Trastuzumab with carboplatin/paclitaxel for treatment of advanced stage and recurrent uterine papillary serous carcinoma: A cost-effectiveness analysis.


OBJECTIVE:Uterine papillary serous carcinoma (UPSC) is a variant of endometrial cancer that is aggressive and associated with poor outcomes. We sought to evaluate the cost effectiveness of carboplatin/paclitaxel alone versus carboplatin/paclitaxel with trastuzumab among patients with Her2/neu-positive advanced or recurrent UPSC. METHODS:We designed a Markov model in TreeAge Pro 2019 software to simulate management of a theoretical cohort of 4000 patients with Her2/neu-positive advanced or recurrent uterine papillary serous carcinoma (UPSC) followed for four years. In the carboplatin/paclitaxel with trastuzumab strategy, we included the cost of testing for Her2/neu status. We obtained all model inputs from the literature and a societal perspective was assumed. Outcomes included progression-free survival, progression, UPSC-specific mortality, cost, and quality-adjusted life years (QALYs). The intervention was considered cost effective if the incremental cost-effectiveness ratio (ICER) was below the willingness-to-pay threshold of $100,000 per QALY. Sensitivity analyses were used to determine the robustness of the results. RESULTS:In our theoretical cohort of 4000 women, treatment with the addition of trastuzumab resulted in 637 fewer deaths and 627 fewer cases of progression compared with treatment with carboplatin/paclitaxel alone. Treatment with trastuzumab was associated with an additional cost of $144,335,895, but was associated with an increase of 2065 QALYs. The ICER was $69,903 per QALY, which was below our willingness-to-pay threshold. Sensitivity analysis demonstrated that this treatment strategy was cost-effective until the cost of 6 months of treatment surpassed $38,505 (baseline input: $27,562). CONCLUSION:We found that the addition of trastuzumab to carboplatin/paclitaxel was a cost-effective treatment strategy for patients with advanced/recurrent Her2/neu-positive UPSC.


Gynecol Oncol


Gynecologic oncology


Batman S,Bohn J,Weisenberger MW,Hersh A,Bruegl A,Caughey A,Winter W 3rd




Has Abstract


2021-01-01 00:00:00














  • Selenium-Binding Protein 1 expression in ovaries and ovarian tumors in the laying hen, a spontaneous model of human ovarian cancer.

    abstract:OBJECTIVE:Reduced Selenium-Binding Protein 1 (SELENBP1) expression was recently shown in multiple cancers. There is little information on the expression and function of SELENBP1 in cancer progression. In order to develop a better understanding of the role of SELENBP1 in ovarian cancer, our objective was to determine if...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Stammer K,Edassery SL,Barua A,Bitterman P,Bahr JM,Hales DB,Luborsky JL

    更新日期:2008-04-01 00:00:00

  • The inherent cellular radiosensitivity of epithelial ovarian carcinoma.

    abstract::Ovarian carcinomas of similar histology have variable responses to radiation therapy. It has been suggested that inherent cellular resistance to radiation may in part underlie radiotherapy failure. To determine in vitro radiobiological parameters of papillary serous adenocarcinoma of the ovary, we investigated the cel...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Rotmensch J,Schwartz JL,Atcher RW,Grdina DJ,Toohill M,Weichselbaum RW

    更新日期:1989-12-01 00:00:00

  • Distribution of involucrin in normal and pathological human uterine cervix.

    abstract::A study was undertaken to determine the potential value of involucrin immunostaining, a protein synthesized by mature squamous epithelial cells, in distinguishing benign from neoplastic lesions in cervical pathology. A total of 146 cervical biopsies were analyzed using an indirect immunoperoxidase method and polyclona...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Serra V,Ramirez AA,Lara C,Marzo C,Castells A,Bonilla-Musoles F

    更新日期:1990-01-01 00:00:00

  • Epigenetics of ovarian cancer: from the lab to the clinic.

    abstract:OBJECTIVE:Ovarian cancer remains the most lethal gynaecological cancer. Various molecular changes have been identified and have shown promise for their diagnostic, prognostic and curative capacity but still need further validation. Among different mechanisms, the present article reviews the importance of epigenetic cha...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Asadollahi R,Hyde CA,Zhong XY

    更新日期:2010-07-01 00:00:00

  • Carboplatin/gemcitabine alternating with carboplatin/pegylated liposomal doxorubicin and carboplatin/cyclophosphamide in platinum-refractory/resistant paclitaxel - pretreated ovarian carcinoma.

    abstract:OBJECTIVE:In this phase II study the efficacy and toxicity of an alternating chemotherapy regimen was examined in platinum-resistant relapsed epithelial ovarian cancer (EOC) patients. METHODS:Forty-five patients with platinum-refractory/resistant relapsed EOC, previously treated with carboplatin+paclitaxel+/-epirubici...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Pectasides D,Pectasides E,Papaxoinis G,Psyrri A,Pliarchopoulou K,Koumarianou A,Macheras A,Athanasas G,Xiros N,Economopoulos T

    更新日期:2010-07-01 00:00:00

  • Ovarian management at the time of radical hysterectomy for cancer of the cervix.

    abstract::Ovarian management at the time of radical hysterectomy for cervical cancer was reviewed retrospectively over a 7-year period. All patients had early-stage cancer except three who had stage IIB disease. Approximately 80% of patients had squamous cancer and 20% adenocarcinoma or adenosquamous carcinoma. The mean age was...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Owens S,Roberts WS,Fiorica JV,Hoffman MS,LaPolla JP,Cavanagh D

    更新日期:1989-12-01 00:00:00

  • Routine lymph node dissection in the treatment of early stage cancer: are we doing the right thing?

    abstract::The role of elective lymphadenectomy in the treatment of patients with early-stage malignancies, although still commonly performed, remains a matter of controversy. This issue is important in the management of cancers and raises questions about the biologic interpretation of their natural history and about motives for...

    journal_title:Gynecologic oncology

    pub_type: 社论


    authors: Santin AD,Parham GP

    更新日期:1998-01-01 00:00:00

  • Prothrombin fragment F 1 + 2 plasma concentrations in patients with gynecologic malignancies.

    abstract::Malignant diseases have been shown to cause hypercoagulable states. Elevated prothrombin fragment F 1 + 2 plasma levels occur, when prothrombin is converted into thrombin by factor Xa. In order to evaluate the role of prothrombin fragment F 1 + 2 as an indicator for hemostatic disorders in patients with gynecologic ma...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Hanzal E,Tatra G

    更新日期:1993-06-01 00:00:00

  • Predictive value of the Age-Adjusted Charlson Comorbidity Index on perioperative complications and survival in patients undergoing primary debulking surgery for advanced epithelial ovarian cancer.

    abstract:OBJECTIVE:To assess the ability of the Age-Adjusted Charlson Comorbidity Index (ACCI) to predict perioperative complications and survival in patients undergoing primary debulking for advanced epithelial ovarian cancer (EOC). METHODS:Data were analyzed for all patients with stage IIIB-IV EOC who underwent primary cytor...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Suidan RS,Leitao MM Jr,Zivanovic O,Gardner GJ,Long Roche KC,Sonoda Y,Levine DA,Jewell EL,Brown CL,Abu-Rustum NR,Charlson ME,Chi DS

    更新日期:2015-08-01 00:00:00

  • Vulvar intraepithelial neoplasia in women infected with human immunodeficiency virus-1.

    abstract::The purpose of this study was to determine the response of vulvar intraepithelial neoplasia (VIN) lesions to standard treatment methods in women infected with human immunodeficiency virus (HIV). We reviewed all cases of VIN over a 4-year period at an inner-city hospital. We reviewed the clinical records of these women...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Korn AP,Abercrombie PD,Foster A

    更新日期:1996-06-01 00:00:00

  • The NCI-MATCH trial and precision medicine in gynecologic cancers.

    abstract::The Precision Medicine Initiative is a National Cancer Institute (NCI) driven interdisciplinary collaborative effort to test the feasibility of trials incorporating genomic profiling when choosing patient therapies. The goal of the initiative is to generate the scientific evidence needed to move the concept of precisi...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Barroilhet L,Matulonis U

    更新日期:2018-03-01 00:00:00

  • Frozen section diagnoses of 578 ovarian tumors made by pathologists with and without expertise on gynecologic pathology.

    abstract:OBJECTIVE:Frozen section is an important diagnostic tool to determine the nature of the ovarian masses intraoperatively. The optimal surgical treatment can be achieved by classifying the masses as benign, borderline and malignant. The aim of this retrospective study was to evaluate the accuracy of frozen section diagno...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Bige O,Demir A,Saygili U,Gode F,Uslu T,Koyuncuoglu M

    更新日期:2011-10-01 00:00:00

  • A pilot randomized control trial to evaluate pelvic floor muscle training for urinary incontinence among gynecologic cancer survivors.

    abstract:OBJECTIVES:We previously reported high rates of urinary incontinence among gynecologic cancer survivors and aimed to evaluate the effectiveness of a simple intervention for treatment of urinary incontinence in this population. METHODS:We recruited 40 gynecologic cancer survivors who reported urinary incontinence on a ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,随机对照试验


    authors: Rutledge TL,Rogers R,Lee SJ,Muller CY

    更新日期:2014-01-01 00:00:00

  • A phase I study of weekly temsirolimus and topotecan in the treatment of advanced and/or recurrent gynecologic malignancies.

    abstract:OBJECTIVE:The mTOR inhibitor, temsirolimus, has clinical activity in the treatment of gynecologic malignancies, particularly endometrial cancer. We sought to determine the tolerability of the combination of weekly topotecan with weekly temsirolimus. METHODS:Women with a history of advanced or recurrent gynecologic mal...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Temkin SM,Yamada SD,Fleming GF

    更新日期:2010-06-01 00:00:00

  • The anterior Obturator Artery Perforator (aOAP) flap: surgical anatomy and application of a method for vulvar reconstruction.

    abstract:OBJECTIVE:Vulvar reconstruction following oncologic resection is challenging. Some flaps used for reconstruction can show adverse characteristics such as excessive tissue bulk or increased distance to the defect. Region of the sulcus genitofemoralis is of thin and pliable tissue proximate to the vulva. Vasculature and ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: O'Dey DM,Bozkurt A,Pallua N

    更新日期:2010-12-01 00:00:00

  • Large B-cell lymphoma of the uterine corpus: case report with immunohistochemical and molecular study.

    abstract::Primary lymphoma of the uterine corpus (PLUC) is an extremely rare neoplasm. We report a case of PLUC in a 78-year-old woman with vaginal bleeding without hepatosplenomegaly, adenopathies, or bone marrow infiltration, classified as stage I. A diagnosis of diffuse large B-cell lymphoma was made in endometrial curettage...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Alvarez A,Ortiz JA,Sacristán F

    更新日期:1997-06-01 00:00:00

  • Survival probability in ovarian clear cell adenocarcinoma.

    abstract:OBJECTIVE:The aim of this study was to evaluate the 5-year survival probability (SP) of patients treated for ovarian clear cell adenocarcinoma (OCCA) at a single tertiary institution and to compare it to the 5-year SP of patients with other histologic subtypes of epithelial ovarian cancer. METHODS:Sixty-four patients ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kennedy AW,Markman M,Biscotti CV,Emery JD,Rybicki LA

    更新日期:1999-07-01 00:00:00

  • Pattern of lymph node metastases in clinically unilateral stage I invasive epithelial ovarian carcinomas.

    abstract:PURPOSE:There is controversy regarding the pattern of lymphatic spread in unilateral stage I invasive ovarian carcinomas. The purpose of this study is to describe the incidence and distribution of lymph node (LN) metastases in ovarian carcinomas clinically confined to one ovary. METHODS:Ninety-six patients with diseas...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Cass I,Li AJ,Runowicz CD,Fields AL,Goldberg GL,Leuchter RS,Lagasse LD,Karlan BY

    更新日期:2001-01-01 00:00:00

  • Techniques of sentinel lymph node identification for early-stage cervical and uterine cancer.

    abstract::Techniques for sentinel lymph node injections have varied over the years in both cervical and uterine malignancy lymph node mapping. There remains considerable variation in techniques, particularly for uterine malignancies. This review summarizes some of the techniques that have been published and are currently utiliz...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Abu-Rustum NR,Khoury-Collado F,Gemignani ML

    更新日期:2008-11-01 00:00:00

  • Anticancer effects of (-)-epigallocatechin-3-gallate on ovarian carcinoma cell lines.

    abstract:PURPOSE:A constituent of green tea, (-)-epigallocatechin-3-gallate (EGCG), has been known to possess anti-cancer properties. In this study, we investigated the time-course anticancer effects of EGCG on human ovarian cancer cells to provide insights into the molecular-level understanding of growth suppression mechanism ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Huh SW,Bae SM,Kim YW,Lee JM,Namkoong SE,Lee IP,Kim SH,Kim CK,Ahn WS

    更新日期:2004-09-01 00:00:00

  • Therapy-related myeloid leukemia after treatment for epithelial ovarian carcinoma: an epidemiological analysis.

    abstract:OBJECTIVE:Therapy related acute myeloid leukemia (t-AML) is a potential late complication of cytotoxic therapy, and it is of particular concern in the treatment of patients with epithelial ovarian carcinoma (EOC) exposed to multiple courses of chemotherapy during the course of their disease. This study examines the inc...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Vay A,Kumar S,Seward S,Semaan A,Schiffer CA,Munkarah AR,Morris RT

    更新日期:2011-12-01 00:00:00

  • Adjunctive radiation after radical hysterectomy in stage IB squamous cell carcinoma of the cervix.

    abstract::The clinical-pathologic records of 178 women with stage IB squamous cell carcinoma treated by radical hysterectomy and pelvic node dissection were reviewed to assess prognostic factors and outcome in relation to adjunctive pelvic radiation. Among 32 women with pelvic nodes metastases, 19 treated with adjunctive radiat...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Remy JC,di Maio T,Fruchter RG,Sedlis A,Boyce JG,Sohn CK,Rotman M

    更新日期:1990-08-01 00:00:00

  • Recruitment and retention results for a population-based cervical cancer biobehavioral clinical trial.

    abstract:OBJECTIVE:Minority and low-income cancer patients are underrepresented in clinical trials, contributing to diminished access to state-of-the-art care and disparities in cancer outcomes including survivorship issues. In cervical cancer, there is a disproportionate disease burden among minority and underserved women and ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,随机对照试验


    authors: Osann K,Wenzel L,Dogan A,Hsieh S,Chase DM,Sappington S,Monk BJ,Nelson EL

    更新日期:2011-06-01 00:00:00

  • The prognostic significance of surgical staging for carcinoma of the endometrium.

    abstract::This study is based on a retrospective review of 156 patients with endometrial carcinoma from 1978 through 1984 who underwent primary surgical evaluation. All cases were retrospectively restaged using the newly adopted FIGO surgical staging. The preoperative FIGO clinical stage distribution for this study was as follo...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Wolfson AH,Sightler SE,Markoe AM,Schwade JG,Averette HE,Ganjei P,Hilsenbeck SG

    更新日期:1992-05-01 00:00:00

  • A predictive model combining human epididymal protein 4 and radiologic features for the diagnosis of ovarian cancer.

    abstract:OBJECTIVE:Ovarian cancer is the leading cause of death in women with gynecologic cancer. CA125 is the commonly used biomarker in the diagnosis of ovarian cancer, but has limitations in both sensitivity and specificity. Human Epididymal secretory protein (HE4) is a promising biomarker and is included in the Risk of Ovar...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Stiekema A,Lok CA,Kenter GG,van Driel WJ,Vincent AD,Korse CM

    更新日期:2014-03-01 00:00:00

  • Carcinoma of the cervix in association with uterine prolapse.

    abstract:BACKGROUND:Carcinoma of the cervix and a prolapsed uterus are common diseases in underdeveloped countries, but their association is quite rare. CASE:We report here the clinical characteristics of two Brazilian patients with carcinoma of the uterine cervix associated with a third-degree prolapsed uterus. The patients, ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: da Silva BB,da Costa Araújo R,Filho CP,Melo JA

    更新日期:2002-02-01 00:00:00

  • The performance of Dynamic Spectral Imaging colposcopy depends on indication for referrals.

    abstract::OBJECTIVE. A previous study has shown that Dynamic Spectral Imaging (DSI) colposcopy increases the sensitivity of the colposcopic examination in women referred with abnormal cytology. In this study we have reanalyzed the performance of DSI and conventional colposcopy for new referral conditions and for low-grade cytol...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Louwers JA,Zaal A,Kocken M,Berkhof J,Papagiannakis E,Snijders PJ,Meijer CJ,Verheijen RH

    更新日期:2015-12-01 00:00:00

  • Efficacy of intraperitoneal cisplatin as consolidation therapy in patients with pathologic complete remission following front-line therapy for epithelial ovarian cancer. Consolidative intraperitoneal cisplatin in ovarian cancer.

    abstract:OBJECTIVE:The aim of this study is to evaluate the efficacy of intraperitoneal cisplatin as consolidation treatment in epithelian ovarian cancer patients with complete pathologic response following front-line platin-based chemotherapy. PATIENTS AND METHODS:Thirty patients who had no evidence of disease as assessed by ...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Topuz E,Eralp Y,Saglam S,Saip P,Aydiner A,Berkman S,Yavuz E

    更新日期:2004-01-01 00:00:00

  • Stage IV ovarian cancer: impact of surgical debulking.

    abstract:OBJECTIVE:To evaluate the influence of surgical debulking performed on patients with Stage IV ovarian cancer and to determine prognostic factors which identify pts who may benefit from aggressive initial surgical debulking. METHODS:A retrospective chart review was conducted (1/1/87-12/31/93). Eligible patients include...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Curtin JP,Malik R,Venkatraman ES,Barakat RR,Hoskins WJ

    更新日期:1997-01-01 00:00:00

  • Benign müllerian inclusions in pelvic and paraaortic lymph nodes.

    abstract:OBJECTIVE:This study was undertaken to determine the incidence and distribution of the location of benign müllerian inclusions in pelvic and paraaortic lymph nodes. METHODS:A total of 114 patients operated on for gynecologic malignancy between 1995 and 1998 underwent surgery including systematic pelvic (n = 114) or pe...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Reich O,Tamussino K,Haas J,Winter R

    更新日期:2000-08-01 00:00:00