Vulvovaginal melanoma: report of seven cases and literature review.


:Five cases of primary vaginal melanoma were treated at UCLA Medical Center between 1976 and 1986. Two additional cases of melanoma arising at the junction of the vulva and vagina are presented. One of seven (13%) patients is alive, with a median time to recurrence of 7 months, and median survival of 31 months. Four of five vaginal melanomas were located in the distal vagina, and all were advanced at diagnosis (greater than 3 mm depth). Mean size was 3 cm. Initial therapy was local excision in four patients and radical surgery in three. All patients had suboptimal surgical margins: two vaginal primaries had positive margins after local excision, both recurred vaginally within 5 months. Two patients had margins less than 1 mm, one died of distant metastases, the other is alive with disease 30 months after radical distal vaginectomy and hemivulvectomy with post-op pelvic radiotherapy. Three patients had melanoma in situ at the surgical margins, and each had pelvic recurrences between 6 and 26 months. Five of seven cases developed local recurrence as the initial site of treatment failure. All five vaginal cases ultimately developed distant disease, but only two patients had distant disease without local-regional recurrence. Chemotherapy and immunotherapy enabled disease stabilization in three patients. The vulvovaginal junction at the introitus is a high risk site for vaginal and vulvar melanoma. Intraoperative management requires assessment of lateral and deep spread of invasive and in situ melanoma.


Gynecol Oncol


Gynecologic oncology


Brand E,Fu YS,Lagasse LD,Berek JS




Has Abstract


1989-04-01 00:00:00














  • Polymorphisms of interleukin (IL)-1alpha, IL-1beta, IL-6, IL-10, and IL-18 and the risk of ovarian cancer.

    abstract:OBJECTIVE:Recent studies of ovarian cancer have suggested a role for inflammation in carcinogenesis. Data from a population-based case-control study in Hawaii were examined to assess the relation between polymorphisms in cytokines involved with the inflammatory response, specifically members of the interleukin (IL) fam...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Bushley AW,Ferrell R,McDuffie K,Terada KY,Carney ME,Thompson PJ,Wilkens LR,Tung KH,Ness RB,Goodman MT

    更新日期:2004-12-01 00:00:00

  • Skull metastasis in primary vulvar adenocarcinoma of the Bartholin's gland: a case report.

    abstract:BACKGROUND:Metastatic bone involvement in vulvar squamous carcinoma is very rare. Here, we present a case of primary adenocarcinoma of the Bartholin's gland giving rise to isolated skull metastasis. CASE:A 74-year-old woman was referred with a diagnosis of primary vulvar adenocarcinoma of the right labium minus. A rig...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Ferrandina G,Testa AC,Zannoni GF,Poerio A,Scambia G

    更新日期:2005-08-01 00:00:00

  • Molecular characterization of adenocarcinoma of the cervix.

    abstract::In an attempt to characterize the molecular alterations of cervical adenocarcinoma, we analyzed 32 paraffin-embedded specimens for the presence of K-ras mutations, p53 overexpression, p16 and Rb protein expression, and the presence of HPV 16 and 18 DNA. Overall 25/32 (78%) of the tumors displayed an abnormality in at ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Parker MF,Arroyo GF,Geradts J,Sabichi AL,Park RC,Taylor RR,Birrer MJ

    更新日期:1997-02-01 00:00:00

  • Prospective cohort study of metabolic syndrome and endometrial cancer survival.

    abstract:OBJECTIVE:Comorbidities are known to increase endometrial cancer risk, but the separate and combined impact of these risk factors on endometrial cancer survival remains unclear. This study aimed to determine the associations between metabolic syndrome and its components with disease-free survival, overall survival, end...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kokts-Porietis RL,McNeil J,Nelson G,Courneya KS,Cook LS,Friedenreich CM

    更新日期:2020-09-01 00:00:00

  • Standardization of lower extremity quantitative lymphedema measurements and associated patient-reported outcomes in gynecologic cancers.

    abstract::Practice changing standardization of lower extremity lymphedema quantitative measurements with integrated patient reported outcomes will likely refine and redefine the optimal risk-reduction strategies to diminish the devastating limb-related dysfunction and morbidity associated with treatment of gynecologic cancers. ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Russo S,Walker JL,Carlson JW,Carter J,Ward LC,Covens A,Tanner EJ 3rd,Armer JM,Ridner S,Hayes S,Taghian AG,Brunelle C,Lopez-Acevedo M,Davidson BA,Schaverien MV,Ghamande SA,Bernas M,Cheville AL,Yost KJ,Schmitz K,Coy

    更新日期:2021-02-01 00:00:00

  • Ovarian serous carcinoma presenting with mediastinal lymphadenopathy 20 months before the intraabdominal mass: role of immunohistochemistry.

    abstract:INTRODUCTION:Metastatic involvement of the mediastinal lymph nodes is an extremely uncommon finding in epithelial ovarian cancers. CASE REPORT:A 63-year-old woman was admitted to hospital for dyspnoea due to an anterior mediastinal mass. The surgical biopsy showed a 6-cm metastatic lymph node with a papillary pattern,...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Zannoni GF,Vellone VG,Distefano MG,Fadda G,Scambia G

    更新日期:2007-02-01 00:00:00

  • Normal pregnancy and delivery following conservative surgery and chemotherapy for ovarian endodermal sinus tumor.

    abstract::Management of younger patients with early stage ovarian endodermal sinus tumor who desire to have children can be a challenging problem. However, after an adequate and thorough staging procedure for the patient's tumor status, a Stage Iai endodermal sinus tumor may be treated with conservative surgery only, followed b...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Bakri YN,Given FT Jr

    更新日期:1984-10-01 00:00:00

  • Intracranial metastases from carcinoma cervix and review of literature.

    abstract::Brain metastases from primary cervical carcinoma are uncommon. Only 41 cases have been reported so far in the English literature. We have seen 2 cases over the last 2 years among 481 patients with cervical cancer. Brain metastases developed 7 and 35 months after the primary diagnosis. One patient with solitary metasta...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Kumar L,Tanwar RK,Singh SP

    更新日期:1992-09-01 00:00:00

  • Postsurgical surveillance of patients with FIGO stage I/II endometrial adenocarcinoma.

    abstract:OBJECTIVE:To examine the effect of postsurgical surveillance on survival of patients with FIGO stage I/II endometrial adenocarcinoma. METHODS:We examined the records of 354 patients who underwent primary surgical therapy for FIGO stage I/II endometrial adenocarcinoma. In patients who developed recurrent disease, we de...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Berchuck A,Anspach C,Evans AC,Soper JT,Rodriguez GC,Dodge R,Robboy S,Clarke-Pearson DL

    更新日期:1995-10-01 00:00:00

  • p53 mutations and presence of HPV DNA do not correlate with radiosensitivity of gynecological cancer cell lines.

    abstract:OBJECTIVE:The correlation between p53 tumor suppressor gene mutations and the presence of high-risk human papillomavirus (HPV) DNA with the in vitro radiosensitivity of gynecological malignancies was studied in 26 cell lines derived from gynecological cancers of 23 patients. METHODS:Comparison of the intrinsic radiose...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Rantanen V,Grénman S,Kurvinen K,Hietanen S,Raitanen M,Syrjänen S

    更新日期:1998-12-01 00:00:00

  • Malignant endometrial polyps in postmenopausal breast cancer tamoxifen-treated patients.

    abstract:BACKGROUND:Endometrial polyps are the most common endometrial pathology described in association with postmenopausal tamoxifen exposure. It is generally accepted that the occurrence of malignancy in endometrial polyps among healthy women is up to 0.5%. However, no one has yet described the incidence of this malignant t...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Cohen I,Bernheim J,Azaria R,Tepper R,Sharony R,Beyth Y

    更新日期:1999-10-01 00:00:00

  • Phase II evaluation of oxaliplatin in previously treated squamous cell carcinoma of the cervix: a gynecologic oncology group study.

    abstract:OBJECTIVE:A phase II study was conducted to determine the efficacy of oxaliplatin therapy in patients with previously treated squamous cell carcinoma of the cervix. METHODS:Eligible patients were to have measurable disease and not more than one prior chemotherapy regimen that could include carboplatin or cisplatin but...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Fracasso PM,Blessing JA,Wolf J,Rocereto TF,Berek JS,Waggoner S

    更新日期:2003-07-01 00:00:00

  • Spontaneous arterial thrombosis with an advanced ovarian malignancy.

    abstract::Arterial thromboembolic disease almost always occurs in the setting of significant cardiovascular disease. Fewer than 10% of patients have no known etiology and only rarely is malignancy implicated. A review of the literature revealed only one prior report associated with a gynecologic malignancy, and this occurred in...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Minjarez DA,Delorit MA,Davidson SA

    更新日期:1997-01-01 00:00:00

  • Contracting for professional service agreements.

    abstract::A review of several professional service agreements (PSA) of managed care organizations which contract with gynecologic oncologists in the Southern California area demonstrates several distinct patterns of practice restrictions and financial benefits which can help guide the physician who is considering signing such a...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Berman ML

    更新日期:1995-08-01 00:00:00

  • The incidence and risk factors associated with postoperative delirium in geriatric patients undergoing surgery for suspected gynecologic malignancies.

    abstract:BACKGROUND:The incidence of postoperative delirium (PD) in the elderly ranges between 3-60% but has never been examined in gynecologic oncology. Our goal was to identify pre, intra, and postoperative risk factors associated with the development of PD. METHODS:English speaking women of 60 years and above undergoing maj...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: McAlpine JN,Hodgson EJ,Abramowitz S,Richman SM,Su Y,Kelly MG,Luther M,Baker L,Zelterman D,Rutherford TJ,Schwartz PE

    更新日期:2008-05-01 00:00:00

  • Inverse correlation between RASSF1A hypermethylation, KRAS and BRAF mutations in cervical adenocarcinoma.

    abstract:OBJECTIVE:Although the incidence of cervical adenocarcinoma is increasing, few genetic and epigenetic changes in its progression have been described. We hypothesized that RASSF1A methylation and KRAS and BRAF mutations may play an important role in cervical adenocarcinoma. METHODS:Archival primary carcinoma tissues (n...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kang S,Kim HS,Seo SS,Park SY,Sidransky D,Dong SM

    更新日期:2007-06-01 00:00:00

  • Human papillomavirus analysis as a prognostic marker following conization of the cervix uteri.

    abstract::Cervical intraepithelial neoplasia grade 3 (CIN 3) is treated surgically. Follow-up of these patients is important to ensure successful treatment. The present study was undertaken to determine whether human papillomavirus (HPV) testing can be used to discriminate patients who will have recurrences from those who will ...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Chua KL,Hjerpe A

    更新日期:1997-07-01 00:00:00

  • Relationship of nonstaging pathological risk factors to lymph node metastasis and recurrence in clinical stage I endometrial carcinoma.

    abstract:OBJECTIVE:To determine if DNA ploidy, hormone receptors, vascular space invasion (VSI), perivascular lymphocytes (PVL), and the oncogenes HER-2/neu, p53, and bcl-2 are independent prognostic indicators for lymph node metastasis and cancer recurrence in clinical stage I endometrial carcinoma. METHODS:Among 349 patients...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Bell JG,Minnick A,Reid GC,Judis J,Brownell M

    更新日期:1997-09-01 00:00:00

  • Neoadjuvant bleomycin, etoposide, and cisplatin in adult neuroblastoma arising from the broad ligament of the uterus.

    abstract:BACKGROUND:A case of primary neuroblastoma arising from the broad ligament with excellent response to neoadjuvant bleomycin, etoposide, and cisplatin (BEP) is reported. CASE:A 48-year-old woman, G0, who presented with acute renal failure, an enlarged pelvic mass, and abdominal pain was diagnosed with adult neuroblasto...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Milam MR,Gabel SF,Milam RA,Liu J,Ramirez PT

    更新日期:2007-11-01 00:00:00

  • FGFR2 mutations are rare across histologic subtypes of ovarian cancer.

    abstract:OBJECTIVE:Ovarian cancer is the leading cause of death from gynecologic malignancies in the Western world. Fibroblast growth factor receptor (FGFR) signaling has been implicated to play a role in ovarian tumorigenesis. Mutational activation of one member of this receptor family, FGFR2, is a frequent event in endometrio...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Byron SA,Gartside MG,Wellens CL,Goodfellow PJ,Birrer MJ,Campbell IG,Pollock PM

    更新日期:2010-04-01 00:00:00

  • Soyasaponin-I-modified invasive behavior of cancer by changing cell surface sialic acids.

    abstract:OBJECTIVE:Sialylation involving tumor formation and invasive behavior goes along with altered sialyltransferase (ST) activity. A potent ST inhibitor, soyasaponin I (SsaI), was discovered to selectively inhibit the cellular alpha2,3-sialyltranserase activity. In this study, we further test the effects of SsaI on modifyi...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Hsu CC,Lin TW,Chang WW,Wu CY,Lo WH,Wang PH,Tsai YC

    更新日期:2005-02-01 00:00:00

  • Vulvar intraepithelial neoplasia in women infected with human immunodeficiency virus-1.

    abstract::The purpose of this study was to determine the response of vulvar intraepithelial neoplasia (VIN) lesions to standard treatment methods in women infected with human immunodeficiency virus (HIV). We reviewed all cases of VIN over a 4-year period at an inner-city hospital. We reviewed the clinical records of these women...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Korn AP,Abercrombie PD,Foster A

    更新日期:1996-06-01 00:00:00

  • Multidisciplinary approach in the management of advanced ovarian cancer patients: A personalized approach. Results from a specialized ovarian cancer unit.

    abstract:OBJECTIVE:The aim of the present study was to evaluate the impact of a multidisciplinary approach in patients' selection with advanced ovarian cancer (AOC) for different therapeutic strategies. METHODS:Patients referred at our institution between 2009 and 2012 for AOC were included. Primary multidisciplinary evaluatio...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Aletti GD,Garbi A,Messori P,Achilarre MT,Zanagnolo V,Rizzo S,Alessi S,Bocciolone L,Landoni F,Biffi R,Carinelli S,Colombo N,Maggioni A

    更新日期:2017-03-01 00:00:00

  • Immunohistochemical detection of somatostatin receptors in human ovarian tumors.

    abstract:OBJECTIVE:It is well established that many human tumors can express somatostatin receptors. This is the molecular basis for the application of long-acting somatostatin analogues for therapeutic and diagnostic purposes. However, there are discrepancies in earlier studies regarding the prevalence of somatostatin receptor...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Schulz S,Schmitt J,Quednow C,Roessner A,Weise W

    更新日期:2002-02-01 00:00:00

  • Malignant ovarian tumor composed of endometrioid adenocarcinoma, clear cell adenocarcinoma, squamous cell carcinoma, yolk sac tumor and immature teratoma with prominent neuroectodermal and rhabdomyosarcomatous differentiation: a case study.

    abstract:BACKGROUND:Cases of malignant ovarian tumor composed of müllerian-type epithelial tumor and malignant germ cell tumor are extremely rare. CASE:We herein report the case of a 34-year-old woman with an ovarian tumor which was composed of endometrioid adenocarcinoma (EAC), clear cell adenocarcinoma (CCC), squamous cell c...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Ohishi Y,Kaku T,Kaneki E,Wake N,Tsuneyoshi M

    更新日期:2007-05-01 00:00:00

  • Cytidine deaminase Apobec3a induction in fallopian epithelium after exposure to follicular fluid.

    abstract:OBJECTIVE:Ovarian carcinomas that originate from fallopian epithelial cells are suggested to arise due to repeated exposure to ovulatory follicular fluid (FF). Mechanistic explanation(s) for how this occurs are unknown. Here, we sought to understand if FF exposure to fallopian epithelial cells could induce DNA damage a...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Brachova P,Alvarez NS,Van Voorhis BJ,Christenson LK

    更新日期:2017-06-01 00:00:00

  • Evaluation of deletions in 7q11.2 and 8p12-p21 as prognostic indicators of tumour development following molar pregnancy.

    abstract:OBJECTIVES:Previous studies have identified loss of chromosomal regions 7p12-q11.2 and 8p12-p21 in choriocarcinoma suggesting that suppressor genes involved in tumour development may be located within these regions. Our objectives were to refine the regions of loss and evaluate these deletions as prognostic indicators ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Burke B,Sebire NJ,Moss J,Hodges MD,Seckl MJ,Newlands ES,Fisher RA

    更新日期:2006-11-01 00:00:00

  • Regional lymph node recurrence following local excision for microinvasive vulvar carcinoma.

    abstract::A case of microinvasive squamous cell carcinoma of the vulva is reported in which regional lymph node recurrence was noted after excisional therapy. Review of the initial pathology revealed only 0.72 mm of invasion. The results of a literature survey regarding microinvasive vulvar carcinoma are discussed. ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Atamdede F,Hoogerland D

    更新日期:1989-07-01 00:00:00

  • Stage II endometrial carcinoma: prognostic factors and the results of treatment.

    abstract::Results of treatment and potential prognostic factors in 54 patients with clinical stage II endometrial carcinoma were analyzed. During the period analyzed, three different treatment techniques were used. The highest cure rate (70.6%) was observed in patients treated with simple hysterectomy and bilateral salpingo-oop...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Andersen ES

    更新日期:1990-08-01 00:00:00

  • Detection of human papillomavirus DNA in malignant lesions from Chinese women with carcinomas of the upper genital tract.

    abstract:OBJECTIVE:The aim of this study was to determine the prevalence of high-risk oncogenic human papillomaviruses (HPVs) in malignant lesions from Hong Kong Chinese women with carcinomas of the upper genital tract. METHODS:The presence of high-risk HPVs in 55 cases of endometrial adenocarcinomas and 60 cases of primary ep...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Ip SM,Wong LC,Xu CM,Cheung AN,Tsang PC,Ngan HY

    更新日期:2002-10-01 00:00:00