri M,Del Zingaro M,Vianello A,Porena M

    更新日期:2011-01-01 00:00:00

  • Thyroid metastases from renal carcinoma.

    abstract::The identification and diagnosis of thyroid metastases from renal adenocarcinoma are rare in living patients, though more frequent during autopsy. A case is reported in which the identification of thyroid metastases indicated a clear-cell renal carcinoma in a kidney treated 12 years earlier for emptying of multiple cy...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000281389

    authors: Prati GF,Muolo A,Dean P,Ghimenton C

    更新日期:1988-01-01 00:00:00

  • Treatment of symptomatic metastatic prostatic cancer with cyproterone acetate versus orchiectomy: a prospective randomized trial.

    abstract::During a 2-year period, 37 patients with symptomatic metastatic prostatic cancer were included in a prospective randomized phase-III trial. Nineteen patients were randomized to subcapsular orchiectomy, and 18 to cyproterone acetate (CPA) treatment with a dose of 50 mg b.i.d. The median age of the patients was 74 years...

    journal_title:Urologia internationalis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000282125

    authors: Ostri P,Bonnesen T,Nilsson T,Frimodt-Møller C

    更新日期:1991-01-01 00:00:00

  • Clear cell adenocarcinoma of the bladder in a male patient: clinicopathologic analysis of a case.

    abstract::Clear cell adenocarcinoma arising in the lower urinary tract is unusual. We report a case of clear cell adenocarcinoma of the bladder in a 54-year-old male. Cystoscopic examination revealed a tumour arising from the dome of the urinary bladder. Histologically, the tumour was chiefly composed of tubulocystic and papill...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审

    doi:10.1159/000071856

    authors: Signori G,Tonini G,Aulenti V,Taher B,Rad FK,Tosana M,Ungari M,Zorzi F

    更新日期:2003-01-01 00:00:00

  • Cyclic adenosine monophosphate production and contractile response induced by beta-adrenoceptor subtypes in rabbit urinary bladder smooth muscle.

    abstract::The spontaneous contractile force of muscle strips isolated from male rabbit urinary bladder dome [detrusor) and base (trigonal muscle) was dose dependently inhibited by isoproterenol, a non-specific beta-adrenoceptor agonist. The relaxant response to 10(-6) M isoproterenol in the detrusor muscle was completely blocke...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000281650

    authors: Morita T,Dohkita S,Kondo S,Nishimoto T,Hirano S,Tsuchida S

    更新日期:1990-01-01 00:00:00

  • Renal milk of calcium: review of the literature and report of 5 cases.

    abstract::To our knowledge only a few cases of renal milk of calcium have been reported. We have encountered 5 such patients. The diagnosis depends upon the demonstration of half-moon-shaped calcification in the lateral decubitus or upright roentgenograms. This condition should be differentiated from a renal calculus to avoid u...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审

    doi:10.1159/000282538

    authors: Biyani CS,Bhatia V

    更新日期:1993-01-01 00:00:00

  • Laparoscopic versus Robotic-Assisted Radical Prostatectomy for the Treatment of Localised Prostate Cancer: A Systematic Review.

    abstract:BACKGROUND:Prostate cancer is a prominent form of cancer diagnosed in men living in developed countries, for which radical prostatectomy is a common frontline treatment. The aim of this systematic review was to determine whether robot-assisted laparoscopic radical prostatectomy (RALP) is more effective in the treatment...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审

    doi:10.1159/000435861

    authors: Allan C,Ilic D

    更新日期:2016-01-01 00:00:00

  • Are referral centers for non-muscle-invasive bladder cancer compliant to EAU guidelines? A report from the vesical antiblastic therapy Italian study.

    abstract:INTRODUCTION:Adherence to international guidelines is viewed as a prerequisite for optimal medical care delivery. Previously reported surveys for non-muscle-invasive bladder cancer (NMIBC) employed mailed questionnaires to urologists or patients resulting in conflicting degrees of agreement with existing guidelines. In...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000321926

    authors: Gontero P,Oderda M,Altieri V,Bartoletti R,Cai T,Colombo R,Curotto A,Di Stasi S,Maffezzini M,Tamagno S,Serretta V,Sogni F,Terrone C,Tizzani A,Morgia G,Mirone V,Carmignani G

    更新日期:2011-01-01 00:00:00

  • Immunohistochemical analysis of low-affinity nerve growth factor receptor in the human urinary bladder.

    abstract:INTRODUCTION:Interest in the regulation of nerve growth factor (NGF) production in the urinary tract derives from its probable involvement in obstructive, inflammatory and developmental disorders. Our aim was to investigate the presence of low-affinity nerve growth factor receptor (LNGFR) in the vesical urothelium of p...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000092939

    authors: Eryildirim B,Tarhan F,Gül AE,Erbay E,Kuyumcuoğlu U

    更新日期:2006-01-01 00:00:00

  • Familial occurrence of congenital stricture of bulbar urethra.

    abstract::We report on the familial occurrence of congenital bulbar urethral stricture in 2 brothers. Embryological mechanisms are briefly discussed and the literature reviewed. ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审

    doi:10.1159/000281795

    authors: Aragona F,Maio G,Oliva G,Calabrò A,Ostardo E,Artibani W

    更新日期:1991-01-01 00:00:00

  • Combination therapy of imipramine with oxybutynin in children with enuresis nocturna.

    abstract:PURPOSE:The treatment approach for enuresis is controversial due to the lack of consensus as to the exact causes of nocturnal enuresis. Despite various treatment modalities, pharmacotherapy still appears to be the common choice. The aim of this prospective study was the evaluation of the efficacy of combination therapy...

    journal_title:Urologia internationalis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000064858

    authors: Tahmaz L,Kibar Y,Yildirim I,Ceylan S,Dayanç M

    更新日期:2000-01-01 00:00:00

  • Carcinoma following augmentation ileocystoplasty.

    abstract::Carcinoma of the bladder following augmentation cystoplasty is rare. Only 15 cases have been reported worldwide. We report a further 2 cases, 1 of which, a squamous cell carcinoma, has not previously been described in this context. ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审

    doi:10.1159/000030479

    authors: Lane T,Shah J

    更新日期:2000-01-01 00:00:00

  • Malignant gonadal stromal tumor with bulky metastasis at diagnosis.

    abstract::A 63-year-old man underwent inguinal orchiectomy for painless enlargement of the left testis. The diagnosis of malignant gonadal stromal tumor was made on the basis of morphology and immunohistochemical studies. At computed tomography there was bulky retroperitoneal metastasis. The patient then underwent retroperitone...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000283061

    authors: Uygur MC,Gür E,Altug U,Ustün H,Emir L,Erol D

    更新日期:1997-01-01 00:00:00

  • Surface topography of the healthy and diseased transitional cell epithelium of the human urinary bladder.

    abstract::51 biopsies from healthy and diseased epithelium from human urinary bladders were examined by scanning electron microscopy. The luminal surface of the cover cells was marked by microvilli and microplicae. The replacement of the cover cells takes place by simple desquamination. This exposes cover cells having numerous ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000280109

    authors: Kjaergaard J,Starklint H,Bierring F,Thybo E

    更新日期:1977-01-01 00:00:00

  • Antifibrotic role of captopril after ureteral injury.

    abstract:OBJECTIVES:To evaluate the antifibrotic role of captopril during ureteral scarring in a New Zealand rabbit model. MATERIALS AND METHODS:The tissue expression and the fluctuation of EGF, TGF-β, FN, Col Ia1, Col Ia2 and Col III of the impaired ureter and the contralateral normal ureter were investigated by RT-PCR. The h...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000341790

    authors: Pan J,Xue W,Chen Q,Chen Y,Chen H,Huang Y

    更新日期:2012-01-01 00:00:00

  • Impact of Obesity on Perioperative Outcomes of Retroperitoneal Laparoscopic Adrenalectomy.

    abstract:INTRODUCTION:Obesity is usually considered a risk factor for postoperative complications; however, previous studies conclude contradictory results in retroperitoneal laparoscopic adrenalectomy (LA). We aim to evaluate the impact of obesity on the perioperative outcomes of LA. METHODS:A retrospective cohort study from ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000431183

    authors: Hu Q,Hang Z,Ho Y,Sun C,Xu K,Xia G,Ding Q

    更新日期:2015-01-01 00:00:00

  • Prostatic malacoplakia.

    abstract::We report here a 70-year-old man with prostatic malacoplakia which is an extremely rare disease. This diagnosis was obtained from histological examination by prostatic biopsy because the patient was suspected having prostatic cancer on digital examination. ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000281024

    authors: Matsumoto T,Ih H,Yamada Y,Kumazawa J,Era S

    更新日期:1985-01-01 00:00:00

  • Bladder carcinoma in patients less than 40 years of age.

    abstract::Between March 1983 and March 1988 we registered and treated 49 patients with bladder cancer less than 40 years of age (7 patients less than 30 years of age). Hematuria was present in 40 cases (81.6%). 33 of the patients had a pTA tumor (67.3%). 47 patients had transitional carcinoma of the bladder, of which 21 (44.7%)...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000281475

    authors: Witjes JA,Debruyne FM

    更新日期:1989-01-01 00:00:00

  • Predictive Factors of Ureterorenoscopy Outcomes in Proximal Ureteral Stones: A Multicenter Study of Aegean Study Group of the Society of Urological Surgery.

    abstract:INTRODUCTION:We aimed to evaluate the predictive factors in a holistic manner for ureterorenoscopy (URS) outcomes in proximal ureteral stones by a multicenter study. MATERIALS AND METHODS:The data of patients who underwent URS for proximal ureteral stones between the years 2015 and 2018 in eight centers were recorded ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000504790

    authors: Sen V,Irer B,Erbatu O,Yildiz A,Ongun Ş,Cinar O,Cihan A,Sahin M,Sahin MO,Ucer O,Kizilay F,Bozkurt O,Aegean Study Group of the Society of Urological Surgery.

    更新日期:2020-01-01 00:00:00

  • Urinary tract-related quality of life after radical prostatectomy: open retropubic versus robot-assisted laparoscopic approach.

    abstract:BACKGROUND:The best technique of radical prostatectomy--open retropubic versus robot-assisted surgery--is a subject of controversy. PATIENTS AND METHODS:Between January 1st, 2007 and December 31st, 2011, 2,177 men underwent radical prostatectomy at our department. 252 (12%) cases were laparoscopic robot-assisted, the ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000345320

    authors: Froehner M,Koch R,Leike S,Novotny V,Twelker L,Wirth MP

    更新日期:2013-01-01 00:00:00

  • Penile sensitivity and sexual satisfaction after circumcision: are we informing men correctly?

    abstract:OBJECTIVES:Currently no consensus exists about the role of the foreskin or the effect circumcision has on penile sensitivity and overall sexual satisfaction. Our study assesses the effect of circumcision on sexually active men and the relative impact this may have on informed consent prior to surgery. MATERIALS AND ME...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000085930

    authors: Masood S,Patel HR,Himpson RC,Palmer JH,Mufti GR,Sheriff MK

    更新日期:2005-01-01 00:00:00