Human immunodeficiency virus infection and invasive cervical cancer in South Africa.

Abstract:

PURPOSE:The goal of this study was to determine whether South African HIV-seropositive women with invasive cervical cancer present with disease that is more advanced than that of HIV-seronegative women and whether degree of immunosuppression affects the extent of disease at initial presentation. METHODS:This study is a retrospective review of 60 HIV-seropositive and 776 HIV-seronegative new cases of invasive cervical carcinoma seen at the combined gynecologic oncology unit of the University of the Witwatersrand, Johannesburg, South Africa. RESULTS:The HIV seroprevalence was 7.2%. Squamous cell carcinoma was the histologic subtype in more than 90% of both cohorts of patients. Although the HIV-positive patients presented with invasive cervical cancer almost 10 years earlier than the HIV-negative patients, i.e., mean age 44 years +/- 9.8 versus 53 years +/- 12.7, respectively (P

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Lomalisa P,Smith T,Guidozzi F

doi

10.1006/gyno.2000.5775

subject

Has Abstract

pub_date

2000-06-01 00:00:00

pages

460-3

issue

3

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(00)95775-5

journal_volume

77

pub_type

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