Role of an early second-look laparotomy in ovarian cancer.

Abstract:

:Of a group of 68 patients treated with standard polychemotherapy (CAP-5), 52 were evaluated by an early second-look laparotomy, preferably after three cycles of treatment. Of 21 patients with initial tumor residuals smaller than 2 cm, only 5 had residual tumor, and of 31 patients with tumor larger than 2 cm, 27 had residuals, which could be surgically debulked in 9 patients. Surgical evaluation led to termination of treatment in 6 patients with stable disease and to intensification of treatment in 5 younger patients with microscopic or bulky residuals. Thus, the second-look influenced therapeutic decisions and treatment policy in a total of 20 patients. The procedure went without severe complications for the duration of anesthesia; there was no difference between biopsy and debulking, but a larger amount of blood was lost during debulking surgery. Second-look laparotomy is well tolerated but should be performed only in selected cases, depending on the therapeutic options available.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

van Lith JM,Bouma J,Aalders JG,Boonstra H,Sleijfer DT,Willemse PH

doi

10.1016/0090-8258(89)90055-3

subject

Has Abstract

pub_date

1989-11-01 00:00:00

pages

255-8

issue

2

eissn

0090-8258

issn

1095-6859

journal_volume

35

pub_type

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