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Mullerian inhibiting substance reduction of colony growth of human gynecologic cancers in a stem cell assay.

Abstract：

:Mullerian Inhibiting Substance (MIS), a fetal testicular product that causes regression of the Mullerian duct in the male mammalian embryo, was evaluated for its antitumor effect on the premise that a substance active against this genital precursor in the fetus might also be active against tumors derived from these tissues. Increasingly pure fractions of biologically active MIS, prepared from newborn calf testes, were tested in the soft agar colony inhibition assay against single cell suspensions of fresh tumors derived in ascitic or solid form from patients with gynecologic malignancies. Twenty-eight tumor specimens placed in soft agar culture have provided sufficient growth to assess an MIS effect. Twenty-five of these 28 tumors showed significant colony inhibition after incubation with MIS. Increased antitumor response correlated with increased purification of MIS when the same tumor was treated with preparations of different purity. Samples obtained from the same patient at different times, from both ascites and solid tumor sources, produced nearly identical responses to MIS. MIS preparations, previously shown to be active in microcytotoxicity and colony inhibition assays against established human ovarian and endometrial carcinoma lines demonstrate consistent antitumor activity against fresh human gynecologic cancers removed at surgery.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Fuller AF Jr,Krane IM,Budzik GP,Donahoe PK

doi

10.1016/0090-8258(85)90019-8

subject

Has Abstract

pub_date

1985-10-01 00:00:00

pages

135-48

issue

2

eissn

0090-8258

issn

1095-6859

journal_volume

22

pub_type

杂志文章

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