The prevalence of HPV16DNA in normal and pathological cervical scrapes using the polymerase chain reaction.

abstract：OBJECTIVES:To estimate the frequency of abnormal surveillance cytology leading to high-grade dysplasia after surgical management for high-grade vulvar intraepithelial neoplasia (VIN) and vulvar cancer and to determine whether prior hysterectomy reduces this risk. METHODS:Women who underwent surgery for high-grade VIN ...

journal_title：Gynecologic oncology

authors： Buchanan TR,Zamorano AS,Massad LS,Liu J,Thaker PH,Powell MA,Mutch DG,Kuroki LM

更新日期：2019-10-01 00:00:00

abstract：:Cyclin E1 (CCNE1) gene amplification occurs in approximately 20% of ovarian high grade serous carcinoma (HGSC) and is associated with chemotherapy resistance and, in some studies, overall poor prognosis. The role of cyclin E1 in inducing S phase entry relies upon its interactions with cyclin dependent kinases (CDK), s...

journal_title：Gynecologic oncology

authors： Kanska J,Zakhour M,Taylor-Harding B,Karlan BY,Wiedemeyer WR

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:Current therapy for cervical cancer includes radiation therapy. Retinoic acid (RA) can increase the sensitivity of cervical cancer cell lines to radiation. The mechanism of this sensitization may not involve the p53 protein because the human papillomavirus (HPV) E6 protein, which is present in the majority of...

journal_title：Gynecologic oncology

authors： Tillmanns TD,Kamelle SA,Guruswamy S,Gould NS,Rutledge TL,Benbrook DM

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:To describe the incidence of isolated paraaortic nodal metastasis in surgically staged endometrial cancer patients with negative pelvic lymph nodes. METHODS:Using a prospectively maintained database we identified all cases of endometrial cancer that had both pelvic and aortic nodal dissection and determined ...

journal_title：Gynecologic oncology

authors： Abu-Rustum NR,Gomez JD,Alektiar KM,Soslow RA,Hensley ML,Leitao MM Jr,Gardner GJ,Sonoda Y,Chi DS,Barakat RR

更新日期：2009-11-01 00:00:00

abstract：:Two-hundred and eighty-eight patients with predominately stage IIB or IIIB cervical carcinoma underwent pretreatment surgical staging including selective paraaortic lymphadenectomy (SPAL), followed by pelvic irradiation with or without paraaortic irradiation (RT). Four patients were excluded from analysis (two receive...

journal_title：Gynecologic oncology

authors： Weiser EB,Bundy BN,Hoskins WJ,Heller PB,Whittington RR,DiSaia PJ,Curry SL,Schlaerth J,Thigpen JT

更新日期：1989-06-01 00:00:00

abstract：OBJECTIVE:Voiding dysfunctions represent a leading morbidity after radical hysterectomy performed in patients with early-stage cervical cancer. The aim of this study was to perform ad hoc analysis of factors influencing voiding recovery in SENTIX (SENTinel lymph node biopsy in cervIX cancer) trial. METHODS:The SENTIX ...

journal_title：Gynecologic oncology

authors： Zapardiel I,Kocian R,Köhler C,Klat J,Germanova A,Jacob A,Bajsova S,Böhmer G,Lay L,Gil-Ibañez B,Havelka P,Kipp B,Szewczyk G,Toth R,Staringer JC,De Santiago J,Coronado PJ,Poka R,Laky R,Luyckx M,Fastrez M,Dusek L,

更新日期：2021-01-05 00:00:00

abstract：OBJECTIVE:Endometrioid endometrial carcinoma is caused by a combination of mutational events and hormonal factors. We used large-scale messenger RNA expression analysis to discover genes that distinguish neoplastic transformation and examine the patterns of tumor expression of those genes which are normally regulated d...

journal_title：Gynecologic oncology

authors： Mutter GL,Baak JP,Fitzgerald JT,Gray R,Neuberg D,Kust GA,Gentleman R,Gullans SR,Wei LJ,Wilcox M

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:To assess the ability of the Age-Adjusted Charlson Comorbidity Index (ACCI) to predict perioperative complications and survival in patients undergoing primary debulking for advanced epithelial ovarian cancer (EOC). METHODS:Data were analyzed for all patients with stage IIIB-IV EOC who underwent primary cytor...

journal_title：Gynecologic oncology

authors： Suidan RS,Leitao MM Jr,Zivanovic O,Gardner GJ,Long Roche KC,Sonoda Y,Levine DA,Jewell EL,Brown CL,Abu-Rustum NR,Charlson ME,Chi DS

更新日期：2015-08-01 00:00:00

abstract：:The patient described synchronous mucinous tumors of the cervix and ovary and concurrent annular tubules, but without the classical stigmata of Peutz-Jeghers syndrome. The cervical tumor was an invasive mucinous adenocarcinoma with mixed components of minimal deviation and less-well-differentiated endometrioid morphol...

journal_title：Gynecologic oncology

authors： Matseoane S,Moscovic E,Williams S,Huang JC

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Treatment with weekly cisplatin (CDDP) plus radiotherapy (RT) is the standard regimen for stage IB to stage IVA cervical carcinoma (CC). We performed a systematic review and meta-analysis of published studies to evaluate whether CDDP-based doublet therapy improves survival compared to weekly CDDP plus RT in ...

journal_title：Gynecologic oncology

authors： Petrelli F,De Stefani A,Raspagliesi F,Lorusso D,Barni S

更新日期：2014-07-01 00:00:00

abstract：:The c-erbB-2 mRNA was detected by the S1 nuclease protection assay and Northern blotting in breast cancer tissues. In contrast to the Northern blot analysis which has been used in all recent publications concerning c-erbB-2 expression on the level of RNA, the S1-nuclease protection assay has distinct advantages with r...

journal_title：Gynecologic oncology

authors： Tanner B,Friedberg T,Mitze M,Beck T,Oesch F,Knapstein PG

更新日期：1992-11-01 00:00:00

abstract：:Radical vulvectomy using warm-knife and open-wound techniques was performed as the first step in a two-phase surgical approach in 274 patients with malignant vulvar tumors. Crude 5-year survival was registered in 133/223 (60%) patients. The complication rate was low and the hospitalization period was short (mean 16 da...

journal_title：Gynecologic oncology

authors： Simonsen E,Johnsson JE,Tropé C

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:The friable and hypervascular nature of a metastatic invasive mole places the patient at risk for significant hemorrhage. Bleeding is the chief cause of morbidity and mortality in patients with a histopathological diagnosis of invasive mole. Bleeding from vaginal metastatic lesions can be controlled by packi...

journal_title：Gynecologic oncology

authors： Method MW,Hirschfield M,Everette HE

更新日期：1996-06-01 00:00:00

abstract：:The methods for preoperative diagnosis and evaluation of the woman with a suspected ovarian neoplasm have evolved significantly with little or no impact on the surgical treatment, which remains removal of the abnormal ovary. Although most adnexal masses are benign, the primary goal of the diagnostic evaluation is the ...

journal_title：Gynecologic oncology

authors： Curtin JP

更新日期：1994-12-01 00:00:00

abstract：:The purpose of this study was to evaluate the differences of blood supply in benign and malignant breast tumors by color Doppler flow measurements. The study included 471 patients, 133 with carcinomas, 325 with benign breast lesions, and 13 with mastitis. An ATL UM9/HDI was used with an electronic 10-MHz linear array ...

journal_title：Gynecologic oncology

authors： Madjar H,Sauerbrei W,Prömpeler HJ,Wolfarth R,Gufler H

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:Invasive vulvar carcinoma is reported to occur in 5 to 20% of patients with vulvar Paget's disease. We report a case in which a clinically inapparent invasive lesion was discovered on reexcision of microscopically persistent vulvar Paget's disease. CASE:A 58-year-old woman presented with a diagnosis of vulv...

journal_title：Gynecologic oncology

authors： Awtrey CS,Marshall DS,Soslow RA,Chi DS

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to study the combination of intraperitoneal alpha-interferon and cisplatin administered second-line in an alternating sequence in small volume residual epithelial ovarian cancer after second-look surgery and the activity of this combination based on prior response to first-line plati...

journal_title：Gynecologic oncology

authors： Berek JS,Markman M,Blessing JA,Kucera PR,Nelson BE,Anderson B,Hanjani P

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:The opioid growth factor (OGF) and its receptor, OGFr, serve as a tonically active inhibitory axis regulating cell proliferation in normal cells and a variety of cancers, including human ovarian cancer. Blockade of OGF and OGFr with the nonselective opioid receptor antagonist naltrexone (NTX) upregulates expr...

journal_title：Gynecologic oncology

authors： Donahue RN,McLaughlin PJ,Zagon IS

更新日期：2011-08-01 00:00:00

abstract：:Human papillomaviruses (HPVs) are small double-stranded DNA viruses that infect the skin and internal squamous mucosae. These viruses were once considered to be the causal agent only of skin or genital warts--lesions of trivial significance. It turns out, however, that HPVs belong to a large virus family that includes...

journal_title：Gynecologic oncology

authors： Stanley M

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Although most patients at high risk of Gestational Trophoblastic Neoplasia (GTN) respond to standard treatments, there is a group of patients that will die because of it. The use of new single or combination drugs in this population has become a priority. CASE REPORT:We present the case of a relapsed high r...

journal_title：Gynecologic oncology

authors： Bianconi M,Jankilevich G,Otero S,Nassif J,Storino C

更新日期：2007-07-01 00:00:00

abstract：:Copyright ...

journal_title：Gynecologic oncology

authors： Wharton JT,Gershenson DM

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:Describing the pattern of and reasons for post-operative tumor residuals in patients with advanced epithelial ovarian cancer (AOC) operated in a specialized gynecologic cancer center following a strategy of maximum upfront debulking followed by systemic chemotherapy. METHODS:All consecutive AOC-patients trea...

journal_title：Gynecologic oncology

authors： Heitz F,Harter P,Alesina PF,Walz MK,Lorenz D,Groeben H,Heikaus S,Fisseler-Eckhoff A,Schneider S,Ataseven B,Kurzeder C,Prader S,Beutel B,Traut A,du Bois A

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:We demonstrate the feasibility of implementing a referral and management system for cryotherapy-ineligible women in a "screen-and-treat" cervical cancer prevention program targeting HIV-infected women in Zambia. METHODS:We established criteria for patient referral, developed a training program for loop elect...

journal_title：Gynecologic oncology

authors： Pfaendler KS,Mwanahamuntu MH,Sahasrabuddhe VV,Mudenda V,Stringer JS,Parham GP

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVES:In this study we evaluated changes in serum Müllerian inhibiting substance (MIS) concentration in a large number of patients with granulosa cell tumors (GCT) to determine whether MIS is elevated at the time of presentation and whether MIS is an index of successful surgical resection and management of recurre...

journal_title：Gynecologic oncology

authors： Lane AH,Lee MM,Fuller AF Jr,Kehas DJ,Donahoe PK,MacLaughlin DT

更新日期：1999-04-01 00:00:00

abstract：:MicroRNA molecules are small, single-stranded RNA molecules that function to regulate networks of genes. They play important roles in normal female reproductive tract biology, as well as in the pathogenesis and progression of epithelial ovarian cancer. DROSHA, DICER, and Argonaute proteins are components of the microR...

journal_title：Gynecologic oncology

authors： Wang X,Ivan M,Hawkins SM

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to determine the efficacy and hematologic toxicity of salvage chemotherapy in patients with recurrent ovarian cancer following high-dose chemotherapy and peripheral blood stem cell transplantation (PBSCT). METHODS:A retrospective analysis of 19 Massachusetts General Hospital c...

journal_title：Gynecologic oncology

authors： Cook S,Penson R,Duska L,Nikrui N,Goodman A,Fuller A,Seiden M

更新日期：2000-04-01 00:00:00

abstract：:The relationship between the amount of silver-stained nucleolar organizer regions (AgNORs) and the DNA content of interphase neoplastic cells in 63 cases of human endometrial adenocarcinoma was studied. Interphase AgNOR content was determined as the mean AgNOR area per nucleus by image cytometry in silver-stained samp...

journal_title：Gynecologic oncology

authors： Trerè D,Melchiorri C,Chieco P,Marabini A,Derenzini M

更新日期：1994-05-01 00:00:00

abstract：:Cyclin D1 is a critical gene controlling the G1 phase progression through the cell cycle. Alterations of cyclin D1 have been demonstrated in a variety of cancer types. We recently reported that increased cyclin D1 expression is associated with malignancy also in ovarian tumors. Three human ovarian cancer cell lines (S...

journal_title：Gynecologic oncology

authors： Cagnoli M,Barbieri F,Bruzzo C,Alama A

更新日期：1998-09-01 00:00:00

abstract：:The bad prognosis of primary Fallopian tube carcinoma (FTC) is mostly ascribed to early lymphogenous metastasis. Yet, there is a lack of information on the tumor size at which lymph node metastasis must be expected to occur. Our study was therefore designed to correlate the anatomopathologic substratum and the histolo...

journal_title：Gynecologic oncology

authors： Klein M,Rosen A,Lahousen M,Graf A,Vavra N,Beck A,Rainer A

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVE:Serum vascular endothelial growth factor (VEGF) levels have been shown to be associated with an adverse outcome in patients with ovarian cancer. We studied the clinical value of serum VEGF as an independent prognostic parameter. METHODS:In the present study, we ascertained preoperative serum VEGF in a series...

journal_title：Gynecologic oncology

authors： Hefler LA,Zeillinger R,Grimm C,Sood AK,Cheng WF,Gadducci A,Tempfer CB,Reinthaller A

更新日期：2006-11-01 00:00:00