Fatty acid composition of lysophosphatidic acid and lysophosphatidylinositol in plasma from patients with ovarian cancer and other gynecological diseases.

abstract：OBJECTIVE:It has been postulated that gemcitabine inhibits DNA repair, and platinum resistance is due to increased DNA repair activity. The addition of gemcitabine to platinum-based agents may have synergistic tumoricidal activity. METHODS:Retrospective chart review of all patients with recurrent, persistent, or progr...

journal_title：Gynecologic oncology

authors： Villella J,Marchetti D,Odunsi K,Rodabaugh K,Driscoll DL,Lele S

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVES:Diagnosis and treatment for a life threatening illness such as cancer are known to be psychologically impactful. However, little is known about the influence that non-cancer life stressors have on the quality of life (QOL) of ovarian cancer patients. The goal of the present study was to examine associations ...

journal_title：Gynecologic oncology

authors： Lutgendorf SK,Slavich GM,Degeest K,Goodheart M,Bender D,Thaker PH,Penedo F,Zimmerman B,Lucci J 3rd,Mendez L,Collins K,Sood AK

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVES:Lymphovascular space invasion (LVSI) is an independent risk factor for recurrence and poor survival in early-stage endometrioid endometrial cancer (EEC), but optimal adjuvant treatment is unknown. We aimed to compare the survival of women with early-stage EEC with LVSI treated postoperatively with observatio...

journal_title：Gynecologic oncology

authors： Beavis AL,Yen TT,Stone RL,Wethington SL,Carr C,Son J,Chambers L,Michener CM,Ricci S,Burkett WC,Richardson DL,Staley AS,Ahn S,Gehrig PA,Torres D,Dowdy SC,Sullivan MW,Modesitt SC,Watson C,Veade A,Ehrisman J,Havril

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to examine whether comorbidity is an independent prognostic factor for 3129 women diagnosed with ovarian cancer from 2005 to 2011. As Performance status (PS) might capture the impact of comorbidity we addressed whether comorbidity can be explained by PS or whether comorbidity has an i...

journal_title：Gynecologic oncology

authors： Sperling C,Noer MC,Christensen IJ,Nielsen ML,Lidegaard Ø,Høgdall C

更新日期：2013-04-01 00:00:00

abstract：:A total of 246 endocervical samples were collected for Papanicolaou staining and one-parameter flow cytometric DNA analysis (FCDA) using 4',6-diamidino-2-phenylindole as a DNA stain. Typical histograms derived from FCDA analysis were designated class I, II, III, and V. Two groups of patients were studied: 135 women re...

journal_title：Gynecologic oncology

authors： Tsou KC,Pearson S,Atkinson BF,Giuntoli R,Mangan C

更新日期：1983-06-01 00:00:00

abstract：:In a study designed to determine the merit of preserving ovarian function and childbearing capability in women with unilateral malignant ovarian tumors, the results of radical surgery (n = 86) and conservative surgery (n = 106) were compared. The mean length of survival was slightly but not significantly shorter follo...

journal_title：Gynecologic oncology

authors： Miyazaki T,Tomoda Y,Ohta M,Kano T,Mizuno K,Sakakibara K

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVE:To evaluate clinicopathological factors and survival outcome of patients with advanced epithelial ovarian carcinoma undergoing multiple bowel resections to achieve optimal (< or = 1 cm) cytoreduction. METHODS:A case-control study was performed identifying patients undergoing optimal primary cytoreductive sur...

journal_title：Gynecologic oncology

authors： Salani R,Zahurak ML,Santillan A,Giuntoli RL 2nd,Bristow RE

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:The aim of this study is to evaluate the efficacy of intraperitoneal cisplatin as consolidation treatment in epithelian ovarian cancer patients with complete pathologic response following front-line platin-based chemotherapy. PATIENTS AND METHODS:Thirty patients who had no evidence of disease as assessed by ...

journal_title：Gynecologic oncology

authors： Topuz E,Eralp Y,Saglam S,Saip P,Aydiner A,Berkman S,Yavuz E

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:The aim of this trial was to investigate the efficacy and toxicity of a relative high-dose of topotecan combined with carboplatin in recurrent or persistent epithelial ovarian cancer (EOC). METHODS:Patients participating in this phase II trial received topotecan at a dose of 1.0 mg/m(2)/day intravenously (IV...

journal_title：Gynecologic oncology

authors： Kang H,Kim TJ,Lee YY,Choi CH,Lee JW,Bae DS,Kim BG

更新日期：2009-08-01 00:00:00

abstract：:The accuracy of preconization cytology and histology was evaluated in 536 patients undergoing combination laser conization. Exact agreement between cytology and cone diagnosis was observed in 41.8% of the patients. The lowest agreement, 13.6% was demonstrated in cytologic cervical intraepithelial neoplasia (CIN) I, th...

journal_title：Gynecologic oncology

authors： Andersen ES,Nielsen K,Pedersen B

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVE:The concept of "platinum sensitivity" has been widely applied in the management of recurrent ovarian cancer. This study aimed to evaluate the applicability of this concept to recurrent endometrial cancer. PATIENTS AND METHODS:In this multicenter retrospective cohort study, the clinical data of patients with ...

journal_title：Gynecologic oncology

authors： Nagao S,Nishio S,Michimae H,Tanabe H,Okada S,Otsuki T,Tanioka M,Fujiwara K,Suzuki M,Kigawa J

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:Invasion of the extracellular matrix and blood vessels by malignant neoplasms, with subsequent distant dissemination, is a key event in tumor progression. This process appears to be mediated largely through the action of matrix metalloproteinases (MMPs), a family of proteolytic enzymes produced by both stroma...

journal_title：Gynecologic oncology

authors： Davidson B,Goldberg I,Kopolovic J,Lerner-Geva L,Gotlieb WH,Weis B,Ben-Baruch G,Reich R

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVES:Chemotherapy is the preferred therapeutic approach for the therapy of advanced ovarian cancer, but a successful long-term treatment is prevented by the development of drug resistance. Recent works have underlined the involvement of non-coding RNAs, microRNAs (miRNAs) in cancer development, with several conje...

journal_title：Gynecologic oncology

authors： Sorrentino A,Liu CG,Addario A,Peschle C,Scambia G,Ferlini C

更新日期：2008-12-01 00:00:00

abstract：:Nucleolar Organizer Regions (NORs) code for ribosomal RNA and are thought to be an accurate representation of the percentage of cells in S-phase. NORs are associated with nonhistone nucleoproteins, which can be stained with silver (AgNORs). An increased number of AgNORs has been observed in many malignancies. AgNORs w...

journal_title：Gynecologic oncology

authors： Chalas E,Chumas J,Barbieri R,Mann WJ

更新日期：1991-03-01 00:00:00

abstract：:Didemnin B was administered to 24 women with recurrent squamous cell cervical carcinoma. The initial dose was 4.2 mg/m2, intravenously, repeated every 28 days. Twenty-three patients were evaluable for toxicity and twenty-one for response. Toxicity was mild, consisting mainly of nausea and vomiting. There were no objec...

journal_title：Gynecologic oncology

authors： Jacobs AJ,Blessing JA,Munoz A

更新日期：1992-03-01 00:00:00

abstract：OBJECTIVE:In 2008 GROINSS-V-I, the largest validation trial on the sentinel node (SN) procedure in vulvar cancer, showed that application of the SN-procedure in patients with early-stage vulvar cancer is safe. The current study aimed to evaluate long-term follow-up of these patients regarding recurrences and survival. ...

journal_title：Gynecologic oncology

authors： Te Grootenhuis NC,van der Zee AG,van Doorn HC,van der Velden J,Vergote I,Zanagnolo V,Baldwin PJ,Gaarenstroom KN,van Dorst EB,Trum JW,Slangen BF,Runnebaum IB,Tamussino K,Hermans RH,Provencher DM,de Bock GH,de Hullu JA,Oo

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To determine the feasibility of docetaxel-cisplatin combination therapy compared with docetaxel-carboplatin combination therapy as first-line chemotherapy for patients with ovarian cancer. METHODS:Fifty patients with International Federation of Gynecology and Obstetrics stage Ic-IV ovarian cancer who underwe...

journal_title：Gynecologic oncology

authors： Minagawa Y,Kigawa J,Kanamori Y,Itamochi H,Terakawa N,Okada M,Kitada F

更新日期：2006-06-01 00:00:00

abstract：:Mullerian Inhibiting Substance (MIS), a fetal testicular product that causes regression of the Mullerian duct in the male mammalian embryo, was evaluated for its antitumor effect on the premise that a substance active against this genital precursor in the fetus might also be active against tumors derived from these ti...

journal_title：Gynecologic oncology

authors： Fuller AF Jr,Krane IM,Budzik GP,Donahoe PK

更新日期：1985-10-01 00:00:00

abstract：OBJECTIVE:For many years, BRCA mutational status has only been considered as a predictor of ovarian cancer susceptibility and as a prognostic factor. Nonetheless, in the era of precision medicine, it has also become a predictive biomarker of response to platinum-based-chemotherapy and, more recently, to PARP-inhibitors...

journal_title：Gynecologic oncology

authors： Marchetti C,Minucci A,D'Indinosante M,Ergasti R,Arcieri M,Capoluongo ED,Pietragalla A,Caricato C,Scambia G,Fagotti A

更新日期：2020-09-01 00:00:00

abstract：:In a prospective, randomized, double-blind trial the combination betamethasone-dixyrazine was compared with high-dose metoclopramide as antiemetic treatment during combination chemotherapy (melphalan-doxorubicin and cisplatin) of ovarian carcinoma. Of 40 evaluable patients, 15 (38%) had previous experience with chemot...

journal_title：Gynecologic oncology

authors： Sorbe B,Hallén C

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:High fatality in ovarian cancer is attributed to metastasis, propagated by the release of multi-cellular aggregates/spheroids into the peritoneal cavity and their subsequent mesothelial invasion of peritoneal organs. Spheroids are therefore a common and clinically relevant in vitro model for ovarian cancer r...

journal_title：Gynecologic oncology

authors： Gunay G,Kirit HA,Kamatar A,Baghdasaryan O,Hamsici S,Acar H

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Radiation-induced or -associated sarcoma is a rare event which has been well described in the literature. However, this entity has been infrequently described in association with genital tract malignancies. To our knowledge it has never been described in association with the management of vulvar cancer. CAS...

journal_title：Gynecologic oncology

authors： Hyde S,Uitterhoeve LJ,Schilthuis MS,ten Kate FJ,van der Velden J

更新日期：2001-05-01 00:00:00

abstract：:A retrospective evaluation of 87 cases of uterine sarcoma treated during 1965-1980 at two Swedish hospitals has been made. Adjuvant postoperative radiotherapy has been compared with adjuvant chemotherapy. Various types of combination treatments were also evaluated. Both types of adjuvant therapy seem to reduce the fai...

journal_title：Gynecologic oncology

authors： Sorbe B

更新日期：1985-03-01 00:00:00

abstract：OBJECTIVES:Pegylated liposomal doxorubicin is one of the preferred alternatives for ovarian cancer patients with early relapse (<6 months) and taxane/carboplatin for late relapse (>12 months), but the optimal therapy for the partially platinum-sensitive (6-12 months) population has not been defined. This single-arm pha...

journal_title：Gynecologic oncology

authors： Power P,Stuart G,Oza A,Provencher D,Bentley JR,Miller WH Jr,Pouliot JF

更新日期：2009-09-01 00:00:00

abstract：:Relative and population attributable risks for invasive cervical cancer in different age strata relative to screening practices have been estimated using data from a case-control study conducted since 1981 in the greater Milan area, northern Italy. A total of 548 women under 75 years of age with a histologically confi...

journal_title：Gynecologic oncology

authors： Parazzini F,Negri E,La Vecchia C,Bocciolone L

更新日期：1990-07-01 00:00:00

abstract：OBJECTIVE:The host-tumor interactions and tumor stroma may participate in the regulation of invasive behavior of tumor cells. In order to better understand the human ovarian cancer invasion we explored the possibility that normal fibroblasts could participate in the control of the spread of human ovarian cancer. RESUL...

journal_title：Gynecologic oncology

authors： Westerlund A,Hujanen E,Puistola U,Turpeenniemi-Hujanen T

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVE:The objective was to determine the frequency with which regression or progression of disease without treatment occurred in women diagnosed with squamous cell cervical carcinoma in situ (CIS) during pregnancy. METHODS:. A retrospective chart review of all women evaluated at the University of Iowa Colposcopy C...

journal_title：Gynecologic oncology

authors： Coppola A,Sorosky J,Casper R,Anderson B,Buller RE

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:While ovarian borderline tumors are common, their fallopian tube counterparts are extremely rare. We describe the first case of a serous borderline paratubal tumor with a review of the literature on paratubal and tubal low malignant potential tumors. CASE:A 26 year-old woman presented with acute onset of sh...

journal_title：Gynecologic oncology

authors： Seamon LG,Holt CN,Suarez A,Richardson DL,Carlson MJ,O'Malley DM

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:To analyze quality of life (QOL) in a randomized, placebo-controlled phase III trial concluding that the addition of concurrent and maintenance bevacizumab (Arm 3) to carboplatin and paclitaxel prolongs progression-free survival in front-line treatment of advanced ovarian cancer compared to chemotherapy alone (...

journal_title：Gynecologic oncology

authors： Monk BJ,Huang HQ,Burger RA,Mannel RS,Homesley HD,Fowler J,Greer BE,Boente M,Liang SX,Wenzel L

更新日期：2013-03-01 00:00:00

abstract：:All patients with bulky (> or =4 cm) Stage Ib or IIa cervical carcinoma treated at Chang Gung Memorial Hospital between August 1988 and December 1991 using a strategy of neoadjuvant chemotherapy with cisplatin, vincristine, and bleomycin and radical hysterectomy were reviewed. Fifty-nine evaluable patients received 1 ...

journal_title：Gynecologic oncology

authors： Lai CH,Hsueh S,Chang TC,Tseng CJ,Huang KG,Chou HH,Chen SM,Chang MF,Shum HC

更新日期：1997-03-01 00:00:00