当前位置： SCI文献检索 > OPHTHALMOLOGY期刊下所有文献 > Boston Keratoprosthesis: Outcomes and Complications: A Report by the American Academy of Ophthalmology.

Boston Keratoprosthesis: Outcomes and Complications: A Report by the American Academy of Ophthalmology.

Abstract：

OBJECTIVE:To review the published literature on safety and outcomes of the Boston type I keratoprosthesis (BI-KPro) for the surgical treatment of corneal opacification not amenable to human cadaveric corneal transplantation. METHODS:Searches of peer-reviewed literature were conducted in PubMed and the Cochrane Library in December 2012, July 2013, and January 2014 without date restrictions. The searches were limited to studies published in English and yielded 587 citations. The abstracts of these articles were reviewed, 48 articles were selected for possible clinical relevance, and 22 were determined to be relevant for the assessment objectives. Nine studies were rated as level II evidence and 13 studies were rated as level III evidence. Excluded were level III evidence, case reports, review articles, letters, editorials, and case series with fewer than 25 eyes. RESULTS:In 9 articles, a best-corrected Snellen visual acuity (BCSVA) of 20/200 or better occurred in 45% to 89% of eyes. Five articles described a BCSVA of 20/50 or better in 43% to 69% of eyes, and 4 articles found a BCSVA of 20/40 or better in 11% to 39% of eyes. Retention rates of the BI-KPro ranged from 65% to 100%. Reasons for loss of vision after BI-KPro implantation most commonly included corneal melts resulting from exposure keratopathy, endophthalmitis, and infectious keratitis or corneal ulceration. The 2 most common complications after surgery were retroprosthetic membrane formation (range, 1.0%-65.0%; mean ± standard deviation [SD], 30.0±19.0%) and elevated intraocular pressure (range, 2.4%-64.0%; mean ± SD, 27.5±18.1%). The 2 most common posterior segment complications were endophthalmitis (range, 0%-12.5%; mean ± SD, 4.6±4.6%) and vitritis (range, 0%-14.5%; mean ± SD, 5.6±4.7%). CONCLUSIONS:The reviewed articles on BI-KPro use suggest that the device improves vision in cases of severe corneal opacification that were not amenable to corneal transplantation using human cadaveric keratoplasty techniques. A number of severe anterior and posterior segment complications can develop as follow-up continues, making ongoing close observation paramount for patients undergoing this surgery. These complications include infection, device extrusion, and permanent vision loss.

journal_name

Ophthalmology

journal_title

Ophthalmology

authors

Lee WB,Shtein RM,Kaufman SC,Deng SX,Rosenblatt MI

doi

10.1016/j.ophtha.2015.03.025

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

1504-11

issue

eissn

0161-6420

issn

1549-4713

pii

S0161-6420(15)00306-1

journal_volume

122

pub_type

杂志文章

在线工具

Boston Keratoprosthesis: Outcomes and Complications: A Report by the American Academy of Ophthalmology.