Abstract:
BACKGROUND:To investigate the effect of hydrodynamic pressure mimicking vesicoureteral reflux on renal tubular epithelial cells in vitro, we constructed an intermittent pressure-loading (IPL) model of Madin-Darby canine kidney (MDCK) cells. MATERIALS AND METHODS:Three grades of pressure were loaded onto the MDCK cells intermittently. The concentration of cytokines in the supernatant, the amount of the protein and its mRNA in the MDCK cells were studied, respectively. RESULTS:After 24 h, the concentration of transforming growth factor-beta1 (TGF-beta1) increased under intense IPL conditions (100 and 200 cm H2O) in the 15-min IPL group (p<0.05, p<0.01). The amount of cellular level of TGF-beta1 protein and its mRNA did not show any significant increase within 24 h under the present conditions. The concentration of monocyte chemoattractant peptide-1 (MCP-1) was not significantly different from that of the control. CONCLUSION:These data suggest that the early TGF-beta1 secretion phenomenon without change in gene expression is the case in the renal tubular epithelial cells under certain intermittent pressure-loading conditions.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Maruyama T,Hayashi Y,Nakane A,Sasaki S,Kohri Kdoi
10.1159/000087170subject
Has Abstractpub_date
2005-01-01 00:00:00pages
150-8issue
2eissn
0042-1138issn
1423-0399pii
87170journal_volume
75pub_type
杂志文章abstract::The authors improved the Nélaton catheter with a pair of carbon fiber electrodes as previously published and also improved the Foley catheter with a pair of carbon fiber electrodes which are less painful and easier to use. We also have made efforts how to record the vesical electromyogram (EMG) simultaneously with cys...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280979
更新日期:1984-01-01 00:00:00
abstract:PURPOSE:The short-term effects of intravesical chemoimmunotherapy with epirubicin and bacillus Calmette-Guérin (BCG) administered repeatedly for prophylaxis of recurrence of superficial bladder cancer (pTa, pT1) were investigated in 24 patients aged a median of 70 years between March 1996 and February 1999, and were co...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000051005
更新日期:2001-01-01 00:00:00
abstract::Penile prosthesis was implanted for erectile impotence of mainly organic origin in 104 patients. The AMS Dynaflex penile prosthesis was inserted in 39 cases, the AMS Malleable 600 prosthesis in 61 and the AMS Ultrex Plus prosthesis in 4. In 1 patient receiving a malleable prosthesis both rods had to be removed owing t...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282820
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to assess the occurrence of ectopic remnants of adrenal cortex tissue encountered in pediatric patients who underwent groin surgical explorations. MATERIALS AND METHODS:We studied 1,862 patients with groin surgical explorations during a period of 12 consecutive years (1995-20...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000151411
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Sunitinib is standard first-line therapy for metastatic clear cell renal cancer (MCRC). It is associated with leucopenia; however, its effects on specific immune cell subsets are unclear. Alterations in immune cell subsets may contribute to tumour progression. METHODS:Lymphocyte subsets (CD3, 4, 8, 19 and 5...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章
doi:10.1159/000319498
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the antifibrotic role of captopril during ureteral scarring in a New Zealand rabbit model. MATERIALS AND METHODS:The tissue expression and the fluctuation of EGF, TGF-β, FN, Col Ia1, Col Ia2 and Col III of the impaired ureter and the contralateral normal ureter were investigated by RT-PCR. The h...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000341790
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To present a review of the literature using evidence-based criteria for diagnosis and treatment of malignant growths in the ureteric remnant following nephrectomy for non-malignant disease. METHODS:A database search using the key search words was performed, producing a total of 16 articles published between ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000349884
更新日期:2013-01-01 00:00:00
abstract::The first case of barium granuloma involving urinary bladder is reported. Surgical removal was the treatment of choice. Histological diagnosis was foreign body granuloma with xanthomatous inflammation. The foreign body was identified as barium by analytical electron microscopy. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281516
更新日期:1989-01-01 00:00:00
abstract::Two cases of colorenocutaneous fistula due to genitourinary tuberculosis are presented. They were successfully managed by single-stage surgery (nephroureterectomy, fistulectomy, and primary repair of the colon) and antitubercular treatment. The literature is briefly reviewed. ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000282568
更新日期:1994-01-01 00:00:00
abstract::The rate of recurrence after internal urethrotomy a.m. Sachse was studied in a prospective, consecutive, randomized series of 43 patients using short-term (1 day) and long-term (14 days) postoperative catheter treatment. No significant difference was found between the two groups according to voiding interview, flowmet...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000280991
更新日期:1984-01-01 00:00:00
abstract::Adherence of human prostate carcinoma (PC 3, DU 145), bladder (647 V, J 82) carcinoma and melanoma (RPMI-8252) cell lines to plastic and bovine endothelial monolayers (BEM) was tested in the presence of 0.5, 1, 5, 10, 20 IU of low-molecular-weight heparin (LMWH), unfractionated heparin (UFH) or saline as a control. Cu...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282848
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Afferents from the urinary tract transmit bladder sensations to the central nervous system. Spinal cord injury (SCI) may affect both efferent motor and afferent sensory pathways. Presence/absence of bladder sensations in patients with complete spinal cord, conus or cauda equina lesions was compared with neur...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000342815
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:No relevant data have been published on the impact of retroperitoneal lymph node dissection (LND) on clinical outcome in patients with castration-resistant prostate cancer. METHODS:We retrospectively studied the records of 6 patients with lymph node metastases from castration-resistant prostate cancer who u...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000335206
更新日期:2012-01-01 00:00:00
abstract::Alternative minimally invasive methods treating benign prostate hyperplasia (BPH) have become more and more important. Transurethral needle ablation (TUNATM) has been demonstrated to be effective in both canine and the human prostate. The goal of our study was to prove the safety, feasibility and tolerance of this new...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章
doi:10.1159/000030298
更新日期:1998-01-01 00:00:00
abstract:INTRODUCTION:International guidelines are ambivalent regarding the recommendations for the management of clinical stage 1 (CS1) seminoma. PATIENTS AND METHODS:During 2008-2013, 1,050 patients with seminoma CS1 were prospectively registered with regard to assessing management modality (radiotherapy, carboplatin, survei...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000443214
更新日期:2016-01-01 00:00:00
abstract::In unilateral kidney disease, it has been suggested that the ipsilateral state could be estimated by measuring contralateral kidney size; thus, a contralateral increase should reflect an ipsilateral impairment and vice versa. This could easily be performed using ultrasound. In our experiments with partial obstruction ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282898
更新日期:1996-01-01 00:00:00
abstract::In 153 patients with verified neoplasias of the genitourinary tract, urinary neopterin excretion was monitored under different conditions. As control, urinary neopterin values were taken from 208 male and 209 female volunteers. Neopterin excretion was measured by high performance liquid chromatography. Patients with e...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281071
更新日期:1985-01-01 00:00:00
abstract::A 63-year-old man with primary malignant lymphoma of the prostate is presented. The patient underwent total cystoprostatectomy and ileal conduit construction. The specimen revealed malignant lymphoma, diffuse small cleaved cell of the gland. Three months after the operation, local recurrence and enlarged lymph node de...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282216
更新日期:1991-01-01 00:00:00
abstract::Urinary incontinence in 80 men was classifed by combined radiological and urodynamic techniques. 28 cases of pure stress incontinence were evaluated for grading of sphincteric loss. Clinical and sphincterometric data were correlated. Functional urethral length, urethral closure pressure at rest and with voluntary sphi...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280348
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Radical cystectomy (RC) still poses a significant risk for mortality and morbidity. OBJECTIVES:We compared in-hospital outcomes after RC in the United States and -Germany using population-based data. METHODS:We compared data from the US Nationwide Inpatient Sample to the German hospital billing database. M...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000496347
更新日期:2019-01-01 00:00:00
abstract::Radiotherapy (RT) is applied in prostate cancer patients with a biochemical recurrence (BcR) after radical prostatectomy (RP). However, for the patients with persistent PSA but not undergoing the process of BcR, it remains unknown whether the application of RT can exempt them from the upcoming BcR. In this study, we i...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000488536
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:This study aimed to evaluate the role of bone scan as a staging investigation in newly diagnosed untreated prostate cancers. MATERIALS AND METHODS:Bone scan results in patients with newly diagnosed prostate cancer were reviewed and correlated with clinical stage, prostate-specific antigen (PSA) and Gleason s...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000091620
更新日期:2006-01-01 00:00:00
abstract::A case with benign renal leiomyoma examined by all the imaging techniques currently available is described. The aspects were conflicting, particularly with regard to sonography and magnetic resonance imaging, and the sole technique which provided more reliable information was the CT scan. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282337
更新日期:1992-01-01 00:00:00
abstract:AIM:To compare the efficacy and safety of silodosin versus tamsulosin as medical expulsive therapy for stones of lower-third ureter in children. PATIENTS AND METHODS:This prospective single-blind placebo-controlled randomized study included 167 pediatric patients who presented with distal ureteric stone (DUS) less tha...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000513074
更新日期:2021-02-01 00:00:00
abstract::We examined a 46-year-old male patient with idiopathic myelofibrosis diagnosed 28 months earlier. After chemotherapy and irradiation, CT showed nonnodular, soft tissue masses in the renal hilum, pelvicaliceal system, perirenal and periureteral spaces. Ultrasound-guided biopsy showed extramedullary hematopoiesis (EMH)....
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000087809
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:To evaluate the difference at different steps of follow-up of the postoperative quality of life (QoL) in patients who had undergone radical cystectomy and ileal orthotopic neobladder derivation. PATIENTS AND METHODS:A multicentric, cross-qualitative study was performed in 5 Italian centers of reference for ...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000443185
更新日期:2016-01-01 00:00:00
abstract::We report a case of clitoral hypertrophy of unknown origin. A 3-year-old girl showed clitoral hypertrophy at birth. Biochemical analysis of peripheral blood and endocrinological examinations were normal. Other virilizing symptoms were not recognized. Clitoroplasty was carried out, and the clitoris has not enlarged 20 ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030385
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:To determine association between urine pH and OAB symptoms and to determine if urinary alkalization improves overactive bladder (OAB) symptoms. METHODS:659 patients with OAB were enrolled in this study between June 2012 and May 2014. 329 patients (group 1) were included in the final analysis. 201 adults wer...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000375322
更新日期:2015-01-01 00:00:00
abstract::We performed sonography in 7 males with membranous and posterior urethral calculi. Sonography demonstrated the urethral calculi in all 7 patients. These findings suggest that sonography is useful as a noninvasive screening technique for urethral calculi. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282484
更新日期:1993-01-01 00:00:00
abstract::Carcinoembryonic antigen (CEA) is elevated in urine and/or serum of patients with transitional cell carcinoma (TCC) of the urinary bladder. A group of 26 patients with TCC of the urinary bladder were evaluated with regard to urine/serum CEA levels and CEA tissue content. CEA could be detected in normal, metaplastic an...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280875
更新日期:1983-01-01 00:00:00