Cardiac metastasis from carcinoma of the cervix: report of two cases.


BACKGROUND:The presence of cardiac metastasis from cervical carcinoma is extremely rare. The diagnosis is made almost exclusively postmortem. There are few cases of premortem diagnosis, and it is believed that when cardiac metastasis are found in vivo, the prognosis is extremely poor. Due to the rarity of this condition it is very difficult to standardize care for these patients. Considering the evidence provided by the cases in this report, it is possible that aggressive therapy may lengthen patients survival and quality of life. CASE:We present two cases of cervical carcinoma with metastasis to the heart. Both patients presented with symptomatology of cardiac tamponade. Both patients had invasion of the myocardium from presumed endomyocardial metastasis where the prognosis is even worse. We took an aggressive therapeutic approach to our patients and had excellent results in one. Our report includes the longest survival reported for a patient to date with premortem diagnosis of intramyocardial metastasis from cervical carcinoma. CONCLUSION:We concluded that the prognosis for cardiac metastasis from cervical carcinoma is extremely poor. The stage of the disease at initial presentation does not predict the future development of cardiac metastasis. Taking an aggressive therapeutic approach, including thoracentesis, chemotherapy, and radiation therapy to the heart, survival and quality of life can be improved.


Gynecol Oncol


Gynecologic oncology


Lemus JF,Abdulhay G,Sobolewski C,Risch VR




Has Abstract


1998-06-01 00:00:00














  • Large B-cell lymphoma of the uterine corpus: case report with immunohistochemical and molecular study.

    abstract::Primary lymphoma of the uterine corpus (PLUC) is an extremely rare neoplasm. We report a case of PLUC in a 78-year-old woman with vaginal bleeding without hepatosplenomegaly, adenopathies, or bone marrow infiltration, classified as stage I. A diagnosis of diffuse large B-cell lymphoma was made in endometrial curettage...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Alvarez A,Ortiz JA,Sacristán F

    更新日期:1997-06-01 00:00:00

  • Clear cell carcinoma of the ovary: a report from the first Ovarian Clear Cell Symposium, June 24th, 2010.

    abstract:OBJECTIVES:Recent literature has highlighted histological types of ovarian carcinoma as distinct diseases, each with unique clinical and molecular features. Historically, the diagnosis of ovarian clear cell carcinoma (CCC) has been of concern to both patients and physicians due to reports that CCC is associated with a ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Anglesio MS,Carey MS,Köbel M,Mackay H,Huntsman DG,Vancouver Ovarian Clear Cell Symposium Speakers.

    更新日期:2011-05-01 00:00:00

  • Distribution of involucrin in normal and pathological human uterine cervix.

    abstract::A study was undertaken to determine the potential value of involucrin immunostaining, a protein synthesized by mature squamous epithelial cells, in distinguishing benign from neoplastic lesions in cervical pathology. A total of 146 cervical biopsies were analyzed using an indirect immunoperoxidase method and polyclona...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Serra V,Ramirez AA,Lara C,Marzo C,Castells A,Bonilla-Musoles F

    更新日期:1990-01-01 00:00:00

  • Risk-stratification of endometrial carcinomas revisited: a combined preoperative and intraoperative scoring system for a reliable prediction of an advanced disease.

    abstract:OBJECTIVE:The aim of this study is to develop a risk-scoring system for predicting lymph node and distant metastasis in endometrial carcinoma. METHODS:A total of 1166 patients, treated at a single institution between 1-2007 and 12-2013, were included in the study. The association of stage IIIC-IV disease with demograp...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Tuomi T,Pasanen A,Luomaranta A,Leminen A,Bützow R,Loukovaara M

    更新日期:2015-04-01 00:00:00

  • Treatment for fertility and risk of ovarian tumors of borderline malignancy.

    abstract::The relationship between fertility drug use and risk of borderline ovarian cancer has been analyzed using data from a case-control study. Cases were 93 women aged 23 to 64 years with histologically confirmed diagnosis of borderline ovarian tumor (according to the World Health Organization criteria) who were admitted t...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Parazzini F,Negri E,La Vecchia C,Moroni S,Polatti A,Chiaffarino F,Surace M,Ricci E

    更新日期:1998-03-01 00:00:00

  • Vascular endothelial growth factor (VEGF) up-regulates epidermal growth factor receptor (EGF-R) in cervical cancer in vitro: this action is mediated through HPV-E6 in HPV-positive cancers.

    abstract:OBJECTIVES:Epidermal Growth Factor Receptor (EGF-R) up-regulation in cervical cancer cells leads to an increase in cell proliferative Insulin-like Growth Factor II (IGF-II) and Vascular Endothelial Growth Factor (VEGF) and a decrease of the anti-proliferative IGF-binding protein-3 (IGF-BP3). The objectives for this stu...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Mathur RS,Mathur SP

    更新日期:2005-04-01 00:00:00

  • Combining multiple serum tumor markers improves detection of stage I epithelial ovarian cancer.

    abstract:OBJECTIVE:Currently available tumor markers for ovarian cancer are still inadequate in both sensitivity and specificity to be used for population-based screening. Artificial neural network (ANN) as a modeling tool has demonstrated its ability to assimilate information from multiple sources and to detect subtle and comp...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Zhang Z,Yu Y,Xu F,Berchuck A,van Haaften-Day C,Havrilesky LJ,de Bruijn HW,van der Zee AG,Woolas RP,Jacobs IJ,Skates S,Chan DW,Bast RC Jr

    更新日期:2007-12-01 00:00:00

  • High prevalence of genital human papillomavirus type 52 and 58 infection in women attending gynecologic practitioners in South Taiwan.

    abstract:BACKGROUND:We attempted to determine the prevalence of genital human papillomavirus (HPV) infection in women attending gynecologic practitioners in South Taiwan. METHODS:The population included 4383 women aged 16-78 seeking HPV testing at primary gynecologic practitioners regardless of their cervical cytology results....

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Lin H,Ma YY,Moh JS,Ou YC,Shen SY,ChangChien CC

    更新日期:2006-04-01 00:00:00

  • Spatial analysis of adherence to treatment guidelines for advanced-stage ovarian cancer and the impact of race and socioeconomic status.

    abstract:OBJECTIVE:To determine the impact of geographic location on advanced-stage ovarian cancer care adherence to the National Comprehensive Cancer Network (NCCN) guidelines in relation to race and socioeconomic status (SES). METHODS:Patients diagnosed with stage IIIC/IV epithelial ovarian cancer (1/1/96-12/31/06) were iden...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Bristow RE,Chang J,Ziogas A,Anton-Culver H,Vieira VM

    更新日期:2014-07-01 00:00:00

  • Is aspirin use associated with a decreased risk of ovarian cancer? A systematic review and meta-analysis of observational studies with dose-response analysis.

    abstract:OBJECTIVE:Currently available epidemiologic evidences concerning the chemopreventive effect of aspirin on ovarian cancer are inconsistent. Therefore, we aimed to further explore the association by synthesizing evidence from population-based studies. METHODS:We searched PubMed, EMBASE, Web of Science, and Scopus using ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,meta分析,评审


    authors: Zhang D,Bai B,Xi Y,Wang T,Zhao Y

    更新日期:2016-08-01 00:00:00

  • Detection of endometrial cancer cells in the fallopian tube lumen is associated with adverse prognostic factors and reduced survival.

    abstract:OBJECTIVE:Stage is a critical determinant of prognosis and treatment for endometrial cancer (EC) patients. Women who have had a tubal ligation for sterilization have improved EC survival, secondary to lower stage at presentation, suggesting that transtubal spread may represent an important route of metastasis. We evalu...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Felix AS,Sinnott JA,Vetter MH,Rhoades J,Cohn DE,Backes FJ,Sherman ME,Suarez AA

    更新日期:2018-07-01 00:00:00

  • Intraoperative hypothermia during primary surgical cytoreduction for advanced ovarian cancer: risk factors and associations with postoperative morbidity.

    abstract:OBJECTIVE:The objective of this study was to evaluate the risk factors and potential morbidity associated with intraoperative hypothermia (IH) during cytoreductive surgery (CRS) for advanced ovarian cancer. METHODS:Demographic and perioperative data were collected for all patients with stage IIIC-IV ovarian, fallopian...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Long KC,Tanner EJ,Frey M,Leitao MM Jr,Levine DA,Gardner GJ,Sonoda Y,Abu-Rustum NR,Barakat RR,Chi DS

    更新日期:2013-12-01 00:00:00

  • Optimal surgical debulking in uterine papillary serous carcinoma affects survival.

    abstract:OBJECTIVE:UPSC is similar to papillary serous ovarian carcinoma in its histology and pattern of spread. The survival advantage with optimal debulking for ovarian cancer has been demonstrated. We examined our experience with UPSC. METHODS:Seventy-eight UPSC patients were seen between 1995 and 2008 at Rush University Me...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Patsavas K,Woessner J,Gielda B,Rotmensch J,Yordan E,Bitterman P,Guirguis A

    更新日期:2011-06-01 00:00:00

  • ras oncogene product p21 expression and prognosis of human ovarian tumors.

    abstract::Monoclonal antibody rp-28 directed against the ras gene product p21 has been studied to evaluate ras p21 expression in malignant and benign ovarian tissues. Some ovarian carcinomas of serous and mucinous cystadenocarcinomas, undifferentiated adenocarcinomas, and clear cell carcinomas demonstrated intense staining of r...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Yaginuma Y,Yamashita K,Kuzumaki N,Fujita M,Shimizu T

    更新日期:1992-07-01 00:00:00

  • Phase 2 trial of single-agent gemcitabine in platinum-paclitaxel refractory ovarian cancer.

    abstract:OBJECTIVE:There is a need to find agents with activity in platinum and taxane refractory ovarian cancer to be employed as second-line therapy in the malignancy. Limited clinical trial experience has suggested that gemcitabine possesses activity in this clinical setting. We wished to further define the level of activity...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Markman M,Webster K,Zanotti K,Kulp B,Peterson G,Belinson J

    更新日期:2003-09-01 00:00:00

  • Pembrolizumab in patients with programmed death ligand 1-positive advanced ovarian cancer: Analysis of KEYNOTE-028.

    abstract:OBJECTIVE:To evaluate safety, tolerability, and antitumor activity of pembrolizumab monotherapy in patients with programmed death ligand 1 (PD-L1)-expressing advanced ovarian cancer enrolled in the multicohort, phase Ib KEYNOTE-028 trial. METHODS:Key inclusion criteria were age ≥18 years; advanced ovarian epithelial, ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Varga A,Piha-Paul S,Ott PA,Mehnert JM,Berton-Rigaud D,Morosky A,Yang P,Ruman J,Matei D

    更新日期:2019-02-01 00:00:00

  • Bladder function after modified posterior exenteration for primary gynecological cancer.

    abstract:OBJECTIVE:Bladder dysfunction caused by autonomic nerve injury is a well-recognized complication of pelvic surgery. Modified posterior exenteration with or without nerve preservation was performed in patients with primary ovarian, tubal, peritoneal, and endometrial cancer. The aim of this retrospective study was to eva...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kato K,Tate S,Nishikimi K,Shozu M

    更新日期:2013-04-01 00:00:00

  • Overall survival results of AGO-OVAR16: A phase 3 study of maintenance pazopanib versus placebo in women who have not progressed after first-line chemotherapy for advanced ovarian cancer.

    abstract:OBJECTIVE:The AGO-OVAR16 study was designed to test the efficacy, safety, and tolerability of pazopanib maintenance after first-line chemotherapy in patients with newly diagnosed advanced ovarian cancer (AOC). METHODS:Nine hundred and forty patients with histologically confirmed AOC, International Federation of Gyneco...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Vergote I,du Bois A,Floquet A,Rau J,Kim JW,Del Campo JM,Friedlander M,Pignata S,Fujiwara K,Colombo N,Mirza MR,Monk BJ,Tsibulak I,Calvert PM,Herzog TJ,Hanker LC,Meunier J,Lee JY,Bologna A,Carrasco-Alfonso MJ,Harter

    更新日期:2019-11-01 00:00:00

  • Examining the effect of minority status and neighborhood characteristics on cervical cancer survival outcomes.

    abstract:OBJECTIVE:Understanding the factors that contribute to mortality and survival is central to health outcome research. The purpose of this study was to investigate the following: (1) differences in survival status by ethnicity and neighborhood median income level; and (2) individual- and neighborhood-level factors influe...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Lim JW,Ashing-Giwa KT

    更新日期:2011-04-01 00:00:00

  • Detection of chromogranin in argyrophil cells of endometrial carcinoma.

    abstract::Normal and neoplastic endometrial tissues were examined immunohistochemically for chromogranin which was shown to be a specific marker for neuroendocrine cells. All 20 normal endometriums and 20 endometrial carcinomas without argyrophilia were chromogranin negative. Endometrial carcinomas with argyrophilia tested were...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Ueda G,Nishino T,Saito J,Abe Y,Shimizu H,Tanizawa O

    更新日期:1987-06-01 00:00:00

  • Platelets promote invasion and induce epithelial to mesenchymal transition in ovarian cancer cells by TGF-β signaling pathway.

    abstract:OBJECTIVE:To test whether platelets could increase invasion potential and initiate EMT in ovarian cancer cells via a TGF-β signaling pathway. METHODS:Blood samples were collected in 69 patients with ovarian cancer, 16 patients with benign ovarian tumor and 64 healthy donors. SK-OV-3 and OVCAR-3 ovarian cancer cells we...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Guo Y,Cui W,Pei Y,Xu D

    更新日期:2019-06-01 00:00:00

  • Inverse expression of Cdk4 and p16 in epithelial ovarian tumors.

    abstract:OBJECTIVES:The aim of this study was to elucidate the expression and the correlation of two cell cycle regulators, cdk4 and its inhibitor p16, in a series of benign, borderline, and malignant ovarian tumors and to evaluate whether their alterations correlate with clinicopathologial parameters and patients' prognosis in...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Sui L,Dong Y,Ohno M,Goto M,Inohara T,Sugimoto K,Tai Y,Hando T,Tokuda M

    更新日期:2000-11-01 00:00:00

  • Application of proteomics in ovarian cancer: which sample should be used?

    abstract:OBJECTIVE:In the last decade several studies have been published using proteomics to unravel molecular pathways and to find biomarkers which can be used for diagnosis and/or prognostication in ovarian cancer. This review gives an overview of proteomic studies performed in ovarian cancer focusing on the nature of sample...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Cadron I,Van Gorp T,Timmerman D,Amant F,Waelkens E,Vergote I

    更新日期:2009-12-01 00:00:00

  • Biochemical and immunohistochemical studies on carcinoembryonic antigen of ovarian mucinous and serous tumors.

    abstract::The carcinoembryonic antigen (CEA) in the cyst fluid of ovarian mucinous and serous tumors was investigated. The molecular weight and antigenicity of the CEA from both ovarian tumors were very similar to those of colon cancer CEA as determined by SDS electrophoresis and double immunodiffusion on agar plates. In the cy...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Tohya T,Iwamasa T,Maeyama M

    更新日期:1986-03-01 00:00:00

  • Standardization of lower extremity quantitative lymphedema measurements and associated patient-reported outcomes in gynecologic cancers.

    abstract::Practice changing standardization of lower extremity lymphedema quantitative measurements with integrated patient reported outcomes will likely refine and redefine the optimal risk-reduction strategies to diminish the devastating limb-related dysfunction and morbidity associated with treatment of gynecologic cancers. ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Russo S,Walker JL,Carlson JW,Carter J,Ward LC,Covens A,Tanner EJ 3rd,Armer JM,Ridner S,Hayes S,Taghian AG,Brunelle C,Lopez-Acevedo M,Davidson BA,Schaverien MV,Ghamande SA,Bernas M,Cheville AL,Yost KJ,Schmitz K,Coy

    更新日期:2021-02-01 00:00:00

  • The role of MicroRNA molecules and MicroRNA-regulating machinery in the pathogenesis and progression of epithelial ovarian cancer.

    abstract::MicroRNA molecules are small, single-stranded RNA molecules that function to regulate networks of genes. They play important roles in normal female reproductive tract biology, as well as in the pathogenesis and progression of epithelial ovarian cancer. DROSHA, DICER, and Argonaute proteins are components of the microR...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Wang X,Ivan M,Hawkins SM

    更新日期:2017-11-01 00:00:00

  • Polymorphisms of interleukin (IL)-1alpha, IL-1beta, IL-6, IL-10, and IL-18 and the risk of ovarian cancer.

    abstract:OBJECTIVE:Recent studies of ovarian cancer have suggested a role for inflammation in carcinogenesis. Data from a population-based case-control study in Hawaii were examined to assess the relation between polymorphisms in cytokines involved with the inflammatory response, specifically members of the interleukin (IL) fam...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Bushley AW,Ferrell R,McDuffie K,Terada KY,Carney ME,Thompson PJ,Wilkens LR,Tung KH,Ness RB,Goodman MT

    更新日期:2004-12-01 00:00:00

  • Endocervical curettage: does it contribute to the management of patients with abnormal cervical cytology?

    abstract::Routine endocervical curettage has been advocated in the colposcopic evaluation of patients with abnormal cervical cytology. To assess the usefulness of this procedure, we reviewed the records of 518 patients referred to the Colposcopy Clinic with abnormal Pap smears. Data was reviewed retrospectively in 411 patients ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Oyer R,Hanjani P

    更新日期:1986-10-01 00:00:00

  • Mucinous adenofibroma of the ovary: case report of the endocrinologic findings.

    abstract::Endocrine and clinicopathologic findings in a 77-year-old woman with ovarian mucinous adenofibroma of borderline malignancy are reported. The preoperative levels of testosterone, androstenedione, estrone, and estradiol in her peripheral blood were 91 ng/ml, 3.78 ng/ml, 82 pg/ml, and 35 pg/ml, respectively, abnormally ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Tohya T,Mizutani H,Katabuchi H,Miyazaki K,Okamura H

    更新日期:1994-08-01 00:00:00

  • A longitudinal study of antigen expression in epithelial ovarian cancer.

    abstract::The extent to which the antigenic phenotype of human epithelial ovarian cancer changes during the course of the disease is an issue that must be addressed in order to maximize the potential of antibody-directed imaging and therapy. We have obtained tumor specimens at two separate operations from ten patients with epit...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Rubin SC,Finstad CL,Hoskins WJ,Federici MG,Lloyd KO,Lewis JL Jr

    更新日期:1989-09-01 00:00:00