Angiogenesis in endometrial carcinoma: Therapies and biomarkers, current options, and future perspectives.


:Endometrial carcinoma is the most common gynecologic malignancy and the fourth most prevalent cancer in women in the modern world. Despite a relatively high chance of surgical cure, for patients with advanced or recurrent disease there are few therapeutic options. Angiogenesis has been extensively studied ever since vascular endothelial growth factor (VEGF) was discovered in the 1980s. Several clinical trials of anti-angiogenic therapy in endometrial carcinoma have been conducted, with mixed results, and many researchers have tried to determine prognostic and therapeutic biomarkers. Recent trials, which shed new light on possible treatment biomarkers and efficacious combination therapies, are reviewed in this text. While we are still far from effectively tailoring anti-angiogenic treatment to each patient, these data have provided valuable insight and have put us on track for the discovery of novel opportunities for angiogenesis therapy in endometrial carcinoma.


Gynecol Oncol


Gynecologic oncology


Berger AA,Dao F,Levine DA




Has Abstract


2020-12-26 00:00:00








  • MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.

    abstract:OBJECTIVES:Most ovarian cancer patients are diagnosed at an advanced stage (67%) and prospects for significant improvement in survival reside in early diagnosis. While expression patterns of a recently identified biomarker family, microRNA, appear to be characteristic of tumor type and developmental origin, microRNA pr...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Taylor DD,Gercel-Taylor C

    更新日期:2008-07-01 00:00:00

  • A comparison of modified MonoPrep2 of liquid-based cytology with ThinPrep Pap test.

    abstract:OBJECTIVE:The purpose of this study is to evaluate a modified MonoPrep2 (MP) of liquid-based cytology (LBC) to search for a less expensive alternative technique usable for screening of cervical cancers. STUDY DESIGN:Cervicovaginal direct-to-vial samples from 1218 consecutive patients were processed with the modified M...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Nam JH,Kim HS,Lee JS,Choi HS,Min KW,Park CS

    更新日期:2004-09-01 00:00:00

  • Advanced endometrial cancer detected at 7 months after childbirth.

    abstract::It is very rare to find endometrial cancers arising within a short period following childbirth, presumably because pregnancy has a protective effect against endometrial cancer mediated by elevated secretion of progesterone. We present the case of a 30-year-old Japanese woman with stage IIIC endometrial cancer that was...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Kodama J,Yoshinouchi M,Miyagi Y,Kobashi Y,Kamimura S,Okuda H,Kudo T

    更新日期:1997-03-01 00:00:00

  • Pattern of lymph node metastases in clinically unilateral stage I invasive epithelial ovarian carcinomas.

    abstract:PURPOSE:There is controversy regarding the pattern of lymphatic spread in unilateral stage I invasive ovarian carcinomas. The purpose of this study is to describe the incidence and distribution of lymph node (LN) metastases in ovarian carcinomas clinically confined to one ovary. METHODS:Ninety-six patients with diseas...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Cass I,Li AJ,Runowicz CD,Fields AL,Goldberg GL,Leuchter RS,Lagasse LD,Karlan BY

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  • The prognostic significance of peritoneal seeding and size of postsurgical residual in patients with stage III epithelial ovarian cancer treated with surgery, chemotherapy, and high-dose radiotherapy.

    abstract:OBJECTIVE:The aim of this study was to retrospectively analyze the prognostic importance of age, histologic type and grade, ascites, lymph node status, size and type of postoperative residual disease, and radiation dose on disease-specific (DSS) and progression-free survival (PFS) in stage III epithelial ovarian cancer...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kapp KS,Kapp DS,Poschauko J,Stücklschweiger GF,Hackl A,Pickel H,Petru E,Winter R

    更新日期:1999-09-01 00:00:00

  • Lymph node metastasis probability in young patients eligible for conservative management of endometrial cancer.

    abstract:OBJECTIVE:Endometrial cancer (EC) is a rare condition in young women. The objective of this study was to evaluate the risk of pelvic lymph node (LN) metastasis in young women with EC who are candidates for conservative management. METHODS:Using the SEER database, a population-based analysis was conducted to identify w...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Gonthier C,Douhnai D,Koskas M

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  • Radiotherapy with concurrent cisplatin-based doublet or weekly cisplatin for cervical cancer: a systematic review and meta-analysis.

    abstract:BACKGROUND:Treatment with weekly cisplatin (CDDP) plus radiotherapy (RT) is the standard regimen for stage IB to stage IVA cervical carcinoma (CC). We performed a systematic review and meta-analysis of published studies to evaluate whether CDDP-based doublet therapy improves survival compared to weekly CDDP plus RT in ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,meta分析,评审


    authors: Petrelli F,De Stefani A,Raspagliesi F,Lorusso D,Barni S

    更新日期:2014-07-01 00:00:00

  • Nucleolar organizer regions in endometriosis, atypical endometriosis, and clear cell and endometrioid carcinomas.

    abstract::Nucleolar Organizer Regions (NORs) code for ribosomal RNA and are thought to be an accurate representation of the percentage of cells in S-phase. NORs are associated with nonhistone nucleoproteins, which can be stained with silver (AgNORs). An increased number of AgNORs has been observed in many malignancies. AgNORs w...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


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    更新日期:1991-03-01 00:00:00

  • Small cell neuroendocrine carcinoma of the cervix: outcome and patterns of recurrence.

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    journal_title:Gynecologic oncology

    pub_type: 杂志文章


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  • Prognostic value of endocervical sampling following loop excision of high grade intraepithelial neoplasia.

    abstract:OBJECTIVE:To assess the role of additional biopsies performed with loop electrosurgical excisional procedure (LEEP) in predicting the likelihood of persistent high grade intraepithelial neoplasia. METHODS:Clinicopathologic data were abstracted from women who underwent excision of high grade intraepithelial lesions bet...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Cui Y,Sangi-Haghpeykar H,Patsner B,Bump JMM,Williams-Brown MY,Binder GL,Masand RP,Anderson ML

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    abstract:OBJECTIVE:Previous studies by the Gynecologic Oncology Group have demonstrated a 7% response rate with bolus etoposide as second-line therapy in nonsquamous cell carcinoma of the cervix. Prolonged oral etoposide, which exploits the schedule dependency of this agent, has demonstrated increased activity in squamous carci...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,多中心研究


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    abstract:OBJECTIVE:To investigate the tumorigenesis of mutant [12Asp]-K-ras in endometrial carcinoma and its relationship with ER. METHODS:We constructed pcDI-[12Asp]K-ras4B by inserting full-length [12Asp]K-ras4B from human endometrial carcinoma Hec-1A cells, into pcDI vector. Cell proliferation of NIH3T3 after transfection w...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Tu Z,Gui L,Wang J,Li X,Sun P,Wei L

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    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Garcia FA,Cornelison T,Nuño T,Greenspan DL,Byron JW,Hsu CH,Alberts DS,Chow HH

    更新日期:2014-02-01 00:00:00

  • Gamma-knife radiosurgery for the treatment of ovarian cancer metastatic to the brain.

    abstract:BACKGROUND:Central nervous system (CNS) metastases from an ovarian malignancy are uncommon. The long-term prognosis for these patients is poor, with studies reporting a mean survival of less than 12 months. CASES:We present three ovarian cancer patients who developed metastatic disease to the brain. All patients were ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Brown JV 3rd,Goldstein BH,Duma CM,Rettenmaier MA,Micha JP

    更新日期:2005-06-01 00:00:00

  • Metastatic dermatofibrosarcoma protuberans of the vulva.

    abstract::Dermatofibrosarcoma protuberans (DFSP) of the vulva is a rare, low- to intermediate-grade sarcoma of dermal origin. This case report represents the 13th reported patient with vulvar DFSP and the first reported patient with metastatic vulvar DFSP. Although metastasis is rare, the possibility remains that the frequent r...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Soergel TM,Doering DL,O'connor D

    更新日期:1998-11-01 00:00:00

  • Transvaginal ultrasound-guided fine needle sampling of deep cancer recurrences in the pelvis: usefulness and limitations.

    abstract::The usefulness of fine needle sampling (FNS) under transvaginal ultrasound guidance in gynecologic oncology patients is evaluated in this study. Between 1990 and 1993, 101 FNS under transvaginal ultrasound guidance were performed in 88 sessions. All targets were located deep in the pelvis and their median diameter was...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Zanetta G,Brenna A,Pittelli M,Lissoni A,Trio D,Riotta S

    更新日期:1994-07-01 00:00:00

  • A retrospective study to evaluate single agent methotrexate treatment in low risk gestational choriocarcinoma in the United Kingdom.

    abstract:OBJECTIVE:To determine whether single agent chemotherapy with intramuscular methotrexate 50mg administered on days 1, 3, 5, and 7 and oral folinic acid 15mg administered on days 2, 4, 6, and 8 in 2 weekly cycles (IM MTX/FA) is an effective treatment regimen for patients with low risk gestational choriocarcinoma. METHO...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Taylor F,Short D,Winter MC,Tidy J,Savage PM,Sarwar N,Hancock BW,Seckl MJ,Coleman RE

    更新日期:2015-02-01 00:00:00

  • Liquid-based cytology and human papillomavirus testing: a pooled analysis using the data from 13 population-based cervical cancer screening studies from China.

    abstract:OBJECTIVE:The objective of this study was to evaluate the impact of introducing HR-HPV testing in cytology regarding cervical cancer screening practice. METHODS:A pooled analysis of liquid-based cytology (LBC) and HR-HPV testing using data from 13 population-based cervical cancer screening studies conducted in China w...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,meta分析


    authors: Pan QJ,Hu SY,Guo HQ,Zhang WH,Zhang X,Chen W,Cao J,Jiang Y,Zhao FH,Qiao YL

    更新日期:2014-05-01 00:00:00

  • Associations among exercise, body weight, and quality of life in a population-based sample of endometrial cancer survivors.

    abstract:OBJECTIVES:Lack of exercise and excess body weight may exacerbate treatment-related declines in quality of life (QoL) in endometrial cancer survivors. The primary purpose of this study was to examine the associations among exercise, body weight, and QoL in a population-based sample of endometrial cancer survivors. MET...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Courneya KS,Karvinen KH,Campbell KL,Pearcey RG,Dundas G,Capstick V,Tonkin KS

    更新日期:2005-05-01 00:00:00

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    abstract:OBJECTIVE:Bilateral oophorectomy (BOE) is often recommended in order to prevent cancer at hysterectomy for non-malignant diseases and when familial risk of ovarian and breast cancer has been identified. Surgical menopause increases the risk of cardiovascular mortality, however, the intervening mechanisms are not clear....

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Dørum A,Tonstad S,Liavaag AH,Michelsen TM,Hildrum B,Dahl AA

    更新日期:2008-06-01 00:00:00

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    abstract:OBJECTIVE:To determine the relationship between history of cervical dysplasia or carcinoma and the development of cervical dysplasia or adenocarcinoma in women who have a diagnosis of atypical glandular cells of undetermined significance (AGUS), favor endocervical origin, or AGUS, not otherwise specified. METHODS:A 6-...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Raab SS,Bishop NS,Zaleski MS

    更新日期:1999-09-01 00:00:00

  • Diaphragmatic peritonectomy vs. full thickness resection with pleurectomy during Visceral-Peritoneal Debulking (VPD) in 100 consecutive patients with stage IIIC-IV ovarian cancer: A surgical-histological analysis.

    abstract:OBJECTIVE:To compare the surgical and histological outcomes of diaphragmatic peritonectomy vs. full thickness resection with pleurectomy during Visceral-Peritoneal Debulking. METHODS:Service evaluation protocol (Trust number 3265). All patients with stage IIIC-IV ovarian cancer who had diaphragmatic surgery between Ap...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Soleymani Majd H,Ferrari F,Manek S,Gubbala K,Campanile RG,Hardern K,Tozzi R

    更新日期:2016-03-01 00:00:00

  • The expression of hepatocyte growth factor (HGF) and c-Met in uterine serous carcinoma.

    abstract:OBJECTIVE:The hepatocyte growth factor (HGF) receptor c-Met plays an important role in tumor dissemination by activating mitogenic signaling pathways. The goal of this study was to investigate immunohistochemical (IHC) staining patterns of HGF and c-Met in endometrioid endometrial cancer (EC) and uterine serous cancer ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Bishop EA,Lengyel ER,Yamada SD,Montag A,Temkin SM

    更新日期:2011-04-01 00:00:00

  • Assessment of DNA Ploidy in the ProMisE molecular subgroups of endometrial cancer.

    abstract:OBJECTIVE:We sought to determine whether DNA ploidy correlates with the four molecular subgroups of endometrial carcinoma (EC) as determined using ProMisE (Proactive Molecular Risk Classifier for Endometrial Cancer). METHODS:90 cases of EC previously characterized by clinicopathological parameters, outcomes, and ProMi...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Proctor L,Pradhan M,Leung S,Cheng A,Lee CH,Soslow RA,Gilks CB,Talhouk A,McAlpine JM,Danielsen HE,Hoang LN

    更新日期:2017-09-01 00:00:00

  • Cell proliferation in ovarian carcinoma: superior accuracy of S-phase fraction (SPF) by DNA labeling index versus flow cytometric SPF, lack of independent prognostic power for SPF and DNA ploidy, and limited effect of SPF on tumor growth rate.

    abstract:OBJECTIVES:The goal of this work was to test the hypotheses that S-phase fraction (SPF) by DNA labeling index (SPF-LI) would predict the course of the disease for ovarian/peritoneal carcinomas and that SPF-LI would correlate better with pathologic classification and outcome than SPF by DNA flow cytometry (SPF-F). METH...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Meyer JS,Gersell DJ,Yim S

    更新日期:2001-06-01 00:00:00

  • Solitary recurrent metastasis of epithelial ovarian cancer in the spleen.

    abstract::In epithelial ovarian cancer, solitary metastasis to and recurrences in the parenchyma of the spleen are rare in the absence of apparent disease in other sites. We report four patients who developed isolated, solitary splenic parenchymal recurrences of their epithelial ovarian adenocarcinomas and underwent a splenecto...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Farias-Eisner R,Braly P,Berek JS

    更新日期:1993-03-01 00:00:00

  • Stage IB carcinoma of the cervix with lymph node metastases.

    abstract::From January 1, 1946, through January 1, 1986, at the University of Michigan, 60 patients were treated with Stage IB (FIGO) carcinoma of the cervix with lymph node metastases. Clinical variables were examined with regard to long-term survival. Prognostically significant variables were (1) highest level of lymph node i...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Terada KY,Morley GW,Roberts JA

    更新日期:1988-11-01 00:00:00

  • Salvage whole-abdominal irradiation following chemotherapy failure in epithelial ovarian carcinoma.

    abstract::During the period 1977 to 1985, 12 patients with FIGO stage II and III epithelial ovarian carcinoma failed to achieve a pathologic complete response with chemotherapy and underwent salvage whole-abdominal irradiation (WAXRT). Six of these patients had gross residual disease present at the time of irradiation, and thre...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Linstadt DE,Stern JL,Quivey JM,Leibel SA,Lacey CG

    更新日期:1990-03-01 00:00:00

  • Palliative radiotherapy for recurrent granulosa cell tumor of the ovary: a report of 3 cases with radiological evidence of response.

    abstract:BACKGROUND:The role of radiotherapy for recurrent or residual granulosa cell tumor of the ovary (GCTO) is controversial. One reason for this controversy may be that most published studies on this topic have not utilized sectional imaging to assess response to radiotherapy. We report on three cases of recurrent or resid...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: E C,Samant R,Fung MF,Le T,Hopkins L,Senterman M

    更新日期:2006-08-01 00:00:00

  • Second primary malignancy in endometrial carcinoma patients.

    abstract::An epidemiologic study of multiple primary malignant neoplasms in endometrial cancer patients in Israel is presented. During the 7-year period of the study, 104 patients (10.3%) out of 1007 patients diagnosed as having endometrial cancer had another primary cancer. There was a significant difference in the incidence o...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Schwartz Z,Ohel G,Birkenfeld A,Anteby SO,Schenker JG

    更新日期:1985-09-01 00:00:00