Abstract：
:We recently studied members from a family with autosomal dominant iris coloboma. All affected members had either unilateral or bilateral iris coloboma and bilateral peripheral corneal changes indistinguishable from those seen in aniridia. The corneal changes consisted of well-demarcated pannus-like growths extending from the limbus onto the peripheral cornea for 360 degrees without any stromal vascularization. In one adolescent member, bilateral lenticular opacities limited to the meridian of the colobomata were seen. No members had primary glaucoma, macular or optic disc hypoplasia, nystagmus, or extraocular malformations. The coexistence of iris coloboma and aniridia-like corneal changes may imply that ocular coloboma and aniridia comprise a continuous spectrum of the same developmental defect or, alternatively, such corneal changes constitute a nonspecific manifestation of iris developmental defects in general.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Soong HK,Raizman MBdoi
10.1016/s0161-6420(86)33738-2subject
Has Abstractpub_date
1986-03-01 00:00:00pages
335-9issue
3eissn
0161-6420issn
1549-4713pii
S0161-6420(86)33738-2journal_volume
93pub_type
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