Serum albumin: its relationship to marrow and renal toxicity from platinum-based combination chemotherapy.

Abstract:

:One hundred and three patients treated with CAP chemotherapy were evaluated to determine the relationship between low prechemotherapy serum albumin (less than 3 g/dl) and low WBC nadir (less than 2000 cells/mm3). Additionally, the relationship of serum albumin to renal toxicity (delta serum creatinine) was examined. Low prechemotherapy serum albumin appears to be a marker for advanced disease, but does not appear to predict marrow or renal toxicity.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Belinson JL,Jarrell MA,McClure M,Kulig PM,Badger GJ

doi

10.1016/0090-8258(90)90315-c

subject

Has Abstract

pub_date

1990-04-01 00:00:00

pages

93-5

issue

1

eissn

0090-8258

issn

1095-6859

journal_volume

37

pub_type

杂志文章
  • Adjunctive hysterectomy following radiation therapy for bulky carcinoma of the uterine cervix: prognostic implications of tumor persistence.

    abstract::Twenty-five patients underwent adjunctive extrafascial hysterectomy 14-60 days following completion of external and intracavitary irradiation for bulky carcinoma of the uterine cervix. Review of the operative histopathology and correlation with subsequent patient outcomes suggests that morphologically persistent cance...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(87)90217-4

    authors: Russell AH,Burt AR,Ek M,Russell KJ,Cain JM,Greer BE,Tamimi HK,Figge DC

    更新日期:1987-10-01 00:00:00

  • Course of chemotherapy-induced peripheral neuropathy and its impact on health-related quality of life among ovarian cancer patients: A longitudinal study.

    abstract:OBJECTIVE:Chemotherapy-induced peripheral neuropathy (CIPN) presents itself as sensory peripheral neuropathy (SPN) or motor peripheral neuropathy (MPN). Our aim was to examine the course of SPN and MPN, and their impact on health-related quality of life (HRQoL) among ovarian cancer patients. METHODS:All newly diagnose...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ygyno.2018.03.052

    authors: Bonhof CS,Mols F,Vos MC,Pijnenborg JMA,Boll D,Vreugdenhil G,Ezendam NPM,van de Poll-Franse LV

    更新日期:2018-06-01 00:00:00

  • A phase II study of leuprolide in advanced/recurrent endometrial cancer.

    abstract::In order to determine the efficacy and toxicity of the gonadotrophin-releasing hormone agonist Leuprolide in the management of patients with recurrent or metastatic endometrial cancer, we performed a phase II study. Patients were included if there was clinical or radiological documentation of bidimensionally measurabl...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章

    doi:10.1006/gyno.1996.4544

    authors: Covens A,Thomas G,Shaw P,Ackerman I,Osborne R,Lukka H,Carey M,Franssen E,Roche K

    更新日期:1997-01-01 00:00:00

  • Clinical audit in gynecological cancer surgery: development of a risk scoring system to predict adverse events.

    abstract:BACKGROUND:Advanced gynecological surgery undertaken in a specialized gynecologic oncology unit may be associated with significant perioperative morbidity. Validated risk prediction models are available for general surgical specialties but currently not for gynecological cancer surgery. OBJECTIVE:The objective of this...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2009.08.004

    authors: Kondalsamy-Chennakesavan S,Bouman C,De Jong S,Sanday K,Nicklin J,Land R,Obermair A

    更新日期:2009-12-01 00:00:00

  • Mutational analysis of the BRCA1 tumor suppressor gene in endometrial carcinoma.

    abstract:OBJECTIVE:To investigate whether alteration of BRCA1 tumor suppressor gene occurs in sporadic endometrial carcinomas. METHODS:Genomic DNAs were prepared from 33 consecutively collected endometrial carcinoma tissues for BRCA1 mutational analysis. To screen for BRCA1 mutation, polymerase chain reaction (PCR) amplificati...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1997.4800

    authors: Liu FS,Ho ES,Shih RT,Shih A

    更新日期:1997-09-01 00:00:00

  • The implementation of critical pathways in gynecologic oncology in a managed care setting: a cost analysis.

    abstract:OBJECTIVES:The aim of the study is to determine whether critical pathways can be implemented at an academic institution to limit cost, without compromising patient satisfaction and quality of care. PATIENTS AND METHODS:Patients undergoing a hysterectomy with either cervical or endometrial cancer were placed on specifi...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.2001.6428

    authors: Ghosh K,Downs LS,Padilla LA,Murray KP,Twiggs LB,Letourneau CM,Carson LF

    更新日期:2001-11-01 00:00:00

  • Effect of levonorgestrel IUD and oral medroxyprogesterone acetate on glandular and stromal progesterone receptors (PRA and PRB), and estrogen receptors (ER-alpha and ER-beta) in human endometrial hyperplasia.

    abstract:OBJECTIVES:The effect on progesterone and estrogen receptor expression in glands and stroma after two different treatment regimens of endometrial hyperplasia was determined. METHODS:Pre- and post-treatment paraffin-embedded endometrial hyperplasia specimens from women treated with levonorgestrel (LNG) intrauterine dev...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2005.10.030

    authors: Vereide AB,Kaino T,Sager G,Arnes M,Ørbo A

    更新日期:2006-05-01 00:00:00

  • Mucinous adenocarcinoma arising in rectovaginal fistulas associated with Crohn's disease.

    abstract:BACKGROUND:Crohn's disease is a chronic inflammatory disorder characterized by focal, transmural inflammation of the intestine. Gynecologic involvement, including rectovaginal fistula formation, is frequent. Case #1. A 53-year-old female with a 30-year history of Crohn's disease and numerous perirectal fistulas develop...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2003.11.056

    authors: Moore-Maxwell CA,Robboy SJ

    更新日期:2004-04-01 00:00:00

  • Breast cancer followed by corpus cancer: is there a higher risk for aggressive histologic subtypes?

    abstract:OBJECTIVE:To analyze corpus cancer patients with a breast cancer history for risk of developing aggressive uterine histologic types. METHODS:Corpus cancer patients with a history of breast cancer were identified from the Surveillance Epidemiology and End Results database from 1988 to 2001. Demographics, clinico-pathol...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2006.01.014

    authors: Chan JK,Manuel MR,Cheung MK,Osann K,Husain A,Teng NN,Rao A,Carlson RW,Whittemore AS

    更新日期:2006-09-01 00:00:00

  • Low-dose oral granisetron (1 mg) plus intravenous dexamethasone: efficacy in gynecologic cancer patients receiving carboplatin-based chemotherapy.

    abstract:OBJECTIVE:The objective of this study was to determine the efficacy of a low-dose oral granisetron plus intravenous dexamethasone prophylactic antiemetic regimen in patients receiving carboplatin-based chemotherapy. PATIENTS AND METHODS:Patients with gynecologic malignancies being treated with either single-agent carb...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章

    doi:10.1006/gyno.1998.5168

    authors: Markman M,Kennedy A,Webster K,Kulp B,Peterson G,Belinson J

    更新日期:1998-10-01 00:00:00

  • Overexpression of gelsolin in human cervical carcinoma and its clinicopathological significance.

    abstract:OBJECTIVES:Cervical carcinoma is the second most common cause of death from gynecological cancers worldwide. Knowledge of the molecular mechanisms underlying the tumorigenesis of cervical cancer cell, except human papilloma virus infection, is limited. METHODS:A microarray was used to study the differential expression...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2010.10.005

    authors: Liao CJ,Wu TI,Huang YH,Chang TC,Wang CS,Tsai MM,Hsu CY,Tsai MH,Lai CH,Lin KH

    更新日期:2011-01-01 00:00:00

  • Clinical outcome of patients with FIGO stage IA2 squamous cell carcinoma of the uterine cervix.

    abstract:OBJECTIVE:The objective of this analysis was to present the clinical outcome of the patients with FIGO stage IA2 squamous cell cervical cancer treated at the Department of Obstetrics and Gynecology between 1973 and 2009, and to clarify the discrepancies in clinical guidelines regarding the radicality of treatment appli...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2011.09.032

    authors: Smrkolj S,Pogačnik RK,Slabe N,Rakar S

    更新日期:2012-01-01 00:00:00

  • Lymphatic vaginal fistula after Wertheim-Taussig hysterectomy: a case report.

    abstract::Significant vaginal discharge of clear fluid after Wertheim-Taussig hysterectomy with bilateral salpingo-oophorectomy is most often due to urinary fistula. Rarely, the same symptom may be caused by lymphatic fistula, which has not been reported previously. The differentiation between lymph and urine is simple. If this...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1994.1071

    authors: Lau TK,Wong WS

    更新日期:1994-03-01 00:00:00

  • Relationship of nonstaging pathological risk factors to lymph node metastasis and recurrence in clinical stage I endometrial carcinoma.

    abstract:OBJECTIVE:To determine if DNA ploidy, hormone receptors, vascular space invasion (VSI), perivascular lymphocytes (PVL), and the oncogenes HER-2/neu, p53, and bcl-2 are independent prognostic indicators for lymph node metastasis and cancer recurrence in clinical stage I endometrial carcinoma. METHODS:Among 349 patients...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1997.4788

    authors: Bell JG,Minnick A,Reid GC,Judis J,Brownell M

    更新日期:1997-09-01 00:00:00

  • Etiologic heterogeneity in endometrial cancer: evidence from a Gynecologic Oncology Group trial.

    abstract:OBJECTIVE:Although the epidemiology of typical endometrial carcinomas (grades 1-2 endometrioid or Type I) is well established, less is known regarding higher grade endometrioid or non-endometrioid carcinomas (Type II). Within a large Gynecologic Oncology Group trial (GOG-210), which included central pathology review, w...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ygyno.2013.02.023

    authors: Brinton LA,Felix AS,McMeekin DS,Creasman WT,Sherman ME,Mutch D,Cohn DE,Walker JL,Moore RG,Downs LS,Soslow RA,Zaino R

    更新日期:2013-05-01 00:00:00

  • Monitoring cancer antigen 125 levels in induction chemotherapy for epithelial ovarian carcinoma and predicting outcome of second-look procedure.

    abstract::A retrospective analysis of 45 patients with epithelial ovarian carcinoma who underwent second-look procedure after initial cytoreduction and platinum-based combination chemotherapy was undertaken. Each patient was evaluated for the result of CA 125 after a third course of chemotherapy, the result of CA 125 prior to s...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1995.1121

    authors: Folk JJ,Botsford M,Musa AG

    更新日期:1995-05-01 00:00:00

  • Osteomalacia due to chemotherapy-induced Fanconi syndrome in an adult patient.

    abstract:BACKGROUND:Chemotherapy-induced Fanconi syndrome is a dangerous condition that could lead to severe electrolyte disturbances and rarely to osteomalacia. CASE:A patient treated with ifosfamide for a metastatic cervix squamous-cell carcinoma was admitted for diffuse, symmetric bilateral pain in bones and articulations. ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2005.05.014

    authors: Duck L,Devogelaer JP,Persu A,Berlière M,Caussin E,Baurain JF,Machiels JP

    更新日期:2005-08-01 00:00:00

  • High-dose-rate brachytherapy for medically inoperable stage I endometrial cancer.

    abstract:PURPOSE:The objective of this study was to determine the efficacy of high-dose-rate (HDR) brachytherapy in 36 medically inoperable patients with stage I endometrial cancer. METHODS AND MATERIALS:From October 1989 to August 1997, 36 patients presented with clinical stage I inoperable endometrial cancer. Surgery was pre...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1998.5148

    authors: Nguyen TV,Petereit DG

    更新日期:1998-11-01 00:00:00

  • PEBA regimen (cisplatin, etoposide, bleomycin, and adriamycin) in the treatment of drug-resistant choriocarcinoma.

    abstract::Twenty-six drug-resistant choriocarcinoma patients were treated with a PEBA regimen (cisplatin, etoposide, bleomycin, and adriamycin), supplemented by radiotherapy or surgery, from January 1988 to June 1992. A total of 80.8% of the patients had received at least four drugs, and 69.2% had received six or more cycles of...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1995.1037

    authors: Chen LP,Cai SM,Fan JX,Li ZT

    更新日期:1995-02-01 00:00:00

  • Primary non-Hodgkin's lymphoma in Bartholin's gland.

    abstract:BACKGROUND:Non-Hodgkin's lymphoma (NHL) may involve the lower female genital tract, most often as a manifestation of systemic disease and rarely as a primarily localisation. CASE:A 73-year-old woman, HIV-negative, presented with a 5-month history of a mass in the left Bartholin's gland. The performed biopsy was report...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.2002.6828

    authors: Tjalma WA,Van de Velde AL,Schroyens WA

    更新日期:2002-12-01 00:00:00

  • A multicenter phase II study with triptorelin (sustained-release LHRH agonist) in advanced or recurrent endometrial carcinoma: a French anticancer federation study.

    abstract::The objective of this phase II multicenter study was to assess the efficacy and tolerance of triptorelin (a sustained-release LHRH agonist) in advanced or recurrent endometrial cancer. A total of 101 monthly intramuscular injections were administered to 24 eligible patients (median number/patient = 3; range 1-12). Mai...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1006/gyno.1999.5538

    authors: Lhommé C,Vennin P,Callet N,Lesimple T,Achard JL,Chauvergne J,Luporsi E,Chinet-Charrot P,Coudert B,Couette JE,Guastalla JP,Lebrun D,Ispas S,Blumberg J

    更新日期:1999-11-01 00:00:00

  • MRP2 (ABCC2) and cisplatin sensitivity in hepatocytes and human ovarian carcinoma.

    abstract:OBJECTIVE:The ABC transporter MRP2 (ABCC2) can mediate cisplatin efflux, and over-expression of MRP2 has been associated with cisplatin resistance in cancer cell lines. The aim of this study was to determine the role of MRP2 in modulating cisplatin cytotoxicity in normal cells as well as the relationship between MRP2 e...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2005.08.046

    authors: Guminski AD,Balleine RL,Chiew YE,Webster LR,Tapner M,Farrell GC,Harnett PR,Defazio A

    更新日期:2006-02-01 00:00:00

  • Single-dose actinomycin D in the treatment of postmolar trophoblastic disease.

    abstract::From 1973 to 1982 single-dose (0.04 mg/kg or 1.25 mg/m2), biweekly actinomycin D was used to treat 28 women with postmolar, good-prognosis trophoblastic disease. Among the 17 patients fully evaluable for response to treatment 12 were nonmetastatic (NMTD) and 5 had lung metastases (MTD). Nine NMTD patients and 5 MTD pa...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(84)90157-4

    authors: Schlaerth JB,Morrow CP,Nalick RH,Gaddis O Jr

    更新日期:1984-09-01 00:00:00

  • Extraperitoneal laparoscopic lymph node staging: the University of Southern California experience.

    abstract:OBJECTIVES:To describe our experience with extraperitoneal lymph node staging in gynecologic oncology. MATERIALS AND METHODS:The extraperitoneal approach was performed to assess the lymph node histology in patients with gynecologic malignancies. The nodes are approached from a lateral approach after dissecting open th...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2004.07.007

    authors: Burnett AF,O'Meara AT,Bahador A,Roman LD,Morrow CP

    更新日期:2004-10-01 00:00:00

  • Radical hysterectomy for cervical cancer: morbidity and survival in relation to weight and age.

    abstract::The records of 123 patients with Stage I cervical cancer who underwent radical hysterectomy with pelvic lymphadenectomy and para-aortic node sampling from 1981 to 1988 were reviewed to assess the risks of surgery associated with increasing weight and age. Fifty-four patients were obese (20% or more over ideal body wei...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(92)90312-7

    authors: Levrant SG,Fruchter RG,Maiman M

    更新日期:1992-06-01 00:00:00

  • Lysophosphatidic acid (LPA) promotes E-cadherin ectodomain shedding and OVCA429 cell invasion in an uPA-dependent manner.

    abstract:OBJECTIVES:To evaluate the role of LPA in regulating E-cadherin cell surface expression, adhesion, and invasion in epithelial ovarian carcinoma (EOC) cells. METHODS:E-cadherin mRNA expression in OVCA429 and IOSE-29 cells was evaluated by real-time RT-PCR. Immunofluorescence and Western blot analysis were performed to ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2007.10.027

    authors: Gil OD,Lee C,Ariztia EV,Wang FQ,Smith PJ,Hope JM,Fishman DA

    更新日期:2008-02-01 00:00:00

  • Treatment of high-risk gestational trophoblastic neoplasia with weekly high-dose methotrexate-etoposide.

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    doi:10.1016/j.ygyno.2012.06.014

    authors: Han SN,Amant F,Leunen K,Devi UK,Neven P,Berteloot P,Vergote I

    更新日期:2012-10-01 00:00:00

  • Patient reported outcomes of a randomized, placebo-controlled trial of bevacizumab in the front-line treatment of ovarian cancer: a Gynecologic Oncology Group Study.

    abstract:PURPOSE:To analyze quality of life (QOL) in a randomized, placebo-controlled phase III trial concluding that the addition of concurrent and maintenance bevacizumab (Arm 3) to carboplatin and paclitaxel prolongs progression-free survival in front-line treatment of advanced ovarian cancer compared to chemotherapy alone (...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ygyno.2012.11.038

    authors: Monk BJ,Huang HQ,Burger RA,Mannel RS,Homesley HD,Fowler J,Greer BE,Boente M,Liang SX,Wenzel L

    更新日期:2013-03-01 00:00:00

  • Normal pregnancy and delivery following conservative surgery and chemotherapy for ovarian endodermal sinus tumor.

    abstract::Management of younger patients with early stage ovarian endodermal sinus tumor who desire to have children can be a challenging problem. However, after an adequate and thorough staging procedure for the patient's tumor status, a Stage Iai endodermal sinus tumor may be treated with conservative surgery only, followed b...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(84)90184-7

    authors: Bakri YN,Given FT Jr

    更新日期:1984-10-01 00:00:00

  • Risk of cervical and vaginal dysplasia after surgery for vulvar intraepithelial neoplasia or cancer: A 6 year follow-up study.

    abstract:OBJECTIVES:To estimate the frequency of abnormal surveillance cytology leading to high-grade dysplasia after surgical management for high-grade vulvar intraepithelial neoplasia (VIN) and vulvar cancer and to determine whether prior hysterectomy reduces this risk. METHODS:Women who underwent surgery for high-grade VIN ...

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    更新日期:2019-10-01 00:00:00