Steroid receptor status of human testicular tumors.

Abstract:

:Biopsies of 9 testicular tumors were examined for the presence of cytoplasmic receptor proteins for estrogens, progestins, androgens, and glucocorticoids. Using an arbitrary threshold value of 10 fmol/mg cytosol protein for a postive assay, only 1 of 9 tumors was estrogen-receptor positive. However, no receptor-specific 8S binding could be detected by low salt sucrose gradient centrifugation. 1 tumor was progesterone-receptor positive. No androgen receptors could be demonstrated. In contrast, 8 of 9 neoplasms contained significant quantities of glucocorticoid receptors exclusively sedimenting at 8S. Our findings suggest that androgens, estrogens, and progestins are unlikely to play a major role in the natural history of testicular tumors. The presence of glucocorticoid receptors might offer a chance for endocrine manipulation of the development and growth of these neoplasms by glucocorticoids.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Bojar H,Weissbach L,Petzinna D,Maar K,Staib W

doi

10.1159/000281072

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

160-3

issue

3

eissn

0042-1138

issn

1423-0399

journal_volume

40

pub_type

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