Impact of antibiotic treatment during platinum chemotherapy on survival and recurrence in women with advanced epithelial ovarian cancer.

abstract：OBJECTIVES:Most ovarian cancer patients are diagnosed at an advanced stage (67%) and prospects for significant improvement in survival reside in early diagnosis. While expression patterns of a recently identified biomarker family, microRNA, appear to be characteristic of tumor type and developmental origin, microRNA pr...

journal_title：Gynecologic oncology

authors： Taylor DD,Gercel-Taylor C

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:The long-term survival of patients with epithelial ovarian cancer is limited by the emergence of tumor cells that are resistant to chemotherapy. We hypothesized that expression of Bcl-x(L), a homologue of Bcl-2 that confers protection from chemotherapy-induced apoptosis, may be predictive of patients' clinica...

journal_title：Gynecologic oncology

authors： Williams J,Lucas PC,Griffith KA,Choi M,Fogoros S,Hu YY,Liu JR

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVE:Neuropilin-1 (NRP-1) is a receptor for both semaphorin and vascular endothelial growth factor and is up-regulated in a variety of human cancers. While there are some reports of NRP-1 expression in ovarian neoplasm, those results differ in pattern of its expression and its role in ovarian cancer is still uncle...

journal_title：Gynecologic oncology

authors： Baba T,Kariya M,Higuchi T,Mandai M,Matsumura N,Kondoh E,Miyanishi M,Fukuhara K,Takakura K,Fujii S

更新日期：2007-06-01 00:00:00

abstract：:The Cavitron Ultrasonic Surgical Aspirator (CUSA) can be used to fragment and aspirate tissue precisely. The CUSA was utilized as an adjunctive procedure to standard operative techniques to optimally debulk 11 women with advanced epithelial carcinoma of the ovary. No significant intraoperative or postoperative complic...

journal_title：Gynecologic oncology

authors： Deppe G,Malviya VK,Malone JM Jr

更新日期：1988-09-01 00:00:00

abstract：:The purpose of this study was to obtain information about the public's awareness and perception of the discipline of gynecologic oncology. The marketing of cancer care and related services has resulted in substantial funding being allocated to market individual institutions. However, little has been done to educate pa...

journal_title：Gynecologic oncology

authors： Noumoff J,Morgan M,King S,Giuntoli R,Mikuta J

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:Although renal cell carcinoma (RCC) is characterized with unpredictable clinical presentation, multiple genital tract metastases are still surprising and mode of spread is obscure. CASE:We report a case of RCC metastases to uterine cervix and vagina 1 year after radical nephrectomy in a 19-year-old virgin. ...

journal_title：Gynecologic oncology

authors： Bozaci EA,Atabekoğlu C,Sertçelik A,Unlü C,Ortaç F

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVES:Endometriosis-associated ovarian carcinoma (EAOC) has recently received increasing attention due to its suggested biological behavior, distinctive from those of usual epithelial ovarian cancer. To elucidate some of the controversies on this intriguing entity, a series of patients with EAOC were compared to o...

journal_title：Gynecologic oncology

authors： Erzen M,Rakar S,Klancnik B,Syrjänen K

更新日期：2001-10-01 00:00:00

abstract：:For the past several years, all women with epithelial ovarian cancer have been treated identically, whether in a clinical trial or off protocol. Over the past decade, we have come to appreciate the magnitude of the heterogeneity of ovarian cancer. The development of the binary grading system for serous carcinoma was a...

journal_title：Gynecologic oncology

authors： Romero I,Sun CC,Wong KK,Bast RC Jr,Gershenson DM

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:Topotecan (1.5 mg/m(2)) administered daily for 5 consecutive days of a 21-day cycle is an established chemotherapeutic regimen in recurrent ovarian cancer. However, noncumulative myelosuppression has limited its use by many clinicians. We sought to determine whether a lower dose of topotecan could provide com...

journal_title：Gynecologic oncology

authors： Rodriguez M,Rose PG

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:To determine if extra-peritoneal laparoscopic para-aortic (PA) lymphadenectomy allows a reliable assessment of PA nodes in patients with endometrial cancer (EC). METHODS:In October of 2005, a single surgeon began performing extra-peritoneal laparoscopic PA lymphadenectomy for patients with EC. A prospective ...

journal_title：Gynecologic oncology

authors： Dowdy SC,Aletti G,Cliby WA,Podratz KC,Mariani A

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:Intraperitoneal (IP) therapy improves survival compared to intravenous (IV) treatment for women with newly diagnosed, optimally cytoreduced, ovarian cancer. However, the role of IP therapy in recurrent disease is unknown. Preclinical data demonstrated IP administration of the proteasome inhibitor, bortezomib pr...

journal_title：Gynecologic oncology

authors： Jandial DA,Brady WE,Howell SB,Lankes HA,Schilder RJ,Beumer JH,Christner SM,Strychor S,Powell MA,Hagemann AR,Moore KN,Walker JL,DiSilvestro PA,Duska LR,Fracasso PM,Dizon DS

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:Increased activity of Sp family of transcription factors is a frequent and critical event in cancer development and progression. Genes governing tumor growth, invasion and angiogenesis are regulated by Sp factors, like Sp1, Sp3 or Sp4, and are frequently over-expressed in tumors. Targeting Sp factors has been...

journal_title：Gynecologic oncology

authors： Previdi S,Malek A,Albertini V,Riva C,Capella C,Broggini M,Carbone GM,Rohr J,Catapano CV

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVES:This phase II study conducted to investigate the efficacy and toxicity of the combination of gemcitabine (GEM) and pegylated liposomal doxorubicin (LDOX) alternating with cisplatin (CDDP) and cyclophosphamide (CTX) in platinum-resistant/refractory, paclitaxel pretreated epithelial ovarian cancer (EOC). PATI...

journal_title：Gynecologic oncology

authors： Pectasides D,Xiros N,Papaxoinis G,Aravantinos G,Sykiotis C,Pectasides E,Psyrri A,Koumarianou A,Gaglia A,Gouveris P,Economopoulos T

更新日期：2008-01-01 00:00:00

abstract：:An epidemiologic study of multiple primary malignant neoplasms in endometrial cancer patients in Israel is presented. During the 7-year period of the study, 104 patients (10.3%) out of 1007 patients diagnosed as having endometrial cancer had another primary cancer. There was a significant difference in the incidence o...

journal_title：Gynecologic oncology

authors： Schwartz Z,Ohel G,Birkenfeld A,Anteby SO,Schenker JG

更新日期：1985-09-01 00:00:00

abstract：OBJECTIVES:SGN-00101 (HspE7, Nventa, San Diego, CA) is a novel therapeutic vaccine consisting of a fusion protein containing an M. bovis BCG heat shock protein (Hsp65) covalently linked to the entire sequence of HPV 16 E7. This trial was designed to evaluate the efficacy and toxicities of HspE7 in women with CIN III. ...

journal_title：Gynecologic oncology

authors： Einstein MH,Kadish AS,Burk RD,Kim MY,Wadler S,Streicher H,Goldberg GL,Runowicz CD

更新日期：2007-09-01 00:00:00

abstract：:A patient with malignant struma ovarii who had elevated thyroglobulin levels at the time of her original surgery was diagnosed with recurrence on the basis of progressive thyroglobulin level elevation while on thyroid suppressive therapy. Subsequent treatment with therapeutic doses of iodine-137 resulted in normalizat...

journal_title：Gynecologic oncology

authors： Rose PG,Arafah B,Abdul-Karim FW

更新日期：1998-09-01 00:00:00

abstract：:Melanoma represents the second most frequent vulvar malignancy, and yet is still considered to be an uncommon neoplasm. Several varieties of melanoma exist. A patient who was diagnosed with a rare subtype of melanoma as a primary vulvar process is presented here. To date, there is only one other reported case of neuro...

journal_title：Gynecologic oncology

authors： Byrne PR,Maiman M,Mikhail A,Harris M,Rosen Y

更新日期：1995-02-01 00:00:00

abstract：:Verrucous carcinoma is a rare variant of epidermoid carcinoma with distinct clinical and histopathologic features. To date, 31 cases have been reported in the cervix. They are typically slow-growing, locally invasive tumors with low potential for lymphatic metastasis and appear to be radioresistant. We report a case w...

journal_title：Gynecologic oncology

authors： de Jesus M,Tang W,Sadjadi M,Belmonte AH,Poon TP

更新日期：1990-02-01 00:00:00

abstract：:Twenty-three evaluable patients with refractory epithelial ovarian cancer were treated with bisantrene (CL216,942). The drug was given as a single-dose injection every 3 weeks. One patient (4%) showed a partial response. The compound thus has limited activity against this malignancy. ...

journal_title：Gynecologic oncology

authors： Kavanagh JJ,Gershenson DM,Saul PB,Copeland LJ

更新日期：1986-01-01 00:00:00

abstract：:Adenocarcinoma of the urethra is a rare neoplasm which is believed to arise from the periurethral ducts. Four such cases have been diagnosed at our institution during the past 25 years and their clinical courses are summarized in this report. In one patient, a disseminated coagulopathy with a predominantly fibrinolyti...

journal_title：Gynecologic oncology

authors： Taylor RN,Lacey CG,Shuman MA

更新日期：1985-10-01 00:00:00

abstract：:Verrucous carcinoma (VC) of the female genital tract is a rare lesion, primarily affecting postmenopausal women. A case of VC of the vulva is reported, bringing the total number of VC of the female genital tract to 89. VC is a slowly growing, locally "pushing" tumor with a rather benign histologic appearance, and the ...

journal_title：Gynecologic oncology

authors： Andersen ES,Sorensen IM

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVE:The oncogenic HPV subtypes responsible for gynecologic malignancies have also been implicated in the development of squamous cell cancer of the anus (SCAC). SCAC is more common in women, typically presenting at an older age than gynecologic cancers. The aim of this study was determine whether women diagnosed ...

journal_title：Gynecologic oncology

authors： Jiménez W,Paszat L,Kupets R,Wilton A,Tinmouth J

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:Describing the pattern of and reasons for post-operative tumor residuals in patients with advanced epithelial ovarian cancer (AOC) operated in a specialized gynecologic cancer center following a strategy of maximum upfront debulking followed by systemic chemotherapy. METHODS:All consecutive AOC-patients trea...

journal_title：Gynecologic oncology

authors： Heitz F,Harter P,Alesina PF,Walz MK,Lorenz D,Groeben H,Heikaus S,Fisseler-Eckhoff A,Schneider S,Ataseven B,Kurzeder C,Prader S,Beutel B,Traut A,du Bois A

更新日期：2016-05-01 00:00:00

abstract：:The distribution of colon--ovarian tumor antigen (COTA) and colon-specific antigen (CSA) was studied immunohistochemically in gynecologic tumors. The antigens were absent in the serous benign tumors of the ovary and in the normal ovarian tissues, whereas they were detected in some of the mucinous benign tumors. COTA a...

journal_title：Gynecologic oncology

authors： Ueda G,Shimizu C,Saito J,Tanaka Y,Inoue M,Tanizawa O

更新日期：1989-10-01 00:00:00

abstract：OBJECTIVES:The role of adjuvant therapy in patients with early stage ovarian carcinoma has not been clearly defined. Most randomized trials examining this issue have not used the vigorous staging exploration accepted as today's standard. This report examines the natural history of patients after surgically documented s...

journal_title：Gynecologic oncology

authors： Le T,Krepart GV,Lotocki RJ,Heywood MS

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVE:The objective was to describe trends over time in key factors surrounding end-of-life care on a gynecologic oncology service at a tertiary cancer center. METHODS:Patients with gynecologic cancers who were hospitalized and died at our institution between 1992 and 1997 were identified using institutional datab...

journal_title：Gynecologic oncology

authors： Dalrymple JL,Levenback C,Wolf JK,Bodurka DC,Garcia M,Gershenson DM

更新日期：2002-05-01 00:00:00

abstract：:Invasive carcinomas of the uterine cervix of 38 patients were examined for the presence of human papillomavirus (HPV) genomes and for the state of the c-myc and Ha-ras oncogenes. A combination of Southern blot hybridization and polymerase chain reaction revealed the presence of the genome of HPV type 16 in 17 tumors (...

journal_title：Gynecologic oncology

authors： Iwasaka T,Yokoyama M,Oh-uchida M,Matsuo N,Hara K,Fukuyama K,Hachisuga T,Fukuda K,Sugimori H

更新日期：1992-09-01 00:00:00

abstract：:Most rhabdomyosarcomas (RMSs) of the female genital tract occur in infants and young children as sarcoma botryoides. Vaginal RMS occurring in a postmenopausal woman is extremely rare. To our knowledge, only three vaginal RMSs have been reported in patients who were over 50 years of age. Herein, the first case in Taiwa...

journal_title：Gynecologic oncology

authors： Shy SW,Lee WH,Chen D,Ho SY

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVE:The purpose of this study is to evaluate the significance of the c-Met/hepatocyte growth factor receptor expression in invasive cervical carcinoma. METHODS:Ninety-Four patients with FIGO stage 1B disease, treated primarily with surgery, were studied immunohistochemically. Of the cases, 67 were squamous carci...

journal_title：Gynecologic oncology

authors： Baykal C,Ayhan A,Al A,Yüce K,Ayhan A

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Glucocorticoid receptor (GR) has emerged as an important steroid nuclear receptor in hormone dependent cancers, however few data are available regarding a potential role of GR in endometrial cancer. The aim of this study was to investigate expression of GR in primary and metastatic endometrial cancer lesions...

journal_title：Gynecologic oncology

authors： Tangen IL,Veneris JT,Halle MK,Werner HM,Trovik J,Akslen LA,Salvesen HB,Conzen SD,Fleming GF,Krakstad C

更新日期：2017-12-01 00:00:00