Abstract:
PURPOSE:To present the long-term outcome of high-risk prostate cancer patients treated by radical retropubic prostatectomy (RRP) and stage-dependent adjuvant androgen deprivation therapy. PATIENTS AND METHODS:Between 1989 and 2005, 2,655 patients underwent RRP by 9 surgeons. All cases (n = 372) with high-risk prostate cancer (serum PSA >20 ng/ml, and/or clinical stage T2c or greater, and/or biopsy Gleason score 8 or greater) were identified and analyzed retrospectively. RESULTS:At 5 and 10 years, cancer-specific survival was 91.3 and 87.2%; overall survival was 84.3 and 72.1%; biochemical progression-free survival (BPFS) was 76.6 and 56.2%; clinical progression-free survival was 86.2 and 79.9%. Kaplan-Meier analysis showed significant differences with respect to pathological stage and Gleason score for cancer-specific survival, BPFS and clinical progression-free survival. In multiple analysis, the only preoperative predictor of BPFS at the 5% level was clinical stage (p = 0.0055). CONCLUSION:In patients with high-risk prostate cancer and a life expectancy of more than 10 years, RRP with stage-dependent adjuvant androgen deprivation therapy is a viable alternative to radiation therapy.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Spahn M,Weiss C,Bader P,Ströbel P,Gerharz EW,Kneitz B,Frohneberg Ddoi
10.1159/000277593subject
Has Abstractpub_date
2010-01-01 00:00:00pages
164-73issue
2eissn
0042-1138issn
1423-0399pii
000277593journal_volume
84pub_type
杂志文章abstract::Nutrition plays a major role in the pathogenesis of the most widespread forms of nephrolithiasis, i.e. calcium (calcium oxalate and phosphate) and uric acid stone disease. For this reason, dietary measures are the first level of intervention in primary prevention, as well as in secondary prevention of recurrences. An ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000076588
更新日期:2004-01-01 00:00:00
abstract::Serum-ionized calcium (Ca++) was measured in 65 patients with idiopathic calcium urolithiasis. The patients were then divided into hypercalciuric and normocalciuric groups based on the mean + SD of the control group, with greater than 180 mg/24 h in males and greater than 176 mg/24 h in females defined as hypercalciur...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280303
更新日期:1980-01-01 00:00:00
abstract::Serum concentrations of testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were determined before and after orchidectomy performed at different intervals (2-29 months) after withdrawal of estrogen therapy in patients with prostatic carcinoma. Patients previously treated with estrogen for mor...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282012
更新日期:1987-01-01 00:00:00
abstract::We report a case of a 75-year-old female with pheochromocytoma of the bladder. Clinical evaluation included ultrasonography, intravenous pyelography, CT scan, I-MIBG scintiscan. A transurethral resection was performed for a exophytic tumor of 2 cm diameter. The histological result indicated the diagnosis of bladder ph...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000064868
更新日期:2000-01-01 00:00:00
abstract:INTRODUCTION:The goal of the study was to define treatment rules for the uncommon, rarely (10%) malignant and chemorefractory Leydig cell tumors (LCT) of the testis. METHODS:The main clinical data of patients treated in centers affiliated to the GUONE (North-Eastern Uro-Oncological Group, Italy) were reviewed. We cons...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000200790
更新日期:2009-01-01 00:00:00
abstract:AIM:To examine the hypothesis that the risk of high-grade bladder cancer can be predicted using noninvasively obtained data. PATIENTS AND METHODS:We retrospectively analyzed the database of 431 patients that had transurethral resection of first-time bladder tumors between June 1998 and December 2009. Pre-operative par...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000328635
更新日期:2011-01-01 00:00:00
abstract::Under standardized conditions, simultaneous urethrocystometry and recording of urethral pressure profile were performed in 10 healthy volunteers and 20 patients suffering from urge incontinence. In the normal subjects, desire to void occurred at a bladder volume of about 300 cm3. At maximum bladder capacity (approxima...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280116
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Radical cystectomy (RC) still poses a significant risk for mortality and morbidity. OBJECTIVES:We compared in-hospital outcomes after RC in the United States and -Germany using population-based data. METHODS:We compared data from the US Nationwide Inpatient Sample to the German hospital billing database. M...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000496347
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Despite advances in immunosuppressant medications, improvement in long-term survival for kidney transplant recipients has been more difficult to achieve. In fact, the number of patients with failing grafts who must either return to dialysis or undergo a second transplant is increasing. Second transplantation...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000499490
更新日期:2019-01-01 00:00:00
abstract::In an acute rat model (in vivo) spontaneous rhythmic bladder contractions were induced by ligation of the urethra. In addition single bladder contractions were recorded during neurostimulation of the pelvic nerve. Spontaneous and electrically induced bladder contractions were sensitive to papaverine and isoprenaline i...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282425
更新日期:1992-01-01 00:00:00
abstract::To evaluate the possible effect of urinary tract infection (UTI) on the fragility of calcium-containing stones (calcium-oxalate, calcium-phosphate), the results of extracorporeal shock wave lithotripsy (ESWL) therapy in 81 patients with UTI and 30 patients with no sign of UTI were comparatively evaluated. ESWL paramet...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282908
更新日期:1996-01-01 00:00:00
abstract:INTRODUCTION:Brief episodes of ischemia followed by periods of reperfusion generate a powerful protective mechanism in cell, tissue or organ, which increase the resistance to further ischemic damage. This is known as ischemic preconditioning, and has not been investigated in testis. The present experiments were underta...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000083289
更新日期:2005-01-01 00:00:00
abstract:INTRODUCTION:Splenectomy had been previously performed in ABO-incompatible kidney transplantation to reduce the B cell pool. However, studies have shown that patients undergoing splenectomy may have a lifelong susceptibility to infection and mortality. Splenectomy may affect the incidence of cytomegalovirus (CMV) disea...
journal_title:Urologia internationalis
pub_type:
doi:10.1159/000504862
更新日期:2020-01-01 00:00:00
abstract::We examined Southern blot analysis of genomic DNAs from 70 patients with sporadic renal cell carcinoma, using the human L-myc oncogene fragment as a hybridization probe. Our purpose was to study the relationship between the restriction fragment length polymorphism (RFLP) of the L-myc and the frequencies of metastasis....
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282261
更新日期:1991-01-01 00:00:00
abstract:INTRODUCTION:There is increasing interest in evaluating the quality of life of patients with cortisol-producing adrenocortical adenoma (CPA). Our objective was to assess patient-reported health-related quality of life (HRQOL) in patients with CPA compared to non-CPA. METHODS:Between January 2012 and September 2015, a ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000508765
更新日期:2020-01-01 00:00:00
abstract::On reviewing the literature most authors were found to have used needle electrodes for recording muscle potentials of pelvic floor muscles. We used for the first time a vaginal tampon electrode to record potentials of musculus levator ani in females and the same electrode to record potentials of the external anal sphi...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000280033
更新日期:1976-01-01 00:00:00
abstract:INTRODUCTION:Uretero-ileal strictures (UES) following urinary diversion are therapeutically challenging. We compared the efficacy, safety and renal outcome following therapeutic endo-urological techniques (EUTs) and open surgical revision of the anastomosis (SRA) for UES. MATERIAL AND METHODS:We retrospectively analys...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000475508
更新日期:2018-01-01 00:00:00
abstract::The first case of carcinosarcoma in the spermatic cord is reported in a 40-year-old man. The tumor was a 2.5 X 2 cm pseudoencapsulated formation located in the connective tissue of the spermatic cord among the blood vessels. Light microscopy examination of the neoplasm revealed two different histological patterns: epi...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281727
更新日期:1990-01-01 00:00:00
abstract:INTRODUCTION:To assess the influence of music therapy on perceived anxiety and pain during outpatient urodynamic study (UDS) in a prospective, randomized fashion. METHODS:Between January and December 2018, a total of 70 patients were randomized to either have music therapy (study) or not have (control) in a 1:1 ratio....
journal_title:Urologia internationalis
pub_type: 杂志文章,随机对照试验
doi:10.1159/000502298
更新日期:2019-01-01 00:00:00
abstract::During 1986 and 1987, 47 patients with renal cell carcinoma were evaluated preoperatively with CT, angiography and MRI. The preoperative tumor stage (T), lymph node metastases and venous involvement determined with the three methods were compared to the operative and histopathological findings. For T stage, angiograph...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282219
更新日期:1991-01-01 00:00:00
abstract::The objective of the study was to evaluate possible changes of the gene expression and localization of the enzymes, heme oxygenase and nitric oxide synthase (NOS), with reference to increase of collagen type III in response to the partial obstruction of the bladder. Following initial obstruction, whole rat bladders we...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000099351
更新日期:2007-01-01 00:00:00
abstract::A technical evaluation of the Exeter recording nappy has been carried out with particular reference to (a) linearity, (b) reproducibility of calibration, (c) the effect of variation in the position of moistened zones produced by consecutive leakages and (d) the effect of variation in the electrical conductivity of the...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280034
更新日期:1976-01-01 00:00:00
abstract:INTRODUCTION:There is a need for more exhaustive data concerning the use of prophylactic ureteral stenting for extended debulking and cytoreductive procedures in the literature. MATERIAL AND METHODS:A retrospective analysis of the CARPEPACEM study protocol database was performed. The trial protocol schedules the posit...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000339920
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:The purpose of this study was to determine whether periurethral injection of allogenic mesenchymal stem cells (MSCs) could increase the leak point pressure (LPP) in a rat model of stress urinary incontinence. MATERIALS AND METHODS:Female Sprague-Dawley rats (230-240 g, n = 30) were divided into 3 groups: sham ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000317322
更新日期:2011-01-01 00:00:00
abstract::Regenerative medicine, tissue engineering and biomedical research give hope to many patients who need bio-implants. Tissue engineering applications have already been developed based on bioreactors. Physiological ureter implants, however, do not still function sufficiently, as they represent tubular hollow structures w...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000368419
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:To determine the efficacy and safety of laparoscopic deroofing of symptomatic simple renal cysts. METHODS:A Cochrane style systematic review was conducted on published literature from 1990 to 2017, to include case series and randomised controlled trials. A pooled meta-analysis was conducted. RESULTS:A tota...
journal_title:Urologia internationalis
pub_type: meta分析
doi:10.1159/000497313
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the safety and feasibility of percutaneous tract dilation by the one-stage method in preschool children. METHODS:Between April 2009 and February 2013, all preschool (<6 years) children who were candidates for percutaneous nephrolithotomy were enrolled in this prospective study. Patients were rand...
journal_title:Urologia internationalis
pub_type: 杂志文章,随机对照试验
doi:10.1159/000356327
更新日期:2014-01-01 00:00:00
abstract::Adrenal cysts are very rare lesions, usually asymptomatic or without characteristic symptoms. They are classified as pseudocysts, endothelial cysts, epithelial cysts or parasitic cysts. Although pseudocysts are reported to be the most common clinically recognized adrenal cysts in surgical series, endothelial cysts are...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000111726
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:This open label, phase I clinical trial (NCT02945462) using 2 consecutive intracavernous autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) for the first time in the treatment of diabetic patients with erectile dysfunction (ED). The primary outcome is to assess the safety and tolerability of int...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000492120
更新日期:2018-01-01 00:00:00
abstract::We present an unusual case of condylomata acuminata arising in the transplanted skin of a neovagina in a male-to-female transsexual. The neovagina had been constructed using a penile and a scrotal skin flap. Resection of the larger condylomata was performed; then all visible lesions were ablated by electrovaporization...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000078811
更新日期:2004-01-01 00:00:00