Impact of E-Cadherin and β-Catenin as Prognostic Factor in Renal Cell Carcinoma with Tumor Thrombus of the Vena Cava.

Abstract:

PURPOSE:Renal cell carcinoma (RCC) forming tumor thrombus (TT) of vena cava (VC) is characterized by poor prognosis. Nevertheless, the outcome of patients after radical surgery varies. To date only limited data concerning prognostic biomarkers in this RCC subgroup are available. METHODS:Out of 159 patients with pT3b/c RCC, 95 patients without synchronous distant metastases at time of diagnosis were included in the study cohort. After immunohistochemical (IHC) evaluation of E-cadherin and β-Catenin expression, association with clinical, histopathological and survival was assessed by univariate analysis, multivariate analysis, and Kaplan-Meier-analysis. Cancer-specific survival (CSS) rates and overall survival (OS) rates were estimated using Kaplan-Meier analysis and compared using Log rank test. RESULTS:We found a significant correlation between E-cadherin overexpression and initial lymph node metastasis (ρ = 0.300, p = 0.003), positive surgical margins (ρ = 0.210, p = 0.043), and the development of distant metastases (ρ = 0.258, p = 0.012). Furthermore, we observed a significant correlation of β-Catenin overexpression with higher tumor stage pT3c (ρ = 0.230, p = 0.028) and initial lymph node metastases (ρ = 0.236, p = 0.025). Survival analysis revealed a statistically significant association of both E-cadherin and β-Catenin overexpression with worse CSS (p < 0.001 and p = 0.007, respectively) and OS (p < 0.001 and p = 0.041, respectively). Multivariate analysis revealed initial lymph node metastasis as the only predictive factor for worse OS (HR 4.54, 95% CI 2.30-8.93; p < 0.001). E-Cadherin and β-Catenin expression failed to be significant in multivariable analysis for OS and CSS. CONCLUSIONS:In a large series of RCC with TT of VC high IHC expression of E-cadherin and β-Catenin was associated with initial lymph node metastasis and with both worse OS and worse CSS. This might help to identify patients at risk for recurrence who might benefit from adjuvant therapy or stricter follow-up.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Spachmann PJ,Breyer J,Kalogirou C,Lausenmeyer EM,Weber F,Prohaska S,Denzinger S,Burger M,Kübler H,Otto W,Vergho D

doi

10.1159/000497279

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

413-420

issue

4

eissn

0042-1138

issn

1423-0399

pii

000497279

journal_volume

102

pub_type

杂志文章
  • Epidermoid cyst of the testis in Klinefelter's syndrome.

    abstract::We report 2 cases of epidermoid cysts of the testis in Klinefelter's syndrome. The literature is reviewed and the relationship between Klinefelter's syndrome and epidermoid cyst of the testis is discussed. ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282003

    authors: Sasagawa I,Nakada T,Kazama T,Sakamoto M,Satomi S,Katayama T

    更新日期:1987-01-01 00:00:00

  • Extrarenal calyces: a rarity.

    abstract::Extrarenal calyces are an extremely rare entity and only a few cases have been reported worldwide. We report a case with extrarenal calyces and give a brief review of the literature. Awareness of this rare entity can prevent inadvertent injury to the pelvicalyceal system during surgery. ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审

    doi:10.1159/000072690

    authors: Garg P,Godara R,Karwasra RK

    更新日期:2003-01-01 00:00:00

  • Value of serum laminin P1 as a diagnostic and monitoring parameter in transitional cell carcinoma of the bladder.

    abstract::In a combined (cross-sectional and longitudinal) study, the serum concentration of laminin P1 was measured by radioimmunoassay in 16 patients with benign inflammatory bladder disorders and 47 patients with transitional cell carcinoma of the bladder. The results were compared with the serum laminin P1 values in 50 heal...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282410

    authors: AbouFarha KM,Menheere PP,Nieman FH,Arends JW,Janknegt RA

    更新日期:1992-01-01 00:00:00

  • Study of calcium oxalate crystalluria on renal and vesical urines in stone formers and normal subjects.

    abstract:OBJECTIVE:The aim of this study is to compare vesical and renal calcium oxalate crystalluria in an attempt to correlate crystal formation with chemical composition and calcium oxalate saturation of renal urine. MATERIAL AND METHODS:Urine specimens were directly collected from the bladder and the kidney, of 11 stone fo...

    journal_title:Urologia internationalis

    pub_type: 临床试验,杂志文章

    doi:10.1159/000030201

    authors: Robert M,Boularan AM,Delbos O,Guiter J,Descomps B

    更新日期:1998-01-01 00:00:00

  • Barium granuloma involving urinary bladder.

    abstract::The first case of barium granuloma involving urinary bladder is reported. Surgical removal was the treatment of choice. Histological diagnosis was foreign body granuloma with xanthomatous inflammation. The foreign body was identified as barium by analytical electron microscopy. ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000281516

    authors: Yanagi S,Ishii T,Tsuji Y,Ariyoshi A

    更新日期:1989-01-01 00:00:00

  • Reduction of Bladder Volume after BCG Immunotherapy.

    abstract::Bacillus Calmette-Guérin (BCG) immunotherapy is the most effective treatment for carcinoma in situ and high-risk non-muscle invasive bladder cancer (NMIBC). However, it can also provoke diverse side effects. We found 1 patient with a significantly and rapidly reduced bladder volume after the instillation of BCG. Few s...

    journal_title:Urologia internationalis

    pub_type:

    doi:10.1159/000510167

    authors: Yang C,Lv Z,Li Y

    更新日期:2021-01-01 00:00:00

  • Verapamil attenuates renal tubular apoptosis in response to partial unilateral ureteral obstruction.

    abstract:INTRODUCTION:Partial unilateral ureteral obstruction (PUUO) is the type of obstruction that is most often encountered in pediatric clinical practice. The majority of our knowledge on PUUO has been derived from experimental studies and the effects of PUUO on the kidney have still been a source of continual investigation...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000111736

    authors: Topcu SO,Erbagci A,Erturhan S,Yagci F,Ucak R

    更新日期:2008-01-01 00:00:00

  • Effect of experimental microvascular orchidopexy on testosterone secretion in the dog.

    abstract::This study was undertaken to investigate the endocrine function of the testis that was autotransplanted by microvascular techniques in 10 healthy dogs. After a control period of 4 weeks, hemicastration was carried out, and 4 weeks later the experimental orchidopexy was done. Finally, the transplanted testis was remove...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000280918

    authors: Garibyan H,de Jong FH,Klopper PJ,van der Molen HJ

    更新日期:1983-01-01 00:00:00

  • Clinical and demographic characteristics of children with urolithiasis: single-center experience from eastern Turkey.

    abstract:OBJECTIVE:To evaluate the clinical and demographic findings of children with urolithiasis in eastern Turkey. METHODS:We retrospectively reviewed the medical records of 67 children with urolithiasis for clinical and laboratory data. RESULTS:Mean age at the time of diagnosis was 39.1 +/- 41.2 months. Complaints at admi...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000230027

    authors: Tabel Y,Akin IM,Tekin S

    更新日期:2009-01-01 00:00:00

  • Effect of mineral water containing calcium and magnesium on calcium oxalate urolithiasis risk factors.

    abstract::Calcium oxalate kidney stone formers are invariably advised to increase their fluid intake. In addition, magnesium therapy is often administered. Recently, a prospective study showed that a high dietary intake of calcium reduces the risk of symptomatic kidney stones. The present study was performed to test whether sim...

    journal_title:Urologia internationalis

    pub_type: 临床试验,杂志文章

    doi:10.1159/000282958

    authors: Rodgers AL

    更新日期:1997-01-01 00:00:00

  • Angioplasic surgery for renal artery aneurysm in pediatric hypertension.

    abstract::Aneurysmectomy and renal angioplasty were performed on a 14-year-old Japanese male and the blood pressure was within normal values 3 years after this surgery. Measurement of renal blood flow was facilitated by using 133Xe washout technique. This incidence is the eighth such case to be reported from Japan. ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000280073

    authors: Kawamura J,Hosokawa S,Yoshida O

    更新日期:1976-01-01 00:00:00

  • Budd-Chiari Syndrome after Bilateral Nephrectomy for Polycystic Kidney Disease in a Kidney Transplant Recipient.

    abstract::We report a rare case of Budd-Chiari syndrome (BCS) as a postoperative complication after bilateral nephrectomy in a kidney transplant recipient with polycystic liver and kidneys. Contrast-enhanced computed tomography of the abdomen showed a narrowed inferior vena cava, compressed by the polycystic liver that moved do...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000504514

    authors: Foresto RD,Uenishi LT,Pestana RC,Neves RFCA,Aguiar WF,Tedesco Silva H Jr,Pestana JM

    更新日期:2020-01-01 00:00:00

  • Immunotherapy of metastasizing renal cell carcinoma. Results of a multicentered trial.

    abstract::119 patients with stage-IV renal cell carcinoma were treated using immunotherapy with autologous tumor vaccine. The immunization was carried out at monthly intervals, the patients were restaged every 3 months using X-ray, ultrasound scanning or computed tomography as well as bone scintigraphy in the follow-up. The pat...

    journal_title:Urologia internationalis

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1159/000281439

    authors: Schärfe T,Müller S,Riedmiller H,Jacobi GH,Hohenfellner R

    更新日期:1989-01-01 00:00:00

  • Low Preoperative Prolactin Levels Predict Non-Organ Confined Prostate Cancer in Clinically Localized Disease.

    abstract:INTRODUCTION:To evaluate the association between preoperative serum prolactin (PRL) levels and risk of non-organ confined prostate cancer (PCa) in clinically localized disease. MATERIALS AND METHODS:From December 2007 to December 2011, 124 patients with clinically localized PCa were retrospectively evaluated. Non-orga...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000496833

    authors: Porcaro AB,Tafuri A,Sebben M,Cacciamani G,Ghimenton C,Brunelli M,Petrozziello A,Monaco C,Migliorini F,Siracusano S,Artibani W

    更新日期:2019-01-01 00:00:00

  • A Comparison between Clinical and Metabolic Features of Renal Calyceal Microlithiasis and Overt Urolithiasis in Different Pediatric Age Groups.

    abstract:INTRODUCTION:This study assesses the differences in the presentations, complications and metabolic abnormalities of children with renal calyceal microlithiasis (RCM) and overt urolithiasis in different pediatric ages. MATERIALS AND METHODS:A total of 465 children with urolithiasis were investigated retrospectively. Pa...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000441126

    authors: Fahimi D,Habibi Zoham M,Sheikh M,Salabati M,Ghazanfari A,Firouzi M,Honarmand M

    更新日期:2016-01-01 00:00:00

  • Vesicourethral anastomotic strictures after radical retropubic prostatectomy: the experience of a single institution.

    abstract:OBJECTIVE:Stricture of the vesicourethral anastomosis remains a well-documented complication after radical retropubic prostatectomy. MATERIALS AND METHODS:We performed a retrospective study of 294 patients with prostate cancer who underwent radical retropubic prostatectomy. Possible correlations between anastomotic st...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000075267

    authors: Kostakopoulos A,Argiropoulos V,Protogerou V,Tekerlekis P,Melekos M

    更新日期:2004-01-01 00:00:00

  • Acute kidney injury induced by various pneumoperitoneum pressures in a rabbit model of mild and severe hydronephrosis.

    abstract:OBJECTIVE:Increased pneumoperitoneum pressure during laparoscopic surgery can result in acute kidney injury. We aimed to clarify whether intraabdominal pressure tolerance is modified in various degrees of unilateral kidney hydronephrosis in rabbits. METHODS:A total 90 rabbits were randomly allocated to three groups (g...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000362845

    authors: Li W,Cao Z,Xia Z,Meng Q,Yu WM,Yao X,Cheng F

    更新日期:2015-01-01 00:00:00

  • The management of T1G3 bladder cancer.

    abstract:INTRODUCTION:The treatment of T1G3 bladder cancer is still a controversial issue. Nowadays, intravesical bacillus Calmette-Guérin (BCG) instillation is considered to be the treatment of choice for patients with high-grade superficial bladder tumour after transurethral resection of all visible tumour. The aim of this re...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000066121

    authors: Bogdanović J,Marusić G,Djozić J,Sekulić V,Budakov P,Dejanović N,Stojkov J

    更新日期:2002-01-01 00:00:00

  • Virtual bladder tumor transurethral resection: an objective evaluation tool to overcome learning curves with and without photodynamic diagnostics.

    abstract:INTRODUCTION:Virtual reality (VR) simulation has been known to shorten learning curves. The aim of this research was to determine whether VR transurethral bladder tumor resection (TURBT) with and without photodynamic diagnostic (PDD) can improve endourological skills in novice and trained endoscopists. MATERIALS AND M...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000328218

    authors: Kruck S,Bedke J,Hennenlotter J,Amend B,Merseburger A,Stenzl A,Sievert KD

    更新日期:2011-01-01 00:00:00

  • Negative-Pressure Ureteroscopic Holmium-YAG Laser Lithotripsy for Ureteral Stones.

    abstract:OBJECTIVES:The aim of this study was to describe a novel negative-pressure laser lithotripsy device to overcome the deficiencies of the conventional procedure. PATIENTS AND METHODS:Between August 2018 and March 2019, 78 patients with a single ureteral stone underwent retrograde ureteroscopy with a Wolf 8F/9.8F rigid u...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000507266

    authors: Wu ZH,Liu TZ,Wang XH,Wang YZ,Zheng H,Zhang YG,Zhang XH

    更新日期:2020-01-01 00:00:00

  • Ureteroscopic Lithotripsy versus Laparoscopic Ureterolithotomy or Percutaneous Nephrolithotomy in the Management of Large Proximal Ureteral Stones: A Systematic Review and Meta-Analysis.

    abstract:OBJECTIVES:To provide a systematic review and meta-analysis of studies comparing ureterolithotripsy (URS) with percutaneous nephrolithotripsy (PCNL) or laparoscopic ureterolithotomy (LU) techniques for the management of large proximal ureteral stones (diameter greater than 10 mm). METHODS:A literature search was perfo...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000471773

    authors: Wu T,Duan X,Chen S,Yang X,Tang T,Cui S

    更新日期:2017-01-01 00:00:00

  • Outcome of repeat supratrigonal obstetric vesicovaginal fistula repair after previous failed repair.

    abstract:INTRODUCTION:Currently, surgical repair for vesicovaginal fistula (VVF) provides excellent results, but the recurrent VVF is difficult to treat as compared to primary. PATIENTS AND METHODS:Sixty-eight patients (44 primipara and 24 multipara) with recurrent VVF repair from January 2002 to December 2007 were included in...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000331503

    authors: Gupta NP,Mishra S,Mishra A,Seth A,Anand A

    更新日期:2012-01-01 00:00:00

  • Antifibrotic role of captopril after ureteral injury.

    abstract:OBJECTIVES:To evaluate the antifibrotic role of captopril during ureteral scarring in a New Zealand rabbit model. MATERIALS AND METHODS:The tissue expression and the fluctuation of EGF, TGF-β, FN, Col Ia1, Col Ia2 and Col III of the impaired ureter and the contralateral normal ureter were investigated by RT-PCR. The h...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000341790

    authors: Pan J,Xue W,Chen Q,Chen Y,Chen H,Huang Y

    更新日期:2012-01-01 00:00:00

  • Extraperitoneal inguinoscrotal herniation of the ureter: a rare case of recurrence after hernia repair.

    abstract::Inguinoscrotal herniation of the ureter is a rare finding with the potential for serious surgical complications. Two anatomic forms are defined. In the more common paraperitoneal variant, the herniating peritoneal sac drags the ureter and sometimes other abdominal structures with it. The uncommon variant--extraperiton...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000224879

    authors: Golgor E,Stroszczynski C,Froehner M

    更新日期:2009-01-01 00:00:00

  • Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study.

    abstract:INTRODUCTION:The German Research Activities on Natural Urologicals (GRANU) study was a randomized, partially blinded, placebo-controlled, parallel-group trial that investigated the efficacy of pumpkin seed in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH/LUTS). SUBJECTS AND METH...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1159/000362903

    authors: Vahlensieck W,Theurer C,Pfitzer E,Patz B,Banik N,Engelmann U

    更新日期:2015-01-01 00:00:00

  • Complete androgen blockade versus chemical castration in advanced prostatic cancer: analysis of an Italian multicentre study. Italian Leuprorelin Group.

    abstract:OBJECTIVES:In spite of a great amount of data, the hormonal treatment of advanced prostatic carcinoma (CaP) still remains controversial. As a relevant amount of dihydrotestosterone is present within the prostate tissue after castration, complete androgen blockade (CAB), with inhibition of the activity of both testicula...

    journal_title:Urologia internationalis

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1159/000056541

    authors: Bono AV,DiSilverio F,Robustelli della Cuna G,Benvenuti C,Brausi M,Ferrari P,Gibba A,Galli L

    更新日期:1998-01-01 00:00:00

  • Efficacy of low-molecular-weight heparin and unfractionated heparin to prevent adhesion of human prostate and bladder carcinoma and melanoma cells to bovine endothelial monolayers. An in vitro study and review of the literature.

    abstract::Adherence of human prostate carcinoma (PC 3, DU 145), bladder (647 V, J 82) carcinoma and melanoma (RPMI-8252) cell lines to plastic and bovine endothelial monolayers (BEM) was tested in the presence of 0.5, 1, 5, 10, 20 IU of low-molecular-weight heparin (LMWH), unfractionated heparin (UFH) or saline as a control. Cu...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282848

    authors: Lersch C,Gericke D,Classen M

    更新日期:1996-01-01 00:00:00

  • Implantation of the urethral stent for treatment of complex urethral strictures. Evaluation of the functional and radiological results.

    abstract::We describe the results after implantation of a urethral stent in 6 patients with recurrent urethral strictures. Four patients had strictures located in close vicinity to the external sphincter. In 3 of these 4 patients open urethroplasty procedures had failed. The treatment was successful in 5 of the 6 patients with ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282181

    authors: Baert L,van Poppel H,Werbrouck P

    更新日期:1991-01-01 00:00:00

  • Rectourethral fistula following LDR brachytherapy.

    abstract::Modern LDR brachytherapy has drastically reduced rectal toxicity and decreased the occurrence of rectourethral fistulas to <0.5% of patients. Therefore, symptoms of late-onset sequelae are often ignored initially. These fistulas cause severe patient morbidity and require interdisciplinary treatment. We report on the o...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000209374

    authors: Borchers H,Pinkawa M,Donner A,Wolter TP,Pallua N,Eble MJ,Jakse G

    更新日期:2009-01-01 00:00:00

  • In vitro evaluation of ureteral contractility: a comparative assessment of human, porcine and sheep ureteral response to vardenafil.

    abstract:OBJECTIVES:Basic science studies of ureteral physiology and pathophysiology are commonly performed on animal ureters due to several limitations associated with human ureteral sampling. In this work we question whether animal ureters are good replicas of human ureteral behavior for pharmacological studies. MATERIALS AN...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000358601

    authors: Kyriazis I,Kallidonis P,Georgiopoulos I,Al-Aown A,Sakellaropoulos G,Stolzenburg JU,Liatsikos E

    更新日期:2015-01-01 00:00:00