Endometrial stromal sarcoma: objective response to letrozole.

abstract：OBJECTIVES:Few studies have comprehensively tested all ovarian cancer patients for BRCA1 and BRCA2 (BRCA1/2) mutations. We sought to determine if clinically identified mutation carriers differed in clinical characteristics and outcomes from mutation carriers not identified during routine clinical care. METHODS:We incl...

journal_title：Gynecologic oncology

authors： Norquist BM,Pennington KP,Agnew KJ,Harrell MI,Pennil CC,Lee MK,Casadei S,Thornton AM,Garcia RL,Walsh T,Swisher EM

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:Approximately one third of patients treated with methotrexate for gestational trophoblastic neoplasia (GTN) following a molar pregnancy are reported to develop resistance to methotrexate and need to change to different chemotherapeutic agents. Previous studies, in other clinical settings, have suggested that ...

journal_title：Gynecologic oncology

authors： Lasecka L,Dixon PH,Molokhia M,Sharma N,Schleh A,Wang CM,Steel JH,Seckl MJ,Savage PM,Fisher RA

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:To estimate the likelihood of occult cancer diagnosis at prophylactic oophorectomy in BRCA1 and BRCA2 carriers in different age groups and to determine the histopathology of these lesions. METHODS:We describe a series of 159 female BRCA1 or BRCA2 carriers who underwent prophylactic oophorectomy at the Univer...

journal_title：Gynecologic oncology

authors： Finch A,Shaw P,Rosen B,Murphy J,Narod SA,Colgan TJ

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Brain metastases (BM) from epithelial ovarian cancer (EOC) are considered a rare and unfavourable event. There is no consensus regarding the best management of these patients. METHODS:A multicenter retrospective analysis of patients with BM from EOC treated between 1997 and 2014 in 18 institutions of the MI...

journal_title：Gynecologic oncology

authors： Marchetti C,Ferrandina G,Cormio G,Gambino A,Cecere S,Lorusso D,De Giorgi U,Bogliolo S,Fagotti A,Mammoliti S,Narducci F,Bergamini A,Scollo P,Biglia N,Breda E,Tamberi S,Marinaccio M,Angioli R,Salerno L,Eusebi MC,Loi

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:To determine the antitumor activity and toxicity profile of gemcitabine as second-line chemotherapy in patients with recurrent or persistent uterine leiomyosarcoma (LMS). METHODS:Intravenous gemcitabine was administered over 30 min at a dose of 1000 mg/m(2) on days 1, 8, 15, with cycles repeated every 28 day...

journal_title：Gynecologic oncology

authors： Look KY,Sandler A,Blessing JA,Lucci JA 3rd,Rose PG,Gynecologic Oncology Group (GOG) Study.

更新日期：2004-02-01 00:00:00

abstract：:Radical vulvectomy using warm-knife and open-wound techniques was performed as the first step in a two-phase surgical approach in 274 patients with malignant vulvar tumors. Crude 5-year survival was registered in 133/223 (60%) patients. The complication rate was low and the hospitalization period was short (mean 16 da...

journal_title：Gynecologic oncology

authors： Simonsen E,Johnsson JE,Tropé C

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVES:Uterine adenosarcomas (AS) are rare tumors composed of malignant stromal and benign epithelial components. We sought to evaluate the role of primary surgery, adjuvant treatments, and salvage therapies for patients with uterine adenosarcomas. METHODS:We identified all patients diagnosed with AS from 1990 to ...

journal_title：Gynecologic oncology

authors： Tanner EJ,Toussaint T,Leitao MM Jr,Hensley ML,Soslow RA,Gardner GJ,Jewell EL

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Paranasal sinus metastasis following endometrial carcinoma is extremely rare and a reflection of disseminated disease. CASE:We report a case of a 72-year-old woman who presented ethmoid and sphenoid sinus metastasis, 14 months after total abdominal hysterectomy and bilateral salpingo-oophorectomy due to an ...

journal_title：Gynecologic oncology

authors： Ilvan S,Akyildiz EU,Calay Z,Celikoyar M,Sahinler I

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:To test if TP53 hot spot mutations (HSMs) confer differential chemotherapy resistance or survival outcomes, the effects of microtubule stabilizers on human ovarian carcinoma cells (OCCs) expressing TP53 HSMs were studied in vitro. Survival outcomes of patients with high grade serous epithelial ovarian carcino...

journal_title：Gynecologic oncology

authors： Seagle BL,Yang CP,Eng KH,Dandapani M,Odunsi-Akanji O,Goldberg GL,Odunsi K,Horwitz SB,Shahabi S

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:Paclitaxel is most commonly infused over 3 hs rather than the original schedule of 24 h as the briefer infusion duration results in greater convenience, similar efficacy, significantly less myelosuppression, and less cost. While differences in toxicity between 3- and 24-h infusions are well described, there i...

journal_title：Gynecologic oncology

authors： Jennens R,Rischin D,Yuen K,Toner G,Millward M

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVES:The aim of the study is to determine whether critical pathways can be implemented at an academic institution to limit cost, without compromising patient satisfaction and quality of care. PATIENTS AND METHODS:Patients undergoing a hysterectomy with either cervical or endometrial cancer were placed on specifi...

journal_title：Gynecologic oncology

authors： Ghosh K,Downs LS,Padilla LA,Murray KP,Twiggs LB,Letourneau CM,Carson LF

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:Retinoids are important modulators of cell growth, differentiation, and proliferation. 9cUAB30, 9cUAB124, and 9cUAB130 are three novel retinoid compounds that show cytotoxic effects in other malignancies. We evaluated these novel retinoids in combination with chemotherapy against ovarian cancer stem cells (CS...

journal_title：Gynecologic oncology

authors： Whitworth JM,Londoño-Joshi AI,Sellers JC,Oliver PJ,Muccio DD,Atigadda VR,Straughn JM Jr,Buchsbaum DJ

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:The purpose of this case-controlled study was to determine the prevalence of anemia and incidence of perioperative blood transfusions in patients undergoing treatment for advanced ovarian cancer with neoadjuvant chemotherapy (NACT) or primary debulking surgery (PDS). METHODS:We performed a single institution...

journal_title：Gynecologic oncology

authors： O'Shea A,McCool K,Harrison R,Sampene E,Connor J,Barroilhet L

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to analyze risk factors for septic complications during adjuvant chemotherapy and their impact on survival in patients with advanced epithelial ovarian cancer treated with neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS). METHODS:We retrospectively revie...

journal_title：Gynecologic oncology

authors： Son JH,Lee JH,Jung JA,Kong TW,Paek J,Chang SJ,Ryu HS

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:To compare surgical morbidity and clinical-pathologic factors for patients with endometrial cancer (EC) undergoing robotic-assisted laparoscopic hysterectomy (RALH) versus total abdominal hysterectomy (TAH) with aortic and/or pelvic lymphadenectomy (LA). METHODS:During the first 14 months of a robotics surgi...

journal_title：Gynecologic oncology

authors： DeNardis SA,Holloway RW,Bigsby GE 4th,Pikaart DP,Ahmad S,Finkler NJ

更新日期：2008-12-01 00:00:00

abstract：:Ovarian carcinoma usually presents in an indolent manner, most often nonspecifically with complaints of abdominal pain or swelling, bloating, constipation, anorexia, early satiety, and evidence of ascites. We present a case of ovarian cancer with a cerebrovascular accident (CVA) as the presenting symptom, with minimal...

journal_title：Gynecologic oncology

authors： Shamonki MI,Squatrito RC,Welander CE

更新日期：1998-08-01 00:00:00

abstract：:Roughly one-third of patients with ataxia-telangiectasia (AT) develop malignant tumors, usually of lymphoid origin. AT patients also exhibit progeric changes. We describe three patients, between the ages of 27 and 32 years, with uterine tumors: one with a frank leiomyosarcoma and chronic T-cell leukemia, one with a mu...

journal_title：Gynecologic oncology

authors： Gatti RA,Nieberg R,Boder E

更新日期：1989-02-01 00:00:00

abstract：OBJECTIVE:Proliferative activity (PA) may be an indicator of a neoplasm's malignant potential, and it has been described as a prognostic factor in different malignant tumors. It was our aim to study the prognostic significance of PA defined by Ki-S5 and Ki-S2 immunohistochemical staining in a large homogeneously treate...

journal_title：Gynecologic oncology

authors： Kommoss S,du Bois A,Schmidt D,Parwaresch R,Pfisterer J,Kommoss F

更新日期：2006-10-01 00:00:00

abstract：:Two cases with squamous cell carcinoma of the cervix stage IIB with primary tumor mass about 2 X 2 X 2 cm were treated with primary chemotherapy of cis-platinum, 20 micrograms/m2 body surface intravenously daily for 5 consecutive days. Papanicolaou smear turned negative after two courses of chemotherapy in both cases....

journal_title：Gynecologic oncology

authors： Kim DS,Moon H,Kang KJ

更新日期：1985-09-01 00:00:00

abstract：:Melanoma represents the second most frequent vulvar malignancy, and yet is still considered to be an uncommon neoplasm. Several varieties of melanoma exist. A patient who was diagnosed with a rare subtype of melanoma as a primary vulvar process is presented here. To date, there is only one other reported case of neuro...

journal_title：Gynecologic oncology

authors： Byrne PR,Maiman M,Mikhail A,Harris M,Rosen Y

更新日期：1995-02-01 00:00:00

abstract：OBJECTIVES:The effect on progesterone and estrogen receptor expression in glands and stroma after two different treatment regimens of endometrial hyperplasia was determined. METHODS:Pre- and post-treatment paraffin-embedded endometrial hyperplasia specimens from women treated with levonorgestrel (LNG) intrauterine dev...

journal_title：Gynecologic oncology

authors： Vereide AB,Kaino T,Sager G,Arnes M,Ørbo A

更新日期：2006-05-01 00:00:00

abstract：:After standard management of stage III-IV ovarian cancer patients by surgical reduction of tumor mass and subsequent cisplatin-based combination chemotherapy, eradication of residual intraabdominal disease remains a major clinical problem. In an effort to increase response to therapy without adding marrow toxicity, af...

journal_title：Gynecologic oncology

authors： Campora E,Bruzzone M,Chiara S,Alama A,Iskra L,Carnino F,Parodi S,Foglia G,Ragni N,Rosso R

更新日期：1990-04-01 00:00:00

abstract：:From September 1986 to November 1988, 38 patients with previously untreated ovarian cancer, FIGO stages III and IV, were allocated to a study testing the efficacy of high-dose platinum delivered as combined carboplatin and cisplatin. The regimen was as follows: Day 1, 250-350 mg/m2 carboplatin and 500 mg/m2 cyclophosp...

journal_title：Gynecologic oncology

authors： Bertelsen K,Bastholt L

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the clinicopathological features of ovarian Sertoli-Leydig cell tumors (SLCTs) and to explore the reasonable therapy. METHODS:A total of 40 cases of SLCTs were retrospectively reviewed. RESULTS:The incidence of SLCTs was 0.41%, with a median age of 28 years. All tumors were confined to one ovary...

journal_title：Gynecologic oncology

authors： Gui T,Cao D,Shen K,Yang J,Zhang Y,Yu Q,Wan X,Xiang Y,Xiao Y,Guo L

更新日期：2012-11-01 00:00:00

abstract：:Between October 1985 and January 1989, 33 patients with stage I (31) or clinically occult stage II (2) endometrial cancer at a high risk for recurrence were entered in a prospective study evaluating adjuvant cisplatin, doxorubicin, and cyclophosphamide (PAC) chemotherapy. Eligibility criteria included grade 2 tumors w...

journal_title：Gynecologic oncology

authors： Stringer CA,Gershenson DM,Burke TW,Edwards CL,Gordon AN,Wharton JT

更新日期：1990-09-01 00:00:00

abstract：:To determine the effects of neoadjuvant chemotherapy (NAC) in the management of cervical carcinoma Stage IB2 (tumor diameter > 4 cm), we reviewed 52 surgically treated patients diagnosed between January 1987 and December 1993. There were 20 patients treated with preoperative neoadjuvant chemotherapy and 32 treated by ...

journal_title：Gynecologic oncology

authors： Serur E,Mathews RP,Gates J,Levine P,Maiman M,Remy JC

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:This study explores patterns of lifestyle change and whether more threatening illness perceptions are associated with lifestyle changes post-treatment for smoking, alcohol consumption and Body Mass Index (BMI) among gynecological cancer patients. METHODS:In total, 395 cancer patients (N=221 endometrial; N=17...

journal_title：Gynecologic oncology

authors： van Broekhoven MECL,de Rooij BH,Pijnenborg JMA,Vos MC,Boll D,Kruitwagen RFPM,van de Poll-Franse LV,Ezendam NPM

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:The natural history of the development of ovarian carcinoma is not known. It also remains undetermined whether ovarian carcinomas develop from benign and/or borderline malignant tumors or arise de novo from the ovarian surface epithelium. METHODS:To address these issues clinicopathologically, we reviewed the...

journal_title：Gynecologic oncology

authors： Horiuchi A,Itoh K,Shimizu M,Nakai I,Yamazaki T,Kimura K,Suzuki A,Shiozawa I,Ueda N,Konishi I

更新日期：2003-03-01 00:00:00

abstract：:Of a group of 68 patients treated with standard polychemotherapy (CAP-5), 52 were evaluated by an early second-look laparotomy, preferably after three cycles of treatment. Of 21 patients with initial tumor residuals smaller than 2 cm, only 5 had residual tumor, and of 31 patients with tumor larger than 2 cm, 27 had re...

journal_title：Gynecologic oncology

authors： van Lith JM,Bouma J,Aalders JG,Boonstra H,Sleijfer DT,Willemse PH

更新日期：1989-11-01 00:00:00

abstract：:To determine the best noninvasive means of evaluating response in patients with advanced ovarian carcinoma, 50 abdominal ultrasound (US) and computed tomography (CT) scans were performed in clinically disease-free ovarian cancer patients. The scans were correlated with the results obtained at a subsequent second- or t...

journal_title：Gynecologic oncology

authors： Lund B,Jacobsen K,Rasch L,Jensen F,Olesen K,Feldt-Rasmussen K

更新日期：1990-05-01 00:00:00