Adjunctive hysterectomy following radiation therapy for bulky carcinoma of the uterine cervix: prognostic implications of tumor persistence.

abstract：BACKGROUND:Nongestational pure ovarian choriocarcinoma is a rare malignancy with only 29 cases described to date. CASE:We describe a case associated with mature cystic teratoma of the contralateral ovary. Details of all 30 cases including clinical features, associations, surgicopathological findings, operative procedu...

journal_title：Gynecologic oncology

authors： Goswami D,Sharma K,Zutshi V,Tempe A,Nigam S

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to clarify the usefulness of cystoscopy in the staging of cervical cancer and to evaluate the clinical indications for performing ureteric catheterization to rule out ureteral obstruction in cervical cancer. METHODS:Both rigid cystoscopy and CT were performed before treatment in pat...

journal_title：Gynecologic oncology

authors： Liang CC,Tseng CJ,Soong YK

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVES:SGN-00101 (HspE7, Nventa, San Diego, CA) is a novel therapeutic vaccine consisting of a fusion protein containing an M. bovis BCG heat shock protein (Hsp65) covalently linked to the entire sequence of HPV 16 E7. This trial was designed to evaluate the efficacy and toxicities of HspE7 in women with CIN III. ...

journal_title：Gynecologic oncology

authors： Einstein MH,Kadish AS,Burk RD,Kim MY,Wadler S,Streicher H,Goldberg GL,Runowicz CD

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:The purpose of this case-controlled study was to determine the prevalence of anemia and incidence of perioperative blood transfusions in patients undergoing treatment for advanced ovarian cancer with neoadjuvant chemotherapy (NACT) or primary debulking surgery (PDS). METHODS:We performed a single institution...

journal_title：Gynecologic oncology

authors： O'Shea A,McCool K,Harrison R,Sampene E,Connor J,Barroilhet L

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:There is a need to find agents with activity in platinum and taxane refractory ovarian cancer to be employed as second-line therapy in the malignancy. Limited clinical trial experience has suggested that gemcitabine possesses activity in this clinical setting. We wished to further define the level of activity...

journal_title：Gynecologic oncology

authors： Markman M,Webster K,Zanotti K,Kulp B,Peterson G,Belinson J

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:Preoperative identification of cervical stromal invasion in endometrial carcinoma is important to select patients for primary radical hysterectomy. The objective of this prospective implementation study was to assess if introduction of magnetic resonance imaging (MRI) in addition to the standardly applied end...

journal_title：Gynecologic oncology

authors： Haldorsen IS,Berg A,Werner HM,Magnussen IJ,Helland H,Salvesen OO,Trovik J,Salvesen HB

更新日期：2012-09-01 00:00:00

abstract：:In a series of 38 nonmetastasizing and 29 metastasizing endometrial cancers, histologic subtype, aneuploidy, nuclear grade, and depth of myometrial invasion were the features most distinctly separating these two groups of patients. The most important factor was histologic type: papillary, papillary serous, adenosquamo...

journal_title：Gynecologic oncology

authors： Symonds DA

更新日期：1990-12-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to determine the utility of DNA flow cytometry as a prognostic indicator for risk of recurrence and overall survival in patients with early stage adenocarcinomas of the uterine cervix. METHODS:DNA flow cytometry was performed to determine ploidy, DNA index, and proliferative ind...

journal_title：Gynecologic oncology

authors： Magtibay PM,Perrone JF,Stanhope CR,Katzmann JA,Keeney GL,Li H

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVES:MKK4 is a metastasis suppressor that is downregulated in some ovarian cancers. We sought to investigate whether promoter methylation, loss of heterozygosity, or changes in phosphorylation are involved in MKK4 dysregulation during ovarian carcinogenesis. METHODS:Bisulfite sequencing was used to determine MKK...

journal_title：Gynecologic oncology

authors： Spillman MA,Lacy J,Murphy SK,Whitaker RS,Grace L,Teaberry V,Marks JR,Berchuck A

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:The standard therapy for invasive uterine cervical cancer causes loss of the woman's fertility. We report a successful pregnancy in a patient who desired fertility-sparing management of invasive cervical cancer and was treated with systemic chemotherapy and conization. CASE:A 28-year-old nulliparous woman w...

journal_title：Gynecologic oncology

authors： Kobayashi Y,Akiyama F,Hasumi K

更新日期：2006-01-01 00:00:00

abstract：:Steroid cell tumors, not otherwise specified, are rare ovarian sex cord-stromal tumors with malignant potential. The majority of these tumors produce steroids with testosterone being the most common. A case of a 46-year-old woman who presented with sudden onset of virilization and a pelvic mass is reported. Various as...

journal_title：Gynecologic oncology

authors： Reedy MB,Richards WE,Ueland F,Uy K,Lee EY,Bryant C,van Nagell JR Jr

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:The goal of this work was to determine the cellular content of inhibin and p53 in granulosa cell tumors (GCTs). METHODS:Clinical records of 47 patients (mean age, 54 years; range, 20-85 years) presenting with GCT surgically managed at our institution were abstracted. International Federation of Gynecology st...

journal_title：Gynecologic oncology

authors： Gebhart JB,Roche PC,Keeney GL,Lesnick TG,Podratz KC

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVES:The aim of this prospective study was to evaluate the impact of integrated PET-CT on treatment management in ovarian carcinoma recurrence suspicion because of increased CA-125. METHODS:Twenty-nine patients (mean age=61 years), initially treated for ovarian carcinoma (FIGO stage I n=2, stage II n=3, stage II...

journal_title：Gynecologic oncology

authors： Soussan M,Wartski M,Cherel P,Fourme E,Goupil A,Le Stanc E,Callet N,Alexandre J,Pecking AP,Alberini JL

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:Our aim was to evaluate the feasibility of a novel technique using single-port laparoscopy for the complete surgical staging of endometrial cancer. METHODS:Total hysterectomy, bilateral salpingo-oophorectomy, pelvic lymphadenectomy and para-aortic lymphadenectomy was performed using a single-port device in t...

journal_title：Gynecologic oncology

authors： Zapardiel I,Moreno E,Piñera A,De Santiago J

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:Although the incidence of cervical adenocarcinoma is increasing, few genetic and epigenetic changes in its progression have been described. We hypothesized that RASSF1A methylation and KRAS and BRAF mutations may play an important role in cervical adenocarcinoma. METHODS:Archival primary carcinoma tissues (n...

journal_title：Gynecologic oncology

authors： Kang S,Kim HS,Seo SS,Park SY,Sidransky D,Dong SM

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Hemangiomas are very rare tumors of the ovary. Here, we report a case of a mixed capillary and cavernous ovarian hemangioma and endometrial carcinoma presenting with postmenopausal bleeding, male pattern receding frontal hairline, and high serum androgen and estradiol levels. CASE:A 70-year-old White female...

journal_title：Gynecologic oncology

authors： Gücer F,Ozyilmaz F,Balkanli-Kaplan P,Mülayim N,Aydin O

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVES:Fixed-dose rate gemcitabine plus docetaxel is active as second-line therapy for metastatic uterine leiomyosarcoma. We sought to determine the activity of this regimen as first-line treatment. METHODS:Eligible women with advanced uterine leiomyosarcoma were treated with gemcitabine 900 mg/m(2) over 90 min, o...

journal_title：Gynecologic oncology

authors： Hensley ML,Blessing JA,Mannel R,Rose PG

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:To test whether platelets could increase invasion potential and initiate EMT in ovarian cancer cells via a TGF-β signaling pathway. METHODS:Blood samples were collected in 69 patients with ovarian cancer, 16 patients with benign ovarian tumor and 64 healthy donors. SK-OV-3 and OVCAR-3 ovarian cancer cells we...

journal_title：Gynecologic oncology

authors： Guo Y,Cui W,Pei Y,Xu D

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:To identify patients with endometrial cancer at risk for hematogenous, lymphatic, or peritoneal recurrence (or combinations of them) who might potentially benefit from target-based therapies. METHODS:During a 13-year period, 915 patients had endometrial cancer managed with hysterectomy and standard adjuvant ...

journal_title：Gynecologic oncology

authors： Mariani A,Dowdy SC,Keeney GL,Long HJ,Lesnick TG,Podratz KC

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Several cytokines have been associated with immune regulation and prognosis in ovarian cancer. CD4+CD25+ Tregs and CD3+CD56+ NK-like T cells are involved in the immune response against the tumor. We have investigated the association of cytokines in the ascites from patients with ovarian cancer with these pop...

journal_title：Gynecologic oncology

authors： Bamias A,Koutsoukou V,Terpos E,Tsiatas ML,Liakos C,Tsitsilonis O,Rodolakis A,Voulgaris Z,Vlahos G,Papageorgiou T,Papatheodoridis G,Archimandritis A,Antsaklis A,Dimopoulos MA

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Treatment with weekly cisplatin (CDDP) plus radiotherapy (RT) is the standard regimen for stage IB to stage IVA cervical carcinoma (CC). We performed a systematic review and meta-analysis of published studies to evaluate whether CDDP-based doublet therapy improves survival compared to weekly CDDP plus RT in ...

journal_title：Gynecologic oncology

authors： Petrelli F,De Stefani A,Raspagliesi F,Lorusso D,Barni S

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:To examine associations between post-diagnosis use of antihypertensive (AH) medications including thiazide diuretics (TDs), angiotensin converting enzyme inhibitors (ACEIs), beta blockers (BBs) [both non-selective (NSBBs) and selective (SBBs)] and calcium channel blockers (CCBs) and ovarian cancer-specific su...

journal_title：Gynecologic oncology

authors： Harding BN,Delaney JA,Urban RR,Weiss NS

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:The aim of this retrospective multicenter study was to assess whether the pre-chemotherapy hemoglobin levels have any impact on the clinical outcome of patients with advanced epithelial ovarian cancer who received a first-line taxane/platinum-based regimen. METHODS:The study was conducted on 315 patients who...

journal_title：Gynecologic oncology

authors： Gadducci A,Sartori E,Landoni F,Zola P,Maggino T,Colombo N,Fanucchi A,Chiudinelli F,Lapresa M,Maria Ferrero A

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to define the clinical-therapeutical approach to endometrial cancer now being followed in some of the most important centers of reference for gynecological cancer in North America by means of a questionnaire. STUDY DESIGN:The questionnaire focused on four principal areas: (1) surgic...

journal_title：Gynecologic oncology

authors： Maggino T,Romagnolo C,Landoni F,Sartori E,Zola P,Gadducci A

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVE:To determine whether written information and/or counseling based on the WOMAN-PRO II Program decreases symptom prevalence in women with vulvar neoplasia by a clinically relevant degree, and to explore the differences between the 2 interventions in symptom prevalence, symptom distress prevalence, and symptom e...

journal_title：Gynecologic oncology

authors： Raphaelis S,Mayer H,Ott S,Mueller MD,Steiner E,Joura E,Senn B

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:The present study was undertaken to analyze the impact of epigenetic alterations with a main focus on nuclear area, aneuploidy, hyperploidy, and proliferation in 70 ovarian cancer specimens. METHODS:Morphometric changes and somatic chromosomal ploidy status were assessed by Feulgen spectrophotometry. DNA-hyp...

journal_title：Gynecologic oncology

authors： Zeimet AG,Fiegl H,Goebel G,Kopp F,Allasia C,Reimer D,Steppan I,Mueller-Holzner E,Ehrlich M,Marth C

更新日期：2011-04-01 00:00:00

abstract：:While several different human papillomaviruses (HPV) have been associated with cancer of the cervix, it is yet to be determined if specific HPV types have clinical or prognostic significance. To address this question, 30 cases of invasive carcinoma (squamous carcinoma, adenosquamous carcinoma, and adenocarcinoma) with...

journal_title：Gynecologic oncology

authors： Barnes W,Delgado G,Kurman RJ,Petrilli ES,Smith DM,Ahmed S,Lorincz AT,Temple GF,Jenson AB,Lancaster WD

更新日期：1988-03-01 00:00:00

abstract：:Epithelial ovarian carcinoma consists of not one, but several, entities. A number of subtypes exist, including high-grade and low-grade serous carcinomas, clear cell, endometrioid carcinoma and mucinous carcinoma. Historically, women with epithelial ovarian cancer have been treated similarly and "lumped" in the same c...

journal_title：Gynecologic oncology

authors： Groen RS,Gershenson DM,Fader AN

更新日期：2015-02-01 00:00:00

abstract：:The purpose of this study was to evaluate the serum tumor markers CYFRA 21-1 and squamous-cell carcinoma antigen (SCC) in the follow-up of squamous-cell cervical cancer patients. One hundred-ninety-three serum samples, which were collected pretherapeutically and during follow-up of 30 patients suffering from squamous-...

journal_title：Gynecologic oncology

authors： Kainz C,Sliutz G,Mustafa G,Bieglmayr C,Koelbl H,Reinthaller A,Gitsch G

更新日期：1995-03-01 00:00:00

abstract：:The usefulness of fine needle sampling (FNS) under transvaginal ultrasound guidance in gynecologic oncology patients is evaluated in this study. Between 1990 and 1993, 101 FNS under transvaginal ultrasound guidance were performed in 88 sessions. All targets were located deep in the pelvis and their median diameter was...

journal_title：Gynecologic oncology

authors： Zanetta G,Brenna A,Pittelli M,Lissoni A,Trio D,Riotta S

更新日期：1994-07-01 00:00:00