Polymorphisms in genes hydroxysteroid-dehydrogenase-17b type 2 and type 4 and endometrial cancer risk.


OBJECTIVE:Hydroxysteroid-dehydrogenase-17b (HSD17b) genes control the last step in estrogen biosynthesis. The isoenzymes HSD17b2 and HSD17b4 in the uterus preferentially catalyze the conversion of estradiol, the most potent and active form of estrogen, to estrone, the inactive form of estrogen. Endometrial adenocarcinoma is linked to excessive exposure to estrogens. We hypothesized that single nucleotide polymorphisms (SNPs) in genes HSD17b2 and HSD17b4 may alter the enzyme activity, estradiol levels and risk of disease. METHODS:Pairwise tag SNPs were selected from the HapMap Caucasian database to capture all known common (minor allele frequency >0.05) genetic variation with a correlation of at least 0.80. Forty-eight SNPs were genotyped in the case-control studies nested within the Nurses' Health Study (NHS) (cases=544, controls=1296) and the Women's Health Study (WHS) (cases=130, controls=389). The associations with endometrial cancer were examined using conditional logistic regression to estimate odds ratio and 95% confidence intervals adjusted for known risk factors. Results from the two studies were using fixed effects models. We additionally investigated whether SNPs are predictive of plasma estradiol and estrone levels in the NHS using linear regression. RESULTS:Four intronic SNPs were significantly associated with endometrial cancer risk (p-value<0.05). After adjustment for multiple testing, we did not observe any significant associations between SNPs and endometrial cancer risk or plasma hormone levels. CONCLUSIONS:This is the first study to comprehensively evaluate variation in HSD17b2 and HSD17b4 in relation to endometrial cancer risk. Our findings suggest that variation in HSD17b2 and HSD17b4 does not substantially influence the risk of endometrial cancer in Caucasians.


Gynecol Oncol


Gynecologic oncology


Karageorgi S,McGrath M,Lee IM,Buring J,Kraft P,De Vivo I




Has Abstract


2011-04-01 00:00:00














  • Direct laparoscopic venous sampling to diagnose a small Sertoli-Leydig tumor.

    abstract:BACKGROUND:Sertoli-Leydig cell tumors (SLCT) constitute only 0.5% of all primary ovarian neoplasms. We report a unique diagnostic method (selective laparoscopic venous sampling) and a rare case of a contralateral second primary tumor. CASE:A 14-year-old female presented with hyperandrogenic complaints and an increased...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: White LC,Buchanan KD,O'Leary TD,Carlan SJ,Boothby R

    更新日期:2003-10-01 00:00:00

  • Lymph node metastasis probability in young patients eligible for conservative management of endometrial cancer.

    abstract:OBJECTIVE:Endometrial cancer (EC) is a rare condition in young women. The objective of this study was to evaluate the risk of pelvic lymph node (LN) metastasis in young women with EC who are candidates for conservative management. METHODS:Using the SEER database, a population-based analysis was conducted to identify w...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Gonthier C,Douhnai D,Koskas M

    更新日期:2020-04-01 00:00:00

  • Multicenter phase II trial of topotecan, cisplatin and bevacizumab for recurrent or persistent cervical cancer.

    abstract:OBJECTIVE:We evaluated the activity and safety of the combination of topotecan, cisplatin and bevacizumab in patients with recurrent or persistent carcinoma of the cervix. METHODS:Eligible patients had persistent or recurrent cervical cancer not amenable to curative intent treatment. No prior chemotherapy for recurren...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Zighelboim I,Wright JD,Gao F,Case AS,Massad LS,Mutch DG,Powell MA,Thaker PH,Eisenhauer EL,Cohn DE,Valea FA,Alvarez Secord A,Lippmann LT,Dehdashti F,Rader JS

    更新日期:2013-07-01 00:00:00

  • Suberoylanilide hydroxamic acid (SAHA) potentiates paclitaxel-induced apoptosis in ovarian cancer cell lines.

    abstract:OBJECTIVES:To determine if SAHA, a histone deacetylase inhibitor, decreases ovarian cancer cell viability when combined with paclitaxel in vitro, and to explore molecular alterations of combined paclitaxel+SAHA treatment. METHODS:SKOV3 and Hey ovarian cancer cell lines were treated for 24 h with paclitaxel, then re-tr...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Dietrich CS 3rd,Greenberg VL,DeSimone CP,Modesitt SC,van Nagell JR,Craven R,Zimmer SG

    更新日期:2010-01-01 00:00:00

  • Prognostic value of endocervical sampling following loop excision of high grade intraepithelial neoplasia.

    abstract:OBJECTIVE:To assess the role of additional biopsies performed with loop electrosurgical excisional procedure (LEEP) in predicting the likelihood of persistent high grade intraepithelial neoplasia. METHODS:Clinicopathologic data were abstracted from women who underwent excision of high grade intraepithelial lesions bet...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Cui Y,Sangi-Haghpeykar H,Patsner B,Bump JMM,Williams-Brown MY,Binder GL,Masand RP,Anderson ML

    更新日期:2017-03-01 00:00:00

  • Topotecan combined with carboplatin in recurrent epithelial ovarian cancer: results of a single-institutional phase II study.

    abstract:OBJECTIVE:The aim of this trial was to investigate the efficacy and toxicity of a relative high-dose of topotecan combined with carboplatin in recurrent or persistent epithelial ovarian cancer (EOC). METHODS:Patients participating in this phase II trial received topotecan at a dose of 1.0 mg/m(2)/day intravenously (IV...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kang H,Kim TJ,Lee YY,Choi CH,Lee JW,Bae DS,Kim BG

    更新日期:2009-08-01 00:00:00

  • Flow cytometric DNA analysis of early stage adenocarcinoma of the cervix.

    abstract:OBJECTIVE:The aim of this study was to determine the utility of DNA flow cytometry as a prognostic indicator for risk of recurrence and overall survival in patients with early stage adenocarcinomas of the uterine cervix. METHODS:DNA flow cytometry was performed to determine ploidy, DNA index, and proliferative index i...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Magtibay PM,Perrone JF,Stanhope CR,Katzmann JA,Keeney GL,Li H

    更新日期:1999-11-01 00:00:00

  • A binary histologic grading system for ovarian serous carcinoma is an independent prognostic factor: a population-based study of 4317 women diagnosed in Denmark 1978-2006.

    abstract:OBJECTIVE:To evaluate the prognostic significance of histologic grade on survival of ovarian serous cancer in Denmark during nearly 30 years. METHODS:Using the nationwide Danish Pathology Data Bank, we evaluated 4317 women with ovarian serous carcinoma in 1978-2006. All pathology reports were scrutinized and tumors cl...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Hannibal CG,Vang R,Junge J,Kjaerbye-Thygesen A,Kurman RJ,Kjaer SK

    更新日期:2012-06-01 00:00:00

  • Adjuvant chemotherapy as treatment of high-risk stage I and II endometrial cancer.

    abstract:OBJECTIVE:This study was performed to define the subgroups of patients who benefit from postoperative adjuvant chemotherapy in stage I and II endometrial carcinoma. METHODS:A retrospective review of 170 International Federation of Gynecology and Obstetrics (FIGO) stage I and II endometrial carcinoma patients treated b...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Aoki Y,Watanabe M,Amikura T,Obata H,Sekine M,Yahata T,Fujita K,Tanaka K

    更新日期:2004-08-01 00:00:00

  • Anti-tumor activity of an anti-DR5 monoclonal antibody, TRA-8, in combination with taxane/platinum-based chemotherapy in an ovarian cancer model.

    abstract:OBJECTIVE:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediates apoptosis via binding to death receptors and enhances the anti-tumor effect of conventional cancer therapies. We evaluated the efficacy of TRA-8, an agonistic antibody to DR5, combined with docetaxel and carboplatin in vitro in an intrap...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Bevis KS,McNally LR,Sellers JC,Della Manna D,Londoño Joshi A,Amm H,Straughn JM Jr,Buchsbaum DJ

    更新日期:2011-04-01 00:00:00

  • Impact of FDG PET-CT imaging on the decision making in the biologic suspicion of ovarian carcinoma recurrence.

    abstract:OBJECTIVES:The aim of this prospective study was to evaluate the impact of integrated PET-CT on treatment management in ovarian carcinoma recurrence suspicion because of increased CA-125. METHODS:Twenty-nine patients (mean age=61 years), initially treated for ovarian carcinoma (FIGO stage I n=2, stage II n=3, stage II...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Soussan M,Wartski M,Cherel P,Fourme E,Goupil A,Le Stanc E,Callet N,Alexandre J,Pecking AP,Alberini JL

    更新日期:2008-01-01 00:00:00

  • Metastatic serous borderline ovarian tumor in an internal mammary lymph node: a case report and review of the literature.

    abstract::Background. Reports of supradiaphragmatic involvement of lymph nodes by serous borderline ovarian tumors are rare. Case. We describe the finding of metastatic tumor involving an internal mammary lymph node in a 74-year-old patient with serous borderline ovarian tumor. The positive lymph node was found incidentally dur...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Chamberlin MD,Eltabbakh GH,Mount SL,Leavitt BJ

    更新日期:2001-07-01 00:00:00

  • Expression of DNA repair proteins in endometrial cancer predicts disease outcome.

    abstract:OBJECTIVE:The consequences of defective homologous recombination and other DNA repair pathways are important in disease outcomes of numerous tumor types. The objective of this study was to explore BRCA1, PARP, FANCD2, PTEN, H2AX, and ATM protein expression in endometrial cancer (EC). METHODS:PARP1, γH2AX, ATM, FANCD2,...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Mhawech-Fauceglia P,Wang D,Kim G,Sharifian M,Chen X,Liu Q,Lin YG,Liu S,Pejovic T

    更新日期:2014-03-01 00:00:00

  • Prediction of short-term surgical complications in women undergoing pelvic exenteration for gynecological malignancies.

    abstract:OBJECTIVE:Pelvic exenteration (PE) is an extensive surgery associated with high rates of postoperative morbidity and mortality. The absence of well-defined preoperative selection criteria to identify patients eligible for PE prompted the assessment of pre-operative predictors of 30-day major surgical complications. ME...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Tortorella L,Casarin J,Mara KC,Weaver AL,Multinu F,Glaser GE,Cliby WA,Scambia G,Mariani A,Kumar A

    更新日期:2019-01-01 00:00:00

  • Increasing genetic counseling referral rates through bundled interventions after ovarian cancer diagnosis.

    abstract:OBJECTIVE:To increase genetic counseling referrals for patients with newly diagnosed epithelial ovarian cancer (EOC). METHODS:A practice-gap analysis was performed after measuring baseline genetic counseling referral rates to identify barriers to referral from the multidisciplinary single institution EOC care group. A...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Swanson CL,Kumar A,Maharaj JM,Kemppainen JL,Thomas BC,Weinhold MR,Slaby KM,Mara KC,Wick MJ,Bakkum-Gamez JN

    更新日期:2018-04-01 00:00:00

  • Cyclooxygenase-2 in cervical neoplasia: a review.

    abstract:OBJECTIVE:Previous data demonstrate an association between cyclooxygenase activity and development of cervical cancer. This review investigates the role of cyclooxygenase-2 (COX-2) in the development of cervical cancer and potential therapeutic options targeting this pathway. METHODS:A literature search was conducted ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Young JL,Jazaeri AA,Darus CJ,Modesitt SC

    更新日期:2008-04-01 00:00:00

  • Effects of beta-carotene and other factors on outcome of cervical dysplasia and human papillomavirus infection.

    abstract::Women with histopathologically confirmed cervical intraepithelial neoplasia (CIN) were followed at 3-month intervals in a randomized double-blinded trial to evaluate the efficacy of beta-carotene to cause regression of CIN. Questionnaire data, plasma levels of micronutrients, and a cervicovaginal lavage for human papi...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Romney SL,Ho GY,Palan PR,Basu J,Kadish AS,Klein S,Mikhail M,Hagan RJ,Chang CJ,Burk RD

    更新日期:1997-06-01 00:00:00

  • Recurrent and persistent squamous cell cervical carcinoma in women under age 35.

    abstract::Forty-five patients with invasive cervical squamous cell carcinoma were registered in the Tom Baker Cancer Centre from 1980 to 1985. The natural history of 22 patients (48.9%) who developed persistent or recurrent disease including 11 Stage IB, 8 Stage IIB, and 3 Stage IIIB is reported. Only one patient who had the un...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Stuart GC,Robertson DI,Fedorkow DM,Duggan MA,Nation JG

    更新日期:1988-06-01 00:00:00

  • The accuracy of magnetic resonance imaging in staging of vulvar cancer: a retrospective multi-centre study.

    abstract:OBJECTIVE:To retrospectively evaluate the diagnostic accuracy and clinical relevance of magnetic resonance imaging (MRI) in the management of primary and recurrent vulvar cancer and to examine the added value of contrast-enhanced MRI (CE-MRI). METHODS:The research ethics committee waived informed consent for this stud...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Kataoka MY,Sala E,Baldwin P,Reinhold C,Farhadi A,Hudolin T,Hricak H

    更新日期:2010-04-01 00:00:00

  • Prognostic significance of differential expression of angiogenic genes in women with high-grade serous ovarian carcinoma.

    abstract:OBJECTIVES:To identify angiogenic biomarkers associated with tumor angiogenesis and clinical outcome in high-grade serous ovarian cancer (HGSC). METHODS:51 HGSC samples were analyzed using Affymetrix HG-U133A microarray. Microvessel density (MVD) counts were determined using CD31 and CD105. Associations between mRNA e...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Siamakpour-Reihani S,Owzar K,Jiang C,Turner T,Deng Y,Bean SM,Horton JK,Berchuck A,Marks JR,Dewhirst MW,Alvarez Secord A

    更新日期:2015-10-01 00:00:00

  • Durability of clinical performance afforded by self-collected HPV testing: A 15-year cohort study in China.

    abstract:OBJECTIVE:Self-collected HPV testing could substantially reduce disparities in cervical cancer screening, with slightly lower sensitivity compared to physician-collected specimens cross-sectionally. We aimed to evaluate the comprehensive long-term performance of self-collected HPV testing prospectively. METHODS:In 199...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Zhang L,Xu XQ,Hu SY,Chen F,Zhang X,Pan QJ,Zhang WH,Feng RM,Dong L,Zhang Q,Ma JF,Sauvaget C,Zhao FH,Qiao YL,Sankaranarayanan R

    更新日期:2018-11-01 00:00:00

  • The timing of normalization of CA-125 levels during primary chemotherapy is predictive of survival in patients with epithelial ovarian cancer.

    abstract:OBJECTIVE:To determine if the timing of normalization of CA-125 levels during primary chemotherapy for epithelial ovarian cancer (EOC) could predict survival. METHODS:Patients who reached a complete clinical response for EOC with primary taxane/platinum-based chemotherapy were eligible. Patient demographics, chemother...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Rocconi RP,Matthews KS,Kemper MK,Hoskins KE,Huh WK,Straughn JM Jr

    更新日期:2009-08-01 00:00:00

  • A case of successful pregnancy after treatment of invasive cervical cancer with systemic chemotherapy and conization.

    abstract:BACKGROUND:The standard therapy for invasive uterine cervical cancer causes loss of the woman's fertility. We report a successful pregnancy in a patient who desired fertility-sparing management of invasive cervical cancer and was treated with systemic chemotherapy and conization. CASE:A 28-year-old nulliparous woman w...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kobayashi Y,Akiyama F,Hasumi K

    更新日期:2006-01-01 00:00:00

  • Efficacy and toxicity of weekly topotecan in recurrent epithelial ovarian and primary peritoneal cancer.

    abstract:OBJECTIVES:We assessed the efficacy and toxicity of once-weekly topotecan (Hycamtin; GlaxoSmithKline) for relapsed or persistent epithelial ovarian cancer (EOC) and primary peritoneal carcinoma (PPC). METHODS:Patients with recurrent or persistent EOC and PPC previously treated with > or = 1 course of platinum-based ch...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Safra T,Menczer J,Bernstein R,Shpigel S,Inbar MJ,Grisaru D,Golan A,Levy T

    更新日期:2007-04-01 00:00:00

  • Does adjuvant chemotherapy dose modification have an impact on the outcome of patients diagnosed with advanced stage ovarian cancer? An NRG Oncology/Gynecologic Oncology Group study.

    abstract:PURPOSE:To determine the relationship between chemotherapy dose modification (dose adjustment or treatment delay), overall survival (OS) and progression-free survival (PFS) for women with advanced-stage epithelial ovarian carcinoma (EOC) and primary peritoneal carcinoma (PPC) who receive carboplatin and paclitaxel. ME...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,随机对照试验


    authors: Olawaiye AB,Java JJ,Krivak TC,Friedlander M,Mutch DG,Glaser G,Geller M,O'Malley DM,Wenham RM,Lee RB,Bodurka DC,Herzog TJ,Bookman MA

    更新日期:2018-10-01 00:00:00

  • Bolus mitomycin C and 5-FU with sequential radiation for poor-prognosis locally advanced cervical cancer.

    abstract::Forty patients with locally advanced cervical carcinoma were entered into a protocol utilizing the bolus administration of both mitomycin C (10 or 15 mg) on Day 1 and 5-fluorouracil (400 mg) on Day 1-5 followed by sequential pelvic irradiation on Day 6 between September 1980 and October 1985. All patients had poor-pro...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,评审


    authors: Denehy TR,Eastman R,SanFilippo L,Gregori CA,Breen JL

    更新日期:1996-01-01 00:00:00

  • Assessment of inhibin and p53 in granulosa cell tumors of the ovary.

    abstract:OBJECTIVE:The goal of this work was to determine the cellular content of inhibin and p53 in granulosa cell tumors (GCTs). METHODS:Clinical records of 47 patients (mean age, 54 years; range, 20-85 years) presenting with GCT surgically managed at our institution were abstracted. International Federation of Gynecology st...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Gebhart JB,Roche PC,Keeney GL,Lesnick TG,Podratz KC

    更新日期:2000-05-01 00:00:00

  • Epithelial ovarian cancer and recreational physical activity: A review of the epidemiological literature and implications for exercise prescription.

    abstract:UNLABELLED:Despite the publication of two dozen observational epidemiological studies investigating the association between recreational physical activity (RPA) and epithelial ovarian cancer (EOC) risk and survival over the past two decades, taken collectively, data from retrospective and prospective studies are mixed ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Cannioto RA,Moysich KB

    更新日期:2015-06-01 00:00:00

  • Compliance with research standards within gynecologic oncology fellowship: A Gynecologic Oncology Fellowship Research Network (GOFRN) study.

    abstract:OBJECTIVES:Participation in clinical and basic science research is emphasized in gynecologic oncology training. We sought to identify trends in adherence to expected research practices and reasons for non-adherence among gynecologic oncology fellows. METHODS:An anonymous 31-question online survey assessing academic be...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Moulton LJ,Michener CM,Levinson K,Cobb L,Tseng J,Jernigan A

    更新日期:2017-09-01 00:00:00

  • High-dose platinum chemotherapy in advanced ovarian cancer: a phase II study.

    abstract::From September 1986 to November 1988, 38 patients with previously untreated ovarian cancer, FIGO stages III and IV, were allocated to a study testing the efficacy of high-dose platinum delivered as combined carboplatin and cisplatin. The regimen was as follows: Day 1, 250-350 mg/m2 carboplatin and 500 mg/m2 cyclophosp...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Bertelsen K,Bastholt L

    更新日期:1992-01-01 00:00:00