Treatment of symptomatic metastatic prostatic cancer with cyproterone acetate versus orchiectomy: a prospective randomized trial.

Abstract:

:During a 2-year period, 37 patients with symptomatic metastatic prostatic cancer were included in a prospective randomized phase-III trial. Nineteen patients were randomized to subcapsular orchiectomy, and 18 to cyproterone acetate (CPA) treatment with a dose of 50 mg b.i.d. The median age of the patients was 74 years (range 48-88 years), with no differences between the treatment groups. At 3, 6, and 12 months after initiation of the therapy and then every 6 months, patients were clinically and biochemically examined, and isotope scans and X-rays were performed. All patients were followed until death. Relief from symptoms was found following 3 months of treatment in 70.6% (95% confidence limits = 44.0-89.7%) of the patients treated with CPA, and in 83.3% (95% confidence limits = 58.6-96.4%) of the orchiectomized patients. The median time to relapse was 9 months in the CPA group, and 11 months in the orchiectomy group (p greater than 0.05). The median survival time was 13 months, with no differences between the groups. The treatment of advanced prostatic cancer with CPA is found to be a valuable alternative to orchiectomy.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Ostri P,Bonnesen T,Nilsson T,Frimodt-Møller C

doi

10.1159/000282125

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

167-71

issue

2

eissn

0042-1138

issn

1423-0399

journal_volume

46

pub_type

临床试验,杂志文章,随机对照试验
  • Urgency, detrusor overactivity and posterior vault prolapse in women who underwent pelvic organ prolapse repair.

    abstract:INTRODUCTION:We investigated the relationship between posterior vault prolapse and overactive bladder (OAB) symptoms or detrusor overactivity (DO) and their changes after surgical repair. METHODS:Forty-three patients with vault prolapse and prevalent posterior compartment prolapse underwent pelvic organ prolapse repai...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000345944

    authors: Costantini E,Lazzeri M,Zucchi A,Mearini L,Fragalà E,Del Zingaro M,Bini V,Porena M

    更新日期:2013-01-01 00:00:00

  • Enhancement of the sensitivity of renal cell carcinoma cells to fas-mediated cytotoxicity and apoptosis by the selective cyclooxygenase-2 inhibitor JTE-522.

    abstract:BACKGROUND:Cyclooxygenase-2 (COX-2) is a key enzyme involved in the production of prostaglandins and its inhibitors have been shown to induce apoptosis in a variety of cancer cells. We reasoned that combination treatment of renal cell carcinoma (RCC) cells with COX-2 inhibitors and anticancer agents may result in syner...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000288243

    authors: Sato N,Mizutani Y,Li YN,Fujiwara J,Ishida H,Toiyama D,Abe K,Hayashi I,Nakanishi H,Kawauchi A,Miki T

    更新日期:2010-01-01 00:00:00

  • Thyroid metastases from renal carcinoma.

    abstract::The identification and diagnosis of thyroid metastases from renal adenocarcinoma are rare in living patients, though more frequent during autopsy. A case is reported in which the identification of thyroid metastases indicated a clear-cell renal carcinoma in a kidney treated 12 years earlier for emptying of multiple cy...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000281389

    authors: Prati GF,Muolo A,Dean P,Ghimenton C

    更新日期:1988-01-01 00:00:00

  • Accuracy of magnetic resonance imaging compared to computerized tomography and renal selective angiography in preoperatively staging renal cell carcinoma.

    abstract::During 1986 and 1987, 47 patients with renal cell carcinoma were evaluated preoperatively with CT, angiography and MRI. The preoperative tumor stage (T), lymph node metastases and venous involvement determined with the three methods were compared to the operative and histopathological findings. For T stage, angiograph...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282219

    authors: Constantinides C,Recker F,Bruehlmann W,von Schulthess G,Goebel N,Zollikofer C,Jaeger P,Hauri D

    更新日期:1991-01-01 00:00:00

  • Negotiating ureteral stenoses and kinks with a hydrophilic wire.

    abstract::Negotiating a tortuous or obstructed ureter with a wire can be time-consuming and sometimes tiring. The principle of using a slippery floppy wire and then replacing it with a stiff wire through a 5-french open-ended ureteral catheter yields a high success rate. The ureteral catheter can be used for a radiocontrast stu...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282713

    authors: Hofmann R,Pickl U,Hartung R

    更新日期:1995-01-01 00:00:00

  • Cystic nephroma, cystic partially differentiated nephroblastoma and cystic Wilms' tumor in children: a spectrum with therapeutic dilemmas.

    abstract:BACKGROUND:Cystic renal tumors are a diagnostic and therapeutic challenge. Cystic nephroma (CN), cystic partially differentiated nephroblastoma (CPDN) and cystic Wilms' tumor (CWT) are a spectrum with CN at the benign end, CWT at the malignant end and CPDN in the intermediate position. CN and stage 1 CPDN are often tre...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000176028

    authors: van den Hoek J,de Krijger R,van de Ven K,Lequin M,van den Heuvel-Eibrink MM

    更新日期:2009-01-01 00:00:00

  • Prognostic factors including Ki-67 and p53 in Bacillus Calmette-Guérin-treated non-muscle-invasive bladder cancer: a prospective study.

    abstract:OBJECTIVES:To prospectively evaluate the prognostic utility of the traditional prognostic factors and molecular markers p53 and Ki-67 in a homogeneous series of patients with non-muscle-invasive bladder cancer (NMIBC) treated with Bacillus Calmette-Guérin (BCG). PATIENTS AND METHODS:192 intermediate- and high-risk NMI...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000343431

    authors: Oderda M,Ricceri F,Pisano F,Fiorito C,Gurioli A,Casetta G,Zitella A,Pacchioni D,Gontero P

    更新日期:2013-01-01 00:00:00

  • Spoilt for Choice: A Survey of Current Practices of Surgical Urinary Stone Treatment and Adherence to Evidence-Based Guidelines among Swiss Urologists.

    abstract:INTRODUCTION:Urologists have to master a variety of techniques to be able to offer the most appropriate surgical stone treatment for each individual patient. Therefore, we performed a survey among board-certified Swiss urologists to assess the availability of the different surgical methods, the current practices of sur...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000502806

    authors: Betschart P,Zumstein V,Jichlinski P,Herrmann TRW,Knoll T,Engeler DS,Müllhaupt G,Schmid HP,Abt D

    更新日期:2019-01-01 00:00:00

  • Human factors in surgery: from Three Mile Island to the operating room.

    abstract::Human factors is a definition that includes the science of understanding the properties of human capability, the application of this understanding to the design and development of systems and services, the art of ensuring their successful applications to a program. The field of human factors traces its origins to the ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审

    doi:10.1159/000241662

    authors: D'Addessi A,Bongiovanni L,Volpe A,Pinto F,Bassi P

    更新日期:2009-01-01 00:00:00

  • High-Grade T1 on Re-Transurethral Resection after Initial High-Grade T1 Confers Worse Oncological Outcomes: Results of a Multi-Institutional Study.

    abstract:INTRODUCTION:The aim of this multicenter study was to investigate the prognostic impact of residual T1 high-grade (HG)/G3 tumors at re-transurethral resection (TUR of bladder tumor) in a large multi-institutional cohort of patients with primary T1 HG/G3 bladder cancer (BC). PATIENTS AND METHODS:The study period was fr...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000490765

    authors: Ferro M,Vartolomei MD,Cantiello F,Lucarelli G,Di Stasi SM,Hurle R,Guazzoni G,Busetto GM,De Berardinis E,Damiano R,Perdonà S,Borghesi M,Schiavina R,Almeida GL,Bove P,Lima E,Grimaldi G,Autorino R,Crisan N,Abu Farhan A

    更新日期:2018-01-01 00:00:00

  • Cadaveric renal transplantation from a non-heart-beating pediatric donor into adult recipients.

    abstract:INTRODUCTION:The use of cadaveric pediatric kidneys has been suggested as a means to overcome organ shortage, but is debated because of technical complications and an increased incidence of functional allograft impairment. METHODS:We experienced 2 cases of cadaveric renal transplantation from a non-heart-beating pedia...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000068778

    authors: Nakatani T,Uchida J,Yamazaki T,Iwai T,Naganuma T,Kim T,Sugimura K

    更新日期:2003-01-01 00:00:00

  • Verapamil attenuates renal tubular apoptosis in response to partial unilateral ureteral obstruction.

    abstract:INTRODUCTION:Partial unilateral ureteral obstruction (PUUO) is the type of obstruction that is most often encountered in pediatric clinical practice. The majority of our knowledge on PUUO has been derived from experimental studies and the effects of PUUO on the kidney have still been a source of continual investigation...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000111736

    authors: Topcu SO,Erbagci A,Erturhan S,Yagci F,Ucak R

    更新日期:2008-01-01 00:00:00

  • A unique case of late complication of rectum mesh erosion after laparoscopic sacrocolpopexy.

    abstract::Sacrocolpopexy, a surgical technique with a low morbidity rate, is a valid procedure for repairing vaginal vault prolapse. To our knowledge, only 1 case of rectum erosion after open sacrocolpopexy has been reported in the literature, and there is no record of any such incident after laparoscopic sacrocolpopexy. We rep...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000353421

    authors: Balzarro M,Rubilotta E,Sarti A,Curti P,Artibani W

    更新日期:2014-01-01 00:00:00

  • Quantitative Polymerase Chain Reaction Detection of Microchimerism in Female Transplant Renal Recipients.

    abstract:INTRODUCTION:Microchimerism (MC) is the presence of a small amount of foreign cells or DNA within a person's circulation or tissues. It has been identified also in recipients of solid organ transplants where it seems to be critical for the development and maintenance of immunological tolerance. Nevertheless, natural an...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000508796

    authors: Villari D,Salvianti F,Zanazzi M,Martini A,Spatafora P,Caroassai Grisanti S,Sebastianelli A,Nicita G,Serni S,Pinzani P

    更新日期:2020-01-01 00:00:00

  • Immunohistochemical analysis of low-affinity nerve growth factor receptor in the human urinary bladder.

    abstract:INTRODUCTION:Interest in the regulation of nerve growth factor (NGF) production in the urinary tract derives from its probable involvement in obstructive, inflammatory and developmental disorders. Our aim was to investigate the presence of low-affinity nerve growth factor receptor (LNGFR) in the vesical urothelium of p...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000092939

    authors: Eryildirim B,Tarhan F,Gül AE,Erbay E,Kuyumcuoğlu U

    更新日期:2006-01-01 00:00:00

  • Perioperative complications and 90-day mortality of radical cystectomy in the elderly (75+): a retrospective, multicentre study.

    abstract:OBJECTIVE:To assess perioperative complications and 90-day mortality of radical cystectomy (RC) in elderly patients with muscle-invasive bladder cancer (MIBC). MATERIALS AND METHODS:This is a retrospective, multicentre (n = 11) study of a consecutive series of patients ≥75 years who underwent RC for MIBC between 2006 ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000357127

    authors: Berger I,Martini T,Wehrberger C,Comploj E,Ponholzer A,Wolfgang M,Breinl E,Dunzinger M,Hofbauer J,Höltl W,Jeschke K,Krause S,Kugler W,Pauer W,Rauchenwald M,Pycha A,Madersbacher S

    更新日期:2014-01-01 00:00:00

  • Evaluation of seminal vesicle characteristics by ultrasonography before and after ejaculation.

    abstract::Twenty males underwent transrectal ultrasonography before and after ejaculation to examine possible alterations that could influence interpretation of seminal vesicle ultrasonography. The preejaculation length of 35 mm was significantly (p < 0.05) decreased to 30 mm after ejaculation. The mean width of the seminal ves...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282404

    authors: Fuse H,Okumura A,Satomi S,Kazama T,Katayama T

    更新日期:1992-01-01 00:00:00

  • Vesicourethral anastomotic strictures after radical retropubic prostatectomy: the experience of a single institution.

    abstract:OBJECTIVE:Stricture of the vesicourethral anastomosis remains a well-documented complication after radical retropubic prostatectomy. MATERIALS AND METHODS:We performed a retrospective study of 294 patients with prostate cancer who underwent radical retropubic prostatectomy. Possible correlations between anastomotic st...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000075267

    authors: Kostakopoulos A,Argiropoulos V,Protogerou V,Tekerlekis P,Melekos M

    更新日期:2004-01-01 00:00:00

  • Effects of antiproteases (aprotinin and gabexate-mesilate) on the postischemic vascular response of the kidney.

    abstract::Both under physiologic conditions and after short-term ischemia (1-3 min) kallikrein and locally synthesized prostaglandins contribute to control renal blood flow. In the present experiment the antiproteases aprotinin and gabexate-mesilate were administered to rabbits in an attempt to show whether the hemodynamic chan...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000280880

    authors: Pflüger H,Maier M,Binder BR

    更新日期:1983-01-01 00:00:00

  • Supine versus Prone Position during Extracorporeal Shockwave Lithotripsy for Treating Distal Ureteral Calculi: A Systematic Review and Meta-Analysis.

    abstract:PURPOSE:We aimed at evaluating the efficacy of extracorporeal shockwave lithotripsy (SWL) for treating distal ureteral calculi performed in supine vs. prone position. MATERIALS AND METHODS:Eligible studies were identified by 2 reviewers using PubMed, Embase, and Web of Science databases. Outcomes included stone-free r...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000439140

    authors: Li T,Gao L,Chen P,Bu S,Cao D,Yang L,Wei Q

    更新日期:2016-01-01 00:00:00

  • Transurethral microwave thermotherapy for symptomatic benign prostatic hyperplasia: short-term experience with Prostcare.

    abstract:PURPOSE:To assess our short-term experience with transurethral microwave thermotherapy (TUMT) for symptomatic benign prostatic hyperplasia (BPH). PATIENTS AND METHODS:From August 1993 through July 1994, in total 65 patients with symptomatic BPH were enrolled into this study. The patients' ages ranged from 56 to 95 yea...

    journal_title:Urologia internationalis

    pub_type: 临床试验,杂志文章

    doi:10.1159/000064846

    authors: Tsai YS,Lin JS,Tong YC,Tzai TS,Yang WH,Chang CC,Cheng HL,Lin YM,Jou YC

    更新日期:2000-01-01 00:00:00

  • Idiopathic clitoral hypertrophy.

    abstract::We report a case of clitoral hypertrophy of unknown origin. A 3-year-old girl showed clitoral hypertrophy at birth. Biochemical analysis of peripheral blood and endocrinological examinations were normal. Other virilizing symptoms were not recognized. Clitoroplasty was carried out, and the clitoris has not enlarged 20 ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000030385

    authors: Shiraishi K,Ishizu K,Takeuchi K,Takai K,Takihara H,Koga M,Naito K

    更新日期:1999-01-01 00:00:00

  • The Time of Spontaneous Resolution of Monosymptomatic Nocturnal Enuresis (MNE) Is Familial.

    abstract:PURPOSE:To investigate whether or not the age of spontaneous resolution of monosymptomatic nocturnal enuresis (MNE) was familial. PATIENTS AND METHODS:A questionnaire was administered to more than 1,500 people, and 100 appropriate participants were identified from four referral hospitals. We included the participants ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000370166

    authors: Oguz U,Aykac A,Demirelli E,Sancak EB,Resorlu B,Sarikaya S,Damar E,Bozkurt OF,Ogreden E,Yalcin O

    更新日期:2015-01-01 00:00:00

  • Less calcium in cremaster muscles of boys with undescended testis supports a deficiency in sympathetic innervation.

    abstract::In addition to an increase in contractility, contracted fibers and small and electron-dense mitochondria have suggested an increase of cytosolic Ca(2+) within the cremaster muscles (CM) associated with undescended testis. Therefore, the Ca(2+) content of CM associated with an undescended testis was determined and comp...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000065558

    authors: Tanyel FC,Ulusu NN,Tezcan EF,Büyükpamukçu N

    更新日期:2002-01-01 00:00:00

  • Long-term follow-up after clam ileocystoplasty. Complications and results including some quality-of-life parameters for 32 patients treated for neuropathic and nonneuropathic bladder disease.

    abstract::The results of clam ileocystoplasty in 32 patients were evaluated. Nineteen patients had a neuropathic (group N) and 13 a nonneuropathic disease (group NN). Mean follow-up was 75 months; 62 months for group N and 95 months for group NN. Mean age was 38 years. Postoperative complications and some quality-of-life parame...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282577

    authors: Geertsen U,Mommsen S

    更新日期:1994-01-01 00:00:00

  • Study of calcium oxalate crystalluria on renal and vesical urines in stone formers and normal subjects.

    abstract:OBJECTIVE:The aim of this study is to compare vesical and renal calcium oxalate crystalluria in an attempt to correlate crystal formation with chemical composition and calcium oxalate saturation of renal urine. MATERIAL AND METHODS:Urine specimens were directly collected from the bladder and the kidney, of 11 stone fo...

    journal_title:Urologia internationalis

    pub_type: 临床试验,杂志文章

    doi:10.1159/000030201

    authors: Robert M,Boularan AM,Delbos O,Guiter J,Descomps B

    更新日期:1998-01-01 00:00:00

  • [Myotropic spasmolysis in the treatment of ureteric colics (author's transl)].

    abstract::The effectiveness of parasympathicolytic drugs in the treatment of ureteric colics is doubtful. Bencyclane is a new myotropic substance. Its spasmolytic effect on smooth muscle is five times stronger than that of papaverine. The results of the clinical use of Bencyclane in cases of ureteric colic are described and dis...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000280208

    authors: Patel VJ

    更新日期:1978-01-01 00:00:00

  • Spontaneous rupture of a renal angiosarcoma.

    abstract::Here we describe the clinical, radiologic, histopathological and immunohistochemical features of a rare spontaneous rupture of renal angiosarcoma detected in the left kidney of a 55-year-old male. Due to the rarity of this neoplasm (less than 15 cases have been reported), there is no unanimous consensus for therapy fo...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000048419

    authors: Aksoy Y,Gürsan N,Ozbey I,Biçgi O,Keleş M

    更新日期:2002-01-01 00:00:00

  • Abscess of corpus cavernosum.

    abstract::A rare case of abscess of the corpus cavernosum is described. Culture of the abscess yielded beta-hemolytic streptococcus. Ultrasound scan and cavernosography confirmed the physical examination findings of involvement of the corpus cavernosum. The patient was treated successfully by percutaneous ultrasound-guided aspi...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282373

    authors: Moskovitz B,Vardi Y,Pery M,Bolkier M,Levin DR

    更新日期:1992-01-01 00:00:00

  • Laparoscopic Transperitoneal Lateral Adrenalectomy for Large Adrenal Tumors.

    abstract:BACKGROUND:Laparoscopic adrenalectomy is the gold standard for treatment of benign adrenal lesions. Tumor size is a factor that might influence decision-making concerning the use of laparoscopic approach. The aim of this study was to analyze the results of adrenalectomy for tumors ≥6 cm in diameter. METHODS:Two groups...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000444146

    authors: Natkaniec M,Pędziwiatr M,Wierdak M,Major P,Migaczewski M,Matłok M,Budzyński A,Rembiasz K

    更新日期:2016-01-01 00:00:00