Preoperative serum vascular endothelial growth factor as a prognostic parameter in ovarian cancer.

abstract：:Cyclin D1 is a critical gene controlling the G1 phase progression through the cell cycle. Alterations of cyclin D1 have been demonstrated in a variety of cancer types. We recently reported that increased cyclin D1 expression is associated with malignancy also in ovarian tumors. Three human ovarian cancer cell lines (S...

journal_title：Gynecologic oncology

authors： Cagnoli M,Barbieri F,Bruzzo C,Alama A

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:The long-term survival of patients with epithelial ovarian cancer is limited by the emergence of tumor cells that are resistant to chemotherapy. We hypothesized that expression of Bcl-x(L), a homologue of Bcl-2 that confers protection from chemotherapy-induced apoptosis, may be predictive of patients' clinica...

journal_title：Gynecologic oncology

authors： Williams J,Lucas PC,Griffith KA,Choi M,Fogoros S,Hu YY,Liu JR

更新日期：2005-02-01 00:00:00

abstract：:Ninety-two patients with early invasive carcinoma of the cervix (5 mm or less) treated between July 1977 and June 1990 are reviewed. Eighty patients had squamous cell carcinomas and 12 had adenocarcinomas. The diagnosis was established by conization in 77 of 92 (83.6%) patients. Thirty-six patients (39%) had a depth o...

journal_title：Gynecologic oncology

authors： Jones WB,Mercer GO,Lewis JL Jr,Rubin SC,Hoskins WJ

更新日期：1993-10-01 00:00:00

abstract：:Eight patients with cervical intraepithelial neoplasia (CIN) were administered perilesional injections of human recombinant interferon gamma (IFN-gamma), and the response was evaluated by colposcopy and exfoliative cytology and then by histopathology. In all patients, colposcopic and cytologic findings improved after ...

journal_title：Gynecologic oncology

authors： Iwasaka T,Hayashi Y,Yokoyama M,Hachisuga T,Sugimori H

更新日期：1990-04-01 00:00:00

abstract：:Nineteen patients with stage III or IV epithelial ovarian cancer treated on a prospective randomized protocol with either adriamycin and cis-diamminedichloroplatinum or tamoxifen, adriamycin, and cis-diamminedichloroplatinum received a modified "CHAP II" regimen at the time of clinical progression of disease or the fi...

journal_title：Gynecologic oncology

authors： Schwartz PE,Keating G,Kohorn EI,Chambers JT

更新日期：1986-11-01 00:00:00

abstract：:Open biopsy of the left scalene lymph nodes has been utilized to identify distant spread of cervical carcinoma in selected groups of patients who do not have other clinical evidence of disseminated disease. Twenty-one patients with primary cervical carcinoma and histologically proven para-aortic lymph node metastases ...

journal_title：Gynecologic oncology

authors： Burke TW,Heller PB,Hoskins WJ,Weiser EB,Nash JD,Park RC

更新日期：1987-11-01 00:00:00

abstract：:In approximately ten months' time, the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected over 34 million people and caused over one million deaths worldwide. The impact of this virus on our health, relationships, and careers is difficult to overstate. As the economic realiti...

journal_title：Gynecologic oncology

authors： Ferriss JS,Rose S,Rungruang B,Urban R,Spencer R,Uppal S,Sinno AK,Duska L,Walsh C

更新日期：2021-01-01 00:00:00

abstract：:During the time interval 1950 through 1980, 48 patients having a mean age of 60.2 years were treated primarily for melanoma of the vulva. In all but one patient, a surgical therapeutic approach was selected, including 40 modified Basset procedures and 23 pelvic lymphadenectomies. The 5-year survival rate of the eligib...

journal_title：Gynecologic oncology

authors： Podratz KC,Gaffey TA,Symmonds RE,Johansen KL,O'Brien PC

更新日期：1983-10-01 00:00:00

abstract：OBJECTIVE:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a classical glycolytic protein. A higher level of GAPDH mRNA was found in lung, pancreas, and prostate cancers, but in cervical carcinoma there have not been any reports about the level of GAPDH gene expression. So, we tried to investigate the GAPDH gene exp...

journal_title：Gynecologic oncology

authors： Kim JW,Kim SJ,Han SM,Paik SY,Hur SY,Kim YW,Lee JM,Namkoong SE

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:The 2018 International Federation of Gynecology and Obstetrics (FIGO) staging system for cervical cancer changed from a clinical system to a clinical/pathologic/radiologic system with stages IIIC1 and IIIC2 indicating positive pelvic and para-aortic lymph nodes, respectively. We evaluated the National Cancer ...

journal_title：Gynecologic oncology

authors： McComas KN,Torgeson AM,Ager BJ,Hellekson C,Burt LM,Maurer KA,Werner TL,Gaffney DK

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the prevalence of high-risk oncogenic human papillomaviruses (HPVs) in malignant lesions from Hong Kong Chinese women with carcinomas of the upper genital tract. METHODS:The presence of high-risk HPVs in 55 cases of endometrial adenocarcinomas and 60 cases of primary ep...

journal_title：Gynecologic oncology

authors： Ip SM,Wong LC,Xu CM,Cheung AN,Tsang PC,Ngan HY

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVES:The objective of this pilot study was to determine if frailty predicts surgical complications among elderly women undergoing gynecologic oncology procedures. METHODS:A cohort of gynecologic oncology patients age ≥ 65, undergoing surgery between March and December 2011 was identified. Frailty was evaluated u...

journal_title：Gynecologic oncology

authors： Courtney-Brooks M,Tellawi AR,Scalici J,Duska LR,Jazaeri AA,Modesitt SC,Cantrell LA

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:Hyperglycosylated hCG (hCG-H) is a glycosylation variant of hCG produced by cytotrophoblast cells at implantation of pregnancy and in choriocarcinoma. We investigated the biological function of hCG-H in invasion in vitro and in vivo and the use of hCG-H antibodies in blocking tumorigenesis and cancer growth i...

journal_title：Gynecologic oncology

authors： Cole LA,Dai D,Butler SA,Leslie KK,Kohorn EI

更新日期：2006-08-01 00:00:00

abstract：:A primary malignant mixed Mullerian tumor (MMMT) was found in the wall of the rectum of a 67-year-old female. The uterus, fallopian tubes, and ovaries had been previously excised for benign disease. The tumor was associated with foci of benign endometriosis. A literature review of extragenital MMMTs indicates that the...

journal_title：Gynecologic oncology

authors： Chumas JC,Thanning L,Mann WJ

更新日期：1986-02-01 00:00:00

abstract：OBJECTIVES:We aimed to evaluate whether carboplatin has a comparable efficacy with cisplatin as part of weekly concurrent chemoradiotherapy for cervical cancer (Car-RT vs. Cis-RT). METHODS:A literature search was conducted and both prospective and retrospective studies that evaluated the efficacy of Car-RT for cervica...

journal_title：Gynecologic oncology

authors： Xue R,Cai X,Xu H,Wu S,Huang H

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to examine whether there is a possible difference in patient survival (1) between node-positive and node-negative groups for Stage I, II, IIIA+B, and IIIC disease and (2) between node-positive Stage I through IIIB disease and Stage IIIC disease. METHODS:Medical records of 125 patien...

journal_title：Gynecologic oncology

authors： Kanazawa K,Suzuki T,Tokashiki M

更新日期：1999-05-01 00:00:00

abstract：:Ovarian, endometrial and cervical cancers are the most prevalent gynecologic cancers in the United States and account for significant mortality. Translational research into these cancers has highlighted the distinctive molecular and genomic profiles of these cancers finding that, even within a disease site, the landsc...

journal_title：Gynecologic oncology

authors： Bregar AJ,Growdon WB

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:Recurrent and advanced cervical cancers are associated with high mortality and a lack of effective treatment options, especially for women who are poor candidates for surgery or radiation therapy. The broad clinical effectiveness and low toxicity of gemcitabine in other human malignancies suggest that it migh...

journal_title：Gynecologic oncology

authors： Mutch DG,Bloss JD

更新日期：2003-08-01 00:00:00

abstract：:Only one case of endometrial transitional cell carcinoma (TCC) has been previously reported in the literature. We report a second case. In both the previously reported case and in this case there was a separate focus of TCC in the adnexa. Both patients were treated with adjuvant whole pelvic radiation and are alive an...

journal_title：Gynecologic oncology

authors： Spiegel GW,Austin RM,Gelven PL

更新日期：1996-02-01 00:00:00

abstract：PURPOSE:The goal of this study was to determine whether South African HIV-seropositive women with invasive cervical cancer present with disease that is more advanced than that of HIV-seronegative women and whether degree of immunosuppression affects the extent of disease at initial presentation. METHODS:This study is ...

journal_title：Gynecologic oncology

authors： Lomalisa P,Smith T,Guidozzi F

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:This study aims to estimate the activity of docetaxel 60mg/m(2) IV over 1h followed by trabectedin 1.1mg/m(2) over 3h with filgrastim, pegfilgrastim, or sargramostim every 3weeks (one cycle). METHODS:Patients with recurrent and measurable disease, acceptable organ function, PS≤2, and ≤3 prior regimens were e...

journal_title：Gynecologic oncology

authors： Monk BJ,Sill MW,Hanjani P,Edwards R,Rotmensch J,De Geest K,Bonebrake AJ,Walker JL

更新日期：2011-03-01 00:00:00

abstract：:Approximately 20,000 women are diagnosed with ovarian cancer in the United States each year, and some 12,000 women die because of it. Epithelial ovarian cancer, the most common histopathologic type, is uncommon before age 40 years, after which incidence rates increase steeply until age 70-79 years and then decrease so...

journal_title：Gynecologic oncology

authors： Whittemore AS

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVES:BRCA1 and BRCA2 germline mutations increase the risk of ovarian and breast cancer. Fallopian tube cancer has occasionally been observed in breast-ovarian cancer families. At our family cancer clinic we recently encountered two cases of Fallopian tube cancer within two families harboring a BRCA1 germline muta...

journal_title：Gynecologic oncology

authors： Zweemer RP,van Diest PJ,Verheijen RH,Ryan A,Gille JJ,Sijmons RH,Jacobs IJ,Menko FH,Kenemans P

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:To investigate racial disparities with respect to adjuvant treatment and survival in patients presenting with malignant ovarian germ cell tumors (OGCT). METHODS:The National Cancer Database (NCDB) was used to identify women diagnosed with OGCT. Demographic data were abstracted, including stratification by ra...

journal_title：Gynecologic oncology

authors： Hinchcliff E,Rauh-Hain JA,Clemmer JT,Diver E,Hall T,Stall J,Growdon W,Clark R,Schorge J

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the efficacy of hysteroscopy, using normal saline (NS) or carbon dioxide (CO2) as the distention medium, in assessing tumor invasion of the uterine cervix by endometrial carcinoma. METHODS:A retrospective study was conducted in 200 consecutive patients with endometrial c...

journal_title：Gynecologic oncology

authors： Lo KW,Cheung TH,Yim SF,Chung TK

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVES:To evaluate the urinary tract dysfunction following a radical hysterectomy and to compare the baseline urodynamical parameters of women who had uterine cervical carcinoma with women who had CIN 3. METHODS:A prospective case-control study was conducted to evaluate preoperative and postoperative urinary tract...

journal_title：Gynecologic oncology

authors： Chen GD,Lin LY,Wang PH,Lee HS

更新日期：2002-05-01 00:00:00

abstract：:The clinical and pathologic features of a vulvar neuroendocrine (Merkel cell) neoplasm are presented. Cytologic studies of material obtained from needle aspiration suggested that the tumor was a small cell neoplasm possibly of neuroendocrine derivation. The light-microscopic findings of sheets of small, uniform cells ...

journal_title：Gynecologic oncology

authors： Copeland LJ,Cleary K,Sneige N,Edwards CL

更新日期：1985-11-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to examine whether comorbidity is an independent prognostic factor for 3129 women diagnosed with ovarian cancer from 2005 to 2011. As Performance status (PS) might capture the impact of comorbidity we addressed whether comorbidity can be explained by PS or whether comorbidity has an i...

journal_title：Gynecologic oncology

authors： Sperling C,Noer MC,Christensen IJ,Nielsen ML,Lidegaard Ø,Høgdall C

更新日期：2013-04-01 00:00:00

abstract：:Between October 1985 and January 1989, 33 patients with stage I (31) or clinically occult stage II (2) endometrial cancer at a high risk for recurrence were entered in a prospective study evaluating adjuvant cisplatin, doxorubicin, and cyclophosphamide (PAC) chemotherapy. Eligibility criteria included grade 2 tumors w...

journal_title：Gynecologic oncology

authors： Stringer CA,Gershenson DM,Burke TW,Edwards CL,Gordon AN,Wharton JT

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVES:Based on our previous report showing that orobol, a potent phosphatidylinositol 4-kinase (PI4K) inhibitor, produced cisplatin (DDP) sensitivity, we have determined the mechanism of orobol-sensitization effect. METHODS AND RESULTS:Orobol produced >2-fold DDP sensitivity in human ovarian carcinoma 2008 cells ...

journal_title：Gynecologic oncology

authors： Isonishi S,Saitou M,Yasuda M,Ochiai K,Tanaka T

更新日期：2003-08-01 00:00:00