Abstract:
:The effects of high (71%) and low (38.6%) water content lenses on antibiotic delivery to the cornea were studied in rabbits by measuring corneal tobramycin concentrations 1, 2, 4 and 6 hours after topical application at intervals of 15 minutes. In the presence of the low water content lens corneal drug levels were higher than in control corneas for every time point assayed. This difference was only significant at 4 hours (P less than 0.05). In eyes wearing the high water content contact lens corneal drug concentration was also higher at every time point tested except one hour. The difference was significant only at 4 hours (P less than 0.01). The data suggest that in the normal, noninflammed eye, the presence of a therapeutic soft contact lens will not compromise aminoglycoside delivery to the cornea.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Matoba AY,McCulley JPdoi
10.1016/s0161-6420(85)34062-9subject
Has Abstractpub_date
1985-01-01 00:00:00pages
97-9issue
1eissn
0161-6420issn
1549-4713pii
S0161-6420(85)34062-9journal_volume
92pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract:OBJECTIVE:To report the fungal isolates, treatment strategies, and clinical outcomes for a large series of patients with exogenous fungal endophthalmitis. DESIGN:Retrospective, single institution, consecutive case series. PARTICIPANTS:All patients treated at Bascom Palmer Eye Institute between January 1, 1990, and Ju...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2008.02.027
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:To investigate the safety and efficacy of a new laser procedure using a q-switched 532-nm neodymium (Nd):YAG laser, also called "selective laser trabeculoplasty," to lower intraocular pressure (IOP) in patients with open-angle glaucoma (OAG). The laser parameters were set to selectively target pigmented trabe...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/S0161-6420(98)91129-0
更新日期:1998-11-01 00:00:00
abstract:PURPOSE:To investigate the association between seatbelt use and (1) the spectrum of ocular injuries and (2) visual acuity outcomes after motor vehicle accidents (MVAs) with airbag deployment. DESIGN:Single-center retrospective observational case series. PARTICIPANTS:Forty-seven patients involved in MVAs with airbag d...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2007.05.053
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:To analyze the association of the polymorphisms in 8-oxoguanine glycosylase-1 (OGG1), X-ray repair cross-complementing-1 (XRCC1), and AP endonuclease-1 (APE1) genes in the base excision repair pathway and xeroderma pigmentosum complementation group D (XPD) in the nucleotide excision repair pathway with the risk...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2011.11.004
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of topical mitomycin-C (MMC) for treatment of postoperative residual conjunctival squamous cell carcinoma (SCC). DESIGN:Retrospective noncomparative case series. PARTICIPANTS:Five patients, two males and three females, with conjunctival and histologically proven incompletely excised c...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(01)00967-8
更新日期:2002-03-01 00:00:00
abstract:PURPOSE:The human orbit is an environment that is vulnerable to inflammation and edema in the setting of autoimmune thyroid disease. Our study investigated the tenet that orbital adipose tissue lacks lymphatic vessels and analyzed the clinicopathologic differences between patients with acute and chronic thyroid eye dis...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2016.05.052
更新日期:2016-09-01 00:00:00
abstract::Unilateral visual loss following periocular corticosteroid injection is a reported complication of injections of tonsillar, nasal, scalp, and retrobulbar sites. This is the first reported case, to our knowledge, of intralesional corticosteroid injection of a chalazion producing ipsilateral microembolization and infarc...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33728-x
更新日期:1986-03-01 00:00:00
abstract:PURPOSE:To expand understanding of presentation, diagnosis, and outcomes of hemorrhagic occlusive retinal vasculitis (HORV). DESIGN:Retrospective case series. PARTICIPANTS:Thirty-six eyes of 23 patients. METHODS:The American Society of Cataract and Refractive Surgery (ASCRS) and the American Society of Retina Specia...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2016.11.042
更新日期:2017-05-01 00:00:00
abstract::Rhabdomyosarcoma is the most common malignant orbital tumor of childhood. It has twice been reported to arise within the globe from the iris. In addition, teratoid medulloepithelioma, a tumor arising from the ciliary epithelium, can contain a rhabdomyoblastic component, often in combination with other heteroplastic el...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(90)32386-2
更新日期:1990-11-01 00:00:00
abstract::Long-term follow-up was recorded on the visual fields of 251 patients with chronic open-angle glaucoma and 826 patients with ocular hypertension. Observation periods exceeded ten years for 73 patients with manifest glaucoma. Initial glaucomatous defects appeared in 98 eyes of 72 patients while under continuous observa...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(82)34798-3
更新日期:1982-03-01 00:00:00
abstract:PURPOSE:To describe the clinical presentation and outcomes of Acanthamoeba keratitis (AK) in rigid gas permeable (RGP) contact lens wearers and to identify modifiable risk factors. DESIGN:Case-control investigation. PARTICIPANTS:Patients were RGP contact lens-wearing United States residents with a diagnosis of AK fro...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2016.03.039
更新日期:2016-07-01 00:00:00
abstract::A 35-year-old white man, on immunosuppressive medications for 3 1/2 years following a renal transplant, presented with a whitish-yellow mass at the medial end of the left lower eyelid. An initial incisional biopsy was performed that was misinterpreted as granular cell myoblastoma. The mass was subsequently excised and...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33633-9
更新日期:1986-08-01 00:00:00
abstract:PURPOSE:To determine the increase in isopter extent, resulting from the measurement of, and correction for, individual reaction time (RT; the latency between stimulus presentation and individual patient response), derived under the standardized conditions of semi-automated kinetic perimetry (SKP), and to model the age-...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.09.030
更新日期:2007-06-01 00:00:00
abstract:PURPOSE:To analyze the success rate of pulsed intravenous (IV) cyclophosphamide (CyP) for noninfectious ocular inflammatory disease and to identify risk factors for failure of therapy. DESIGN:Retrospective, interventional, noncomparative cohort study. PARTICIPANTS:One hundred ten eyes of 65 patients. METHODS:Through...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2013.01.031
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To determine the most appropriate method for measuring the effect on contrast sensitivity of neodymium:YAG (Nd:YAG) posterior capsulotomy for early posterior capsular opacification (PCO). DESIGN:Prospective comparison of five different methods for luminous contrast sensitivity testing in patients undergoing ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(99)90154-9
更新日期:1999-04-01 00:00:00
abstract:PURPOSE:To investigate the characteristics and prognosis of immune rejection after allogeneic cultivated limbal epithelial transplantation (CLET). DESIGN:Retrospective, noncomparative case series. PARTICIPANTS:Forty-two eyes of 41 patients undergoing allogeneic CLET for total limbal stem cell deficiency who completed...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.11.001
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To evaluate the outcomes of changing immunosuppressive therapy for noninfectious uveitis after failure. DESIGN:Retrospective cohort study. PARTICIPANTS:Patients with noninfectious uveitis managed at 2 tertiary uveitis clinics in the United Kingdom and Australia. METHODS:Participants with a history of using i...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2013.11.032
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To determine the long-term reproducibility of the retinal nerve fiber layer (RNFL) thickness deviation map in glaucoma patients. DESIGN:Retrospective, longitudinal study. PARTICIPANTS:One hundred two eyes of 102 glaucoma patients. METHODS:From a total of 318 screened glaucoma patients who had undergone at ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.11.008
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:To evaluate whether, in the Italian-American natural history study, cataract surgery in one eye influences the incidence/progression rate of lens opacities in the fellow eye. DESIGN:Follow-up study of age-related cataract. PARTICIPANTS:A total of 1399 participants with age-related cataracts were regularly f...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(99)90061-1
更新日期:1999-02-01 00:00:00
abstract:PURPOSE:To determine the refractive predictability, stability, efficacy, and complication rate of femtosecond laser-enabled astigmatic keratotomy for post-keratoplasty astigmatism. DESIGN:A retrospective case series (pilot study). PARTICIPANTS:Thirty-seven eyes of 34 patients. METHODS:All eyes underwent IntraLase-en...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2009.10.041
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:To investigate the impact of age-related change of macular and circumpapillary retinal nerve fiber layer (RNFL) measurements on evaluation of glaucoma progression. DESIGN:Prospective, longitudinal study. PARTICIPANTS:A total of 150 eyes of 90 patients with glaucoma and 72 eyes of 40 normal individuals. MET...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2013.07.021
更新日期:2013-12-01 00:00:00
abstract::The present paper documents the clinical characteristics and ocular pathology in a patient with abetalipoproteinemia. Noteworthy were: the predominant involvement of the posterior fundus characterized by a loss of photoreceptors; loss or attenuation of the pigment epithelium (producing a sharply demarcated white appea...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(84)34203-8
更新日期:1984-08-01 00:00:00
abstract:PURPOSE:To evaluate the progression rate of macular and circumpapillary retinal nerve fiber layer (RNFL) thickness in advanced glaucomatous eyes using spectral domain optical coherence tomography (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, CA). DESIGN:Longitudinal, observational study. PARTICIPANTS:A total of 98 eyes...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2011.08.022
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Radioactive episcleral plaque brachytherapy is a treatment method for selected retinoblastomas. The authors have used this technique since 1976 as both a primary and a secondary treatment method after other methods failed to achieve tumor control. METHODS:A review of the records of 400 consecutive children ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(93)31667-2
更新日期:1993-02-01 00:00:00
abstract:PURPOSE:To characterize reticular pseudodrusen, a potential risk factor for late age-related macular degeneration. DESIGN:Retrospective, observational case series. PARTICIPANTS:Fifty-eight eyes of 33 patients with pseudodrusen (20 female). METHODS:Consecutive patients with reticular pseudodrusen, diagnosed by their ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2009.07.014
更新日期:2010-02-01 00:00:00
abstract::We compared the ocular-hypotensive efficacy and systemic and ocular safety of an ophthalmic solution of levobunolol (0.5% and 1%) twice daily, with timolol (0.5%) twice daily in a long-term double-masked study of 391 patients with open-angle glaucoma or ocular hypertension. Patients received the test medication in bot...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1985-09-01 00:00:00
abstract::Progression of the maculopathy in North Carolina macular dystrophy (NCMD) was not well documented. Thus, the author recently examined 22 affected members of the original kindred. Evidence of progression of the macular disease was sought through comparison of the recent fundus findings with old fundus photographs and f...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32655-8
更新日期:1989-12-01 00:00:00
abstract:PURPOSE:Intraoperative floppy iris syndrome (IFIS) caused by systemic alpha-blockers has been associated with an increased risk of cataract surgical complications when the surgeon was unaware of the medication history and did not anticipate its occurrence. This study was undertaken to evaluate the surgical outcomes and...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2007.01.011
更新日期:2007-05-01 00:00:00
abstract::Methods of testing for lacrimal drainage insufficiency and a modification of the Jones fluorescein dye tests are presented. Despite their excellence, Jones tests have never been widely employed because of difficulty in dye retrieval. The modification consists of instilling one drop of the dye three times at 15 second ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(78)35559-7
更新日期:1978-12-01 00:00:00
abstract::An experimental dog model was used to reproduce the clinical picture of bilateral arteriole and choriocapillaris occlusion from a unilateral intracarotid injection of long-acting corticosteroids combined with other drugs including lidocaine, epinephrine, and penicillin. All five known long-acting corticosteroids, when...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(78)35593-7
更新日期:1978-09-01 00:00:00