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Prognostic implications of large volume residual disease in patients with advanced stage epithelial ovarian cancer.

Abstract：

:Thirty-two patients with Stage III or IV epithelial ovarian cancer and residual tumor volumes in excess of 2 cm in diameter after initial debulking were treated with platinum and cyclophosphamide chemotherapy. Twenty-seven patients (84%) received at least six courses of chemotherapy. Six patients developed grade 3 or 4 hematologic toxicity and one patient died with granulocytopenia and sepsis. The actuarial survival of the total group of patients was 78% at 12 months, 27% at 24 months, and 11% at 36 month. Of patients with residual disease 2-4 cm in diameter, 82% were alive 12 months after diagnosis and 46% were alive at 24 months. In contrast, patients with greater than 4 cm residual disease had a 12-month survival of 73% and a 24-month survival of only 7%. The size of residual tumor after surgery remains a very important prognostic factor in patients treated with platinum-based combination chemotherapy. Reoperation with further tumor debulking should be considered in ovarian cancer patients referred for chemotherapy with large volume residual disease to maximize response to combination chemotherapy.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Gallion HH,van Nagell JR,Donaldson ES,Hanson MB,Kryscio RJ

doi

10.1016/0090-8258(87)90296-4

subject

Has Abstract

pub_date

1987-06-01 00:00:00

pages

220-5

issue

2

eissn

0090-8258

issn

1095-6859

pii

0090-8258(87)90296-4

journal_volume

27

pub_type

杂志文章

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