Psychological impact of prophylactic oophorectomy in women at increased risk of developing ovarian cancer: a prospective study.


OBJECTIVES:The objectives of this study were twofold: to prospectively assess whether expressed intention to undergo prophylactic oophorectomy translated into uptake and to evaluate the psychological impact of the procedure in a sample of unaffected women with a strong family history of breast/ovarian cancer. METHODS:Ninety-five women, initially assessed at the time of their first attendance at a familial cancer clinic, were followed-up 3 years later. A total of 22 women (23.2%) in this study had undergone a prophylactic oophorectomy. Ten women (10.5%) who had undergone a prophylactic oophorectomy during the 3-year follow-up period were compared to 73 women (76.9%) who did not have a prophylactic oophorectomy. Twelve women (12.6%) who had the procedure prior to study entry were also assessed for psychological adjustment and associated information needs. RESULTS:Age emerged as a significant predictor of uptake of prophylactic oophorectomy (chi(2) = 7.13, P = 0.009). Among those who had the procedure after study entry, a significant reduction in ovarian cancer anxiety was observed (Z = -2.19, P = 0.029). Of the 22 women who had undergone a prophylactic oophorectomy in total (both before and after study entry), 86.4% reported a high degree of satisfaction with their decision to have the procedure. A low level of screening uptake was also reported by women who did not have a prophylactic oophorectomy but for whom screening was recommended. CONCLUSION:Findings demonstrate that prophylactic oophorectomy is successful in reducing anxiety about ovarian cancer. The results also suggest that women perceive that the benefit of anxiety reduction may outweigh the potentially adverse effects of the procedure, given that women expressed a high level of satisfaction with their decision.


Gynecol Oncol


Gynecologic oncology


Tiller K,Meiser B,Butow P,Clifton M,Thewes B,Friedlander M,Tucker K




Has Abstract


2002-08-01 00:00:00














  • Risk of malignancy index in the preoperative evaluation of patients with adnexal masses.

    abstract:OBJECTIVE:The aim of this study was to evaluate the use of a Risk of Malignancy Index (RMI) in primary evaluation of patients with adnexal masses. METHODS:The RMI is based on menopausal status, ultrasonographic findings, and serum CA 125 level. A cutoff level of 200 was chosen as the threshold for referral for central...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Andersen ES,Knudsen A,Rix P,Johansen B

    更新日期:2003-07-01 00:00:00

  • Immunotherapy and radiation combinatorial trials in gynecologic cancer: A potential synergy?

    abstract::Immunotherapy (IO) is an important new pillar in the treatment of solid tumors, and the integration of IO agents with chemotherapy, targeted therapy, surgery and radiation has yet to be defined. As preclinical and clinical studies have described synergistic activity with the combination of radiation and immunotherapy,...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Lee L,Matulonis U

    更新日期:2019-07-01 00:00:00

  • Effect of race/ethnicity on risk of complete and partial molar pregnancy after adjustment for age.

    abstract:OBJECTIVE:To quantify the effect of race/ethnicity on risk of complete and partial molar pregnancy. METHODS:We conducted a cross-sectional study including women who were followed for complete or partial mole and those who had a live singleton birth in a teaching hospital in the northeastern United States between 2000 ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Melamed A,Gockley AA,Joseph NT,Sun SY,Clapp MA,Goldstein DP,Berkowitz RS,Horowitz NS

    更新日期:2016-10-01 00:00:00

  • Radical vulvectomy with warm-knife and open-wound techniques in vulvar malignancies.

    abstract::Radical vulvectomy using warm-knife and open-wound techniques was performed as the first step in a two-phase surgical approach in 274 patients with malignant vulvar tumors. Crude 5-year survival was registered in 133/223 (60%) patients. The complication rate was low and the hospitalization period was short (mean 16 da...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Simonsen E,Johnsson JE,Tropé C

    更新日期:1984-01-01 00:00:00

  • Risk factors for prolonged hospitalization after gynecologic laparoscopic surgery.

    abstract:OBJECTIVE:To determine perioperative risk factors for prolonged hospitalization after gynecologic laparoscopic surgery. METHODS:Data on patients who underwent gynecologic laparoscopic surgery at a single academic institution from January 2000 to January 2009 were evaluated. Patient demographics, clinical history, intr...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Zand B,Frumovitz M,Jofre MF,Nick AM,Dos Reis R,Munsell MF,Sangi-Haghpeykar H,Levenback C,Soliman PT,Schmeler KM,Ramirez PT

    更新日期:2012-09-01 00:00:00

  • Laparoscopic splenectomy for secondary cytoreduction of ovarian cancer in a woman with localized splenic recurrence.

    abstract:OBJECTIVE/BACKGROUND:Laparoscopic splenectomy is a potential surgical option for the treatment of isolated gynecologic cancer recurrence to the spleen [1-7]. The purpose of this video is to demonstrate a step-by-step approach for laparoscopic splenectomy in the setting of recurrent, oligometastatic ovarian cancer. MET...

    journal_title:Gynecologic oncology



    authors: Acosta-Torres S,Fader AN

    更新日期:2020-03-01 00:00:00

  • Ovarian serous carcinoma presenting with mediastinal lymphadenopathy 20 months before the intraabdominal mass: role of immunohistochemistry.

    abstract:INTRODUCTION:Metastatic involvement of the mediastinal lymph nodes is an extremely uncommon finding in epithelial ovarian cancers. CASE REPORT:A 63-year-old woman was admitted to hospital for dyspnoea due to an anterior mediastinal mass. The surgical biopsy showed a 6-cm metastatic lymph node with a papillary pattern,...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Zannoni GF,Vellone VG,Distefano MG,Fadda G,Scambia G

    更新日期:2007-02-01 00:00:00

  • A novel technique for gynecologic oncology surgery in the presence of abdominal wall mesh prosthesis.

    abstract::Incisional herniae are relatively frequent complications of abdominal incisions. Hernia repair techniques have taken advantage of the strength provided by prosthetic mesh grafts. Subsequent surgery in these patients must incorporate a strategy for managing the mesh material. The goals are adequate exposure for surgery...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Buekers TE,Sorosky JI,Buller RE

    更新日期:1998-07-01 00:00:00

  • Use of CA 125 to monitor patients with ovarian epithelial carcinomas.

    abstract::The CA 125 radioimmunoassay has been increasingly used to monitor the course of patients with ovarian epithelial carcinomas. The purpose of this report is to describe our experience in the use of this assay and to better define its clinical utility. Fifty-one patients had serum CA 125 follow-up during primary chemothe...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Podczaski E,Whitney C,Manetta A,Larson JE,Kirk J,Stevens CW,Lyter J,Mortel R

    更新日期:1989-05-01 00:00:00

  • Endometrial cancer and obesity: epidemiology, biomarkers, prevention and survivorship.

    abstract::Endometrial cancer is the most common gynecologic malignancy in the Western world and is strongly associated with obesity. Despite the fact that most cases are diagnosed in early, more favorable stages, endometrial cancer incidence and mortality rates are on the rise. Morbidly obese women with endometrial cancer are m...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Fader AN,Arriba LN,Frasure HE,von Gruenigen VE

    更新日期:2009-07-01 00:00:00

  • Results from a single arm, single stage phase II trial of trametinib and GSK2141795 in persistent or recurrent cervical cancer.

    abstract:BACKGROUND:Improved treatment for advanced cervical cancer is needed; currently, treatment options include combined chemotherapy and bevacizumab or pembrolizumab monotherapy for PD-L1 positive disease. PIK3CA and KRAS mutations have been reported in cervical cancers; this study therefore tested dual inhibition of PI3K ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Liu JF,Gray KP,Wright AA,Campos S,Konstantinopoulos PA,Peralta A,MacNeill K,Morrissey S,Whalen C,Dillon D,Matulonis UA

    更新日期:2019-07-01 00:00:00

  • Overall survival results of AGO-OVAR16: A phase 3 study of maintenance pazopanib versus placebo in women who have not progressed after first-line chemotherapy for advanced ovarian cancer.

    abstract:OBJECTIVE:The AGO-OVAR16 study was designed to test the efficacy, safety, and tolerability of pazopanib maintenance after first-line chemotherapy in patients with newly diagnosed advanced ovarian cancer (AOC). METHODS:Nine hundred and forty patients with histologically confirmed AOC, International Federation of Gyneco...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Vergote I,du Bois A,Floquet A,Rau J,Kim JW,Del Campo JM,Friedlander M,Pignata S,Fujiwara K,Colombo N,Mirza MR,Monk BJ,Tsibulak I,Calvert PM,Herzog TJ,Hanker LC,Meunier J,Lee JY,Bologna A,Carrasco-Alfonso MJ,Harter

    更新日期:2019-11-01 00:00:00

  • Gynecologic cancer clues to Lynch syndrome II diagnosis: a family report.

    abstract::Lynch syndrome II was diagnosed when two sisters manifested early-onset synchronous carcinomas of the ovary and endometrium and a third sister was found to have Duke's A carcinoma of the cecum. A detailed cancer family history indicated paternal transmission of the deleterious genotype. The pattern of carcinoma of the...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Lynch HT,Cavalieri RJ,Lynch JF,Casey MJ

    更新日期:1992-02-01 00:00:00

  • Effect of recombinant human tumor necrosis factor on A2774 human ovarian cancer cell line: potentiation of mitoxantrone cytotoxicity.

    abstract::Recombinant human tumor necrosis factor (rHuTNF) is a macrophage-secretory protein with antitumor activity. In vivo and in vitro cytotoxicity studies have been carried out to test the effectiveness of rHuTNF alone or in combination with chemotherapeutic agents. We have evaluated the direct cytotoxic effect of rHuTNF o...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Vigani A,Chiara S,Miglietta L,Repetto L,Conte PF,Cimoli G,Morelli L,Billi G,Parodi S,Russo P

    更新日期:1991-04-01 00:00:00

  • Diaphragmatic peritonectomy vs. full thickness resection with pleurectomy during Visceral-Peritoneal Debulking (VPD) in 100 consecutive patients with stage IIIC-IV ovarian cancer: A surgical-histological analysis.

    abstract:OBJECTIVE:To compare the surgical and histological outcomes of diaphragmatic peritonectomy vs. full thickness resection with pleurectomy during Visceral-Peritoneal Debulking. METHODS:Service evaluation protocol (Trust number 3265). All patients with stage IIIC-IV ovarian cancer who had diaphragmatic surgery between Ap...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Soleymani Majd H,Ferrari F,Manek S,Gubbala K,Campanile RG,Hardern K,Tozzi R

    更新日期:2016-03-01 00:00:00

  • A case of successful pregnancy after treatment of invasive cervical cancer with systemic chemotherapy and conization.

    abstract:BACKGROUND:The standard therapy for invasive uterine cervical cancer causes loss of the woman's fertility. We report a successful pregnancy in a patient who desired fertility-sparing management of invasive cervical cancer and was treated with systemic chemotherapy and conization. CASE:A 28-year-old nulliparous woman w...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kobayashi Y,Akiyama F,Hasumi K

    更新日期:2006-01-01 00:00:00

  • Metabolic monitoring of advanced uterine cervical cancer neoadjuvant chemotherapy by using [F-18]-Fluorodeoxyglucose positron emission tomography: preliminary results in three patients.

    abstract:OBJECTIVE:The aim of this report is to describe the potential clinical utility of tracer [F-18]-Fluorodeoxyglucose (FDG) uptake, quantitated as a standardized uptake value (SUV) by positron emission tomography (PET), to evaluate treatment response to neoadjuvant chemotherapy (NAC) in advanced uterine cervical cancer. ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Yoshida Y,Kurokawa T,Kawahara K,Yagihara A,Tsuchida T,Okazawa H,Fujibayashi Y,Yonekura Y,Kotsuji F

    更新日期:2004-12-01 00:00:00

  • Oncologic outcome of fertility-sparing radical trachelectomy versus radical hysterectomy for stage IB1 cervical carcinoma.

    abstract:OBJECTIVE:To compare the oncologic outcomes of women who underwent a fertility-sparing radical trachelectomy (RT) to those who underwent a radical hysterectomy (RH) for stage IB1 cervical carcinoma. METHODS:We performed a case-control study of all patients with stage IB1 cervical carcinoma who underwent a vaginal or a...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Diaz JP,Sonoda Y,Leitao MM,Zivanovic O,Brown CL,Chi DS,Barakat RR,Abu-Rustum NR

    更新日期:2008-11-01 00:00:00

  • Radical hysterectomy followed by tailored postoperative therapy in the treatment of stage IB2 cervical cancer: feasibility and indications for adjuvant therapy.

    abstract:OBJECTIVE:To determine the outcome, complications and likelihood of requiring adjuvant therapy of patients with stage IB2 cervical cancer treated with primary radical hysterectomy and lymph node dissection. METHODS:Clinical and pathologic data between 1985 and 1999 were reviewed. Associations between clinical and path...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Yessaian A,Magistris A,Burger RA,Monk BJ

    更新日期:2004-07-01 00:00:00

  • Human papillomavirus genotype distribution in low-grade squamous intraepithelial lesions in France and comparison with CIN2/3 and invasive cervical cancer: the EDiTH III study.

    abstract:OBJECTIVES:In the present study (EDiTH III study), the genotype-specific prevalence of HPV in low-grade squamous intraepithelial lesions (LSIL) was estimated to predict the potential benefit of HPV vaccination in France. This prevalence was compared to that previously reported in France in high-grade cervical intraepit...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Prétet JL,Jacquard AC,Saunier M,Clavel C,Dachez R,Gondry J,Pradat P,Soubeyrand B,Leocmach Y,Mougin C,Riethmuller D,EDiTH study group.

    更新日期:2008-08-01 00:00:00

  • Neurotropic desmoplastic melanoma: a rare vulvar malignancy.

    abstract::Melanoma represents the second most frequent vulvar malignancy, and yet is still considered to be an uncommon neoplasm. Several varieties of melanoma exist. A patient who was diagnosed with a rare subtype of melanoma as a primary vulvar process is presented here. To date, there is only one other reported case of neuro...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Byrne PR,Maiman M,Mikhail A,Harris M,Rosen Y

    更新日期:1995-02-01 00:00:00

  • Phase II trial of doxorubicin, 5-fluorouracil, etoposide, and cisplatin in advanced or recurrent endometrial carcinoma.

    abstract::We have previously reported an overall response rate of 41% and a median survival duration of 14 months in a series of 49 patients with metastatic or recurrent endometrial carcinoma treated by a combination of etoposide, 5-fluorouracil, and cisplatin. In order to increase response rate and survival duration, doxorubic...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Pierga JY,Diéras V,Beuzeboc P,Dorval T,Palangié T,Jouve M,Scholl SM,Garcia-Giralt E,Pouillart P

    更新日期:1997-08-01 00:00:00

  • Comparison of two Lynch screening strategies in endometrial cancer in a California health system.

    abstract:OBJECTIVE:Compare detection of Lynch syndrome in endometrial cancer between regions of a health care system with different screening strategies. METHODS:A retrospective study of endometrial cancer (EC) cases from 2 regions of an integrated health care system (Kaiser Permanente Northern (KPNC) and Southern (KPSC) Calif...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Lentz SE,Salyer CV,Dontsi M,Armstrong MA,Hoodfar E,Alvarado MM,Avila M,Nguyen NT,Powell CB

    更新日期:2020-07-01 00:00:00

  • Immunization with adenoviral vectors carrying recombinant IL-12 and E7 enhanced the antitumor immunity to human papillomavirus 16-associated tumor.

    abstract:OBJECTIVE:Human papillomavirus (HPV) infection play a significant role in cervical carcinogenesis, and HPV oncoprotein E7 has important functions in the formation and maintenance of cervical cancers. Interleukin-12 (IL-12) has been reported to induce cellular immune responses, and has also been demonstrated to suppress...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Jin HS,Park EK,Lee JM,NamKoong SE,Kim DG,Lee YJ,Jun HJ,Han BD,Bae SM,Ahn WS

    更新日期:2005-05-01 00:00:00

  • Overexpression of kallikrein 10 in epithelial ovarian carcinomas.

    abstract:OBJECTIVE:We wanted to identify genes up-regulated in ovarian tumors that might serve as early markers for ovarian cancer. One promising focus is the family of genes that encode secreted proteases, which play essential roles in tumor invasion and metastasis. Kallikrein 10 (KLK10) is a member of the kallikrein family of...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Shvartsman HS,Lu KH,Lee J,Lillie J,Deavers MT,Clifford S,Wolf JK,Mills GB,Bast RC Jr,Gershenson DM,Schmandt R

    更新日期:2003-07-01 00:00:00

  • Palliative treatment of upper intestinal obstruction by gynecological malignancy: the usefulness of percutaneous endoscopic gastrostomy.

    abstract::The usefulness of percutaneous endoscopic gastrostomy (PEG) for decompression in patients with unresolving intestinal obstruction by gynecological malignancy is examined. Between April 1993 and August 1995, 34 consecutive patients with small-bowel obstruction by gynecological cancer, heavily pretreated with surgery an...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Campagnutta E,Cannizzaro R,Gallo A,Zarrelli A,Valentini M,De Cicco M,Scarabelli C

    更新日期:1996-07-01 00:00:00

  • Lymph node dissection in endometrial cancer and clinical outcome: A population-based study in 5546 patients.

    abstract:BACKGROUND:According to current treatment guidelines, comprehensive surgical staging procedures in endometrial cancer confined to the uterus depend on uterine risk factors: a systematic lymph node dissection (LND) is recommended in high risk patients and should be omitted in low risk patients. Its role in intermediate ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Pölcher M,Rottmann M,Brugger S,Mahner S,Dannecker C,Kiechle M,Brambs C,Grab D,Anthuber C,von Koch F,Schnelzer A,Engel J

    更新日期:2019-07-01 00:00:00

  • Maximizing the diversity of participants in a phase II clinical trial of optical technologies to detect cervical neoplasia.

    abstract:INTRODUCTION:We compare the racial and ethnic demographics of our participants with the populations where our clinics are located (Texas and British Columbia) and investigate the reasons cited for participation. METHODS:We compared the distribution of participants by race/ethnicity to numbers from the 2000 United Stat...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Pham B,Earle N,Rabel K,Follen M,Scheurer ME

    更新日期:2007-10-01 00:00:00

  • Tumor lysis syndrome associated with weekly paclitaxel treatment in a case with ovarian cancer.

    abstract:BACKGROUND:Tumor lysis syndrome (TLS) is characterized by biochemical changes such as hyperuricemia and hyperkalemia due to rapid tumor lysis of malignant cells, usually after chemotherapy. TLS is a rare complication in nonhematological malignancies. CASE:A 53-year-old female received intravenous weekly paclitaxel for...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Yahata T,Nishikawa N,Aoki Y,Tanaka K

    更新日期:2006-11-01 00:00:00

  • Trimetrexate in the treatment of recurrent or advanced leiomyosarcoma of the uterus: a phase II study of the Gynecologic Oncology Group.

    abstract:OBJECTIVE:This study was conducted to determine the objective response of trimetrexate in patients with advanced or recurrent leiomyosarcoma of the uterus. METHODS:Eligibility was restricted to patients with measurable disease who had received no more than one prior chemotherapy regimen, who had adequate bone marrow, ...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Smith HO,Blessing JA,Vaccarello L

    更新日期:2002-01-01 00:00:00