Effects of chemoimmunotherapy with and without surgery in murine MBT-2 bladder tumor.

Abstract:

:Using C3H/He JCr mice bearing the syngeneic MBT-2 bladder tumor, it was found that cyclophosphamide (CYC 100 mg/kg i.p.) treatment, 1 day before and 2 weeks after surgery, followed by postoperative autologous tumor vaccine immunization can be an effective adjuvant anticancer therapy. The short-term exogeneous addition of low dose Il-2 administration to the protocol provided no further benefit. Suppression of tumor growth was observed in a classical Winn assay when splenocytes were obtained on day 23 from mice receiving this effective adjuvant therapy with surgery on day 8. Splenocytes from tumor-bearing mice (TBM) treated with CYC were augmented in terms of their proliferative response to concanavalin A during the first 2 weeks after CYC treatment. Studies using 3-day TBM established that significant suppression of tumor growth and prolonged survivals were dependent upon CYC treatment being combined with tumor vaccine and/or interleukin-2; single agent treatments were ineffective.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Tzai TS,Lin JS,Chow NH

doi

10.1159/000282623

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

6-11

issue

1

eissn

0042-1138

issn

1423-0399

journal_volume

53

pub_type

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