Diagnosing the location of carcinoma in situ (CIS) of the urinary bladder using pirarubicin hydrochloride.

Abstract:

INTRODUCTION:No established technique for locating solitary carcinoma in situ (CIS) of the urinary bladder or CIS accompanying bladder cancer has been determined. Here we investigated whether the location of CIS of the urinary bladder can be macroscopically ascertained by instilling pirarubicin hydrochloride (THP) into the urinary bladder. PATIENTS AND METHODS:We dissolved 50 mg of THP in 50 ml of distilled water, and instilled the resulting solution into the urinary bladder. After 5 min, the urinary bladder is examined using a cystoscope. The study group consisted of 30 subjects (23 men and 7 women). RESULTS:THP uptake was seen in 19 flat (nontumorous) areas of the bladder mucosa in 13 patients. Of these, 11 lesions in 6 patients were confirmed to be CIS. THP uptake was also seen in flat malignant lesions such as bladder cancer invasion into the prostatic urethra, and in benign lesions such as chronic cystitis and urothelial hyperplasia. CONCLUSIONS:The present method can be useful to find easily and macroscopically the location of flat malignant lesions such as CIS.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Uchikoba T,Horiuchi K,Oka F,Sato M,Tsuboi N,Ohaki Y,Nishimura T

doi

10.1159/000083555

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

235-9

issue

3

eissn

0042-1138

issn

1423-0399

pii

83555

journal_volume

74

pub_type

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