Abstract:
PURPOSE:Renal cell carcinoma (RCC) forming tumor thrombus (TT) of vena cava (VC) is characterized by poor prognosis. Nevertheless, the outcome of patients after radical surgery varies. To date only limited data concerning prognostic biomarkers in this RCC subgroup are available. METHODS:Out of 159 patients with pT3b/c RCC, 95 patients without synchronous distant metastases at time of diagnosis were included in the study cohort. After immunohistochemical (IHC) evaluation of E-cadherin and β-Catenin expression, association with clinical, histopathological and survival was assessed by univariate analysis, multivariate analysis, and Kaplan-Meier-analysis. Cancer-specific survival (CSS) rates and overall survival (OS) rates were estimated using Kaplan-Meier analysis and compared using Log rank test. RESULTS:We found a significant correlation between E-cadherin overexpression and initial lymph node metastasis (ρ = 0.300, p = 0.003), positive surgical margins (ρ = 0.210, p = 0.043), and the development of distant metastases (ρ = 0.258, p = 0.012). Furthermore, we observed a significant correlation of β-Catenin overexpression with higher tumor stage pT3c (ρ = 0.230, p = 0.028) and initial lymph node metastases (ρ = 0.236, p = 0.025). Survival analysis revealed a statistically significant association of both E-cadherin and β-Catenin overexpression with worse CSS (p < 0.001 and p = 0.007, respectively) and OS (p < 0.001 and p = 0.041, respectively). Multivariate analysis revealed initial lymph node metastasis as the only predictive factor for worse OS (HR 4.54, 95% CI 2.30-8.93; p < 0.001). E-Cadherin and β-Catenin expression failed to be significant in multivariable analysis for OS and CSS. CONCLUSIONS:In a large series of RCC with TT of VC high IHC expression of E-cadherin and β-Catenin was associated with initial lymph node metastasis and with both worse OS and worse CSS. This might help to identify patients at risk for recurrence who might benefit from adjuvant therapy or stricter follow-up.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Spachmann PJ,Breyer J,Kalogirou C,Lausenmeyer EM,Weber F,Prohaska S,Denzinger S,Burger M,Kübler H,Otto W,Vergho Ddoi
10.1159/000497279subject
Has Abstractpub_date
2019-01-01 00:00:00pages
413-420issue
4eissn
0042-1138issn
1423-0399pii
000497279journal_volume
102pub_type
杂志文章abstract::We report 2 cases of epidermoid cysts of the testis in Klinefelter's syndrome. The literature is reviewed and the relationship between Klinefelter's syndrome and epidermoid cyst of the testis is discussed. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282003
更新日期:1987-01-01 00:00:00
abstract::Extrarenal calyces are an extremely rare entity and only a few cases have been reported worldwide. We report a case with extrarenal calyces and give a brief review of the literature. Awareness of this rare entity can prevent inadvertent injury to the pelvicalyceal system during surgery. ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000072690
更新日期:2003-01-01 00:00:00
abstract::In a combined (cross-sectional and longitudinal) study, the serum concentration of laminin P1 was measured by radioimmunoassay in 16 patients with benign inflammatory bladder disorders and 47 patients with transitional cell carcinoma of the bladder. The results were compared with the serum laminin P1 values in 50 heal...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282410
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study is to compare vesical and renal calcium oxalate crystalluria in an attempt to correlate crystal formation with chemical composition and calcium oxalate saturation of renal urine. MATERIAL AND METHODS:Urine specimens were directly collected from the bladder and the kidney, of 11 stone fo...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章
doi:10.1159/000030201
更新日期:1998-01-01 00:00:00
abstract::The first case of barium granuloma involving urinary bladder is reported. Surgical removal was the treatment of choice. Histological diagnosis was foreign body granuloma with xanthomatous inflammation. The foreign body was identified as barium by analytical electron microscopy. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281516
更新日期:1989-01-01 00:00:00
abstract::Bacillus Calmette-Guérin (BCG) immunotherapy is the most effective treatment for carcinoma in situ and high-risk non-muscle invasive bladder cancer (NMIBC). However, it can also provoke diverse side effects. We found 1 patient with a significantly and rapidly reduced bladder volume after the instillation of BCG. Few s...
journal_title:Urologia internationalis
pub_type:
doi:10.1159/000510167
更新日期:2021-01-01 00:00:00
abstract:INTRODUCTION:Partial unilateral ureteral obstruction (PUUO) is the type of obstruction that is most often encountered in pediatric clinical practice. The majority of our knowledge on PUUO has been derived from experimental studies and the effects of PUUO on the kidney have still been a source of continual investigation...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000111736
更新日期:2008-01-01 00:00:00
abstract::This study was undertaken to investigate the endocrine function of the testis that was autotransplanted by microvascular techniques in 10 healthy dogs. After a control period of 4 weeks, hemicastration was carried out, and 4 weeks later the experimental orchidopexy was done. Finally, the transplanted testis was remove...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280918
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the clinical and demographic findings of children with urolithiasis in eastern Turkey. METHODS:We retrospectively reviewed the medical records of 67 children with urolithiasis for clinical and laboratory data. RESULTS:Mean age at the time of diagnosis was 39.1 +/- 41.2 months. Complaints at admi...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000230027
更新日期:2009-01-01 00:00:00
abstract::Calcium oxalate kidney stone formers are invariably advised to increase their fluid intake. In addition, magnesium therapy is often administered. Recently, a prospective study showed that a high dietary intake of calcium reduces the risk of symptomatic kidney stones. The present study was performed to test whether sim...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章
doi:10.1159/000282958
更新日期:1997-01-01 00:00:00
abstract::Aneurysmectomy and renal angioplasty were performed on a 14-year-old Japanese male and the blood pressure was within normal values 3 years after this surgery. Measurement of renal blood flow was facilitated by using 133Xe washout technique. This incidence is the eighth such case to be reported from Japan. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280073
更新日期:1976-01-01 00:00:00
abstract::We report a rare case of Budd-Chiari syndrome (BCS) as a postoperative complication after bilateral nephrectomy in a kidney transplant recipient with polycystic liver and kidneys. Contrast-enhanced computed tomography of the abdomen showed a narrowed inferior vena cava, compressed by the polycystic liver that moved do...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000504514
更新日期:2020-01-01 00:00:00
abstract::119 patients with stage-IV renal cell carcinoma were treated using immunotherapy with autologous tumor vaccine. The immunization was carried out at monthly intervals, the patients were restaged every 3 months using X-ray, ultrasound scanning or computed tomography as well as bone scintigraphy in the follow-up. The pat...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1159/000281439
更新日期:1989-01-01 00:00:00
abstract:INTRODUCTION:To evaluate the association between preoperative serum prolactin (PRL) levels and risk of non-organ confined prostate cancer (PCa) in clinically localized disease. MATERIALS AND METHODS:From December 2007 to December 2011, 124 patients with clinically localized PCa were retrospectively evaluated. Non-orga...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000496833
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:This study assesses the differences in the presentations, complications and metabolic abnormalities of children with renal calyceal microlithiasis (RCM) and overt urolithiasis in different pediatric ages. MATERIALS AND METHODS:A total of 465 children with urolithiasis were investigated retrospectively. Pa...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000441126
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Stricture of the vesicourethral anastomosis remains a well-documented complication after radical retropubic prostatectomy. MATERIALS AND METHODS:We performed a retrospective study of 294 patients with prostate cancer who underwent radical retropubic prostatectomy. Possible correlations between anastomotic st...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000075267
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:Increased pneumoperitoneum pressure during laparoscopic surgery can result in acute kidney injury. We aimed to clarify whether intraabdominal pressure tolerance is modified in various degrees of unilateral kidney hydronephrosis in rabbits. METHODS:A total 90 rabbits were randomly allocated to three groups (g...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000362845
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:The treatment of T1G3 bladder cancer is still a controversial issue. Nowadays, intravesical bacillus Calmette-Guérin (BCG) instillation is considered to be the treatment of choice for patients with high-grade superficial bladder tumour after transurethral resection of all visible tumour. The aim of this re...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000066121
更新日期:2002-01-01 00:00:00
abstract:INTRODUCTION:Virtual reality (VR) simulation has been known to shorten learning curves. The aim of this research was to determine whether VR transurethral bladder tumor resection (TURBT) with and without photodynamic diagnostic (PDD) can improve endourological skills in novice and trained endoscopists. MATERIALS AND M...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000328218
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to describe a novel negative-pressure laser lithotripsy device to overcome the deficiencies of the conventional procedure. PATIENTS AND METHODS:Between August 2018 and March 2019, 78 patients with a single ureteral stone underwent retrograde ureteroscopy with a Wolf 8F/9.8F rigid u...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000507266
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:To provide a systematic review and meta-analysis of studies comparing ureterolithotripsy (URS) with percutaneous nephrolithotripsy (PCNL) or laparoscopic ureterolithotomy (LU) techniques for the management of large proximal ureteral stones (diameter greater than 10 mm). METHODS:A literature search was perfo...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000471773
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:Currently, surgical repair for vesicovaginal fistula (VVF) provides excellent results, but the recurrent VVF is difficult to treat as compared to primary. PATIENTS AND METHODS:Sixty-eight patients (44 primipara and 24 multipara) with recurrent VVF repair from January 2002 to December 2007 were included in...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000331503
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the antifibrotic role of captopril during ureteral scarring in a New Zealand rabbit model. MATERIALS AND METHODS:The tissue expression and the fluctuation of EGF, TGF-β, FN, Col Ia1, Col Ia2 and Col III of the impaired ureter and the contralateral normal ureter were investigated by RT-PCR. The h...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000341790
更新日期:2012-01-01 00:00:00
abstract::Inguinoscrotal herniation of the ureter is a rare finding with the potential for serious surgical complications. Two anatomic forms are defined. In the more common paraperitoneal variant, the herniating peritoneal sac drags the ureter and sometimes other abdominal structures with it. The uncommon variant--extraperiton...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000224879
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:The German Research Activities on Natural Urologicals (GRANU) study was a randomized, partially blinded, placebo-controlled, parallel-group trial that investigated the efficacy of pumpkin seed in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH/LUTS). SUBJECTS AND METH...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000362903
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:In spite of a great amount of data, the hormonal treatment of advanced prostatic carcinoma (CaP) still remains controversial. As a relevant amount of dihydrotestosterone is present within the prostate tissue after castration, complete androgen blockade (CAB), with inhibition of the activity of both testicula...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1159/000056541
更新日期:1998-01-01 00:00:00
abstract::Adherence of human prostate carcinoma (PC 3, DU 145), bladder (647 V, J 82) carcinoma and melanoma (RPMI-8252) cell lines to plastic and bovine endothelial monolayers (BEM) was tested in the presence of 0.5, 1, 5, 10, 20 IU of low-molecular-weight heparin (LMWH), unfractionated heparin (UFH) or saline as a control. Cu...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282848
更新日期:1996-01-01 00:00:00
abstract::We describe the results after implantation of a urethral stent in 6 patients with recurrent urethral strictures. Four patients had strictures located in close vicinity to the external sphincter. In 3 of these 4 patients open urethroplasty procedures had failed. The treatment was successful in 5 of the 6 patients with ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282181
更新日期:1991-01-01 00:00:00
abstract::Modern LDR brachytherapy has drastically reduced rectal toxicity and decreased the occurrence of rectourethral fistulas to <0.5% of patients. Therefore, symptoms of late-onset sequelae are often ignored initially. These fistulas cause severe patient morbidity and require interdisciplinary treatment. We report on the o...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000209374
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:Basic science studies of ureteral physiology and pathophysiology are commonly performed on animal ureters due to several limitations associated with human ureteral sampling. In this work we question whether animal ureters are good replicas of human ureteral behavior for pharmacological studies. MATERIALS AN...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000358601
更新日期:2015-01-01 00:00:00