Cardiac metastasis from carcinoma of the cervix: report of two cases.


BACKGROUND:The presence of cardiac metastasis from cervical carcinoma is extremely rare. The diagnosis is made almost exclusively postmortem. There are few cases of premortem diagnosis, and it is believed that when cardiac metastasis are found in vivo, the prognosis is extremely poor. Due to the rarity of this condition it is very difficult to standardize care for these patients. Considering the evidence provided by the cases in this report, it is possible that aggressive therapy may lengthen patients survival and quality of life. CASE:We present two cases of cervical carcinoma with metastasis to the heart. Both patients presented with symptomatology of cardiac tamponade. Both patients had invasion of the myocardium from presumed endomyocardial metastasis where the prognosis is even worse. We took an aggressive therapeutic approach to our patients and had excellent results in one. Our report includes the longest survival reported for a patient to date with premortem diagnosis of intramyocardial metastasis from cervical carcinoma. CONCLUSION:We concluded that the prognosis for cardiac metastasis from cervical carcinoma is extremely poor. The stage of the disease at initial presentation does not predict the future development of cardiac metastasis. Taking an aggressive therapeutic approach, including thoracentesis, chemotherapy, and radiation therapy to the heart, survival and quality of life can be improved.


Gynecol Oncol


Gynecologic oncology


Lemus JF,Abdulhay G,Sobolewski C,Risch VR




Has Abstract


1998-06-01 00:00:00














  • Soluble urokinase plasminogen activator receptor in preoperatively obtained plasma from patients with gynecological cancer or benign gynecological diseases.

    abstract:OBJECTIVE:The present study was planned to measure preoperative levels of soluble urokinase plasminogen activator receptor (suPAR) in plasma from patients with gynecological diseases, and to test for a relationship to clinical and biochemical patient characteristics. METHODS:Using a specific and sensitive kinetic ELIS...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Riisbro R,Stephens RW,Brünner N,Christensen IJ,Nielsen HJ,Heilmann L,von Tempelhoff GF

    更新日期:2001-09-01 00:00:00

  • Solitary recurrent metastasis of epithelial ovarian cancer in the spleen.

    abstract::In epithelial ovarian cancer, solitary metastasis to and recurrences in the parenchyma of the spleen are rare in the absence of apparent disease in other sites. We report four patients who developed isolated, solitary splenic parenchymal recurrences of their epithelial ovarian adenocarcinomas and underwent a splenecto...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Farias-Eisner R,Braly P,Berek JS

    更新日期:1993-03-01 00:00:00

  • Skull metastasis in primary vulvar adenocarcinoma of the Bartholin's gland: a case report.

    abstract:BACKGROUND:Metastatic bone involvement in vulvar squamous carcinoma is very rare. Here, we present a case of primary adenocarcinoma of the Bartholin's gland giving rise to isolated skull metastasis. CASE:A 74-year-old woman was referred with a diagnosis of primary vulvar adenocarcinoma of the right labium minus. A rig...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Ferrandina G,Testa AC,Zannoni GF,Poerio A,Scambia G

    更新日期:2005-08-01 00:00:00

  • Enhanced radiosensitization with interferon-alpha-2b and cisplatin in the treatment of locally advanced cervical carcinoma.

    abstract:PURPOSE:To evaluate the efficacy and toxicity of interferon-alpha-2b (IFN-alpha) and cisplatin given concomitantly with radiation therapy (RT) in the treatment of locally advanced cervical carcinoma. MATERIALS AND METHODS:Twenty-one patients with stage bulky Ib-IIIb (Ib, 2; IIa, 2; IIb, 8; IIIb, 9) cervical carcinoma ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Stock RG,Dottino P,Jennings TS,Terk M,DeWyngaert JK,Beddoe AM,Cohen C

    更新日期:1997-12-01 00:00:00

  • Tolfenamic acid inhibits ovarian cancer cell growth and decreases the expression of c-Met and survivin through suppressing specificity protein transcription factors.

    abstract:OBJECTIVE:The aberrant expression of hepatocyte growth factor and its receptor c-Met are associated with aggressive disease and poor prognosis in a variety of human malignancies including ovarian cancer (OC). Specificity protein (Sp) transcription factors have high relevance in the signaling cascade associated with c-M...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Basha R,Ingersoll SB,Sankpal UT,Ahmad S,Baker CH,Edwards JR,Holloway RW,Kaja S,Abdelrahim M

    更新日期:2011-07-01 00:00:00

  • A phase II trial of high-dose mitoxantrone, carboplatin, and cyclophosphamide with autologous bone marrow rescue for recurrent epithelial ovarian carcinoma: analysis of risk factors for clinical outcome.

    abstract::Despite high initial response rates to platinum-based chemotherapy, most patients with advanced ovarian carcinoma die of drug-resistant disease. Drug resistance can be overcome in the hematologic malignancies and lymphomas with high-dose therapy and bone marrow transplantation (BMT) when used early, suggesting that th...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Stiff P,Bayer R,Camarda M,Tan S,Dolan J,Potkul R,Loutfi S,Kinch L,Sosman J,Peace D

    更新日期:1995-06-01 00:00:00

  • BARD1, a possible biomarker for breast and ovarian cancer.

    abstract::Breast cancer is the leading cause of cancer death in women. Ovarian cancer, although less frequent, is detected very late, and survival is correlated to early detection. Therefore, better methods for early detection would help to increase the number of survivors. The incidence of young women diagnosed with breast can...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Irminger-Finger I

    更新日期:2010-05-01 00:00:00

  • Breast cancer metastatic to the vulva.

    abstract:BACKGROUND:Primary cancer of the vulva is not common, constituting only 3-5% of all gynecologic malignancies and <1% of all cancer in the female. Metastatic tumors of the vulva are even more unusual, constituting only 5-8% of all vulvar cancers. CASE:A 32-year-old female underwent total mastectomy with axillary lymph ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Sheen-Chen SM,Eng HL,Huang CC

    更新日期:2004-09-01 00:00:00

  • Endometrial cancer in the oldest old: Tumor characteristics, patterns of care, and outcome.

    abstract:OBJECTIVE:Despite the fact that endometrial cancer commonly occurs in elderly women, little is known about the outcome of the oldest old, those > 80 years of age. We examined the patterns of care and outcome of the oldest old women with endometrial cancer. METHODS:An analysis of women > 65 years of age with endometrio...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Wright JD,Lewin SN,Barrena Medel NI,Sun X,Burke WM,Deutsch I,Herzog TJ

    更新日期:2011-07-01 00:00:00

  • Disparities in hospice care among older women dying with ovarian cancer.

    abstract:BACKGROUND:Timely hospice referral is an essential component of quality end-of-life care, although a growing body of research suggests that for patients with various types of cancer, hospice referrals often occur very late in the course of care, and are marked by sociodemographic disparities. However, little is known a...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Fairfield KM,Murray KM,Wierman HR,Han PK,Hallen S,Miesfeldt S,Trimble EL,Warren JL,Earle CC

    更新日期:2012-04-01 00:00:00

  • Endometrial response to endogenous hormones after pelvic irradiation for genital malignancies.

    abstract::Two cases are presented which demonstrate histologically an endometrial response to endogenous hormones after pelvic teletherapy and brachytherapy in patients who have undergone lateral ovarian transposition. Reasons for such a response are briefly discussed. ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Larson JE,Whitney CW,Zaino R,Kaminski P,Podczaski E,Mortel R

    更新日期:1990-01-01 00:00:00

  • Primary mucinous cystoadenocarcinoma of the retroperitoneum: two cases.

    abstract::Two cases of primary retroperitoneal mucinous cystoadenocarcinoma of the ovarian type are reported. Both tumors occurred in females with bilateral normal ovaries and contained benign, borderline, and malignant mucinous epithelium. Full-thickness infiltration of the cyst wall was not found. In addition to surgery, one ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Tenti P,Carnevali L,Tateo S,Durola R

    更新日期:1994-11-01 00:00:00

  • Intraoperative hypothermia during primary surgical cytoreduction for advanced ovarian cancer: risk factors and associations with postoperative morbidity.

    abstract:OBJECTIVE:The objective of this study was to evaluate the risk factors and potential morbidity associated with intraoperative hypothermia (IH) during cytoreductive surgery (CRS) for advanced ovarian cancer. METHODS:Demographic and perioperative data were collected for all patients with stage IIIC-IV ovarian, fallopian...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Long KC,Tanner EJ,Frey M,Leitao MM Jr,Levine DA,Gardner GJ,Sonoda Y,Abu-Rustum NR,Barakat RR,Chi DS

    更新日期:2013-12-01 00:00:00

  • Comparison of MRI and 18F-FDG PET/CT in the preoperative evaluation of uterine carcinosarcoma.

    abstract:OBJECTIVE:To compare the validities of magnetic resonance imaging (MRI) and (18)F-fluoro-deoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) in preoperative evaluation of uterine carcinosarcoma. METHODS:Pathologic results of primary tumor lesions and paraaortic and pelvic lymph node (LN) a...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Lee HJ,Park JY,Lee JJ,Kim MH,Kim DY,Suh DS,Kim JH,Kim YM,Kim YT,Nam JH

    更新日期:2016-03-01 00:00:00

  • Characteristics of women with ovarian carcinoma who have BRCA1 and BRCA2 mutations not identified by clinical testing.

    abstract:OBJECTIVES:Few studies have comprehensively tested all ovarian cancer patients for BRCA1 and BRCA2 (BRCA1/2) mutations. We sought to determine if clinically identified mutation carriers differed in clinical characteristics and outcomes from mutation carriers not identified during routine clinical care. METHODS:We incl...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Norquist BM,Pennington KP,Agnew KJ,Harrell MI,Pennil CC,Lee MK,Casadei S,Thornton AM,Garcia RL,Walsh T,Swisher EM

    更新日期:2013-03-01 00:00:00

  • Loop electrocautery excisional procedure: therapeutic effectiveness as an ablation and a conization equivalent.

    abstract::This study was designed to compare the effectiveness of loop excision procedures as ablation and conization equivalents, and their use in recurrent cervical high-grade dysplasia patients. We retrospectively reviewed patients undergoing loop procedures between January 1992 and April 1994. Conization equivalents were de...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Gold M,Dunton CJ,Murray J,Macones G,Hanau C,Carlson JA Jr

    更新日期:1996-05-01 00:00:00

  • A phase II study of intraperitoneal cisplatin and thiotepa in residual ovarian carcinoma: a Gynecologic Oncology Group study.

    abstract:OBJECTIVE:Patients with advanced epithelial ovarian cancer treated with salvage therapy using new combinations of systemic chemotherapy, radiation therapy, and systemic immunotherapy have had limited success. Since the most common site of relapse or failure to conventional systemic chemotherapy has been the peritoneal ...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Feun LG,Blessing JA,Major FJ,DiSaia PJ,Alvarez RD,Berek JS

    更新日期:1998-12-01 00:00:00

  • Sentinel lymph node biopsy in the management of early-stage cervical carcinoma.

    abstract:OBJECTIVES:We aimed to determine the sentinel lymph node detection rates, accuracy in predicting the status of lymph node metastasis, and if pathologic ultrastaging improves the detection of micrometastases and isolated tumor cells at the time of primary surgery for cervical cancer. METHODS:A prospective, non-randomiz...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Diaz JP,Gemignani ML,Pandit-Taskar N,Park KJ,Murray MP,Chi DS,Sonoda Y,Barakat RR,Abu-Rustum NR

    更新日期:2011-03-01 00:00:00

  • Impact of robotics on the outcome of elderly patients with endometrial cancer.

    abstract:OBJECTIVE:To evaluate the impact of introducing a robotics program on clinical outcome of elderly patients with endometrial cancer. METHODS:Evaluation and comparison of peri-operative morbidity and disease-free interval in 163 consecutive elderly patients (≥70years) with endometrial cancer undergoing staging procedure...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Lavoue V,Zeng X,Lau S,Press JZ,Abitbol J,Gotlieb R,How J,Wang Y,Gotlieb WH

    更新日期:2014-06-01 00:00:00

  • The prognostic significance of peritoneal seeding and size of postsurgical residual in patients with stage III epithelial ovarian cancer treated with surgery, chemotherapy, and high-dose radiotherapy.

    abstract:OBJECTIVE:The aim of this study was to retrospectively analyze the prognostic importance of age, histologic type and grade, ascites, lymph node status, size and type of postoperative residual disease, and radiation dose on disease-specific (DSS) and progression-free survival (PFS) in stage III epithelial ovarian cancer...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kapp KS,Kapp DS,Poschauko J,Stücklschweiger GF,Hackl A,Pickel H,Petru E,Winter R

    更新日期:1999-09-01 00:00:00

  • A prognostic nomogram to predict overall survival in women with recurrent ovarian cancer treated with bevacizumab and chemotherapy.

    abstract:OBJECTIVE:To develop a nomogram to predict overall survival (OS) in women with recurrent ovarian cancer treated with bevacizumab and chemotherapy. METHODS:A multicenter retrospective study was conducted. Potential prognostic variables included age; stage; grade; histology; performance status; residual disease; presenc...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Previs RA,Bevis KS,Huh W,Tillmanns T,Perry L,Moore K,Chapman J,McClung C,Kiet T,Java J,Chan J,Secord AA

    更新日期:2014-03-01 00:00:00

  • Etiologic heterogeneity in endometrial cancer: evidence from a Gynecologic Oncology Group trial.

    abstract:OBJECTIVE:Although the epidemiology of typical endometrial carcinomas (grades 1-2 endometrioid or Type I) is well established, less is known regarding higher grade endometrioid or non-endometrioid carcinomas (Type II). Within a large Gynecologic Oncology Group trial (GOG-210), which included central pathology review, w...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Brinton LA,Felix AS,McMeekin DS,Creasman WT,Sherman ME,Mutch D,Cohn DE,Walker JL,Moore RG,Downs LS,Soslow RA,Zaino R

    更新日期:2013-05-01 00:00:00

  • Phase II study of concurrent chemoradiotherapy with high-dose-rate intracavitary brachytherapy in patients with locally advanced uterine cervical cancer: efficacy and toxicity of a low cumulative radiation dose schedule.

    abstract:OBJECTIVE:A multicenter phase II trial was conducted to assess the efficacy and toxicity of concurrent chemoradiotherapy (CCRT) with high-dose-rate intracavitary brachytherapy (HDR-ICBT) using a low cumulative prescribed dose schedule in patients with locally advanced uterine cervical cancer. METHODS:The Japanese Gyne...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Toita T,Kitagawa R,Hamano T,Umayahara K,Hirashima Y,Aoki Y,Oguchi M,Mikami M,Takizawa K,Cervical Cancer (Vulva Cancer) Committee of Japanese Gynecologic Oncology Group (JGOG).

    更新日期:2012-08-01 00:00:00

  • Travel distance, hospital volume and their association with ovarian cancer short- and long-term outcomes.

    abstract:OBJECTIVE:To examine patterns of patient travel among women with ovarian cancer and to explore the association between travel distance and short and long-term outcomes. METHODS:Women with stage II-IV epithelial ovarian cancer diagnosed from 2004 to 2016 who underwent primary surgery were identified in the National Can...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Knisely A,Huang Y,Melamed A,Tergas AI,St Clair CM,Hou JY,Khoury-Collado F,Ananth CV,Neugut AI,Hershman DL,Wright JD

    更新日期:2020-08-01 00:00:00

  • Durability of clinical performance afforded by self-collected HPV testing: A 15-year cohort study in China.

    abstract:OBJECTIVE:Self-collected HPV testing could substantially reduce disparities in cervical cancer screening, with slightly lower sensitivity compared to physician-collected specimens cross-sectionally. We aimed to evaluate the comprehensive long-term performance of self-collected HPV testing prospectively. METHODS:In 199...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Zhang L,Xu XQ,Hu SY,Chen F,Zhang X,Pan QJ,Zhang WH,Feng RM,Dong L,Zhang Q,Ma JF,Sauvaget C,Zhao FH,Qiao YL,Sankaranarayanan R

    更新日期:2018-11-01 00:00:00

  • Urinary tract dysfunction after radical hysterectomy for cervical cancer.

    abstract:OBJECTIVES:To evaluate the urinary tract dysfunction following a radical hysterectomy and to compare the baseline urodynamical parameters of women who had uterine cervical carcinoma with women who had CIN 3. METHODS:A prospective case-control study was conducted to evaluate preoperative and postoperative urinary tract...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Chen GD,Lin LY,Wang PH,Lee HS

    更新日期:2002-05-01 00:00:00

  • Participation of the general gynecologist in surgical staging of endometrial cancer: analysis of cost and perioperative outcomes.

    abstract:OBJECTIVE:To compare the cost and perioperative outcomes of endometrial cancer staging when the procedure is performed by a gynecologic oncologist alone or when a general gynecologist participates in the procedure. METHODS:A retrospective analysis was performed on a series of women with clinical stage I endometrial ca...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Hoekstra A,Singh DK,Garb M,Arekapudi S,Rademaker A,Lurain JR

    更新日期:2006-12-01 00:00:00

  • K-ras mutations in Müllerian inclusion cysts associated with serous borderline tumors of the ovary.

    abstract:OBJECTIVE:Müllerian inclusion cysts (MIC) are small benign appearing glands that are occasionally noted in lymph nodes and peritoneal biopsies. They occur most frequently in women with serous ovarian tumors, with borderline tumors (SBOT) having a higher incidence than invasive cancers. The aim of this study was to exam...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Alvarez AA,Moore WF,Robboy SJ,Bentley RC,Gumbs C,Futreal PA,Berchuck A

    更新日期:2001-02-01 00:00:00

  • Women with HIV are more commonly infected with non-16 and -18 high-risk HPV types.

    abstract:OBJECTIVE:To review and summarize evidence from clinical, translational and epidemiologic studies which have examined the clinically relevant aspects of HPV type prevalence and cervical dysplasia in HIV-infected women. METHODS:Relevant studies were identified through a MEDLINE search. References of identified reports ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: McKenzie ND,Kobetz EN,Hnatyszyn J,Twiggs LB,Lucci JA 3rd

    更新日期:2010-03-01 00:00:00

  • Optimal surgical cytoreduction in patients with Stage III and Stage IV endometrial carcinoma: a study of morbidity and survival.

    abstract:OBJECTIVE:To evaluate the survival impact of residual disease at the time of primary surgery for patients with Stage III and IV endometrial carcinoma; to assess morbidity associated with surgical cytoreduction. METHOD:All patients with endometrial carcinoma who underwent primary surgical therapy at the University of M...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Lambrou NC,Gómez-Marín O,Mirhashemi R,Beach H,Salom E,Almeida-Parra Z,Peñalver M

    更新日期:2004-06-01 00:00:00