Abstract:
BACKGROUND:IL-6 has been reported to be a significant prognostic factor for prostate cancer and induces synthesis of C-reactive protein (CRP) by hepatocytes. The present study was undertaken to evaluate the clinical value of serum CRP in prostate cancer patients with metastases. METHODS:The prognostic significance of serum CRP as well as tumor histology, extent of disease (EOD) on bone scan, serum levels of prostate-specific antigen (PSA) and alkaline phosphatase (ALP) and hemoglobin was assessed using Cox's proportional hazards model analyses in 126 prostate cancer patients with metastases treated with endocrine therapy. RESULTS:Serum levels of CRP, PSA and ALP significantly increased and hemoglobin significantly decreased with advancing EOD grade. Univariate analysis demonstrated that EOD, CRP, PSA, ALP, hemoglobin and tumor histology are significantly associated with disease-specific survival. Multivariate analysis demonstrated that serum CRP and EOD were significant prognostic factors. The 5-year survival rates in low-risk patients (CRP < or = 0.15 mg/dl and EOD < or = 1) and high-risk patients (CRP > 0.15 mg/dl and EOD > or = 2) were 74 and 24%, respectively. CONCLUSION:These results indicate that a combination of serum CRP and EOD can identify patients with a poor prognosis who may be candidates for innovative treatments among prostate cancer patients with metastases.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Nakashima J,Kikuchi E,Miyajima A,Nakagawa K,Oya M,Ohigashi T,Murai Mdoi
10.1159/000112601subject
Has Abstractpub_date
2008-01-01 00:00:00pages
129-33issue
2eissn
0042-1138issn
1423-0399pii
000112601journal_volume
80pub_type
杂志文章abstract:PURPOSE:Renal cell carcinoma (RCC) forming tumor thrombus (TT) of vena cava (VC) is characterized by poor prognosis. Nevertheless, the outcome of patients after radical surgery varies. To date only limited data concerning prognostic biomarkers in this RCC subgroup are available. METHODS:Out of 159 patients with pT3b/c...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000497279
更新日期:2019-01-01 00:00:00
abstract::Sex-dependent stone formation following portacaval shunt (PCS) was investigated in 82 male and 71 female Sprague-Dawley rats. 72.6% of male PCS rats and none of the female PCS rats developed urolithiasis, in 90.2%, potassium-hydrogen-urate stones formed. Hormonal analysis revealed significant alterations in steroid ho...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282544
更新日期:1993-01-01 00:00:00
abstract:INTRODUCTION:The study aimed to present our experience of surgical treatment for urorectal fistulas (URF) that develop after cancer surgery. MATERIALS AND METHODS:Fourteen patients with URF who were treated at our institution from 2005 through 2015 were retrospectively analyzed. Among these, 7 patients had previous su...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000457835
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Laparoscopic adrenalectomy is the gold standard for treatment of benign adrenal lesions. Tumor size is a factor that might influence decision-making concerning the use of laparoscopic approach. The aim of this study was to analyze the results of adrenalectomy for tumors ≥6 cm in diameter. METHODS:Two groups...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000444146
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:To compare the effects of retroperitoneal laparoscopic surgery (RPL) and transperitoneal laparoscopic surgery (TPL) on the hemodynamic and ventilatory functions in old patients. METHODS:Thirty-two senior patients underwent either RPL or TPL. Swan-Ganz and radial artery catheters were placed to monitor hemodyna...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000251183
更新日期:2009-01-01 00:00:00
abstract::Modern LDR brachytherapy has drastically reduced rectal toxicity and decreased the occurrence of rectourethral fistulas to <0.5% of patients. Therefore, symptoms of late-onset sequelae are often ignored initially. These fistulas cause severe patient morbidity and require interdisciplinary treatment. We report on the o...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000209374
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Gene-modified cell vaccines are now considered to be the best way to achieve immunotherapy for a variety of cancers including prostate cancer (PCa). XAGE-1b is a member of the cancer/testis antigen family which has demonstrated strong immunogenicity. We investigated whether XAGE-1b is an ideal target for P...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000363333
更新日期:2015-01-01 00:00:00
abstract::The prevalence, pathogenesis and clinical aspects of bacterial infections of the female urinary tract are described and the efficacy of therapies used at present is discussed. Based on a retrospective compilation of data on 142 female patients with urinary tract infections, the pathogen spectrum is defined and the the...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281989
更新日期:1987-01-01 00:00:00
abstract:INTRODUCTION:To present the incidence of bacterial colonization on ureteral double J stents (DJS); isolate the uropathogens; define the rate of multi-resistant bacteria strains (MRBS) and present their clinical importance.
MATERIALS AND METHODS:
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000486798
更新日期:2018-01-01 00:00:00
abstract::We report on the familial occurrence of congenital bulbar urethral stricture in 2 brothers. Embryological mechanisms are briefly discussed and the literature reviewed. ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000281795
更新日期:1991-01-01 00:00:00
abstract::We describe the 2 unique Asian cases of pure urinary bladder lymphoepithelioma-like carcinoma (LELCA). One patient had metastatic pelvic lymphoadenopathy and the other with superficial tumor. The EBER in situ hybridization both showed negative results despite racial or geographical factors might influence the peculiar...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000083565
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Limited data are available for the use of agents in metastatic castration-resistant prostate cancer (mCRPC) beyond the third-line. We provide data during treatment with cabazitaxel (CAB), helping to improve the informed-consent process. PATIENTS AND METHODS:We retrospectively reviewed patients treated with ...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究,评审
doi:10.1159/000477943
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:To investigate whether congenital renal vein anomalies are involved in the etiology of hematuria by analyzing abdominal multidetector computed tomography (MDCT) results. METHODS:Six hundred and eighty patients undergoing MDCT for various abdominal pathologies in whom possible causes of hematuria were exclud...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000365664
更新日期:2015-01-01 00:00:00
abstract::15 patients with urinary infection were selected and analyzed in relation to infection in the vaginal and perianal areas. After treatment, 12 patients with urinary infection were cured, but bacterial organisms persisted in their vaginal and perianal areas. In spite of the persistence of the vaginal and perianal infect...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280207
更新日期:1978-01-01 00:00:00
abstract:INTRODUCTION:Intravesical recurrence after treatment of primary upper urinary tract urothelial carcinomas (UUT-UCs) is common. While intravesical instillation is widely used to prevent recurrence after transurethral resection for primary bladder tumors, there is still no consensus on the prophylactic capability of intr...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000350508
更新日期:2013-01-01 00:00:00
abstract::Biopsies of 9 testicular tumors were examined for the presence of cytoplasmic receptor proteins for estrogens, progestins, androgens, and glucocorticoids. Using an arbitrary threshold value of 10 fmol/mg cytosol protein for a postive assay, only 1 of 9 tumors was estrogen-receptor positive. However, no receptor-specif...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281072
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVES:To introduce our modified retroperitoneoscopic living-donor nephrectomy (RPLDN) techniques and estimate the learning curve. METHODS:We retrospectively evaluated 121 consecutive donors who underwent modified RPLDN performed by a single surgeon. While the surgeon controlled the renal vessels, one hand was ins...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000493765
更新日期:2018-01-01 00:00:00
abstract::Verrucous carcinoma (VC) is a rare variant of squamous cell carcinoma (SCC) with an extremely well-differentiated microscopic appearance. It is able to show extensive local invasion, but practically never metastasizes. VCs mostly occur in the oral cavity, larynx, nasal cavity, esophagus, vulva, vagina, anorectal regio...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000330906
更新日期:2012-01-01 00:00:00
abstract:UNLABELLED:BACKGROUND/AIMS/OBJECTIVES: To describe the depth of the laser coagulation zone in vivo based on histological examinations and the functional outcome of a 1,318-nm diode laser for enucleation in benign prostatic enlargement (BPE). METHODS:A total of 20 patients with BPE were treated by laser Eraser® enuclea...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000353554
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Appropriate management of renal trauma is controversial. The purpose of this study is to present our 5-year experience in renal trauma and review the literature. MATERIALS AND METHODS:From 1999 to 2003, 28 patients were identified with renal injuries. 25 (89.3%) of the injuries were caused by blunt trauma...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000093899
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:To compare the safety and efficacy of standard-tract combined with mini-tract to single standard-tract in percutaneous nephrolithotomy (PCNL) for renal staghorn calculi. METHODS:The records of 216 patients with staghorn calculi (110 (50.9%) had complete and 106 (49.1%) had partial) who received PCNL were revie...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000354427
更新日期:2014-01-01 00:00:00
abstract::We studied the impact of antireflux surgery on bladder compliance, which was an important clinical parameter in terms of urinary incontinence and upper tract deterioration, in 20 myelodysplastics (group A). For control groups, 31 myelodysplastic children with or without reflux who were conservatively treated (group B)...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282253
更新日期:1991-01-01 00:00:00
abstract::Renal angiomyolipoma (AML), a rare benign mesenchymal neoplasm, is characterized by the presence of vessels, smooth muscle, and adipose tissue. Treatment should be considered for symptomatic patients or for those at risk for complications, in particular for retroperitoneal bleeding, which is correlated to the size of ...
journal_title:Urologia internationalis
pub_type:
doi:10.1159/000485518
更新日期:2019-01-01 00:00:00
abstract::The momentary entry of urine into the proximal urethra during coughing can be demonstrated by a new test which can be conducted using apparatus now commonly available for urodynamic investigations. If the bladder neck opens, a fluid bridge is established between points of pressure measurement in the bladder and in the...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280287
更新日期:1979-01-01 00:00:00
abstract:PURPOSE:The treatment approach for enuresis is controversial due to the lack of consensus as to the exact causes of nocturnal enuresis. Despite various treatment modalities, pharmacotherapy still appears to be the common choice. The aim of this prospective study was the evaluation of the efficacy of combination therapy...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000064858
更新日期:2000-01-01 00:00:00
abstract::A partial urethral obstruction was induced in female rats. After 6 weeks, detrusor weight had increased eightfold and collagen concentration had decreased to about 40% compared to controls. Due to the weight gain, the total amount of detrusor collagen had increased more than threefold. Removal of the obstruction led t...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282230
更新日期:1991-01-01 00:00:00
abstract::24 h urinary pyrophosphate excretion was studied in 20 normal healthy subjects and 75 idiopathic stone formers from north-western regions of India. The mean 24-hour urinary excretion of pyrophosphate was significantly low in stone formers (50.67 +/- 2.16 mumol/24 h) as compared to that of normal subjects (71.46 +/- 5....
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000282364
更新日期:1992-01-01 00:00:00
abstract::It is well known that diabetes mellitus is accompanied by complications of sexual dysfunction and it is believed that diabetic neuropathy may cause impotence. In our study, we found that not all the patients who visited our center with the chief complaint of diabetic impotence were suffering from organic impotence, an...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282978
更新日期:1997-01-01 00:00:00
abstract::We examined a 46-year-old male patient with idiopathic myelofibrosis diagnosed 28 months earlier. After chemotherapy and irradiation, CT showed nonnodular, soft tissue masses in the renal hilum, pelvicaliceal system, perirenal and periureteral spaces. Ultrasound-guided biopsy showed extramedullary hematopoiesis (EMH)....
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000087809
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the antifibrotic role of captopril during ureteral scarring in a New Zealand rabbit model. MATERIALS AND METHODS:The tissue expression and the fluctuation of EGF, TGF-β, FN, Col Ia1, Col Ia2 and Col III of the impaired ureter and the contralateral normal ureter were investigated by RT-PCR. The h...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000341790
更新日期:2012-01-01 00:00:00