当前位置： SCI文献检索 > GYNECOLOGIC ONCOLOGY期刊下所有文献 > Feasibility of tumor testing for BRCA status in high-grade serous ovarian cancer using fresh-frozen tissue based approach.

Feasibility of tumor testing for BRCA status in high-grade serous ovarian cancer using fresh-frozen tissue based approach.

Abstract：

OBJECTIVE:For many years, BRCA mutational status has only been considered as a predictor of ovarian cancer susceptibility and as a prognostic factor. Nonetheless, in the era of precision medicine, it has also become a predictive biomarker of response to platinum-based-chemotherapy and, more recently, to PARP-inhibitors, also in the frontline setting. We assessed the feasibility of a fresh frozen tissue-based-BRCA-screening workflow in a tertiary referral center. METHODS:We consecutively enrolled a series of 456 newly diagnosed FIGO-Stage IIIC-IV, high grade serous-ovarian cancer patients. All patients receiving tumor-biopsy underwent tBRCA-testing. RESULTS:Clinically relevant tissue-BRCA (tBRCA) variants were observed in 145 women (31.8%), particularly we recognized 89 (61.4%) patients with BRCA1-pathogenetic variants (PVs) and 56 women (38.6%) with BRCA2-PVs. Among 292 tBRCA wild-type (wt) patients, 88 cases were germline BRCA tested (gBRCA) and 86 (97.8%) were confirmed as gBRCAwt, while 1 (1.1%) had gBRCA variant of uncertain significance and 1 had gBRCA mutation (1.1%). The concordance of tumor test versus germline BRCA test was 86.3% (209/242). Large genomic rearrangements (LGRs) were suspected in 13/292 tBRCAwt patients (4.5%) by using bioinformatic algorithm and multiplex ligation-dependent probe amplification (MLPA) was performed, with evidence of PVs in only 1 case. CONCLUSIONS:Fresh-frozen tissue-based BRCA screening workflow is feasible and reliable. It allows to enlarge the BRCA mutated population that might receive PARPi with the greatest benefit, without missing cascade testing for family members and therefore, maintaining its preventive role.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Marchetti C,Minucci A,D'Indinosante M,Ergasti R,Arcieri M,Capoluongo ED,Pietragalla A,Caricato C,Scambia G,Fagotti A

doi

10.1016/j.ygyno.2020.06.479

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

740-746

issue

3

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(20)32294-0

journal_volume

158

pub_type

杂志文章

相关文献

GYNECOLOGIC ONCOLOGY文献大全
  • Contemporary management of ovarian germ cell tumors and remaining controversies.

    abstract：:Ovarian germ cell tumors (GCTs) are rare in adults, but are more common in adolescents and young adults. Contemporary management of ovarian GCTs is evolving as collaboration among pediatric, medical, and gynecologic oncologists increases, and studies increasingly incorporate female adult patients. Despite an improved ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ygyno.2020.05.007

    authors： Veneris JT,Mahajan P,Frazier AL

    更新日期：2020-08-01 00:00:00

  • Modified fragility index and surgical complexity score are able to predict postoperative morbidity and mortality after cytoreductive surgery for advanced ovarian cancer.

    abstract：OBJECTIVE:The aim of this study was to assess the impact of surgical complexity on postoperative complications and mortality, according to patient's frailty (mFI) following surgery for ovarian cancer. METHODS:Patients undergoing cytoreductive surgery for ovarian cancer from 2008 to 2018 were identified from our databa...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2020.08.022

    authors： Di Donato V,Di Pinto A,Giannini A,Caruso G,D'Oria O,Tomao F,Fischetti M,Perniola G,Palaia I,Muzii L,Benedetti Panici P

    更新日期：2020-09-04 00:00:00

  • Radiotherapy of primary carcinoma of the vagina: management and results of different therapy schemes.

    abstract：:Three hundred and sixty-two cases of primary vaginal carcinoma were treated at the Irradiation Department of the University Clinic for Obstetrics and Gynecology, Vienna, from 1950 to 1977. As the method of choice an individually dosed, fractioned, and protracted radium-telecobalt therapy was employed. Comparing the la...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/0090-8258(85)90236-7

    authors： Kucera H,Langer M,Smekal G,Weghaupt K

    更新日期：1985-05-01 00:00:00

  • Predictive value of HPV DNA in lymph nodes in surgically treated cervical carcinoma patients--a prospective study.

    abstract：OBJECTIVE:High-risk types of HPV are etiological factors in cervical cancer. Lymph node involvement in cervical cancer patients reduces 5-year survival rates by 25-60%. However, the influence on survival of HPV DNA positivity in histopathologically negative lymph nodes remains unresolved. METHODS:The study included 11...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2006.10.018

    authors： Lukaszuk K,Liss J,Gulczynski J,Nowaczyk M,Nakonieczny M,Piatkowski M,Sliwinski W,Baay M,Wozniak I,Maj B,Lukaszuk M

    更新日期：2007-03-01 00:00:00

  • Liquid-based cytology and human papillomavirus testing: a pooled analysis using the data from 13 population-based cervical cancer screening studies from China.

    abstract：OBJECTIVE:The objective of this study was to evaluate the impact of introducing HR-HPV testing in cytology regarding cervical cancer screening practice. METHODS:A pooled analysis of liquid-based cytology (LBC) and HR-HPV testing using data from 13 population-based cervical cancer screening studies conducted in China w...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.ygyno.2014.03.008

    authors： Pan QJ,Hu SY,Guo HQ,Zhang WH,Zhang X,Chen W,Cao J,Jiang Y,Zhao FH,Qiao YL

    更新日期：2014-05-01 00:00:00

  • Reconstructive surgery following resection of primary vulvar cancers.

    abstract：OBJECTIVE:This study describes the surgical treatment and follow-up of 213 patients with primary vulvar cancer; particular attention is given to reconstructive surgical procedures. METHODS:The clinical and pathological parameters of the patients were recorded according to standardized procedures, and the data concerni...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2005.05.031

    authors： Weikel W,Hofmann M,Steiner E,Knapstein PG,Koelbl H

    更新日期：2005-10-01 00:00:00

  • Detection of endometrial cancer via molecular analysis of DNA collected with vaginal tampons.

    abstract：OBJECTIVE:We demonstrate the feasibility of detecting EC by combining minimally-invasive specimen collection techniques with sensitive molecular testing. METHODS:Prior to hysterectomy for EC or benign indications, women collected vaginal pool samples with intravaginal tampons and underwent endometrial brushing. Specim...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2015.01.552

    authors： Bakkum-Gamez JN,Wentzensen N,Maurer MJ,Hawthorne KM,Voss JS,Kroneman TN,Famuyide AO,Clayton AC,Halling KC,Kerr SE,Cliby WA,Dowdy SC,Kipp BR,Mariani A,Oberg AL,Podratz KC,Shridhar V,Sherman ME

    更新日期：2015-04-01 00:00:00

  • Phase II clinical trial of capecitabine in ovarian carcinoma recurrent 6-12 months after completion of primary chemotherapy, with exploratory TS, DPD, and TP correlates: a Gynecologic Oncology Group study.

    abstract：PURPOSE:A phase II trial was conducted to evaluate the anti-tumor activity and adverse effects of capecitabine in women with measurable platinum-sensitive ovarian cancer or platinum-sensitive primary peritoneal cancer and to explore the ability of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), and th...

    journal_title：Gynecologic oncology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.ygyno.2004.11.037

    authors： Garcia AA,Blessing JA,Lenz HJ,Darcy KM,Mannel RS,Miller DS,Husseinzadeh N,Gynecologic Oncology Group.

    更新日期：2005-03-01 00:00:00

  • Anti-Yo positive paraneoplastic cerebellar degeneration associated with ovarian carcinoma: case report and review of the literature.

    abstract：:Paraneoplastic cerebellar degeneration (PCD) is a rare nonmetastatic neurological complication in cancer patients. Anti-Yo is one of the anti-onconeural antibodies found in PCD patients. It is believed that anti-Yo occurs almost always in women and is most likely associated with gynecologic or breast cancers, although...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,评审

    doi：10.1006/gyno.1999.5553

    authors： Cao Y,Abbas J,Wu X,Dooley J,van Amburg AL

    更新日期：1999-10-01 00:00:00

  • The association between endometriosis and gynecological cancers and breast cancer: a review of epidemiological data.

    abstract：OBJECTIVE:This article critically reviews the literature on the association between endometriosis and gynecological cancers and breast cancer, based on epidemiologic data. METHODS:Literature review of the English language literature based on searching in the MEDLINE (PubMed) database and additional collection of repor...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ygyno.2011.06.017

    authors： Munksgaard PS,Blaakaer J

    更新日期：2011-10-01 00:00:00

  • Treatment results of adjuvant chemotherapy after radical hysterectomy for intermediate- and high-risk stage IB-IIA cervical cancer.

    abstract：OBJECTIVE:To determine the effectiveness of chemotherapy alone as postoperative adjuvant therapy for intermediate- and high-risk cervical cancer. METHODS:The study group comprised of 65 consecutive patients with stage IB or IIA squamous cell or adenosquamous cervical cancer who were initially treated with radical hyst...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2006.04.019

    authors： Takeshima N,Umayahara K,Fujiwara K,Hirai Y,Takizawa K,Hasumi K

    更新日期：2006-11-01 00:00:00

  • Effect of intravenously administered iron sucrose on the prevention of anemia in the cervical cancer patients treated with concurrent chemoradiotherapy.

    abstract：OBJECTIVE:The incidence of anemia in the cervical cancer patients treated with concurrent chemoradiotherapy is estimated to be more than 50%. Transfusion has been the mainstay of hematologic support with its inherent hazards including infection and transfusion reaction. The aim of this study was to examine the impact o...

    journal_title：Gynecologic oncology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.ygyno.2006.11.014

    authors： Kim YT,Kim SW,Yoon BS,Cho HJ,Nahm EJ,Kim SH,Kim JH,Kim JW

    更新日期：2007-04-01 00:00:00

  • Effect of recombinant human tumor necrosis factor on A2774 human ovarian cancer cell line: potentiation of mitoxantrone cytotoxicity.

    abstract：:Recombinant human tumor necrosis factor (rHuTNF) is a macrophage-secretory protein with antitumor activity. In vivo and in vitro cytotoxicity studies have been carried out to test the effectiveness of rHuTNF alone or in combination with chemotherapeutic agents. We have evaluated the direct cytotoxic effect of rHuTNF o...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/0090-8258(91)90254-3

    authors： Vigani A,Chiara S,Miglietta L,Repetto L,Conte PF,Cimoli G,Morelli L,Billi G,Parodi S,Russo P

    更新日期：1991-04-01 00:00:00

  • Positron emission tomography/computed tomography imaging for the detection of recurrent ovarian and fallopian tube carcinoma: a retrospective review.

    abstract：PURPOSE:Imaging modalities to evaluate ovarian/fallopian tube cancer patients for recurrence are limited. Positron emission tomography (PET), computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound lack the sensitivity to consistently detect recurrence or measurable disease in these patients. A new t...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.2002.6606

    authors： Makhija S,Howden N,Edwards R,Kelley J,Townsend DW,Meltzer CC

    更新日期：2002-04-01 00:00:00

  • Informational needs of gynecologic cancer survivors.

    abstract：OBJECTIVES:In preparation for the launch of a gynecologic oncology survivorship program, this study looked at the informational needs of women with gynecologic cancers. Although studies have touched on some of these needs, no published literature has investigated the comprehensive informational needs of gynecologic onc...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2011.10.030

    authors： Papadakos J,Bussière-Côté S,Abdelmutti N,Catton P,Friedman AJ,Massey C,Urowitz S,Ferguson SE

    更新日期：2012-03-01 00:00:00

  • Radiotherapy is not indicated in patients with vulvar squamous cell carcinoma and only one occult intracapsular groin node metastasis.

    abstract：OBJECTIVE:Most guidelines advise no adjuvant radiotherapy in vulvar squamous cell carcinoma and a single occult intracapsular lymph node metastasis. However, several recent studies have questioned the validity of this recommendation. The aim of this study was to analyze the groin recurrence rate in patients with a sing...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2020.10.008

    authors： van der Velden J,Pleunis N,Barlow E,Zijlmans H,de Hullu J,Hacker NF,Fons G

    更新日期：2021-01-01 00:00:00

  • Efficacy and hematologic toxicity of salvage chemotherapy following stem cell-supported high-dose chemotherapy in women with recurrent ovarian cancer.

    abstract：OBJECTIVE:The objective of this study was to determine the efficacy and hematologic toxicity of salvage chemotherapy in patients with recurrent ovarian cancer following high-dose chemotherapy and peripheral blood stem cell transplantation (PBSCT). METHODS:A retrospective analysis of 19 Massachusetts General Hospital c...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.1999.5710

    authors： Cook S,Penson R,Duska L,Nikrui N,Goodman A,Fuller A,Seiden M

    更新日期：2000-04-01 00:00:00

  • Ovarian cancer in female-to-male transsexuals: report of two cases.

    abstract：BACKGROUND:Ovarium cancer is the fifth most common cause of cancer-related death in women and is the most common fatal gynecologic malignancy. So far, ovarium carcinoma has not been reported to have occurred in female-to-male transsexuals. OBJECTIVE AND METHOD:We report on two such cases. Long-term exposure to increas...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1006/gyno.1999.5720

    authors： Hage JJ,Dekker JJ,Karim RB,Verheijen RH,Bloemena E

    更新日期：2000-03-01 00:00:00

  • Clinical outcome of patients with FIGO stage IA2 squamous cell carcinoma of the uterine cervix.

    abstract：OBJECTIVE:The objective of this analysis was to present the clinical outcome of the patients with FIGO stage IA2 squamous cell cervical cancer treated at the Department of Obstetrics and Gynecology between 1973 and 2009, and to clarify the discrepancies in clinical guidelines regarding the radicality of treatment appli...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2011.09.032

    authors： Smrkolj S,Pogačnik RK,Slabe N,Rakar S

    更新日期：2012-01-01 00:00:00

  • Oncolytic adenovirus Ad5/3-delta24 and chemotherapy for treatment of orthotopic ovarian cancer.

    abstract：OBJECTIVE:Oncolytic adenoviruses capable of replication selectively in tumor cells are an appealing approach for the treatment of neoplastic diseases refractory to conventional therapies. The aim of this study was to evaluate the effect of dose and scheduling of a tropism-modified, adenovirus serotype 3 receptor-target...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2007.09.013

    authors： Raki M,Särkioja M,Desmond RA,Chen DT,Bützow R,Hemminki A,Kanerva A

    更新日期：2008-01-01 00:00:00

  • Associations between etiologic factors and mortality after endometrial cancer diagnosis: the NRG Oncology/Gynecologic Oncology Group 210 trial.

    abstract：BACKGROUND:Few studies have analyzed relationships between risk factors for endometrial cancer, especially with regard to aggressive (non-endometrioid) histologic subtypes, and prognosis. We examined these relationships in the prospective NRG Oncology/Gynecologic Oncology Group 210 trial. METHODS:Prior to surgery, par...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2015.08.022

    authors： Felix AS,Scott McMeekin D,Mutch D,Walker JL,Creasman WT,Cohn DE,Ali S,Moore RG,Downs LS,Ioffe OB,Park KJ,Sherman ME,Brinton LA

    更新日期：2015-10-01 00:00:00

  • Soyasaponin-I-modified invasive behavior of cancer by changing cell surface sialic acids.

    abstract：OBJECTIVE:Sialylation involving tumor formation and invasive behavior goes along with altered sialyltransferase (ST) activity. A potent ST inhibitor, soyasaponin I (SsaI), was discovered to selectively inhibit the cellular alpha2,3-sialyltranserase activity. In this study, we further test the effects of SsaI on modifyi...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2004.10.010

    authors： Hsu CC,Lin TW,Chang WW,Wu CY,Lo WH,Wang PH,Tsai YC

    更新日期：2005-02-01 00:00:00

  • Radiotherapy with concurrent cisplatin-based doublet or weekly cisplatin for cervical cancer: a systematic review and meta-analysis.

    abstract：BACKGROUND:Treatment with weekly cisplatin (CDDP) plus radiotherapy (RT) is the standard regimen for stage IB to stage IVA cervical carcinoma (CC). We performed a systematic review and meta-analysis of published studies to evaluate whether CDDP-based doublet therapy improves survival compared to weekly CDDP plus RT in ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ygyno.2014.04.049

    authors： Petrelli F,De Stefani A,Raspagliesi F,Lorusso D,Barni S

    更新日期：2014-07-01 00:00:00

  • Phase II trial of gemcitabine as second-line chemotherapy of uterine leiomyosarcoma: a Gynecologic Oncology Group (GOG) Study.

    abstract：OBJECTIVE:To determine the antitumor activity and toxicity profile of gemcitabine as second-line chemotherapy in patients with recurrent or persistent uterine leiomyosarcoma (LMS). METHODS:Intravenous gemcitabine was administered over 30 min at a dose of 1000 mg/m(2) on days 1, 8, 15, with cycles repeated every 28 day...

    journal_title：Gynecologic oncology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.ygyno.2003.11.023

    authors： Look KY,Sandler A,Blessing JA,Lucci JA 3rd,Rose PG,Gynecologic Oncology Group (GOG) Study.

    更新日期：2004-02-01 00:00:00

  • Phase III randomized trial of second-line ixabepilone versus paclitaxel or doxorubicin in women with advanced endometrial cancer.

    abstract：OBJECTIVE:The purpose of this multicenter, open label, randomized phase III study was to determine whether ixabepilone resulted in improved overall survival (OS) compared with commonly used single-agent chemotherapy (doxorubicin or paclitaxel) in women with locally advanced, recurrent, or metastatic endometrial cancer ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ygyno.2015.04.026

    authors： McMeekin S,Dizon D,Barter J,Scambia G,Manzyuk L,Lisyanskaya A,Oaknin A,Ringuette S,Mukhopadhyay P,Rosenberg J,Vergote I

    更新日期：2015-07-01 00:00:00

  • Closed-suction drainage versus no drainage following radical abdominal hysterectomy with pelvic lymphadenectomy for stage IB cervical cancer.

    abstract：:Over a 7-year period from 1987 to 1994, 120 patients consecutive patients with FIGO stage IB invasive cervical cancer who underwent type 3 radical abdominal hysterectomy and bilateral pelvic lymphadenectomy had either Jackson-Pratt closed-suction drainage (Group 1, patients 1-60) or no drainage (Group 2, patients 61-1...

    journal_title：Gynecologic oncology

    pub_type： 临床试验,杂志文章

    doi：10.1006/gyno.1995.1131

    authors： Patsner B

    更新日期：1995-05-01 00:00:00

  • The role of vaginal cuff brachytherapy in endometrial cancer.

    abstract：OBJECTIVE:The purpose of this article is to review the data, rationale, and recommendations of vaginal brachytherapy (VBT) in the post-operative treatment of endometrial cancer patients. METHODS:The authors performed a thorough review of the medical literature regarding the use of adjuvant VBT in the treatment of endo...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ygyno.2014.12.036

    authors： Harkenrider MM,Block AM,Siddiqui ZA,Small W Jr

    更新日期：2015-02-01 00:00:00

  • SV40 early genes induce neoplastic properties in serous borderline ovarian tumor cells.

    abstract：OBJECTIVE:Serous borderline ovarian tumors (SBOT) are slow growing, noninvasive ovarian epithelial neoplasms, which tend to recur as low-grade invasive carcinomas (LGC) with a much worse prognosis. We investigated the molecular basis of this progression. METHODS:We established cultures of three SBOTs and one LGC from ...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/j.ygyno.2008.06.021

    authors： Woo MM,Salamanca CM,Symowicz J,Stack MS,Miller DM,Leung PC,Gilks CB,Auersperg N

    更新日期：2008-10-01 00:00:00

  • Phase II study of sequential doublets: topotecan and carboplatin, followed by paclitaxel and carboplatin, in patients with newly diagnosed advanced ovarian cancer.

    abstract：OBJECTIVE:Incorporating topotecan into standard platinum/taxane chemotherapy for advanced ovarian cancer has been complicated by myelosuppression. This study evaluated sequential doublets of topotecan and carboplatin, followed by paclitaxel and carboplatin, in newly diagnosed advanced ovarian cancer patients. METHODS:...

    journal_title：Gynecologic oncology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.ygyno.2004.05.021

    authors： Gordon AN,Asmar L,Messing MJ,Street DG,Pippitt CH Jr,Bailey CL,Savage J,Young JA

    更新日期：2004-08-01 00:00:00

  • Gynecologic cancer clues to Lynch syndrome II diagnosis: a family report.

    abstract：:Lynch syndrome II was diagnosed when two sisters manifested early-onset synchronous carcinomas of the ovary and endometrium and a third sister was found to have Duke's A carcinoma of the cecum. A detailed cancer family history indicated paternal transmission of the deleterious genotype. The pattern of carcinoma of the...

    journal_title：Gynecologic oncology

    pub_type： 杂志文章

    doi：10.1016/0090-8258(92)90040-p

    authors： Lynch HT,Cavalieri RJ,Lynch JF,Casey MJ

    更新日期：1992-02-01 00:00:00