A multicenter phase II study with triptorelin (sustained-release LHRH agonist) in advanced or recurrent endometrial carcinoma: a French anticancer federation study.

Abstract:

:The objective of this phase II multicenter study was to assess the efficacy and tolerance of triptorelin (a sustained-release LHRH agonist) in advanced or recurrent endometrial cancer. A total of 101 monthly intramuscular injections were administered to 24 eligible patients (median number/patient = 3; range 1-12). Mainly due to progression, only 16 patients received 3 or more injections. Among the 23 evaluable patients, 1 complete and 1 partial response (response rate of 8.7%) and 5 disease stabilizations were observed, often of long duration, but never in an irradiated area or after progestogens treatment failure. Median survival for eligible patients was 7.2 months (range: 1-36 months). Only grade 1 toxicities possibly related to the treatment were observed in 4 patients. In conclusion, triptorelin was safe, well tolerated, and easily manageable, and the very low toxicity did not impair the quality of life in these patients with a very poor prognosis. Although the response rate was disappointing, several patients showed early evidence of efficacy which may be of long duration. Response rates range between 0 and 45% in different published studies. Additional studies with stricter inclusion criteria and a larger sample size are necessary to better evaluate the role of LHRH agonists in endometrial adenocarcinomas.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Lhommé C,Vennin P,Callet N,Lesimple T,Achard JL,Chauvergne J,Luporsi E,Chinet-Charrot P,Coudert B,Couette JE,Guastalla JP,Lebrun D,Ispas S,Blumberg J

doi

10.1006/gyno.1999.5538

subject

Has Abstract

pub_date

1999-11-01 00:00:00

pages

187-93

issue

2

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(99)95538-5

journal_volume

75

pub_type

临床试验,杂志文章,多中心研究
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