Abstract：
OBJECTIVES:The aim of this prospective study was to evaluate the impact of integrated PET-CT on treatment management in ovarian carcinoma recurrence suspicion because of increased CA-125. METHODS:Twenty-nine patients (mean age=61 years), initially treated for ovarian carcinoma (FIGO stage I n=2, stage II n=3, stage III n=21 and stage IV n=3), presenting with increased CA-125 (mean=160 IU/ml, range 33-1930), underwent subsequently a CT and a PET-CT scans. The recurrence was acknowledged by the referring physicians for all patients. The impact of PET-CT on patient's management was evaluated by comparing the therapeutic decision mentioned respectively on the pre and post PET-CT questionnaires filled in by the oncologists. RESULTS:The CT scan was positive in 22/29 patients (76%) and negative in 7/29 patients (24%). The PET-CT scan was positive in 27/29 patients (93%) and negative in 2/29 (7%) patients. Five out of the seven patients with a negative CT scan had a positive PET-CT scan. In comparison to CT scan alone, the PET-CT scan modified the disease distribution for 16 patients (55%; p<0.001) in the following ways: more advanced disease (n=11), more limited disease (n=4), and different localizations (n=1). The assessment of pre and post PET-CT questionnaires showed a statistically significant change in the decision making for 10 patients (34%, p<0.0001). CONCLUSION:This questionnaire-based study showed that PET-CT imaging allows a better restaging than CT and induces a change in clinical management in over one third of patients with suspected ovarian carcinoma recurrence on increased CA-125.
journal_name
Gynecol Oncoljournal_title
Gynecologic oncologyauthors
Soussan M,Wartski M,Cherel P,Fourme E,Goupil A,Le Stanc E,Callet N,Alexandre J,Pecking AP,Alberini JLdoi
10.1016/j.ygyno.2007.07.082subject
Has Abstractpub_date
2008-01-01 00:00:00pages
160-5issue
1eissn
0090-8258issn
1095-6859pii
S0090-8258(07)00754-8journal_volume
108pub_type
杂志文章abstract：OBJECTIVE:The purpose of this phase II study was to evaluate on an intent-to-treat basis the activity and toxicity of single-agent vinorelbine (VRL) as second-line chemotherapy of patients with platinum-resistant ovarian cancer. Platinum-resistant disease was defined as disease refractory to or relapsing within 12 mont...
journal_title：Gynecologic oncology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1006/gyno.2000.6089
更新日期：2001-04-01 00:00:00
abstract：:C-reactive protein (CRP) is an acute phase reactant that appears to have a variety of biologic effects, including stimulation of prostaglandin production by peripheral blood monocytes. Both CRP and 6-keto prostaglandin F 1-alpha (6-keto PGF1-alpha) have been noted to be elevated in the sera of patients with malignant ...
journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1016/0090-8258(90)90175-k
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abstract：OBJECTIVE:To evaluate the value of the combination of p16 and HPV detection in the screening for cervical cancer. METHODS:186 patients with previous abnormal cervical lesion were studied. After colposcopic examination, two conventional Pap slides were prepared: the first was Papanicolaou-stained and examined by cytolo...
journal_title：Gynecologic oncology
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doi：10.1016/j.ygyno.2006.01.033
更新日期：2006-10-01 00:00:00
abstract：:Techniques for sentinel lymph node injections have varied over the years in both cervical and uterine malignancy lymph node mapping. There remains considerable variation in techniques, particularly for uterine malignancies. This review summarizes some of the techniques that have been published and are currently utiliz...
journal_title：Gynecologic oncology
pub_type： 杂志文章,评审
doi：10.1016/j.ygyno.2008.07.027
更新日期：2008-11-01 00:00:00
abstract：OBJECTIVE:Recent randomized controlled data suggest that neoadjuvant chemotherapy (NACT) with interval debulking (ID) may produce similar overall survival and progression free survival compared to standard primary cytoreduction followed by chemotherapy. The object of our study was to assess current patterns of care amo...
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doi：10.1016/j.ygyno.2010.06.021
更新日期：2010-10-01 00:00:00
abstract：PURPOSE:A constituent of green tea, (-)-epigallocatechin-3-gallate (EGCG), has been known to possess anti-cancer properties. In this study, we investigated the time-course anticancer effects of EGCG on human ovarian cancer cells to provide insights into the molecular-level understanding of growth suppression mechanism ...
journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1016/j.ygyno.2004.05.031
更新日期：2004-09-01 00:00:00
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journal_title：Gynecologic oncology
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journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1016/j.ygyno.2009.04.016
更新日期：2009-08-01 00:00:00
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journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1016/j.ygyno.2011.05.002
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更新日期：2018-04-01 00:00:00
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journal_title：Gynecologic oncology
pub_type： 杂志文章,评审
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更新日期：2015-12-01 00:00:00
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journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1006/gyno.1996.0037
更新日期：1996-02-01 00:00:00
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doi：10.1016/j.ygyno.2010.11.012
更新日期：2011-03-01 00:00:00
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journal_title：Gynecologic oncology
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doi：10.1016/j.ygyno.2005.05.031
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doi：10.1016/j.ygyno.2009.11.031
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journal_title：Gynecologic oncology
pub_type： 杂志文章,评审
doi：10.1006/gyno.1996.0344
更新日期：1996-12-01 00:00:00
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journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1016/j.ygyno.2003.11.024
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pub_type： 杂志文章
doi：10.1016/0090-8258(85)90269-0
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journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1006/gyno.1993.1214
更新日期：1993-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-04-01 00:00:00
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journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1016/j.ygyno.2012.02.022
更新日期：2012-06-01 00:00:00
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journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1006/gyno.2001.6357
更新日期：2001-10-01 00:00:00
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journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1016/0090-8258(86)90087-9
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journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1006/gyno.1994.1059
更新日期：1994-03-01 00:00:00
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journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1016/s0090-8258(03)00133-1
更新日期：2003-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0090-8258(92)90194-n
更新日期：1992-07-01 00:00:00
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journal_title：Gynecologic oncology
pub_type： 杂志文章
doi：10.1016/0090-8258(85)90208-2
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